Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16(INK4a)

Nature

Volumn 395, Issue 6699, 1998, Pages 237-243

  Russo, Alicia A ^a   Tong, Lily ^b   Lee, Jie Oh ^b   Jeffrey, Philip D ^a   Pavletich, Nikola P ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN P16;

ANIMAL CELL; ARTICLE; BINDING SITE; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; TUMOR SUPPRESSOR GENE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P19; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; ESCHERICHIA COLI; GENES, TUMOR SUPPRESSOR; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; ARACHNIDA; HEXAPODA;

EID: 0032541623     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/26155     Document Type: Article

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