HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

Oncogene

Volumn 23, Issue 30, 2004, Pages 5185-5192

  Di Stefano, Valeria ^a   Blandino, Giovanni ^a   Sacchi, Ada ^a   Soddu, Silvia ^a   D'Orazi, Gabriella ^a,b  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Apoptosis; HIPK2; MDM2; Nuclear export; p53; Ubiquitination

Indexed keywords

HOMEODOMAIN INTERACTING PROTEIN KINASE 2; PROTEIN MDM2; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CARRIER PROTEIN; CISPLATIN; CYSTEINE PROTEINASE INHIBITOR; HIPK2 PROTEIN, HUMAN; LEUPEPTIN; LUCIFERASE; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; UBIQUITIN;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; COLON CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN FUNCTION; STRESS; UBIQUITINATION; ADENOCARCINOMA; CELL NUCLEUS; COLON TUMOR; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; SERODIAGNOSIS; TRANSACTIVATION; TUMOR CELL LINE; WESTERN BLOTTING;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CISPLATIN; COLONIC NEOPLASMS; CYSTEINE PROTEINASE INHIBITORS; DNA DAMAGE; HUMANS; LEUPEPTINS; LUCIFERASES; LUNG NEOPLASMS; NUCLEAR PROTEINS; OSTEOSARCOMA; PRECIPITIN TESTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

EID: 3142682521     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207656     Document Type: Article

References (47)

1. Appella E and Anderson CW. (2001). Eur. J. Biochem., 268, 2764-2772.
2. Barak Y, Juven T, Haffner R and Oren M. (1993). EMBO J., 12, 461-468.
3. Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E and Fornace AJ. (1999). EMBO J., 18, 6845-6854.
4. Chen J, Wu X, Lin J and Levine AJ. (1996). Mol. Cell. Biol., 16, 2445-2452.
5. Chene P. (2003). Nat. Rev. Cancer, 3, 102-109.
6. Craig AL, Burch L, Vojtesek B, Mikutowska J, Thompson A and Hupp TR. (1999). Biochem. J., 342, 133-141.
7. D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M and Soddu S. (2002). Nat. Cell Biol., 4, 11-19.
8. Di Stefano V, Rinaldo C, Sacchi A, Soddu S and D'Orazi G. (2004). Exp. Cell Res., 293, 311-320.
9. Eymin B, Gazzeri S, Brambilla C and Brambilla E. (2002). Oncogene, 21, 2750-2761.
10. Freedman DA and Levine AJ. (1998). Mol. Cell. Biol., 18, 7288-7293.
11. Fuchs SY, Fried VA and Ronai Z. (1998). Oncogene, 17, 1483-1490.
12. Giaccia J and Kastan LB. (1998). Genes Dev., 12, 2973-2983.
13. Gottlieb TM and Oren M. (1996). Biochim. Biophys. Acta, 1287, 77-102.
14. Haupt Y, Barak Y and Oren M. (1996). EMBO J., 15, 1596-1606.
15. Haupt Y, Maya R, Kazaz A and Oren M. (1997). Nature, 387, 296-299.
16. Hofmann TG, Moller A, Sirma H, Zentgraf H, Taya Y, Droge W, Will H and Schmitz ML. (2002). Nat. Cell Biol., 4, 1-10.
17. Jones SN, Roe AE, Donehower LA and Bradley A. (1995). Nature, 378, 206-208.
18. Kim E-J, Park J-S and Um S-J. (2002). J. Biol. Chem., 277, 32020-32028.
19. Kubbutat MH, Jones SN and Vousden KH. (1997). Nature, 387, 299-303.
20. Lakin ND and Jackson S. (1999). Oncogene, 1, 7644-7655.
21. Leite KR, Franco MF, Srougi M, Nesrallah LJ, Nesrallah A, Bevilacqua RG, Darini E, Carnalho M, Meirelles MI, Santana I and Camara-Lopes LH. (2001). Mod. Pathol., 12, 428-436.
22. Lu H and Levine AJ. (1995). Proc. Natl. Acad. Sci. USA, 92, 5154-5158.
23. Miyashita T and Reed JC. (1995). Cell, 80, 293-299.
24. Moll UM, Riou G and Levine AJ. (1992). Proc. Natl. Acad. Sci. USA, 89, 7262-7266.
25. Momand J, Jung D, Wilczynski S and Niland J. (1998). Nucleic Acid Res., 26, 3453-3459.
26. Momand J, Zambett GP, Olson DC, Gorge D and Levine AJ. (1992). Cell, 69, 1237-1245.
27. Montes de Oca Luca R, Wagner DS and Lozano G. (1995). Nature, 378, 203-206.
28. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yanashita T, Tokino T, Taniguchi T and Tanaka N. (2000a). Science, 288, 1053-1058.
29. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y and Taya Y. (2000b). Cell, 102, 849-862.
30. Oliner JD, Kinzler KW, Meltzer PS, George DL and Vogelstein B. (1992). Nature, 358, 80-83.
31. Picksley SM and Lane DP. (1993). BioEssay, 15, 689-690.
32. Polsky D, Bastian BC, Hazan C, Melzer K, Pack J, Houghton A, Busan K, Cordon-Cardo C and Osman I. (2001). Cancer Res., 61, 7642-7646.
33. Polyak K, Xia Y, Zweir JL, Kinzler KW and Vogelstein B. (1997). Nature, 389, 300-305.
34. Prives C. (1998). Cell, 95, 5-8.
35. Prives C and Hall PA. (1999). J. Pathol., 187, 112-126.
36. Roth J, Dobbelstein M, Freedman DA, Shenk T and Levine AJ. (1998). EMBO J., 17, 554-564.
37. Sakaguchi K, Saito S, Higashimoto Y, Roy S, Anderson CW and Appella E. (2000). J. Biol. Chem., 275, 9278-9283.
38. Shieh S-Y, Ikeda M, Taya Y and Prives C. (1997). Cell, 9, 325-334.
39. Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E and Kastan MB. (1997). Genes Dev., 11, 3471-3481.
40. Tao W and Levine AJ. (1999). Proc. Natl. Acad. Sci. USA, 96, 3077-3080.
41. Unger T, Juven-Gershon T, Moallem E, Berger M, Vogt Sionov R, Lozano G, Oren M and Haupt Y. (1999). EMBO J., 18, 1805-1814.
42. Unger T, Nau MM, Segal S and Minna JD. (1992). EMBO J., 11, 1383-1390.
43. Valculescu VE and El Deiry WS. (1996). Clin. Chem., 42, 858-868.
44. Vogt Sionov R and Haupt Y. (1999). Oncogene, 18, 6145-6157.
45. Vousden KH. (2000). Cell, 103, 691-694.
46. Wang Y, Bedatin K-M and Hug H. (2001). BMC Mol. Biol., 2, 8-16.
47. Wu X, Bayle JH, Olson D and Levine AJ. (1993). Genes Dev., 7, 1126-1132.