Stress and neurosteroids in adult and aged rats

Experimental Gerontology

Volumn 33, Issue 7-8, 1998, Pages 697-712

  Barbaccia, M L ^a   Concas, A ^b   Serra, M ^b   Biggio, G ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

CO2 inhalation; Foot shock stress; GABA(A) receptor; HPA axis; Neurosteroids; Rats

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; DEOXYCORTICOSTERONE; NEUROSTEROID; PROGESTERONE DERIVATIVE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GABAERGIC TRANSMISSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; METABOLIC REGULATION; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; STEROIDOGENESIS; STRESS; SYNAPTIC TRANSMISSION; SYNAPTOSOME;

AGING; ANIMALS; BRAIN; CARBOLINES; DESOXYCORTICOSTERONE; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; ISONIAZID; MALE; PITUITARY-ADRENAL SYSTEM; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY; STRESS; SYNAPTIC TRANSMISSION;

EID: 0032447233     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(98)00042-4     Document Type: Conference Paper

References (53)

1. Ait-Chaoui A., Rakotondrazafy J., Brudieux R. Age-related changes in plasma corticosterone and aldosterone responses to exogenous ACTH in the rat. Horm. Res. 43:1995;181-187.
2. Barbaccia M.L., Roscetti G., Trabucchi M., Purdy R.H., Mostallino M.C., Concas A., Biggio G. The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations. Br. J. Pharmacol. 120:1997;1582-1588.
3. 2 inhalation . Eur. J. Pharmacol. 261:1994;317-320.
4. Barbaccia M.L., Roscetti G., Bolacchi F., Concas A., Mostallino M.C., Purdy R.H., Biggio G. Stress-induced decrease in brain neuroactive steroids Antagonism by abecarnil . Pharmacol. Biochem. Behav. 54:1996;205-210.
5. Barbaccia M.L., Roscetti G., Trabucchi M., Ambroscio C., Massotti M. Cyclic AMP-dependent increase of steroidogenesis in brain cortical minces. Eur. J. Pharmacol. 219:1992;495-496.
6. A receptor function after acute stress. Neuroendocrinology. 63:1996;166-172.
7. Baulieu E.E., Robel P. Neurosteroid A new brain function . J. Steroid Biochem. Mol. Biol. 37:1990;395-403.
8. Biggio, G. Concas, A., Corda, M.G., Giorgi, O., Sanna, E., and Serra, M., GABAergic and dopaminergic transmission in the rat cerebral cortex: Effect of stress, an anxiolytic and anxiogenic drugs. Pharmacol. Ther. 48, 121-142, 1990.
9. Biggio, G. Concas, A., Mostallino, M.C., Purdy, R.H., Trabucchi, M., and Barbaccia, M.L., Inhibition of GABAercgic transmission enhances neurosteroid concentrations in the rat brain. In: The Brain: Source and Target for Sex Steroid Hormones, Genazzani, A.R., Petraglia, F., and Purdy, R.H. (Editors), pp. 43-62. London, Parthenon, 1996.
10. Calogero A.E., Gallucci W.T., Chrousos G.P., Gold P.W. Interaction between GABAergic neurotransmission and rat hypothalamic corticotropin-releasing hormone secretion in vitro. Brain Res. 463:1988;223-228.
11. Celotti F., Melcangi R.C., Martini L. The 5α-reductase in the brain Molecular aspects and relation to brain function . Front. Neuroendocrinol. 13:1992;163-215.
12. Cheney D., Uzunov D., Costa E., Guidotti A. GA-cromatographic mass frafmentographic quantitation of 3α-hydroxy-5αpregnan 20one (allopregnanolone) and its precursors in blood and brain of adrenalectomized/castrated rats. J. Neurosci. 15:1995;4641-4650.
13. 35S] TBPS binding in the brain of rats exposed to isoniazid, pentylenetetrazol or stress. Br. J. Pharmacol. 118:1996;839-846.
14. - flux in rat brain membrane vesicles. Life Sci. 43:1988;1761-1771.
15. 35S]butylbicyclophosphorothionate binding in the rat cerebral cortex, an effect opposite to anxiolytics and γ-aminobutyric acid mimetics. J. Neurochem. 51:1986;1868-1876.
16. Concas A. Mostallino M.C., Porcu P., Follesa P., Barbaccia M.L., Trabucchi M., Purdy R.H., Grisenti P., and Biggio G. ,Role of brain allopregnanolone in the plasticity of γ-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc. Natl. Acad. Sci. USA (in press).
17. Corda M.G., Biggio G. Stress and GABAergic transmission Biochemical and behavioral studies . Biggio G., Costa E. GABAergic Transmission and Anxiety. vol. 41:1986;121-136 Raven, New York.
18. Costa E., Auta J., Guidotti A., Korneyev A., Romeo E. The pharmacology of neurosteroidogenesis. J. Steroid Biochem. Mol. Biol. 49:1994;382-385.
19. A receptor subunit. Nature. 385:1997;820-823.
20. Dorow R., Horowski R., Paschelke G., Amin M., Braestrup C. Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors. Lancet. 41:1983;98-99.
21. Drugan R.C., Morrow A.L., Weizman R., Weizman A., Deutsch S.I., Crawley J.N., Paul S.M. Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy. Brain Res. 487:1989;45-51.
