Bringing kinases into focus: Efficient drug design through the use of chemogenomic toolkits

Current Medicinal Chemistry

Volumn 13, Issue 15, 2006, Pages 1735-1748

  Birault, Veronique ^a   Harris, C John ^a   Le, Joelle ^a   Lipkin, Mike ^a   Nerella, Ravi ^a   Stevens, Adrian ^a  

^a BioFocus DPI   (United Kingdom)

Author keywords

2D roadmap ; CDK2; CDK4; Chemogenomics; Cyclin dependent kinases; Focused libraries; Kinases; Kinome similarity analysis ; KSA; p38; Selectivity profiling; SoftFocus ; Toolkit

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (2,6 DICHLOROPHENYL) 2 (2,4 DIFLUOROPHENYLTHIO)PYRIMIDO[1,6 B]PYRIDAZIN 6 ONE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 4 INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; IMATINIB; ION CHANNEL; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; TRASTUZUMAB; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; BINDING SITE; BIOINFORMATICS; CHRONIC MYELOID LEUKEMIA; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; GENE TARGETING; GENETIC ANALYSIS; HUMAN; HUMAN GENOME; IC 50; MULTIGENE FAMILY; PHARMACOGENOMICS; PREDICTION; PROTEIN FAMILY; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW;

AMINO ACID SEQUENCE; DRUG DESIGN; GENOMICS; MOLECULAR SEQUENCE DATA; PROTEIN KINASES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33745029735     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706777452452     Document Type: Review

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