Neurosteroid quantification in human brain regions: Comparison between alzheimer's and nondemented patients

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 11, 2002, Pages 5138-5143

  Weill Engerer, Sébastien ^a,b,c,d   David, Jean Philippe ^a,b,c,d   Sazdovitch, Véronique ^a,b,c,d   Liere, Philippe ^a,b,c,d   Eychenne, Bernard ^a,b,c,d   Pianos, Antoine ^a,b,c,d   Schumacher, Michael ^a,b,c,d   Delacourte, André ^a,b,c,d   Baulieu, Etienne Emile ^a,b,c,d   Akwa, Yvette ^a,b,c,d  

^a INSERM   (France)

^b HÔPITAL ROTHSCHILD   (France)

^c Hôpitaux Universitaires Henri Mondor   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; NEUROSTEROID; PRASTERONE SULFATE; PREGNENOLONE; PREGNENOLONE SULFATE; PROGESTERONE;

AGED; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ARTICLE; BRAIN LEVEL; BRAIN REGION; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; FEMALE; FRONTAL CORTEX; GAS CHROMATOGRAPHY; HIPPOCAMPUS; HORMONE DETERMINATION; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; MALE; MASS SPECTROMETRY; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYGDALA; AMYLOID BETA-PROTEIN; BRAIN CHEMISTRY; CEREBELLUM; CORPUS STRIATUM; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; FRONTAL LOBE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HIPPOCAMPUS; HUMANS; HYPOTHALAMUS; MALE; PREGNANOLONE; PREGNENOLONE; PROGESTERONE; PROTEIN STRUCTURE, SECONDARY; STEROIDS; TAU PROTEINS;

RODENTIA;

EID: 0036846534     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020878     Document Type: Article

References (44)