22. A receptor-coupled chloride ionophore in rat cerebral cortex. J. Neurochem.53, 648-651, 1989.
23. Guarneri P., Papadopoulus V., Paul B., Costa E. Regulation of pregnenolone synthesis in C6-2B glioma cells by 4′-chlorodiazepam. Proc. Natl. Acad. Sci. USA. 89:1992;5118-5122.
24. Guo A.L., Petraglia F., Criscuolo M., Ficarra G., Nappi R.E., Palumbo M.A., Trentini G.P., Purdy R.H., Genazzani A.R. Evidence for a role of neurosteroid in modulation of diurnal changes and acute stress-induced corticosterone secretion in rats. Gynecol. Endocrinol. 9:1995;1-7.
25. A receptor subunits and glutamic acid decarboxylase in the rat inferior colliculus. J. Neurosci. 14:1994;7469-7477.
26. A receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging. Mol. Brain Res. 45:1997;59-70.
27. Hu Z.Y., Bourreau E., Jung Testas I., Robel P., Baulieu E.E. Neurosteroid Oligodendrocyte mitochondria convert cholesterol to pregnenolone . Proc. Natl. Acad. Sci. USA. 84:1987;8215-8219.
28. A receptor function. Trends Pharmacol. Sci. 16:1995;295-303.
29. 500 in rat brain . Science. 237:1987;1212-1214.
30. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007.
31. McEwen B. Adrenal steroid actions on brain: Dissecting the fine line between protection and damage. Friedman M.J., Charney D.S., Deutch A.Y. Neurobiological and Clinical Consequences of Stress From Normal Adaptation to PTSD . 1995;135-147 Wiley, New York.
32. Mellon S.H., Deschepper C.F. Neurosteroid biosynthesis Genes for adrenal steroidogenic enzymes are expressed in the brain . Brain Res. 629:1993;283-292.
33. A receptor subunit mRNA levels in Fischer rats. Mol. Brain Res. 14:1992;71-78.
34. Michelson D., Licinio J., Gold P.W. Mediation of the stress response by the hypothalamic-pituitary-adrenal axis. Friedman M.J., Charney D.S., Deutch A.Y. Neurobiological and Clinical Consequences of Stress From Normal Adaptation to PTSD . 1995;225-238 Wiley, New York.
35. Owens M.J., Vargas M.A., Knight D.L., Nemeroff C.B. The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain Acute time course, chronic treatment and abrut withdrawal . J. Pharmacol. Exp. Ther. 258:1991;349-356.
36. Papadopoulus V., Guarneri P., Krueger K.E., Guidotti A., Costa E. Pregnenolone biosynthesis in C6 glioma cell mitochondria Regulation by diazepam binding inhibitor mitochondrial receptor . Proc. Natl. Acad. Sci. USA. 89:1992;5113-5117.
37. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
38. Popplewell P.Y., Tsubokawa M., Ramachandran J., Salman A. Differential effects of aging on adrenocorticotropin receptors, adenosine 3′5′-monophosphate response, and corticosterone secretion in adrenocortical cells from Sprague-Dawley rats. Endocrinology. 119:1986;2206-2213.
39. A receptor subunit composition? Receptor Channel. 1:1993;135-142.
40. A receptors. Neuron. 4:1990;759-765.
41. - currents. Mol. Pharmacol. 39:1991;691-696.
42. Purdy R.H., Morrow A.L., Moore P.H. Jr, Paul S.M. Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the brain. Proc. Natl. Acad. Sci. USA. 88:1991;4553-4557.
43. Rapp P.R., Amaral D.G. Individual differences in the cognitive and neurobiological consequences of normal aging. Trends Neurosci. 15:1992;340-345.
44. Roscetti G., Ambrosio C., Trabucchi M., Massotti M., Barbaccia M.L. Modulatory mechanisms of cyclic AMP-stimulated steroid content in rat brain cortex. Eur. J. Pharmacol. - Mol. Pharmacol. 269:1994;17-24.
45. Roscetti, G., DEL CARMINE, R., Trabucchi, M., Massotti, M., Purdy, R.H., and Barbaccia, M.L.,Modulation of neurosteroid synthesis/accumulation by L-ascorbic acid in rat brain tissue: Inhibition by selected serotonin antagonists. J. Neurochem. (in press).
46. A receptors in the rat brain. Eur. J. Pharmacol. 216:1992;457-458.
47. Sapolsky R.M., Krey L.E., McEwen B.S. Corticosterone receptors decline in site-specific manner in the aged rat in rat brain. Brain Res. 289:1983;235-240.
48. Scaccianoce S., Di Sciullo A., Angelucci L. Age-related changes in hypothalamo-pituitary-adrenocortical axis activity in the rat. Neuroendocrinology. 52:1990;150-155.
49. A receptors in neocortex. Mol. Brain Res. 14:1992;207-212.
50. A receptor subtypes. Pharmacol. Rev. 47:1995;181-214.
51. Tang F., Phillips J.G. Some age-related changes in pituitary-adrenal function in the male laboratory rat. J. Gerontol. 33:1978;377-382.
52. Woods S.W., Charney D.S., Loke J., Goodman W.K., Redmond D.E., Heninger G.R. Carbon dioxide sensitivity in panic anxiety. Arch. Gen. Psychiatry. 43:1986;900-909.
53. A receptors. J. Neurosci. 16:1996;6648-6656.