Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 4, 1998, Pages 1852-1857

  Kimonides, V G ^a   Khatibi, N H ^a   Svendsen, C N ^a   Sofroniew, M V ^a   Herbert, J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BETA TUBULIN; EXCITATORY AMINO ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; PRASTERONE; PRASTERONE SULFATE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; EMBRYO; FETUS; HIPPOCAMPUS; MALE; NERVE CELL CULTURE; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; KAINIC ACID; N-METHYLASPARTATE; NEURONS; RATS; TIME FACTORS;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0032539540     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.4.1852     Document Type: Article

References (24)

1. Orentreich, N., Brind, J. L., Vogelman, J. H., Andres, R. & Baldwin, H. (1992) J. Clin Endocrin. Metab. 75, 1002-1004.
2. Goodyer, I. M., Herbert, J., Altham, P. M. E., Pearson, J., Secher, S. M. & Shiers, H. M. (1996) Psychol. Med. 26, 245-256.
3. Herbert, J., Goodyer, I. M., Altham, P. M. E., Pearson, J., Secher, S. M. & Shiers, H. M. (1996) Psychol. Med. 26, 257-263.
4. Hedman, M., Nilsson, E. & Torre, B. (1992) Clin. Exp. Rheumatol. 10, 25-30.
5. Spratt, D. I, Longcope, C., Cox, P. M., Bigos, S. T. & Wilbur-Welling, C. (1993) J. Clin. Endocrin. Metab. 72, 1542-1547.
6. Majewska, M. D., Demigoren, S., Spivak, C. E. & London, E. D. (1990) Brain Res. 526, 143-146.
7. French-Mullen, J. M. H. & Spence, K. T. (1991) Eur. J. Pharmacol. 202, 269-272.
8. Flood, J. F., Morley, J. E. & Roberts, E. (1992) Proc. Natl. Acad. Sci. USA. 89, 1567-1571.
9. Schlegel, M. L., Spetz, J. F., Robel, P. & Haug, M. (1985) Physiol. Behav. 34, 867-870.
10. Sapolsky, R. M. (1992) Stress, the Aging Brain, and the Mechanisms of Neuron Death (MIT Press, Cambridge, MA).
11. Simon, R. P., Swan, J. H., Griffiths, T. & Meldrum, B. S. (1984) Science 226, 850-852.
12. Benveniste, H., Drejer, J., Schousboe, A. & Diemer, N. H. (1984) J. Neurochem. 43, 1369-1374.
13. Choi, D. W. (1988) Neuron 1, 623-634.
14. Brewer, G. J. & Cotman, C. W. (1989) Brain Res. 494, 65-74.
15. Svendsen, C. N., Kew, J. N. C., Staley, K. & Sofroniew, M. V. (1994) J. Neurosci. 14, 75-87.
16. Koh, J. Y. & Choi, D. W. (1987) J. Neurosci. Methods 20, 83-90.
17. Guazzo, E. P., Kirkpatrick, P. J., Goodyer, I. M., Shiers, H. M. & Herbert, J. (1996) J. Clin. Endocrin. Metab. 81, 3951-3960.
18. Garthwaite, G. & Garthwaite, J. (1986) Neurosci. Lett. 66, 193-198.
19. May, M., Holmes, E., Rogers, W. & Poth, M. (1990) Life Sci. 46, 1627-1631.
20. Kerr, D., Campbell, L., Thibault, O. & Landfield, P. (1992) Proc. Natl. Acad. Sci. USA 89, 8527-8531.
21. Armanini, M. P., Hutchins, C., Stein, B. A. & Sapolsky, R. M. (1990) Brain Res. 532, 7-12.
22. Ebeling, P. & Kiovisto, V. A. (1994) Lancet 343, 1479-1481.
23. Bergeron, R., de Montigny, C. & Debonnel, G. (1996) J Neurosci. 16, 1193-1202.
24. Lipton, S. A. & Rosenberg, P. A. (1994) N. Engl. J. Med. 330, 613-622.