Structural aspects of protein kinase control - Role of conformational flexibility

Pharmacology and Therapeutics

Volumn 93, Issue 2-3, 2002, Pages 99-111

  Engh, Richard A ^a   Bossemeyer, Dirk ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Activity modulation sites; ATP binding site; Drug design; Induced fit; Ligand contact surface; Protein kinase A

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 5 (2 AMINO 4 PYRIMIDINYL) 4 (4 FLUOROPHENYL) 1 (4 PIPERIDINYL)IMIDAZOLE; BALANOL; EMODIN; FASUDIL; IMATINIB; LIGAND; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PD 173074; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PURVALANOL; STAUROSPORINE; SU 4984; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE;

CATALYSIS; CONFERENCE PAPER; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; EUKARYOTIC CELL; HYDROPHOBICITY; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; BINDING SITE; CONFORMATION; DRUG EFFECT; METABOLISM; PHYSIOLOGY; REVIEW; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; BINDING SITES; MOLECULAR CONFORMATION; PROTEIN KINASES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; PROTEIN KINASE INHIBITORS;

EID: 0035990907     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00180-8     Document Type: Conference Paper

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