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Volumn 4, Issue 2, 2006, Pages 291-302

Potential antivirals and antiviral strategies against SARS coronavirus infections

Author keywords

Coronavirus; Interferon; Monoclonal antibody; Protease inhibitors; S protein; SARS; SARS CoV inhibitors; siRNA

Indexed keywords

ALPHA INTERFERON; ANTIVIRUS AGENT; AURINTRICARBOXYLIC ACID; BETA INTERFERON; CALPASTATIN; CELL RECEPTOR; CHLOROQUINE; CINANSERIN; CONSENSUS INTERFERON; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ENFUVIRTIDE; EREMOMYCIN; GLYCYRRHIZA EXTRACT; GLYCYRRHIZIC ACID; HESPERETIN; ISATIS INDIGOTICA EXTRACT; MONOCLONAL ANTIBODY; NELFINAVIR; NICLOSAMIDE; PLANT EXTRACT; PLANT LECTIN; POLYPEPTIDE ANTIBIOTIC AGENT; RNA DIRECTED RNA POLYMERASE; SMALL INTERFERING RNA; TEICOPLANIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALINOMYCIN; VANCOMYCIN; VIRUS GLYCOPROTEIN;

EID: 33646166978     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.4.2.291     Document Type: Review
Times cited : (158)

References (94)
  • 1
    • 0242717589 scopus 로고    scopus 로고
    • Coronavirus as a possible cause of severe acute respiratory syndrome
    • Peiris JS, Lai ST, Poon LL et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361, 1319-1325 (2003).
    • (2003) Lancet , vol.361 , pp. 1319-1325
    • Peiris, J.S.1    Lai, S.T.2    Poon, L.L.3
  • 2
    • 0013074820 scopus 로고    scopus 로고
    • A major outbreak of severe acute respiratory syndrome in Hong Kong
    • Lee N, Hui D, Wu A et al. A major outbreak of severe acute respiratory syndrome in Hong Kong. N. Engl. J. Med. 348, 1986-1994 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1986-1994
    • Lee, N.1    Hui, D.2    Wu, A.3
  • 3
    • 0038076030 scopus 로고    scopus 로고
    • A novel coronavirus associated with severe acute respiratory syndrome
    • Ksiazek TG, Erdman D, Goldsmith CS et al. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 348, 1953-1966 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1953-1966
    • Ksiazek, T.G.1    Erdman, D.2    Goldsmith, C.S.3
  • 4
    • 0038523806 scopus 로고    scopus 로고
    • Identification of a novel coronavirus in patients with severe acute respiratory syndrome
    • Drosten C, Gunther S, Preiser W et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med. 348, 1967-1976 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1967-1976
    • Drosten, C.1    Gunther, S.2    Preiser, W.3
  • 5
    • 0042198682 scopus 로고    scopus 로고
    • Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
    • Kuiken T, Fouchier RA, Schutten M et al. Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 362, 263-270 (2003).
    • (2003) Lancet , vol.362 , pp. 263-270
    • Kuiken, T.1    Fouchier, R.A.2    Schutten, M.3
  • 6
    • 0038011859 scopus 로고    scopus 로고
    • Aetiology: Koch's postulates fulfilled for SARS virus
    • Fouchier RA, Kuiken T, Schutten M et al. Aetiology: Koch's postulates fulfilled for SARS virus. Nature 423, 240 (2003).
    • (2003) Nature , vol.423 , pp. 240
    • Fouchier, R.A.1    Kuiken, T.2    Schutten, M.3
  • 7
    • 11144353592 scopus 로고    scopus 로고
    • Identification of a new human coronavirus
    • van der Hoek L, Pyrc K, Jebbink MF et al. Identification of a new human coronavirus. Nature Med. 10, 368-373 (2004).
    • (2004) Nature Med. , vol.10 , pp. 368-373
    • van der Hoek, L.1    Pyrc, K.2    Jebbink, M.F.3
  • 9
    • 17144400819 scopus 로고    scopus 로고
    • New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus
    • Oxford A Balasingam S, Chan C, Catchpole A, Lambkin R. New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus. Antiviral Chem. Chemother. 16, 13-21 (2005).
    • (2005) Antiviral Chem. Chemother. , vol.16 , pp. 13-21
    • Oxford, A.1    Balasingam, S.2    Chan, C.3    Catchpole, A.4    Lambkin, R.5
  • 11
    • 4444256678 scopus 로고    scopus 로고
    • Antivirals and antiviral strategies
    • De Clercq E. Antivirals and antiviral strategies. Nature Rev. Microbial. 2, 704-720 (2004).
    • (2004) Nature Rev. Microbial. , vol.2 , pp. 704-720
    • De Clercq, E.1
  • 12
    • 0344395657 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
    • Li W, Moore MJ, Vasilleva. N et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426, 450-454 (2003).
