Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase

Journal of Biological Chemistry

Volumn 279, Issue 3, 2004, Pages 1637-1642

  Fan, Keqiang ^a   Wei, Ping ^a   Feng, Qian ^b   Chen, Sidi ^b   Huang, Changkang ^a   Ma, Liang ^a   Lai, Bing ^a   Pei, Jianfeng ^a,b   Liu, Ying ^a   Chen, Jianguo ^b   Lai, Luhua ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DIMERS; DISEASE CONTROL; DRUG PRODUCTS; ENZYMES; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MONOMERS; POLYPEPTIDES; PULMONARY DISEASES;

DRUG DESIGN; ENZYME ASSAYS;

GENETIC ENGINEERING;

3C LIKE PROTEINASE; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; CATALYSIS; CONCENTRATION (PARAMETERS); CORONAVIRUS; DRUG DESIGN; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SYNTHESIS; GEL FILTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME;

CATALYSIS; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ESCHERICHIA COLI; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

CORONAVIRUS; RNA VIRUSES; SARS CORONAVIRUS;

EID: 9144268403     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310875200     Document Type: Article

References (25)

1. Drosten, C., Gunther, S., Preiser, W., van der, W. S., Brodt, H. R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A., Berger, A., Burguiere, A. M., Cinatl, J., Eickmann, M., Escriou, N., Grywna, K., Kramme, S., Manuguerra, J. C., Muller, S., Rickerts, V., Sturmer, M., Vieth, S., Klenk, H. D., Osterhaus, A. D., Schmitz, H., and Doerr, H. W. (2003) N. Engl. J. Med. 348, 1967-1976
2. Ksiazek, T. G., Erdman, D., Goldsmith, C. S., Zaki, S. R., Peret, T., Emery, S., Tong, S., Urbani, C., Comer, J. A., Lim, W., Rollin, P. E., Dowell, S. F., Ling, A. E., Humphrey, C. D., Shieh, W. J., Guarner, J., Paddock, C. D., Rota, P., Fields, B., DeRisi, J., Yang, J. Y., Cox, N., Hughes, J. M., LeDuc, J. W., Bellini, W. J., and Anderson, L. J. (2003) N. Engl. J. Med. 348, 1953-1966
3. Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R., Icenogle, J. P., Penaranda, S., Bankamp, B., Maher, K., Chen, M. H., Tong, S., Tamin, A., Lowe, L., Frace, M., DeRisi, J. L., Chen, Q., Wang, D., Erdman, D. D., Peret, T. C., Burns, C., Ksiazek, T. G., Rollin, P. E., Sanchez, A., Liffick, S., Holloway, B., Limor, J., McCaustland, K., Olsen-Rasmussen, M., Fouchier, R., Gunther, S., Osterhaus, A. D., Drosten, C., Pallansch, M. A., Anderson, L. J., and Bellini, W. J. (2003) Science 300, 1394-1399
4. Marra, M. A., Jones, S. J., Astell, C. R., Holt, R. A., Brooks-Wilson, A., Butterfield, Y. S., Khattra, J., Asano, J. K., Barber, S. A., Chan, S. Y., Cloutier, A., Coughlin, S. M., Freeman, D., Girn, N., Griffith, O. L., Leach, S. R., Mayo, M., McDonald, H., Montgomery, S. B., Pandoh, P. K., Petrescu, A. S., Robertson, A. G., Schein, J. E., Siddiqui, A., Smailus, D. E., Stott, J. M., Yang, G. S., Plummer, F., Andonov, A., Artsob, H., Bastien, N., Bernard, K., Booth, T. F., Bowness, D., Czub, M., Drebot, M., Fernando, L., Flick, R., Garbutt, M., Gray, M., Grolla, A., Jones, S., Feldmann, H., Meyers, A., Kabani, A., Li, Y., Normand, S., Stroher, U., Tipples, G. A., Tyler, S., Vogrig, R., Ward, D., Watson, B., Brunham, R. C., Krajden, M., Petric, M., Skowronski, D. M., Upton, C., and Roper, R. L. (2003) Science 300, 1399-1404
5. Anand, K., Palm, G. J., Mesters, J. R., Siddell, S. G., Ziebuhr, J., and Hilgenfeld, R. (2002) EMBO J. 21, 3213-3224
6. Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J. R., and Hilgenfeld, R. (2003) Science 300, 1763-1767
