The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus

Neuropsychopharmacology

Volumn 15, Issue 6, 1996, Pages 533-540

  Patchev, V K ^a   Hassan, A H S ^a   Holsboer, F ^a   Almeida, O F X ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Cortico steroid receptors; Glucocorticoids; Neurosteroids; Progesterone; Stress; Vasopressin

Indexed keywords

CORTICOSTERONE; DEXAMETHASONE; GLUCOCORTICOID; PROGESTERONE; TETRAHYDROPROGESTERONE; VASOPRESSIN;

ANIMAL EXPERIMENT; ARTICLE; EMOTION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030560881     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(96)00096-6     Document Type: Article

References (42)

1. Antoni FA (1993): Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age. Front Neuroendocrinol 14:76-122
2. Arriza JL, Simerly WB, Swanson LW, Evans RM (1988): The neuronal mineralocorticoid receptor as a mediator of the glucocorticoid response. Neuron 1:887-900
3. Baulieu E-E (1992): Neurosteroids: An overview. In Biggio G, Concas A, Costa E (eds), GABAergic Synaptic Transmission. New York, Raven Press, pp 1-16
4. A receptor. Brain Res 561:157-161
5. Brady LS, Smith M, Gold PW, Herkenham M (1990): Altered expression of hypothalamic neuropeptide mRNA in food-restricted and food-deprived rats. Neuroendocrinology 52:441-447
6. Castrén M, Patchev VK, Almeida OFX, Holsboer F, Trapp T, Castrén E (1995): Regulation of rat mineralocorticoid receptor expression in neurons by progesterone. Endocrinology 136:3800-3806
7. Chao HM, Choo PH, McEwen BS (1989): Glucocorticoid and mineralocorticoid receptor mRNA expression in rat brain. Neuroendocrinology 50:365-371
8. Davis LG, Arentzen R, Reid JM, Manning RW, Wolfson B, Lawrence KL, Baldino F Jr (1986): Glucocorticoid sensitivity of vasopressin mRNA levels in the paraventricular nucleus of the rat. Proc Natl Acad Sci USA 83:1145-1149
9. Gee KW, Bolger MB, Brinton RE, Coirini H, McEwen BS (1988): Steroid modulation of the chloride ionophore in the rat brain: Structure-activity requirements, regional dependence and mechanisms of action. J Pharmacol Exp Ther 246:803-812
10. Gillies GE, Linton EA, Lowry PJ (1982): Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin. Nature 299:355-357
11. Herman JP (1993): regulation of adrenocorticosteroid receptor mRNA expression in the central nervous system. Cell Mol Neurobiol 13:349-371
12. Herman JP, Thomas GJ, Gash DM (1986): Behavioral characteristics of Roman high avoidance rats homozygous for diabetes insipidus (RHA:di/di). Behav Brain Res 20:27-38
13. Herman JP, Schaefer MK-H, Young EA, Thompson R, Douglass J, Akil H, Watson SJ (1989): Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis. J Neurosci 9:3072-3082
14. Ivell R, Richter D (1984): Structure and comparison of the oxytocin and vasopressin genes from rat. Proc Natl Acad SCi USA 81:2006-2010
15. Kavaliers M, Wiebe JP (1987): Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one, and possible modes of action in mice. Brain Res 415:393-398
16. Landgraf R, Gerstberger R, Montkowski A, Probst JC, Wotjak CT, Holsboer F, Engelmann M (1995): Vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats. J Neurosci 15:4250-4258
17. Loeffler JP, Demeneix BA, Pittius CW, Kley N, Haegele KD, Höllt V (1986): GABA differentially regulates the gene expression of proopiomelanocortin in rat intermediate and anterior pituitary. Peptides 7:253-258
18. MacLusky NJ, Lieberburg I, Krey LC, McEwen BS (1980): Progestin receptors in the brain and pituitary of the bonnet monkey (Macaca radiata): Differences between the monkey and the rat in the distribution of progestin receptors. Endocrinology 106:185-191
19. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986): Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232:1004-1007