    • (2003) Nature , vol.426 , pp. 450-454
    • Li, W.1    Moore, M.J.2    Vasilleva, N.3
  • 13
    • 2942548115 scopus 로고    scopus 로고
    • Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor
    • Hofmann H, Geier M, Marzi A et al. Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem. Biophys. Res. Commun. 319, 1216-1221 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.319 , pp. 1216-1221
    • Hofmann, H.1    Geier, M.2    Marzi, A.3
  • 14
    • 27744580592 scopus 로고    scopus 로고
    • ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia
    • Jia HP, Look DC, Shi L et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J. Virol. 79, 14614-14621 (2005).
    • (2005) J. Virol. , vol.79 , pp. 14614-14621
    • Jia, H.P.1    Look, D.C.2    Shi, L.3
  • 15
    • 0942298133 scopus 로고    scopus 로고
    • A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2
    • Wong SK, Li W, Moore MJ, Choe H, Farzan M. A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J. Biol. Chem. 279, 3197-3201 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 3197-3201
    • Wong, S.K.1    Li, W.2    Moore, M.J.3    Choe, H.4    Farzan, M.5
  • 16
    • 10744229285 scopus 로고    scopus 로고
    • Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association
    • Sul J, Li W, Murakami A et al. Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc. Natl Acad. Sci. USA 101, 2536-2541 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 2536-2541
    • Sul, J.1    Li, W.2    Murakami, A.3
  • 17
    • 2342418543 scopus 로고    scopus 로고
    • ACE2 X-ray structures reveal a large hingebending motion important for inhibitor binding and catalysis
    • Towler P, Staker B, Prasad SG et al. ACE2 X-ray structures reveal a large hingebending motion important for inhibitor binding and catalysis. J. Biol. Chem. 279, 17996-18007 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 17996-18007
    • Towler, P.1    Staker, B.2    Prasad, S.G.3
  • 19
    • 12144287276 scopus 로고    scopus 로고
    • Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: Implications for virus fusogenic mechanism and identification of fusion inhibitors
    • Liu S, Xiao G, Chen Y et al. Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. Lancet 363, 938-947 (2004).
    • (2004) Lancet , vol.363 , pp. 938-947
    • Liu, S.1    Xiao, G.2    Chen, Y.3
  • 20
    • 2442705099 scopus 로고    scopus 로고
    • Following the rule: Formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors
    • Zhu J, Xiao G, Xu Y et al. Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors. Biochem. Biophys. Res. Commun. 319, 283-288 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.319 , pp. 283-288
    • Zhu, J.1    Xiao, G.2    Xu, Y.3
  • 21
    • 15444363201 scopus 로고    scopus 로고
    • Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain
    • Ni L, Zhu J, Zhang J, Yan M, Gao GF, Tien P. Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain. Biochem. Biophys. Res. Commun. 330, 39-45 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.330 , pp. 39-45
    • Ni, L.1    Zhu, J.2    Zhang, J.3    Yan, M.4    Gao, G.F.5    Tien, P.6
  • 22
    • 29044440663 scopus 로고    scopus 로고
    • Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions
    • Veiga S, Yuan Y, Li X et al. Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions. Biochim. Biophys. Acta 1760, 55-61 (2006).
    • (2006) Biochim. Biophys. Acta , vol.1760 , pp. 55-61
    • Veiga, S.1    Yuan, Y.2    Li, X.3
  • 24
    • 2542501662 scopus 로고    scopus 로고
    • Inhibition of severe acute respiratory syndrome-associated coronavirus; (SARSCoV) by calpain inhibitors and β-D-N4-hydroxycytidine
    • Barnard DL, Hubbard VD, Burton J et al. Inhibition of severe acute respiratory syndrome-associated coronavirus; (SARSCoV) by calpain inhibitors and β-D-N4-hydroxycytidine. Antiviral Chem. Chemother. 15, 15-22 (2004).
    • (2004) Antiviral Chem. Chemother. , vol.15 , pp. 15-22
    • Barnard, D.L.1    Hubbard, V.D.2    Burton, J.3
  • 25
    • 0038120984 scopus 로고    scopus 로고
    • Coronavirus main proteinase (3CLpro) structure: Basis for design of anti-SARS drugs
    • Anand K, Ziebuhr J. Wadhwani P, Mesters JR, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science 300, 1763-1767 (2003).