7. Matthews, D. A., Smith, W. W., Ferre, R. A., Condon, B., Budahazi, G., Sisson, W., Villafranca, J. E., Janson, C. A., McElroy, H. E., Gribskov, C. L., and Worland, S. (1994) Cell 77, 761-771
8. Seipelt, J., Guarne, A., Bergmann, E., James, M., Sommergruber, W., Fita, I., and Skern, T. (1999) Virus Res. 62, 159-168
9. Dragovich, P. S., Prins, T. J., Zhou, R., Brown, E. L., Maldonado, F. C., Fuhrman, S. A., Zalman, L. S., Tuntland, T., Lee, C. A., Patick, A. K., Matthews, D. A., Hendrickson, T. F., Kosa, M. B., Liu, B., Batugo, M. R., Gleeson, J. P., Sakata, S. K., Chen, L., Guzman, M. C., Meador, J. W., III, Ferre, R. A., and Worland, S. T. (2002) J. Med. Chem. 45, 1607-1623
10. Dragovich, P. S., Prins, T. J., Zhou, R., Johnson, T. O., Brown, E. L., Maldonado, F. C., Fuhrman, S. A., Zalman, L. S., Patick, A. K., Matthews, D. A., Hou, X., Meador, J. W., Ferre, R. A., and Worland, S. T. (2002) Bioorg. Med. Chem. Lett. 12, 733-738
11. Dragovich, P. S., Zhou, R., Webber, S. E., Prins, T. J., Kwok, A. K., Okano, K., Fuhrman, S. A., Zalman, L. S., Maldonado, F. C., Brown, E. L., Meador, J. W., III, Patick, A. K., Ford, C. E., Brothers, M. A., Binford, S. L., Matthews, D. A., Ferre, R. A., and Worland, S. T. (2000) Bioorg. Med. Chem. Lett. 10, 45-48
12. Dragovich, P. S., Webber, S. E., Prins, T. J., Zhou, R., Marakovits, J. T., Tikhe, J. G., Fuhrman, S. A., Patick, A. K., Matthews, D. A., Ford, C. E., Brown, E. L., Binford, S. L., Meador, J. W., III, Ferre, R. A., and Worland, S. T. (1999) Bioorg. Med. Chem. Lett. 9, 2189-2194
13. Dragovich, P. S., Prins, T. J., Zhou, R., Webber, S. E., Marakovits, J. T., Fuhrman, S. A., Patick, A. K., Matthews, D. A., Lee, C. A., Ford, C. E., Burke, B. J., Rejto, P. A., Hendrickson, T. F., Tuntland, T., Brown, E. L., Meador, J. W., III, Ferre, R. A., Harr, J. E., Kosa, M. B., and Worland, S. T. (1999) J. Med. Chem. 42, 1213-1224
14. Dragovich, P. S., Prins, T. J., Zhou, R., Fuhrman, S. A., Patick, A. K., Matthews, D. A., Ford, C. E., Meador, J. W., III, Ferre, R. A., and Worland, S. T. (1999) J. Med. Chem. 42, 1203-1212
15. Dragovich, P. S., Webber, S. E., Babine, R. E., Fuhrman, S. A., Patick, A. K., Matthews, D. A., Reich, S. H., Marakovits, J. T., Prins, T. J., Zhou, R., Tikhe, J., Littlefield, E. S., Bleckman, T. M., Wallace, M. B., Little, T. L., Ford, C. E., Meador, J. W., III, Ferre, R. A., Brown, E. L., Binford, S. L., DeLisle, D. M., and Worland, S. T. (1998) J. Med. Chem. 41, 2819-2834
16. Xiong, B., Gui, C. S., Xu, X. Y., Luo, C., Chen, J., Luo, H. B., Chen, L. L., Li, G. W., Sun, T., Yu, C. Y., Yue, L. D., Duan, W. H., Shen, J. K., Qin, L., Shi, T. L., Li, Y. X., Chen, K. X., Luo, X. M., Shen, X., Shen, J. H., and Jiang, H. L. (2003) Acta Pharmacol. Sin. 24, 497-504
17. Liu, S., Pei, J., Chen, H., Zhu, X., Liu, Z., Ma, W., He, F., and Lai, L. (2003) Beijing Da. Xue. Xue. Bao. 35, (suppl.) 62-65
18. Chou, K. C., Wei, D. Q., and Zhong, W. Z. (2003) Biochem. Biophys. Res. Commun. 308, 148-151
19. Hegyi, A., and Ziebuhr, J. (2002) J. Gen. Virol. 83, 595-599
20. Johnson, W. C., Jr. (1988) Annu. Rev. Biophys. Biophys. Chem. 17, 145-166
21. Fields, G. B., and Noble, R. L. (1990) Int. J. Pept. Protein Res. 35, 161-214
22. Ziebuhr, J., Herold, J., and Siddell, S. G. (1995) J. Virol. 69, 4331-4338
23. Ziebuhr, J., Heusipp, G., and Siddell, S. G. (1997) J. Virol. 71, 3992-3997
24. Deleted in proof
25. Cordingley, M. G., Callahan, P. L., Sardana, V. V., Garsky, V. M., and Colonno, R. J. (1990) J. Biol. Chem. 265, 9062-9065