1. Baulieu EE 1991 Neurosteroids: A new function in the brain. Biol Cell 71:3-10
2. A receptor, ln: Baulieu EE, Robel P, Schumacher M, eds. Neurosteroids: A New Regulatory Function in the Nervous System. Totowa: Humana Press; 125-142
3. Akwa Y, Baulieu EE 1999 Neurosteroids: Behavioral aspects and physiological implications. J Soc Biol 193:293-298
4. Mathis C, Paul SM, Crawley JN 1994 The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task. Psychopharmacology 116:201-206
5. Flood JF, Roberts E 1988 Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res 448:178-181
6. Gursoy E, Cardounel A, Kalimi M 2001 Pregnenolone protects mouse hippocampal (HT-22) cells against glutamate and amyloid β protein toxicity. Neurochem Res 26:15-21
7. Cardounel A, Regelson W, Kalimi M 1999 Dehydroepiandrosterone protects hippocampal neurons against neurotoxin-induced cell death: Mechanism of action. Proc Soc Exp Biol Med 222:145-149
8. Mao X, Barger SW 1998 Neuroprotection by dehydroepiandrosterone-sulfate: Role of an NFKB-like factor. NeuroReport 9:759-763
9. Bixo M, Backstrom T, Winblad B, Andersson A 1995 Estradiol and testosterone in specific regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 55:297-303
10. Bixo M, Andersson A, Winblad B, Purdy RH, Backstrom T 1997 Progesterone, 5α-pregnane-3,20-dione and 3α-hydroxy-5α-pregnane-20-one in specific regions of the human female brain in different endocrine states. Brain Res 764:173-178
11. Hammond GL, Hirvonen J, Vihko R 1983 Progesterone, androstenedione, testosterone, 5α-dihydrotestosterone and androsterone concentrations in specific regions of the human brain. J Steroid Biochem 18:185-189
12. Lacroix C, Fiet J, Benais JP, Gueux B, Bonete R, Villette JM, Gourmel B, Dreux C 1987 Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogester-one in specific regions of human brain. J Steroid Biochem 28:317-325
13. Morley JE, Kaiser F, Raum WJ, Perry HM, 3rd, Flood JF, Jensen J, Silver AJ, Roberts E 1997 Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. Proc Natl Acad Sci USA 94:7537-7542
14. Ferrario E, Massaia M, Aimo G, Pallavicino di Ceva A, Fabris F 1999 Dehydroepiandrosterone sulfate serum levels: No significance in diagnosing Alzheimer's disease. J Endocrinol Invest 22:81
15. Hillen T, Lun A, Reischies FM, Borchelt M, Steinhagen-Thiessen E, Schaub RT 2000 DHEA-S plasma levels and incidence of Alzheimer's disease. Biol Psychiatry 47:161-163
16. Leblhuber F, Neubauer C, Peichl M, Reisecker F, Steinparz FX, Windhager E, Dienstl E 1993 Age and sex differences of dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels in normal controls and Alzheimer's disease (AD). Psychopharmacology 111:23-26
17. Yanase T, Fukahori M, Taniguchi S, Nishi Y, Sakai Y, Takayanagi R, Haji M, Nawata H 1996 Serum dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) in Alzheimer's disease and in cerebrovascular dementia. Endocr J 43:119-123
18. Braak H, Braak E 1991 Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol 1:213-216
19. Glenner GG 1988 Alzheimer's disease: Its proteins and genes. Cell 52:307-308
20. American Psychiatric Association 1987 DSM-III-R. Diagnostic and Statistical Manual of Mental Disorders. Washington DC: APA Press
21. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM 1984 Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944
22. Delacourte A, David JP, Sergeant N, Buee L, Wattez A, Vermersch P, Ghozali F, Fallet-Bianco C, Pasquier F, Lebert F, Petit H, Di Menza C 1999 The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease. Neurology 52:1158-1165
23. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L 1991 The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486
24. Braak H, Braak E 1991 Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259
25. Buee-Scherrer V, Condamines O, Mourton-Gilles C, Jakes R, Goedert M, Pau B, Delacourte A 1996 AD2, a phosphorylation-dependent monoclonal antibody directed against τ- proteins found in Alzheimer's disease. Brain Res Mol Brain Res 39:79-88
26. Permanne B, Buee L, David JP, Fallet-Bianco C, Di Menza C, Delacourte A 1995 Quantitation of Alzheimer's amyloid peptide and identification of related amyloid proteins by dot-blot immunoassay. Brain Res 685:154-162
27. Sergeant N, David JP, Goedert M, Jakes R, Vermersch P, Buee L, Lefranc D, Wattez A, Delacourte A 1997 Two-dimensional characterization of paired helical filament-τ from Alzheimer's disease: Demonstration of an additional 74-kDa component and age-related biochemical modifications. J Neurochem 69:834-844
28. Vermersch P, Frigard B, Delacourte A 1992 Mapping of neurofibrillary degeneration in Alzheimer's disease: Evaluation of heterogeneity using the quantification of abnormaI τ- proteins. Acta Neuropathol 85:48-54
29. Liere P, Akwa Y, Weill-Engerer S, Eychenne B, Pianos A, Robel P, Sjovall J, Schumacher M, Baulieu EE 2000 Validation of an analytical procedure to measure trace amounts of neurosteroids in brain tissue by gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl 739:301-312
30. Shimada K, Mukai Y, Yago K 1998 Studies on neurosteroids. VII. Characterization of pregnenolone, its sulfate and dehydroepiandrosterone in rat brains using liquid chromatography/mass spectrometry. J Li Qchrom Rel Technol 21:765-775
31. Lanthier A, Patwardhan VV 1986 Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves. J Steroid Biochem 25:445-449
32. Maurice T, Su TP, Privat A 1998 σ1 (sigma 1) receptor agonists and neurosteroids attenuate β25-amyloid peptide-induced amnesia in mice through a common mechanism. Neuroscience 83:413-428
33. Roberts E, Bologa L, Flood JF, Smith GE 1987 Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice. Brain Res 406:357-362
34. Bologa L, Sharma J, Roberts E 1987 Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures. J Neurosci Res 17:225-234
35. Kimonides VG, Khatibi NH, Svendsen CN, Sofroniew MV, Herbert J 1998 Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci USA 95:1852-1857
36. Hill M, Lukac D, Lapcik O, Sulcova J, Hampl R, Pouzar V, Starka L 1999 Age relationships and sex differences in serum levels of pregnenolone and 17-hydroxypregnenolone in healthy subjects. Clin Chem Lab Med 37:439-447
37. 19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 82:2396-2402
38. Cummings JL, Vinters HV, Cole GM, Khachaturian ZS 1998 Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 51:S2-S17
39. Goldman J, Côté L, Schwartz JH, Jessel TM 1991 Aging of the brain: Dementia of the Alzheimer's type. In: Kandl EK, ed. Principles of Neural Science, 3rd Ed. Amsterdam: Elsevier; 974-983
40. Joachim CL, Morris JH, Selkoe DJ 1989 Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol 135:309-319
41. Wolf DS, Gearing M, Snowdon DA, Mori H, Markesbery WR, Mirra SS 1999 Progression of regional neuropathology in Alzheimer disease and normal elderly: Findings from the Nurt study. Alzheimer Dis Assoc Disord 13:226-231
42. Giannakopoulos P, Hof PR, Giannakopoulos AS, Herrmann FR, Michel JP, Bouras C 1995 Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients. Arch Neurol 52:1150-1159
43. Price JL, Morris JC 1999 Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol 45:358-368
44. Danenberg HD, Haring R, Heldman E, Gurwitz D, Ben-Nathan D, Pittel Z, Zuckerman A, Fisher A 1995 Dehydroepiandrosterone augments M1-muscarinic receptor-stimulated amyloid precursor protein secretion in desensitized PC12M1 cells. Ann NY Acad Sci 774:300-303