20. Majzoub JA, Emanuel R, Adler G, Martinez C, Robinson B, Wittert G (1993): Second messenger regulation of mRNA for corticotropin-releasing factor. In Chadwick DJ, Marsh J, Ackrill K (eds), Corticotropin-Releasing Factor. Chichester, UK, John Wiley & Sons, pp 30-43
21. McEwen BS, Brinton RE (1987): Neuroendocrine aspects of adaptation. Prog Brain Res 72:11-26
22. Meyer ME, Gronemeyer H, Turcotte B, Bocquel MT, Tasseet D, Chambon P (1989): Steroid hormone receptors compete for factors that mediate their enhancer function. Cell 57:433-442
23. Miesfeld R, Rusconi S, Godowski PJ, Maler BA, Okret S, Wikström AC, Gustafsson J-Å, Yamamoto KR (1986): Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA. Cell 46:389-399
24. Parsons B, Rainbow TC, MacLusky NJ, McEwen BS (1982): Progestin receptor levels in rat hypothalamic and limbic nuclei. J Neurosci 2:1446-1452
25. Patchev VK, Shoaib M, Holsboer F, Almeida OFX (1994a): The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropinreleasing hormone in the rat hypothalamus. Neuroscience 62:265-271
26. Patchev VK, Brady LS, Karl M, Chrousos GP (1994b): Regulation of HSP90 and corticosteroid receptor mRNA by corticosterone in vivo. MoL Cell Endocrinol 103:57-64
27. Paul SM, Purdy RH (1992): Neuroactive steroids. Fed Proc Am Soc Exp Biol 6:2311-2322
28. Puia G, Santi MR, Vicini S, Pritchett DB, Purdy RH, Paul SM, Seeburg PH, Costa E (1990): Neurosteroids act on recombinant human GABA receptors. Neuron 4:759-765
29. Purdy RH, Morrow AL, Moore PH Jr, Paul SM (1991): Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain. Proc Natl Acad Sci USA 88:4553-4557
30. Reul JMHM, De Kloet ER (1985): Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation. Endocrinology 117:2505-2511
31. Reul JMHM, Pearce PT, Funder JW, Krozowski ZS (1989): Type I and type II corticosteroid gene expression in the rat: Effect of adrenalectomy and dexamethasone administration. Mol Endocrinol 3:1674-1680
32. Rupprecht R, Reul JMHM, Trapp T, van Steensel B, Wetzel C, Zieglgänsberger W, Damm K, Holsboer F (1993): Progesterone receptor mediated effects of neurosteroids. Neuron 11:523-530
33. Sapolsky RM, Armanini MP, Packan DR, Sutton SW, Plotsky PM (1990): Glucocorticoid feedback inhibition of adrenocorticotropic hormone secretagogue release. Neuroendocrinology 51:328-336
34. Sawchenko PE (1987): Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvocellular neurosecretory neurons: Anatomic, peptide, and steroid specificity. J Neurosci 7:1093-1106
35. Sawchenko PE, Swanson LW (1993): The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat. J Comp Neurol 218:121-144
36. Sawchenko PE, Imaki T, Vale W (1992): Co-localization of neuroactive substances in the endocrine hypothalamus. In Chadwick DJ, March J (eds), Functional Anatomy of the Neuroendocrine Hypothalamus. Chichester, UK, John Wiley & Sons, pp 16-30
37. Silviotti L, Nistri A (1991): GABA receptor mechanisms in the central nervous system. Prog Neurobiol 36:35-92
38. Spencer RL, Miller AH, Stein M, McEwen BS (1991): Corticosterone regulation of type I and type II adrenal steroid receptors in brain, pituitary, and immune tissue. Brain Res 549:236-246
39. Taylor GT, Scherrer J, Weiss J, Pitha J (1994): Endocrine interactions: Adrenal steroids and precursors. Am J Physiol 266:E676-E681
40. Trapp T, Rupprecht R, Castrén M, Reul JMHM, Holsboer F (1994): Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS. Neuron 13:1-20
41. Whitfield HJ Jr, Brady LS, Smith MA, Mamalaki E, Fox R, Herkenham M (1990); Optimization of cRNA probe in situ hybridization methodology for localization of glucocorticoid receptor mRNA in rat brain: A detailed protocol. Cell Mol Neurobiol 10:145-157
42. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12:1040-1062