Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1β, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanisms

American Journal of Respiratory Cell and Molecular Biology

Volumn 22, Issue 5, 2000, Pages 582-589

  Bergmann, Martin ^a,b,c   Barnes, Peter J ^a,b,c   Newton, Robert ^a,b,c  

^a FRANZ VOLHARD CLINIC   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034106340     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.22.5.3889     Document Type: Article

References (43)

1. 1. Barnes, P. J. 1994. Cytokines as mediators of chronic asthma. Am. J. Respir. Crit. Care Med. 150(Suppl.):S42-S49.
2. 2. Cox, G., T. Ohtoshi, C. Vancheri, J. A. Denburg, J. Dolovich, J. Gauldie, and M. Jordana. 1991. Promotion of eosinophil survival by human bronchial epithelial cells and its modulation by steroids. Am. J. Respir. Cell Mol. Biol. 4:525-531.
3. 3. Marini, M., M. Soloperto, M. Mezzetti, A. Fasoli, and A. Mattoli. 1991. Interleukin-1 binds to specific receptors on human bronchial epithelial cells and upregulates granulocyte/macrophage colony-stimulating factor synthesis and release. Am. J. Respir. Cell Mol. Biol. 4:519-524.
4. 4. Humbert, M., S. Ying, C. Corrigan, G. Menz, J. Barkans, R. Pfister, Q. Meng, D. J. Van, G. Opdenakker, S. R. Durham, and A. B. Kay. 1997. Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophil-activc cytokines interleukin (IL)-5, granulocyte macrophage-colony-stimulating factor, and IL-3. Am. J. Respir. Cell Mol. Biol. 16:1-8.
5. 5. Jenkins, F., P. N. Cockerill, D. Bohmann, and M. F. Shannon. 1995. Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells. J. Immunol. 155:1240-1251.
6. 6. Ye, J., X. Zhang, and Z. Dong. 1996. Characterization of the human granulocyte-macrophage colony-stimulating factor gene promoter: an API complex and an Sp1-relatcd complex transactivate the promoter activity that is suppressed by a YY1 complex. Mol. Cell. Biol. 16:157-167.
7. 7. Ghiorzo, P., M. Musso, M. Mantelli, C. Garre, R. Ravazzoio, and G. Bianchi-Scarra. 1997. cRel and p65 subunits bind to an upstream NF-kappaB site in human granulocyte macrophage-colony stimulating factor promoter involved in phorbol ester response in 5637 cells. FEBS Lett. 418:215-218.
8. 8. Cockerill, P. N., A. G. Bert, F. Jenkins, G. R. Ryan, M. R. Shannon, and M. A. Vadas. 1995. Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c. Mol. Cell. Biol. 15:2071-2079.
9. 9. Cockerill, P. N., M. F. Shannon, A. G. Bert, G. R. Ryan, and M. A. Vadas. 1993. The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc. Natl. Acad. Sci. USA 90:2466-2470.
10. 10. Razanajaona, D., C. Maroc, M. Lopez, P. Mannoni, and J. Gabert. 1992. Shift from posttranscriptional to predominant transcriptional control of the expression of the GM-CSF gene during activation of human Jurkat cells. Cell Growth Differ. 3:299-305.
11. 11. Bickel, M., R. B. Cohen, and D. H. Pluznik. 1990. Post-transcriptional regulation of granulocyte-macrophage colony-stimulating factor synthesis in murine T cells. J. Immunol. 145:840-845.
12. 12. Akashi, M., G. Shaw, M. Hachiya, E. Elstner, G. Suzuki, and P. Koeffler. 1994. Number and location of AUUUA motifs: role in regulating transiently expressed RNAs. Blood 83:3182-3187.
13. 13. Kruys, V., O. Marinx, G. Shaw, J. Deschamps, and G. Huez. 1989. Translational blockade imposed by cytokine-derived UA-rich sequences. Science 245:852-855.
14. 14. de Waal Malefyt, R., C. G. Figdor, R. Huijbens, S. Mohan Peterson, B. Bennett, J. Culpepper, W. Dang, G. Zurawski, and J. E. de Vries. 1993. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL-4 and modulation by IFN-gamma or IL-10. J. Immunol. 151:6370-6381.
15. 15. Yanagawa, H., S. Sone, T. Haku, K. Mizuno, S. Yano, Y. Ohmoto, and T. Ogura. 1995. Contrasting effect of interleukin-13 on interleukin-1 receptor antagonist and proinflammatory cytokine production by human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 12:71-76.
16. 16. Palmer, C. R., C. C. Hughes, and J. S. Pober. 1996. IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain. J. Clin. Invest. 98:604-609.
17. 17. Keegan, A. D., J. A. Johnston, P. J. Tortolani, L. J. McReynolds, C. Kinzer, J. J. O'Shea, and W. E. Paul. 1995. Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. Proc. Natl. Acad. Sci. USA 92:7681-7685.
18. 18. Kohler, I., P. Alliger, A. Minty, D. Caput, P. Ferrara, N. B. Holl, G. Rank, and E. P. Rieber. 1994. Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-gamma-induced nuclear binding factor. FEBS Lett. 345:187-192.
