메뉴 건너뛰기




Volumn 11, Issue 6, 2004, Pages 596-607

p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK

Author keywords

Caspases; Growth arrest; p53 target; Protein degradation; Signal transduction

Indexed keywords

CASPASE; CASPASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN P21; PROTEIN P53;

EID: 2942724090     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401368     Document Type: Article
Times cited : (38)

References (43)
  • 1
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis TS, Shapiro PS and Ahn NG (1998) Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74: 49-139
    • (1998) Adv. Cancer Res. , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 2
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 3
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley S, Paterson H, Kemp P and Marshall CJ (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77: 841-852
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 4
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M and Lowe SW (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12: 3008-3019
    • (1998) Genes Dev. , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 6
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 7
    • 0032892932 scopus 로고    scopus 로고
    • Activation of p53 by oncogenes
    • Lowe SW (1999) Activation of p53 by oncogenes. Endocr. Relat. Cancer 6: 45-48
    • (1999) Endocr. Relat. Cancer , vol.6 , pp. 45-48
    • Lowe, S.W.1
  • 8
    • 0034682469 scopus 로고    scopus 로고
    • Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
    • Lee SW, Fang L, Igarashi M, Ouchi T, Lu KP and Aaronson SA (2000) Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc. Natl. Acad. Sci. USA 97: 8302-8305
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8302-8305
    • Lee, S.W.1    Fang, L.2    Igarashi, M.3    Ouchi, T.4    Lu, K.P.5    Aaronson, S.A.6
  • 9
    • 0034735896 scopus 로고    scopus 로고
    • Direct transactivation of c-Ha-ras gene by p53: Evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis
    • Deguin-Chambon V, Vacher M, Jullien M, May E and Bourdon J-C (2000) Direct transactivation of c-Ha-ras gene by p53: evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis. Oncogene 19: 5831-5841
    • (2000) Oncogene , vol.19 , pp. 5831-5841
    • Deguin-Chambon, V.1    Vacher, M.2    Jullien, M.3    May, E.4    Bourdon, J.-C.5
  • 14
    • 0034671751 scopus 로고    scopus 로고
    • Requirement for ERK activation in cisplatin-induced apoptosis
    • Wang X, Martindale JL and Holbrook NJ (2000) Requirement for ERK activation in cisplatin-induced apoptosis. J. Biol. Chem. 275: 39435-39443
    • (2000) J. Biol. Chem. , vol.275 , pp. 39435-39443
    • Wang, X.1    Martindale, J.L.2    Holbrook, N.J.3
  • 16
    • 0030831534 scopus 로고    scopus 로고
    • CRM1 is responsible for intracellular transport mediated by the nuclear export signal
    • Fukuda M, Asano S, Nakamura T, Adachi M, Yoshida M, Yanagida M and Nishida E (1997) CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390: 308-311
    • (1997) Nature , vol.390 , pp. 308-311
    • Fukuda, M.1    Asano, S.2    Nakamura, T.3    Adachi, M.4    Yoshida, M.5    Yanagida, M.6    Nishida, E.7
  • 17
    • 0031724593 scopus 로고    scopus 로고
    • Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
    • Freedman DA and Levine AJ (1998) Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 18: 7288-7293
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7288-7293
    • Freedman, D.A.1    Levine, A.J.2
  • 18
    • 0343044332 scopus 로고    scopus 로고
    • Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B
    • Smart P, Lane EB, Lane DP, Midgley C, Vojtesek B and Laín S (1999) Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. Oncogene 18: 7378-7386
    • (1999) Oncogene , vol.18 , pp. 7378-7386
    • Smart, P.1    Lane, E.B.2    Lane, D.P.3    Midgley, C.4    Vojtesek, B.5    Laín, S.6
  • 21
    • 0032127463 scopus 로고    scopus 로고
    • p53 facilitates pRb cleavage in IL-3-deprived cells: Novel pro-apoptotic activity of p53
    • Gottlieb E and Oren M (1998) p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53. EMBO J. 17: 3587-3596
    • (1998) EMBO J. , vol.17 , pp. 3587-3596
    • Gottlieb, E.1    Oren, M.2
  • 24
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: The executioners of apoptosis
    • Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem. J. 326: 1-16
    • (1997) Biochem. J. , vol.326 , pp. 1-16
    • Cohen, G.M.1
  • 25
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp TR, Bernards R and Agami R (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 26
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko LJ and Prives C (1996) p53: puzzle and paradigm. Genes Dev. 10: 1054-1072
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 27
    • 0034703742 scopus 로고    scopus 로고
    • p53: Death star
    • Vousden KH (2000) p53: death star. Cell 103: 691-694
    • (2000) Cell , vol.103 , pp. 691-694
    • Vousden, K.H.1
  • 28
    • 0033590179 scopus 로고    scopus 로고
    • DNA-damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