    • (2003) Science , vol.300 , pp. 1763-1767
    • Anand, K.1    Ziebuhr, J.2    Wadhwani, P.3    Mesters, J.R.4    Hilgenfeld, R.5
  • 26
    • 0041848237 scopus 로고    scopus 로고
    • Binding mechanisms of coronavirus main proteinase with ligands and its implication to drug design against SARS
    • Chou KC, Wei DQ, Zhong WZ. Binding mechanisms of coronavirus main proteinase with ligands and its implication to drug design against SARS. Biochem. Biophys. Res. Commun. 308, 148-151 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.308 , pp. 148-151
    • Chou, K.C.1    Wei, D.Q.2    Zhong, W.Z.3
  • 27
    • 0345255626 scopus 로고    scopus 로고
    • The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
    • Yang H, Yang M, Ding Y et al. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc. Natl Acad. Sci. USA 100, 13190-13195 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13190-13195
    • Yang, H.1    Yang, M.2    Ding, Y.3
  • 28
    • 27144538090 scopus 로고    scopus 로고
    • Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide
    • Lee T-W, Cherney MM, Huitema C et al. Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide. J. Mol. Biol. 353, 1137-1151 (2005).
    • (2005) J. Mol. Biol. , vol.353 , pp. 1137-1151
    • Lee, T.-W.1    Cherney, M.M.2    Huitema, C.3
  • 29
    • 9144268403 scopus 로고    scopus 로고
    • Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase
    • Fan K, Wei P, Feng Q et al. Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase. J. Biol. Cbem.279, 1637-1642 (2004).
    • (2004) J. Biol. Cbem. , vol.279 , pp. 1637-1642
    • Fan, K.1    Wei, P.2    Feng, Q.3
  • 30
    • 27444439747 scopus 로고    scopus 로고
    • Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor
    • Martina E, Stiefl N, Degel B et al. Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor. Bioorg. Med. Chem. Lett. 15, 5365-5369 (2005).
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 5365-5369
    • Martina, E.1    Stiefl, N.2    Degel, B.3
  • 31
    • 9744247544 scopus 로고    scopus 로고
    • Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro
    • Jain RP, Pettersson HI, Zhang J et al. Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro. J. Med. Chem. 47, 6113-6116 (2004).
    • (2004) J. Med. Chem. , vol.47 , pp. 6113-6116
    • Jain, R.P.1    Pettersson, H.I.2    Zhang, J.3
  • 32
    • 27444437908 scopus 로고    scopus 로고
    • Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors
    • Ghosh AK, Xi K, Ratia K et al. Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. J. Med. Chem. 48, 6767-6771 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 6767-6771
    • Ghosh, A.K.1    Xi, K.2    Ratia, K.3
  • 33
    • 21244442337 scopus 로고    scopus 로고
    • Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease
    • Shie J-J, Fang J-M, Kuo C-J et al. Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. J. Med. Chem. 48, 4469-4473 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 4469-4473
    • Shie, J.-J.1    Fang, J.-M.2    Kuo, C.-J.3
  • 34
    • 27444440007 scopus 로고    scopus 로고
    • A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods
    • Kaeppler U, Stiefl N, Schiller M et al. A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods. J. Med. Chem. 48, 6832-6842 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 6832-6842
    • Kaeppler, U.1    Stiefl, N.2    Schiller, M.3
  • 35
    • 19944378080 scopus 로고    scopus 로고
    • Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors
    • Chen L-R, Wang Y-C, Lin YW et al. Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors. Bioorg. Med, Chem. Lett. 15, 3058-3062 (2005).
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3058-3062
    • Chen, L.-R.1    Wang, Y.-C.2    Lin, Y.W.3
  • 36
    • 20444433493 scopus 로고    scopus 로고
    • Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease
    • Liu Y-C, Huang V, Chao T-C et al. Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease. Biochem. Biophys. Res. Commun. 333, 194-199 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.333 , pp. 194-199
    • Liu, Y.-C.1    Huang, V.2    Chao, T.-C.3
  • 37
    • 24344464802 scopus 로고    scopus 로고
    • Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3′-digallate (TF3)
    • Chen C-N, Lin CPC, Huang K-K et al. Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3′-digallate (TF3). Evid. Based Complement Alternat Med. 2, 209-215 (2005).
    • (2005) Evid. Based Complement Alternat Med. , vol.2 , pp. 209-215
    • Chen, C.-N.1    Lin, C.P.C.2    Huang, K.-K.3
  • 38
    • 22844437876 scopus 로고    scopus 로고
    • Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
    • Shie J-J, Fang J-M, Kuo T-H et al. Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters. Bioorg. Med. Chem. 13, 5240-5252 (2005).
    • (2005) Bioorg. Med. Chem. , vol.13 , pp. 5240-5252
    • Shie, J.-J.1    Fang, J.-M.2    Kuo, T.-H.3
  • 39
    • 21044456863 scopus 로고    scopus 로고
    • Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro
    • Chen L, Gui C, Luo X et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro, J. Virol. 79, 7095-7103 (2005).
