Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice

Neuropharmacology

Volumn 35, Issue 8, 1996, Pages 1049-1056

  Kokate, T G ^a   Cohen, A L ^a   Karp, E ^a   Rogawski, M A ^a,b  

^a National Institute of Neurological Disorders   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Kainic acid; N methyl D aspartate (NMDA); Neuroactive steroid; Pilocarpine; Seizure; Status epilepticus

Indexed keywords

CLONAZEPAM; CORTICOSTERONE DERIVATIVE; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; PILOCARPINE; PROGESTERONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EPILEPSY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ANIMALS; ANTICONVULSANTS; CLONAZEPAM; DESOXYCORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; ISOMERISM; KAINIC ACID; MALE; MICE; MUSCARINIC AGONISTS; N-METHYLASPARTATE; PILOCARPINE; PROGESTERONE; SEIZURES; STATUS EPILEPTICUS; STEROIDS;

EID: 0030472538     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00021-4     Document Type: Article

References (25)

1. Belelli D., Bolger M. B. and Gee K. W. (1989) Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur. J. Pharmacol. 166: 325-329.
2. A receptor. Brain Res. 561: 157-161.
3. Chin L. S., Havill J. H. and Rothwell R. P. G. (1979) Status epilepticus controlled by althesin infusion. Anaesth. Intensive Care 7: 50-52.
4. Gee K. W., Bolger M. B., Brinton R. E., Coirini H. and McEwen B. S. (1988) Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J. Pharmacol. exp. Ther. 246: 803-812.
5. Harrison N. L., Majewska M. D., Harrington J. W. and Barker J. L. (1987) Structure-activity relationships for steroid interactions with the γ-aminobutyric acid-A receptor complex. J. Pharmacol. exp. Ther. 241: 346-353.
6. Heggli D. E. and Malthe-Sorenssen D. (1982) Kainic acid neurotoxicity: effect on neurotransmitter, amygdaloid complex and hippocampus and protection by cortical lesioning and anticonvulsants. Neuroscience 7: 1257-1263.
7. Hogskilde S., Wagner J., Carl P., Anker N., Angelo H. R. and Sorensen M. B. (1988) Anticonvulsive properties of pregnanolone emulsion compared with althesin and thiopentone in mice. Br. J. Anaesth. 61: 462-467.
8. Kokate T. G., Svensson B. E. and Rogawski M. A. (1994) Anticonvulsant activity of neurosteroids: Correlation with γ-aminobutyric acid-evoked chloride current potentiation. J. Pharmacol. exp. Ther. 270: 1223-1229.
9. Majewska M. D., Harrison N. L., Schwartz R. D., Barker J. L. and Paul S. M. (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232: 1004-1007.
10. A receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 38: 379-395.
11. Munari C., Casaroli D., Matteuzzi G. and Pacific L. (1979) The use of althesin in drug-resistant status epilepticus. Epilepsia 20: 475-484.
12. Paul S. M. and Purdy R. H. (1992) Neuroactive steroids. FASEB J. 6: 2311-2322.
13. A receptor by depressant barbiturates and pregnane steroids. Br. J. Pharmacol. 94: 1257-1269.
14. Peterson S. L. (1989) Anticonvulsant profile of an anesthetic steroid. Neuropharmacology 28: 877-879.
15. Saady A., Wong D. and Hicks R. G. (1979) Case report: Althesin in status epilepticus. Anaesth. Intensive Care 7: 267-270.
16. Tallarida R. J. and Murray R. B. (1987) Manual of Pharmacologic Calculations with Computer Programs. Springer-Verlag, New York.
17. Turski W. A., Cavalheiro E. A., Schwarz M., Czuczwar S. J., Kleinrok Z. and Turski L. (1983) Limbic seizures produced by pilocarpine in rats: a behavioral, electroencephalographic and neuropathological study. Behav. Brain Res. 9: 315-336.
18. Turski W. A., Cavalheiro E. A., Bortolotto Z. A., Moraes Mello L. E. A., Schwarz M. and Turski L. (1984) Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis. Brain Res. 321: 237-253.
19. Turski W. A., Cavalheiro E. A., Coimbra C., Berzaghi M., Ikonomidou-Turski C. and Turski L. (1987) Only certain antiepileptic drugs prevent seizures induced by pilocarpine. Brain Res. Rev. 12: 281-305.
20. Turski L., Ikonomidou C., Turski W. A., Bortolotto Z. A. and Cavalheiro E. A. (1989) Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy. Synapse 3: 154-171.
21. Turski L., Niemann W. and Stephens D. N. (1990) Differential effects of antiepileptic drugs and β-carbolines on seizures induced by excitatory amino acids. Neuroscience 39: 799-807.
22. Walsh G. O. and Delgado-Escueta A. V. (1993) Status epilepticus. Neurol Clin. 11: 835-856.
23. Wieland S., Lan N. C., Mirasedeghi S. and Gee K. W. (1991) Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Brain Res. 565: 263-268.
24. Yamaguchi S., Donevan S. D. and Rogawski M. A. (1993) Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBQX in maximal electroshock and chemoconvulsant seizure models. Epilepsy Res. 15: 179-184.
25. Zaczek R., Nelson M. and Coyle J. T. (1981) Kainic acid neurotoxicity and seizures. Neuropharmacology 20: 183-189.