GPCR antitarget modeling: Pharmacophore models for biogenic amine binding GPCRs to avoid GPCR-mediated side effects

ChemBioChem

Volumn 6, Issue 5, 2005, Pages 876-889

  Klabunde, Thomas ^a   Evers, Andreas ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Amines; Drug design; G protein coupled receptors; Pharmacophore modeling; Structure activity relationship

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1 [2 [4 (6 FLUORO 1,2 BENZISOXAZOL 3 YL) 1 PIPERIDYL]ETHYL] 3 PHENYL 2 IMIDAZOLINONE; 2 [2 (4 HYDROXYPHENYL)ETHYLAMINOMETHYL]TETRALONE; 2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; 5 CHLORO N [2 (2 CYCLOPROPYLMETHOXYPHENOXY)ETHYL] ALPHA,ALPHA DIMETHYL 1H INDOLE 3 ETHANAMINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1A ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BIOGENIC AMINE; BUSPIRONE; CETIRIZINE; CHLORPROMAZINE; CLOZAPINE; CYCLAZOSIN; CYPROHEPTADINE; DOMPERIDONE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOXAZOSIN; ETICLOPRIDE; FAMOTIDINE; FEXOFENADINE; FLUPENTIXOL; G PROTEIN COUPLED RECEPTOR; HALOPERIDOL; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; IMITEX; IPRATROPIUM BROMIDE; KETANSERIN; LORATADINE; LOXAPINE; METOPROLOL; METOPROLOL TARTRATE; MIANSERIN; MUSCARINIC M1 RECEPTOR ANTAGONIST; OLANZAPINE; PRAZOSIN; RANITIDINE; RECEPTOR BLOCKING AGENT; RISPERIDONE; RITANSERIN; RMI 60947; SALMETEROL; SALMETEROL XINAFOATE; SEROTONIN 1 ANTAGONIST; SEROTONIN 2 ANTAGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SPIPERONE; SUMATRIPTAN; SUMATRIPTAN SUCCINATE; TAMSULOSIN; UNCLASSIFIED DRUG; WB 4104;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; COMPUTER ANALYSIS; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; IC 50; LIGAND BINDING; MODEL; ORTHOSTATIC HYPOTENSION; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR BINDING; SIDE EFFECT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

ADRENERGIC ANTAGONISTS; BIOGENIC AMINES; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; REPRODUCIBILITY OF RESULTS; SEROTONIN ANTAGONISTS;

EID: 21044451732     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200400369     Document Type: Article

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