    • (2005) J. Virol. , vol.79 , pp. 7095-7103
    • Chen, L.1    Gui, C.2    Luo, X.3
  • 40
    • 33646199608 scopus 로고    scopus 로고
    • Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase
    • (Epub ahead of print)
    • Gan Y-R, Huang H, Huang Y-D et al. Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase. Peptides (2005) (Epub ahead of print).
    • (2005) Peptides
    • Gan, Y.-R.1    Huang, H.2    Huang, Y.-D.3
  • 41
    • 29744455503 scopus 로고    scopus 로고
    • The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity
    • Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J. Virol. 79, 15189-15198 (2005).
    • (2005) J. Virol. , vol.79 , pp. 15189-15198
    • Barretto, N.1    Jukneliene, D.2    Ratia, K.3    Chen, Z.4    Mesecar, A.D.5    Baker, S.C.6
  • 42
    • 29744463886 scopus 로고    scopus 로고
    • The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme
    • Lindner HA, Fotouhi-Ardakani N, Lytvyn V, Lachance P, Sulea T, Ménard R. The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme. J. Virol. 79, 15199-15208 (2005).
    • (2005) J. Virol. , vol.79 , pp. 15199-15208
    • Lindner, H.A.1    Fotouhi-Ardakani, N.2    Lytvyn, V.3    Lachance, P.4    Sulea, T.5    Ménard, R.6
  • 43
    • 0141960168 scopus 로고    scopus 로고
    • The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5′ to 3′ viral helicases
    • Tanner JA, Watt RM, Chai YB et al. The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5′ to 3′ viral helicases. J. Biol. Chem. 278, 39578-39582 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 39578-39582
    • Tanner, J.A.1    Watt, R.M.2    Chai, Y.B.3
  • 44
    • 20144381480 scopus 로고    scopus 로고
    • The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
    • Tanner JA, Zheng B-J, Zhou J et al. The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus. Chem. Biol. 12, 303-311 (2005).
    • (2005) Chem. Biol. , vol.12 , pp. 303-311
    • Tanner, J.A.1    Zheng, B.-J.2    Zhou, J.3
  • 45
    • 0346888670 scopus 로고    scopus 로고
    • Molecular model of SARS coronavirus polymerase: Implications for biochemical functions and drug design
    • Xu X, Liu Y, Weiss S, Arnold E, Sarafianos SG, Ding J. Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design. Nucleic Acids Res. 31, 7117-7130 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 7117-7130
    • Xu, X.1    Liu, Y.2    Weiss, S.3    Arnold, E.4    Sarafianos, S.G.5    Ding, J.6
  • 46
    • 17444431570 scopus 로고    scopus 로고
    • Expression, purification, and characterization of SARS coronavirus RNA polymerase
    • Cheng A, Zhang W, Xie Y et al. Expression, purification, and characterization of SARS coronavirus RNA polymerase. Virology 335, 165-176 (2005).
    • (2005) Virology , vol.335 , pp. 165-176
    • Cheng, A.1    Zhang, W.2    Xie, Y.3
  • 47
    • 27144474958 scopus 로고    scopus 로고
    • Mutational analysis of the SARS virus Nsp 15 endoribonuclease: Identification of residues affecting hexamer formation
    • Guarino LA, Bhardwaj K, Dong W, Sun J, Holzenburg A, Kao C. Mutational analysis of the SARS virus Nsp 15 endoribonuclease: identification of residues affecting hexamer formation. J. Mol. Biol. 353, 1106-1117 (2005).
    • (2005) J. Mol. Biol. , vol.353 , pp. 1106-1117
    • Guarino, L.A.1    Bhardwaj, K.2    Dong, W.3    Sun, J.4    Holzenburg, A.5    Kao, C.6
  • 48
    • 20944444682 scopus 로고    scopus 로고
    • Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants
    • Sui J. Li W, Roberts A et al. Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants. J. Virol. 79, 5900-5906 (2005).
    • (2005) J. Virol. , vol.79 , pp. 5900-5906
    • Sui, J.1    Li, W.2    Roberts, A.3
  • 49
    • 3042606257 scopus 로고    scopus 로고
    • Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets
    • ter Meulen J, Bakker ABH, van den Brink EN et al. Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Lancet 363, 2139-2141 (2004).
    • (2004) Lancet , vol.363 , pp. 2139-2141
    • ter Meulen, J.1    Bakker, A.B.H.2    van den Brink, E.N.3
  • 50
    • 1842614358 scopus 로고    scopus 로고
    • Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice
    • Subbarao K, McAuliffe J, Vogel L et al. Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice. J. Virol. 78, 3572-3577 (2004).
