Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified

Journal of Biological Chemistry

Volumn 280, Issue 28, 2005, Pages 25953-25959

  Mayo, Lindsey D ^a   Seo, Young Rok ^b   Jackson, Mark W ^c   Smith, Martin L ^b   Guzman, Javier Rivera ^b   Korgaonkar, Chandrashekhar K ^b   Donner, David B ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELLS; CHEMOTHERAPY; ENZYME INHIBITION; ENZYMES; GENES; TUMORS;

APOPTOSIS; DNA DAMAGING AGENTS; DNA REPAIR; GENE INDUCTION;

DNA;

ALANINE; ASPARTIC ACID; DNA; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; SERINE; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; AUTOREGULATION; CELL NUCLEUS; CHEMOTHERAPY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DRUG MEGADOSE; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; LOW DRUG DOSE; MDM2 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; PTEN GENE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; COMET ASSAY; DNA DAMAGE; ETOPOSIDE; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; IMMUNOBLOTTING; MUTATION; NUCLEAR PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SERINE; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 22544433198     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M503026200     Document Type: Article

References (73)

1. Levine, A. J. (1997) Cell 88, 323-331
2. Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Jr., Butel, J. S., and Bradley, A. (1992) Nature 356, 215-221
3. Harvey, M., McArthur, M. J., Montgomery, C. A., Jr., Bradley, A., and Donehower, L. A. (1993) FASEB J. 7, 938-943
4. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. (1991) Science 253, 49-53
5. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. (1994) Cancer Res. 54, 4855-4878
6. Chen, H. E., Chang, S., Trub, T., and Neel, B. G. (1996) Mol. Cell. Biol. 16, 3685-3697
7. Finlay, C. A. (1993) Mol. Cell. Biol. 13, 301-306
8. Freedman, D. A., Wu, L., and Levine, A. J. (1999) Cell. Mol. Life Sci. 55, 96-107
9. Honda, R., Tanaka, H., and Yasuda, H. (1997) FEBS Lett. 420, 25-27
10. Juven-Gershon, T., and Oren, M. (1999) Mol. Med. 5, 71-83
11. Kubbutat, M. H., Jones, S. N., and Vousden, K. H. (1997) Nature 387, 299-303
12. Momand, J., Zambetti, G. P., Olson, D. C., George, D., and Levine, A. J. (1992) Cell 69, 1237-1245
13. Momand, J., Wu, H. H., and Dasgupta, G. (2000) Gene (Amst.) 242, 15-29
14. Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997) Nature 387, 296-299
15. McCoy, M. A., Gesell, J. J., Senior, M. M., and Wyss, D. F. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 1645-1648
16. Barak, Y., Juven, T., Haffner, R., and Oren, M. (1993) EMBO J. 12, 461-468
17. Chen, J., Marechal, V., and Levine, A. J. (1993) Mol. Cell. Biol. 13, 4107-4114
18. Oliner, J. D., Pietenpol, J. A., Thiagalingam, S., Gyuris, J., Kinzler, K. W., and Vogelstein, B. (1993) Nature 362, 857-860
19. Kubbutat, M. H., Ludwig, R. L., Levine, A. J., and Vousden, K. H. (1999) Cell Growth & Differ. 10, 87-92
20. Roth, J., Dobbelstein, M., Freedman, D. A., Shenk, T., and Levine, A. J. (1998) EMBO J. 17, 554-564
21. Tao, W., and Levine, A. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3077-3080
22. Wu, X., Bayle, J. H., Olson, D., and Levine, A. J. (1993) Genes Dev. 7, 1126-1132
23. Maehama, T., and Dixon, J. E. (1999) Trends Cell Biol. 9, 125-128
24. Maehama, T., and Dixon, J. E. (1998) J. Biol. Chem. 273, 13375-13378
25. Maehama, T., Taylor, G. S., and Dixon, J. E. (2001) Annu. Rev. Biochem. 70, 247-279
26. Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., and Mak, T. W. (1998) Cell 95, 29-39
27. Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P., and Tonks, N. K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13513-13518
28. Haas-Kogan, D., Shalev, N., Wong, M., Mills, G., Yount, G., and Stokoe, D. (1998) Curr. Biol. 8, 1195-1198
29. Furnari, F. B., Huang, H. J., and Cavenee, W. K. (1998) Cancer Res. 58, 5002-5008
30. Brazil, D. P., and Hemmings, B. A. (2001) Trends Biochem. Sci. 26, 657-664
31. Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. (1997) Science 275, 661-665
32. Kulik, G., Klippel, A., and Weber, M. J. (1997) Mol. Cell. Biol. 17, 1595-1606
33. Sabbatini, P., and McCormick, F. (1999) J. Biol. Chem. 274, 24263-24269
34. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Cell 91, 231-241
35. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Cell 96, 857-868
36. Mayo, L., and Donner, D. (2002) Trends Biochem. Sci. 27, 462
37. Mayo, L. D., and Donner, D. B. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 11598-11603
38. Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M. C. (2001) Nat. Cell Biol. 3, 973-982