19. 19. Schwarz, E. M., P. Salgame, and B. R. Bloom. 1993. Molecular regulation of human interleukin 2 and T-cell function by interleukin 4. Proc. Natl. Acad. Sci. USA 90:7734-7738.
20. 20. Gruber, M. F., C. C. Williams, and T. L. Gerrard. 1994. Macrophage-colony-stimulating factor expression by anti-CD45 stimulated human monocytes is transcriptionally up-regulated by IL-1 beta and inhibited by IL-4 and IL-10. J. Immunol 152:1354-1361.
21. 21. Sands, W. A., V. Bulut, A. Severn, D. Xu, and F. Y. Liew. 1994. Inhibition of nitric oxide synthesis by interleukin-4 may involve inhibiting the activation of protein kinase C epsilon. Eur. J. Immunol. 24:2345-2350.
22. 22. Bennett, B. L., R. Cruz, R. G. Lacson, and A. M. Manning. 1997. Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB. J. Biol. Chem. 272:10212-10219.
23. 23. Donnelly, R. P., M. J. Fenton, J. D. Kaufman, and T. L. Gerrard. 1991. IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4. J. Immunol. 146:3431-3436.
24. 24. Suk, K., and K. L. Erickson. 1996. Differential regulation of tumour necrosis factor-alpha mRNA degradation in macrophages by interleukin-4 and interferon-gamma. Immunology 87:551-558.
25. 25. Brinckmann, R., M. S. Top, I. Zalan, D. Heydeck, P. Ludwig, H. Kuhn, W. E. Berdel, and J. R. Habenicht. 1996. Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4. Biochem. J. 318:305-312.
26. 26. Newton, R., L. M. Kuiterl, M. Bergmann, I. M. Adcock, and P. J. Barnes. 1997. Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta. Biochem. Biophys. Res. Commun. 237:28-32.
27. 27. Chomezynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
28. 2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells. Life Sci. 60:67-78.
29. 29. Rousell, J., E. B. Haddad, J. C. Mak, and P. J. Barnes. 1995. Transcriptional down-regulation of m2 muscarinic receptor gene expression in human embryonic lung (HEL 299) cells by protein kinase C. J Biol. Chem. 270:7213-7218.
30. 30. Cockerill, G. W., A. G. Bert, G. R. Ryan, J. R. Gamble, M. A. Vadas, and P. N. Cockerill. 1995. Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT. Blood 86:2689-2698.
31. 31. Miyatake, S., T. Otsuka, T. Yokota, F. Lee, and K. Arai. 1985. Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J. 4:2561-2568.
32. 32. Kaushansky, K., P. J. O'Hara, K. Berkner, G. M. Segal, F. S. Hagen, and J. W. Adamson. 1986. Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA 83:3101-3105.
33. 33. Fiorentini, P., M. Musso, S. Penco, R. Giuffrida, V. Pistoia, C. Garre, and G. Bianchi Scarra. 1995. Characterization of a distal 5′-flanking region (-2010/-630) of human GM-CSF. Biochem. Biophys. Res. Commun. 214: 1015-1022.
34. 34. Israel, N., U. Hazan, J. Alcami, A. Munier, S. F. Arenzana, F. Bachelerie, A. Israel, and J. L. Virelizier. 1989. Tumor necrosis factor stimulates transcription of HIV-1 in human T lymphocytes, independently and synergistically with mitogens. J. Immunol. 143:3956-3960.
35. 35. Bergmann, M., L. Hart, M. Lindsay, P. J. Barnes, and R. Newton. 1998. 1κBα degradation and nuclear factor-κB DNA binding are insufficient for IL-1β and TNF-α-induced κB-dependent transcription: requirement for an additional activation pathway. J. Biol. Chem. 273:6607-6610.
36. 36. Kwon, O. J., B. T. Au, P. D. Collins, I. M. Adcock, J. C. Mak, R. R. Robbins, K. F. Chung, and P. J. Barnes. 1994. Tumor necrosis factor-induced interleukin-8 expression in cultured human airway epithelial cells. Am. J. Physiol. 267:L398-L405.
37. 37. Newton, R., I. M. Adcock, and P. J. Barnes. 1996. Superinduction of NF-κB by actinomycin D and cycloheximide in epithelial cells. Biochem. Biophys. Res. Commun. 218:518-523.
38. 38. Nimer, S. D., M. J. Gates, H. P. Koeffler, and J. C. Gasson. 1989. Multiple mechanisms control the expression of granulocyte-macrophage colony-stimulating factor by human fibroblasts. J. Immunol. 143:2374-2377.
39. 39. Newton, R., D. A. Stevens, L. A. Hart, M. Lindsay, I. M. Adcock, and P. J. Barnes. 1997. Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation. FEBS Lett. 418:135-138.
40. 40. Mijatovic, T., V. Kruys, D. Caput, P. Defrance, and G. Huez. 1997. Interleukin-4 and -13 inhibit tumor necrosis factor-alpha mRNA translational activation in lipopolysaccharide-induced mouse macrophages. J. Biol. Chem. 272:14394-14398.
41. 41. Dinarello, C. A. 1996. Biological basis for interleukin-1 in disease. Blood 87: 2095-2147.
42. 42. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701-1706.
43. 43. Manna, S. K., and B. B. Aggarwal. 1998. IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis. J. Immunol. 161:2863-2872.