    • (2004) J. Virol. , vol.78 , pp. 3572-3577
    • Subbarao, K.1    McAuliffe, J.2    Vogel, L.3
  • 51
    • 28944441428 scopus 로고    scopus 로고
    • Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
    • Zhang L, Zhang F, Yu W et al. Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals. J. Med. Virol. 78, 1-8 (2006).
    • (2006) J. Med. Virol. , vol.78 , pp. 1-8
    • Zhang, L.1    Zhang, F.2    Yu, W.3
  • 52
    • 0038690593 scopus 로고    scopus 로고
    • Treatment of severe acute respiratory syndrome with convalescent plasma
    • Wong VWS, Dai D, Wu AKL, Sung JJY. Treatment of severe acute respiratory syndrome with convalescent plasma. Hong Kong Med. J. 9, 199-201 (2003).
    • (2003) Hong Kong Med. J. , vol.9 , pp. 199-201
    • Wong, V.W.S.1    Dai, D.2    Wu, A.K.L.3    Sung, J.J.Y.4
  • 53
    • 28844481759 scopus 로고    scopus 로고
    • Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV gp120. A new therapeutic concept to hit the Achilles heel of HIV
    • Baizarini J, Van Laethem K, Hatse S et al. Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV gp120. A new therapeutic concept to hit the Achilles heel of HIV. J. Biol. Chem. 280, 41005-41014 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 41005-41014
    • Baizarini, J.1    Van Laethem, K.2    Hatse, S.3
  • 56
    • 18344419173 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome-related coronavirus is inhibited by interferon-α
    • Ströher U, DiCaro A, Li Y et al. Severe acute respiratory syndrome-related coronavirus is inhibited by interferon-α. J. Infect. Dis. 189, 1164-1167 (2004).
    • (2004) J. Infect. Dis. , vol.189 , pp. 1164-1167
    • Ströher, U.1    DiCaro, A.2    Li, Y.3
  • 57
    • 3242885894 scopus 로고    scopus 로고
    • Potent inhibition of SARS-associated coronavirus (SCoV) infection and replication by type I interferons (IFN-α/β) but not by type II interferon (IFN-γ)
    • Zheng B, He M-L, Wong K-L et al. Potent inhibition of SARS-associated coronavirus (SCoV) infection and replication by type I interferons (IFN-α/β) but not by type II interferon (IFN-γ). J Interferon Cytokine Res. 24, 388-390 (2004).
    • (2004) J Interferon Cytokine Res. , vol.24 , pp. 388-390
    • Zheng, B.1    He, M.-L.2    Wong, K.-L.3
  • 58
    • 2442512030 scopus 로고    scopus 로고
    • The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein
    • Spiegel M, Pichlmair A, Mühlberger E, Haller O, Weber F. The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein. J. Clin. Virol. 30, 211-213 (2004).
    • (2004) J. Clin. Virol. , vol.30 , pp. 211-213
    • Spiegel, M.1    Pichlmair, A.2    Mühlberger, E.3    Haller, O.4    Weber, F.5
  • 59
    • 5144219591 scopus 로고    scopus 로고
    • Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)
    • Sainz B Jr, Mossel EC, Peters CJ, Garry RF. Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Virology 329, 11-17 (2004).
    • (2004) Virology , vol.329 , pp. 11-17
    • Sainz Jr., B.1    Mossel, E.C.2    Peters, C.J.3    Garry, R.F.4
  • 60
    • 0348136783 scopus 로고    scopus 로고
    • Interferon alfacon- 1 plus corticosteroids in severe acute respiratory syndrome
    • Loutfy MR, Blatt LM, Siminovitch KA et al. Interferon alfacon- 1 plus corticosteroids in severe acute respiratory syndrome. JAMA 290, 3222-3228 (2003).
    • (2003) JAMA , vol.290 , pp. 3222-3228
    • Loutfy, M.R.1    Blatt, L.M.2    Siminovitch, K.A.3
  • 61
    • 32044432614 scopus 로고    scopus 로고
    • Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide
    • Bao M, Zhang Y, Wan M et al. Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide. Clin. Immunol. 118(2-3), 180-187 (2006).
    • (2006) Clin. Immunol. , vol.118 , Issue.2-3 , pp. 180-187
    • Bao, M.1    Zhang, Y.2    Wan, M.3
  • 62
    • 2342645538 scopus 로고    scopus 로고
    • Pegylated interferon-α protects type 1 pneumocytes against SARS coronavirus infection in macaques
    • Haagmans BL, Kuiken T, Martina BE et al. Pegylated interferon-α protects type 1 pneumocytes against SARS coronavirus infection in macaques. Nature Med. 10, 290-293 (2004).