    • Dasika GK, Lin SC, Zhao S, Sung P, Tomkinson A and Lee EY (1999) DNA-damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 18: 7883-7899
    • (1999) Oncogene , vol.18 , pp. 7883-7899
    • Dasika, G.K.1    Lin, S.C.2    Zhao, S.3    Sung, P.4    Tomkinson, A.5    Lee, E.Y.6
  • 30
    • 0035895663 scopus 로고    scopus 로고
    • Ras-dependent cell cycle commitment during G2 phase
    • Hitomi M and Stacey DW (2001) Ras-dependent cell cycle commitment during G2 phase. FEBS Lett. 490: 123-131
    • (2001) FEBS Lett. , vol.490 , pp. 123-131
    • Hitomi, M.1    Stacey, D.W.2
  • 31
    • 0033622521 scopus 로고    scopus 로고
    • Activation of p53/p21waf1 pathway is associated with senescence during v-Ha-ras transformation of immortal C2C12 myoblasts
    • D'Orazi G, Soddu S and Sacchi A (2000) Activation of p53/p21waf1 pathway is associated with senescence during v-Ha-ras transformation of immortal C2C12 myoblasts. Anticancer Res. 20: 3497-3502
    • (2000) Anticancer Res. , vol.20 , pp. 3497-3502
    • D'Orazi, G.1    Soddu, S.2    Sacchi, A.3
  • 32
    • 0032549670 scopus 로고    scopus 로고
    • Caspase-dependent cleavage of signaling proteins during apoptosis
    • Widmann C, Gibson S and Johnson GL (1998) Caspase-dependent cleavage of signaling proteins during apoptosis. J. Biol. Chem. 273: 7141-7147
    • (1998) J. Biol. Chem. , vol.273 , pp. 7141-7147
    • Widmann, C.1    Gibson, S.2    Johnson, G.L.3
  • 33
    • 0032548105 scopus 로고    scopus 로고
    • A 60 kD MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells
    • Pochampally R, Fodera B, Chen L, Shao W, Levine EA and Chen J (1998) A 60 kD MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells. Oncogene 17: 2629-2636
    • (1998) Oncogene , vol.17 , pp. 2629-2636
    • Pochampally, R.1    Fodera, B.2    Chen, L.3    Shao, W.4    Levine, E.A.5    Chen, J.6
  • 35
    • 0035901496 scopus 로고    scopus 로고
    • p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades
    • Fang L, Li G, Liu G, Lee SW and Aaronson SA (2001) p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades. EMBO J. 20: 1931-1939
    • (2001) EMBO J. , vol.20 , pp. 1931-1939
    • Fang, L.1    Li, G.2    Liu, G.3    Lee, S.W.4    Aaronson, S.A.5
  • 36
    • 0033588217 scopus 로고    scopus 로고
    • Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis
    • Sabbatini P and McCormick F (1999) Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis. J. Biol. Chem. 274: 24263-24269
    • (1999) J. Biol. Chem. , vol.274 , pp. 24263-24269
    • Sabbatini, P.1    McCormick, F.2
  • 37
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW and Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 38
    • 0033656021 scopus 로고    scopus 로고
    • Exogenous wt-p53 protein is active in transformed cells but not in their non-transformed counterparts: Implications for cancer gene therapy without tumor targeting
    • D'Orazi G, Marchetti A, Crescenzi M, Coen S, Sacchi A and Soddu S (2000) Exogenous wt-p53 protein is active in transformed cells but not in their non-transformed counterparts: implications for cancer gene therapy without tumor targeting. J. Gene Med. 2: 11-21
    • (2000) J. Gene Med. , vol.2 , pp. 11-21
    • D'Orazi, G.1    Marchetti, A.2    Crescenzi, M.3    Coen, S.4    Sacchi, A.5    Soddu, S.6
  • 39
    • 9344237152 scopus 로고    scopus 로고
    • Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo
    • Del Bufalo D, Cucco C, Leonetti C, Citro G, Dagnano I, Benassi M, Geiser T, Zon G, Calabretta B and Zupi G (1996) Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo. Br. J. Cancer 74: 387-393
    • (1996) Br. J. Cancer , vol.74 , pp. 387-393
    • Del Bufalo, D.1    Cucco, C.2    Leonetti, C.3    Citro, G.4    Dagnano, I.5    Benassi, M.6    Geiser, T.7    Zon, G.8    Calabretta, B.9    Zupi, G.10
  • 40
    • 0002025785 scopus 로고
    • Manipulation of adenovirus
    • Murray EJ, ed (Clifton, NJ: Humana Press)
    • Graham F and Prevec L (1991) Manipulation of adenovirus. In Methods of Molecular Biology, Murray EJ, ed (Clifton, NJ: Humana Press) Vol. 7, pp. 109-128
    • (1991) Methods of Molecular Biology , vol.7 , pp. 109-128
    • Graham, F.1    Prevec, L.2
  • 41
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis
    • Agami R, Blandino G, Oren M and Shaul Y (1999) Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 399: 809-813
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 42
    • 0025352187 scopus 로고
    • Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
    • Morgenstern JP and Land H (11990) Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18: 3587-3596
    • (1992) Nucleic Acids Res. , vol.18 , pp. 3587-3596
    • Morgenstern, J.P.1    Land, H.2
  • 43
    • 0026446686 scopus 로고
    • Identification of a minimal transforming domain of p53: Negative dominance through abrogation of sequence-specific DNA binding
    • Shaulian E, Zauberman A, Ginsberg D and Oren M (1992) Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol. Cell. Biol. 12: 5581-5592
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5581-5592
    • Shaulian, E.1    Zauberman, A.2    Ginsberg, D.3    Oren, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.