39. Ashcroft, M., Ludwig, R. L., Woods, D. B., Copeland, T. D., Weber, H. O., MacRae, E. J., and Vousden, K. H. (2002) Oncogene 21, 1955-1962
40. Mayo, L. D., Dixon, J. E., Durden, D. L., Tonks, N. K., and Donner, D. B. (2002) J. Biol. Chem. 277, 5484-5489
41. Stambolic, V., MacPherson, D., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S., and Mak, T. W. (2001) Mol. Cell 8, 317-325
42. Braybrooke, J. P., Levitt, N. C., Joel, S., Davis, T., Madhusudan, S., Turley, H., Wilner, S., Harris, A. L., and Talbot, D. C. (2003) Clin. Cancer Res. 9, 4682-4688
43. Clark, P. I., Slevin, M. L., Joel, S. P., Osborne, R. J., Talbot, D. I., Johnson, P. W., Reznek, R., Masud, T., Gregory, W., and Wrigley, P. F. (1994) J. Clin. Oncol. 12, 1427-1435
44. Joel, S. P., Clark, P. I., Heap, L., Webster, L., Robbins, S., Craft, H., and Slevin, M. L. (1995) Cancer Chemother. Pharmacol. 37, 125-133
45. Joel, S. P., Ellis, P., O'Byrne, K., Papamichael, D., Hall, M., Penson, R., Nicholls, S., O'Donnell, C., Constantinou, A., Woodhull, J., Nicholson, M., Smith, I., Talbot, D., and Slevin, M. (1996) J. Clin. Oncol. 14, 1903-1912
46. Millward, M. J., Newell, D. R., Yuen, K., Matthews, J. P., Balmanno, K., Charlton, C. J., Gumbrell, L., Lind, M. J., Chapman, F., Proctor, M., Simmonds, D., Cantwell, B. M. J., and Calvert, A. H. (1995) Cancer Chemother. Pharmacol. 37, 161-167
47. Liu, W. M., Lawrence, A. J., and Joel, S. P. (2002) Eur. J. Cancer 38, 842-850
48. Huigsloot, M., Tijdens, I. B., Mulder, G. J., and van de Water, B. (2001) Biochem. Pharmacol. 62, 1087-1097
49. Rehm, M., Dussmann, H., Janicke, R. U., Tavare, J. M., Kogel, D., and Prehn, J. H. (2002) J. Biol. Chem. 277, 24506-24514
50. Engels, I. H., Stepczynska, A., Stroh, C., Lauber, K., Berg, C., Schwenzer, R., Wajant, H., Janicke, R. U., Porter, A. G., Belka, C., Gregor, M., Schulze-Osthoff, K., and Wesselborg, S. (2000) Oncogene 19, 4563-4573
51. Virolle, T., Adamson, E. D., Baron, V., Birle, D., Mercola, D., Mustelin, T., and de Belle, I. (2001) Nat. Cell Biol. 3, 1124-1128
52. Zhang, Y., Xiong, Y., and Yarbrough, W. G. (1998) Cell 92, 725-734
53. Llanos, S., Clark, P. A., Rowe, J., and Peters, G. (2001) Nat. Cell Biol. 3, 445-452
54. Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., and Taya, Y. (2000) Cell 102, 849-862
55. D'Orazi, G., Cecchinelli, B., Bruno, T., Manni, I., Higashimoto, Y., Saito, S., Gostissa, M., Coen, S., Marchetti, A., Del Sal, G., Piaggio, G., Fanciulli, M., Appella, E., and Soddu, S. (2002) Nat. Cell Biol. 4, 11-19
56. Hofmann, T. G., Moller, A., Sirma, H., Zentgraf, H., Taya, Y., Droge, W., Will, H., and Schmitz, M. L. (2002) Nat. Cell Biol. 4, 1-10
57. Furnari, F. B., Lin, H., Huang, H. S., and Cavenee, W. K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12479-12484
58. Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R., and Tonks, N. K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9052-9057
59. Vogelstein, B., Lane, D., and Levine, A. J. (2000) Nature 408, 307-310
60. Fakharzadeh, S. S., Trusko, S. P., and George, D. L. (1991) EMBO J. 10, 1565-1569
61. Jones, S. N., Sands, A. T., Hancock, A. R., Vogel, H., Donehower, L. A., Linke, S. P., Wahl, G. M., and Bradley, A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14106-14111
62. Maier, D., Zhang, Z., Taylor, E., Hamou, M. F., Gratzl, O., Van Meir, E. G., Scott, R. J., and Merlo, A. (1998) Oncogene 16, 3331-3335
63. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. (1997) Science 275, 1943-1947
64. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H., and Tavtigian, S. V. (1997) Nat. Genet. 15, 356-362
65. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. (1997) Nat. Genet. 16, 64-67
66. Marsh, D. J., Coulon, V., Lunetta, K. L., Rocca-Serra, P., Dahia, P. L., Zheng, Z., Liaw, D., Caron, S., Duboue, B., Lin, A. Y., Richardson, A. L., Bonnetblanc, J. M., Bressieux, J. M., Cabarrot-Moreau, A., Chompret, A., Demange, L., Eeles, R. A., Yahanda, A. M., Fearon, E. R., Fricker, J. P., Gorlin, R. J., Hodgson, S. V., Huson, S., Lacombe, D., LePrat, F., Odent, S., Toulouse, C., Olopade, O. I., Sobol, H., Tishler, S., Woods, C. G., Robinson, B. G., Weber, H. C., Parsons, R., Peacocke, M., Longy, M., and Eng, C. (1998) Hum. Mol. Genet. 7, 507-515
67. Myers, M. P., and Tonks, N. K. (1997) Am. J. Hum. Genet. 61, 1234-1238
68. Cantley, L. C., and Neel, B. G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4240-4245
69. Bode, A. M., and Dong, Z. (2004) Mutat Res. 555, 33-51
70. Oren, M. (2003) Cell Death Differ. 10, 431-442
71. Holmberg, C. I., Tran, S. E., Eriksson, J. E., and Sistonen, L. (2002) Trends Biochem. Sci. 27, 619-627
72. Xu, Y. (2003) Cell Death Differ. 10, 400-403
73. Mayo, L. D., Turchi, J. J., and Berberich, S. J. (1997) Cancer Res. 57, 5013-5016