    • (2004) Nature Med. , vol.10 , pp. 290-293
    • Haagmans, B.L.1    Kuiken, T.2    Martina, B.E.3
  • 63
    • 6044248871 scopus 로고    scopus 로고
    • Therapeutic potential of RNA interference
    • Stevenson M. Therapeutic potential of RNA interference. N. Engl. J. Med. 351, 1772-1777 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1772-1777
    • Stevenson, M.1
  • 64
    • 0344430079 scopus 로고    scopus 로고
    • Inhibition of SARS-associated coronavirus infection and replication by RNA interference
    • He M-L, Zheng B, Peng Y et al. Inhibition of SARS-associated coronavirus infection and replication by RNA interference. JAMA 290, 2665-2666 (2003).
    • (2003) JAMA , vol.290 , pp. 2665-2666
    • He, M.-L.1    Zheng, B.2    Peng, Y.3
  • 65
    • 10744221444 scopus 로고    scopus 로고
    • Silencing SARS-CoV spike protein expression in cultured cells by RNA interference
    • Zhang Y, Li T, Fu L et al. Silencing SARS-CoV spike protein expression in cultured cells by RNA interference. FEBS Lett. 560, 141-146 (2004).
    • (2004) FEBS Lett. , vol.560 , pp. 141-146
    • Zhang, Y.1    Li, T.2    Fu, L.3
  • 66
    • 24744466699 scopus 로고    scopus 로고
    • Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in rhesus macaque
    • Li B-j, Tang Q, Cheng D et al. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in rhesus macaque. Nature Med. 11, 944-951 (2005).
    • (2005) Nature Med. , vol.11 , pp. 944-951
    • Li, B.-J.1    Tang, Q.2    Cheng, D.3
  • 67
    • 33646188306 scopus 로고    scopus 로고
    • RNAi therapeutics: Can siRNAs conquer SARS?
    • (Epub ahead of print)
    • Chang Z, Hu J. RNAi therapeutics: can siRNAs conquer SARS? Gene Ther. (2005) (Epub ahead of print).
    • (2005) Gene Ther.
    • Chang, Z.1    Hu, J.2
  • 68
    • 22544444953 scopus 로고    scopus 로고
    • Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers
    • Neuman BW, Stein DA, Kroeker AD et al. Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J. Virol, 79, 9665-9676 (2005).
    • (2005) J. Virol. , vol.79 , pp. 9665-9676
    • Neuman, B.W.1    Stein, D.A.2    Kroeker, A.D.3
  • 69
    • 3142594446 scopus 로고    scopus 로고
    • Small molecules targeting severe acute respiratory syndrome human coronavirus
    • Wu C-Y, Jan J-T, Ma S-H et al. Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc. Natl Acad. Sci. USA 101, 10012-10017 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 10012-10017
    • Wu, C.-Y.1    Jan, J.-T.2    Ma, S.-H.3
  • 70
    • 33646174829 scopus 로고    scopus 로고
    • Inhibitory activity of vancomycin, eremomycin and teicoplanin aglycon derivatives against feline and human coronaviruses (i.e. SARS)
    • AZ, USA, 2-6 May 2004. Antiviral Res
    • Balzarini J, Keyaerts E, Vijgen L, De Clercq E, Preobrazhenskaya M, Van Ranst M. Inhibitory activity of vancomycin, eremomycin and teicoplanin aglycon derivatives against feline and human coronaviruses (i.e. SARS). 17th International Conference an Antiviral Research. AZ, USA, 2-6 May 2004. Antiviral Res. 62(A59), 78 (2004).
    • (2004) 17th International Conference an Antiviral Research , vol.62 , Issue.A59 , pp. 78
    • Balzarini, J.1    Keyaerts, E.2    Vijgen, L.3    De Clercq, E.4    Preobrazhenskaya, M.5    Van Ranst, M.6
  • 71
    • 33646200058 scopus 로고    scopus 로고
    • Mannose-specific plant lectins are potent inhibitors of coronavirus infection including the virus causing SARS
    • AZ, USA, 2-6 May 2004. Antiviral Res
    • Balzarini J, Vijgen L, Keyaerts E et al, Mannose-specific plant lectins are potent inhibitors of coronavirus infection including the virus causing SARS. l7th International Conference on Antiviral Research. AZ, USA, 2-6 May 2004. Antiviral Res. 62(A76), 122 (2004).
    • (2004) L7th International Conference on Antiviral Research , vol.62 , Issue.A76 , pp. 122
    • Balzarini, J.1    Vijgen, L.2    Keyaerts, E.3
  • 72
    • 4444294891 scopus 로고    scopus 로고
    • Antiviral effect of plant compounds of the Alliaceae family against the SARS coronavirus
    • AZ, USA, 2-6 May 2004. Antiviral Res
    • Vijgen L, Keyaerts E, Van Damme E et al. Antiviral effect of plant compounds of the Alliaceae family against the SARS coronavirus. 17th International Conference on Antiviral Research. AZ, USA, 2-6 May 2004. Antiviral Res. 62(A76), 123 (2004).
    • (2004) 17th International Conference on Antiviral Research , vol.62 , Issue.A76 , pp. 123
    • Vijgen, L.1    Keyaerts, E.2    Van Damme, E.3
  • 73
    • 25144432483 scopus 로고    scopus 로고
    • Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds
    • Lin C-W, Tsai F-J, Tsai C-H et al. Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Res. 68, 36-42 (2005).
    • (2005) Antiviral Res. , vol.68 , pp. 36-42
    • Lin, C.-W.1    Tsai, F.-J.2    Tsai, C.-H.3
  • 74
    • 0023120973 scopus 로고
    • Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus
    • [HIV (HTLV-III/LAV)]
    • Ito M, Nakashima H, Baba M et al. Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)]. Antiviral Res. 7, 127-137 (1987).
    • (1987) Antiviral Res. , vol.7 , pp. 127-137
    • Ito, M.1    Nakashima, H.2    Baba, M.3
  • 75
    • 0024216780 scopus 로고
    • Mechanism of inhibitory effect of glycyrrhizin on replication human immunodeficiency virus (HIV)
    • Ito M, Sato A, Hirabayashi K et al. Mechanism of inhibitory effect of glycyrrhizin on replication human immunodeficiency virus (HIV). Antiviral Res. 10, 289-298 (1988).
    • (1988) Antiviral Res. , vol.10 , pp. 289-298
    • Ito, M.1    Sato, A.2    Hirabayashi, K.3
  • 76
    • 0038047657 scopus 로고    scopus 로고
    • Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
    • Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW, Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361, 2045-2046 (2003).
    • (2003) Lancet , vol.361 , pp. 2045-2046
    • Cinatl, J.1    Morgenstern, B.2    Bauer, G.3    Chandra, P.4    Rabenau, H.5    Doerr, H.W.6
  • 77
    • 13944251304 scopus 로고    scopus 로고
    • Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus
    • Hoever G, Baltina L, Michaelis M et al. Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus. J. Med. Chem. 48, 1256-1259 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 1256-1259
    • Hoever, G.1    Baltina, L.2    Michaelis, M.3
  • 78
    • 3142661081 scopus 로고    scopus 로고
    • Potent and selective inhibition of SARS coronavirus replicatoin by aurintricarboxylic acid
    • He R, Adonov A, Traykova-Adonova M et al. Potent and selective inhibition of SARS coronavirus replicatoin by aurintricarboxylic acid. Biochem. Biophys. Res. Commun. 320, 1199-1203 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.320 , pp. 1199-1203
    • He, R.1    Adonov, A.2    Traykova-Adonova, M.3
  • 79
    • 20444486621 scopus 로고    scopus 로고
    • Structural analysis of inhibition mechanisms of aurintricarboxylic acid on SARS-CoV polymerase and other proteins
    • Ya YL, Zhang XW, Andonov A, He RT. Structural analysis of inhibition mechanisms of aurintricarboxylic acid on SARS-CoV polymerase and other proteins. Comp. Biol. Chem. 29, 212-219 (2005).
    • (2005) Comp. Biol. Chem. , vol.29 , pp. 212-219
    • Ya, Y.L.1    Zhang, X.W.2    Andonov, A.3    He, R.T.4
  • 80
    • 0026063679 scopus 로고
    • Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: Direct correlation of antiviral potency with molecular weight
    • Cushman M, Wang P, Chang SH et al. Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight. J. Med. Chem. 34, 329-337 (1991).
    • (1991) J. Med. Chem. , vol.34 , pp. 329-337
    • Cushman, M.1    Wang, P.2    Chang, S.H.3
  • 81
    • 0025969493 scopus 로고
    • Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds
    • Cushman M, Kanamathareddy S, De Clercq E, Schols D, Goldman ME, Bowen JA. Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds. J. Med. Chem. 34, 337-342 (1991).
    • (1991) J. Med. Chem. , vol.34 , pp. 337-342
    • Cushman, M.1    Kanamathareddy, S.2    De Clercq, E.3    Schols, D.4    Goldman, M.E.5    Bowen, J.A.6
  • 82
    • 0022500351 scopus 로고
    • Aurintricarboxylic acid and Evans blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus
    • Balzarini J, Mitsuya H, De Clercq E, Broder S. Aurintricarboxylic acid and Evans blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus. Biochem. Biophys. Res. Commun. 136, 64-71 (1986).
    • (1986) Biochem. Biophys. Res. Commun. , vol.136 , pp. 64-71
    • Balzarini, J.1    Mitsuya, H.2    De Clercq, E.3    Broder, S.4
  • 83
    • 0345196609 scopus 로고
    • Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor
    • Schols D, Baba M, Pauwels R, Desmyter J, De Clercq E. Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor. Proc. Natl/Acad. Sci. USA 86, 3322-3326 (1989).
    • (1989) Proc. Natl/Acad. Sci. USA , vol.86 , pp. 3322-3326
    • Schols, D.1    Baba, M.2    Pauwels, R.3    Desmyter, J.4    De Clercq, E.5
  • 84
    • 0015523596 scopus 로고
    • Broad-spectrum antiviral activity of virazole: 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
    • Sidwell RW, Huffman JH, Khare GP Allen LB, Witkowski JT, Robins RK. Broad-spectrum antiviral activity of virazole: 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science 177, 705-706 (1972).
    • (1972) Science , vol.177 , pp. 705-706
    • Sidwell, R.W.1    Huffman, J.H.2    Khare, G.P.3    Allen, L.B.4    Witkowski, J.T.5    Robins, R.K.6
  • 85
    • 0015609404 scopus 로고
    • Mechanism of action of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole), a new broadspectrum antiviral agent
    • Streeter DG, Witkowski JT, Khare GP et al. Mechanism of action of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole), a new broadspectrum antiviral agent. Proc. Natl/Acad. Sci. USA 70, 1174-1178 (1973).
    • (1973) Proc. Natl/Acad. Sci. USA , vol.70 , pp. 1174-1178
    • Streeter, D.G.1    Witkowski, J.T.2    Khare, G.P.3
  • 86
    • 19344370471 scopus 로고    scopus 로고
    • Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus
    • Saijo M, Morikawa S, Fukushi S et al. Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus. Antiviral Res. 66, 159-163 (2005).
    • (2005) Antiviral Res. , vol.66 , pp. 159-163
    • Saijo, M.1    Morikawa, S.2    Fukushi, S.3
  • 87
    • 0242355070 scopus 로고    scopus 로고
    • Effects of chloroquine on viral infections: An old drug against today's diseases?
    • Savarino, A, Boelaert JR, Cassone A, Majori G, Cauda R. Effects of chloroquine on viral infections: an old drug against today's diseases? Lancet Infect. Dis. 3, 722-727 (2003).
    • (2003) Lancet Infect. Dis. , vol.3 , pp. 722-727
    • Savarino, A.1    Boelaert, J.R.2    Cassone, A.3    Majori, G.4    Cauda, R.5
  • 89
    • 25444508979 scopus 로고    scopus 로고
    • Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
    • Vincent MJ, Bergeron E, Benjannet S et al. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol. J. 2, 69 (2005).
    • (2005) Virol. J. , vol.2 , pp. 69
    • Vincent, M.J.1    Bergeron, E.2    Benjannet, S.3
  • 90
    • 3242730197 scopus 로고    scopus 로고
    • Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound
    • Keyaerts E, Vijgen L, Chen L, Maes P, Hedenstierna G, Van Ranst M. Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound. Int. J. Infect. Dis. 8, 223-226 (2004).
    • (2004) Int. J. Infect. Dis. , vol.8 , pp. 223-226
    • Keyaerts, E.1    Vijgen, L.2    Chen, L.3    Maes, P.4    Hedenstierna, G.5    Van Ranst, M.6
  • 91
    • 3042675488 scopus 로고    scopus 로고
    • Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide
    • Wu C-J, Jan J-T, Chen C-M et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob. Agents Chemother. 48, 2693-2696 (2004).
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 2693-2696
    • Wu, C.-J.1    Jan, J.-T.2    Chen, C.-M.3
  • 92
    • 2442545542 scopus 로고    scopus 로고
    • HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus
    • Yamamoto N, Yang R, Yoshinaka Y et al. HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus. Biochem. Biophys. Res. Commun. 318, 719-725 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.318 , pp. 719-725
    • Yamamoto, N.1    Yang, R.2    Yoshinaka, Y.3
  • 93
    • 12144290587 scopus 로고    scopus 로고
    • Role of lopinavir/ritonavir in the treatment of SARS: Initial virological and clinical findings
    • Chu CM, Cheng VCC, Hung IFN et al. Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. Thorax 59, 252-256 (2004).
    • (2004) Thorax , vol.59 , pp. 252-256
    • Chu, C.M.1    Cheng, V.C.C.2    Hung, I.F.N.3
  • 94
    • 10744223243 scopus 로고    scopus 로고
    • Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: A multicentre retrospective matched cohort study
    • Chan KS, Lai ST, Chu CM et al. Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study. Hong Kong Med. J. 9, 399-406 (2003).
    • (2003) Hong Kong Med. J. , vol.9 , pp. 399-406
    • Chan, K.S.1    Lai, S.T.2    Chu, C.M.3


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