Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3′- digallate (TF3)

Evidence-based Complementary and Alternative Medicine

Volumn 2, Issue 2, 2005, Pages 209-215

  Chen, Chia Nan ^a   Lin, Coney P C ^a   Huang, Kuo Kuei ^a   Chen, Wei Cheng ^a   Hsieh, Hsin Pang ^a   Liang, Po Huang ^b   Hsu, John T A ^a,c,d  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^d ACADEMIA SINICA   (Taiwan)

Author keywords

3CLPro; Black tea; Natural products; TF2B; TF3

Indexed keywords

BLACK TEA EXTRACT; CAFFEINE; CATECHIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; GREEN TEA EXTRACT; NATURAL PRODUCT; POLYPHENOL; PROTEINASE; TANNIN; THEAFLAVIN 3,3' DIGALLATE; VIRUS ENZYME;

ARTICLE; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; IC 50; NONHUMAN; PRIORITY JOURNAL; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; TEA;

EID: 24344464802     PISSN: 1741427X     EISSN: None     Source Type: Journal    
DOI: 10.1093/ecam/neh081     Document Type: Article

References (21)

1. Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003;348:1953-66.
2. Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Becker S et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003;348:1967-76.
3. Enserink M. Infectious diseases: calling all coronavirologists. Science 2003;300:413-1.
4. Enserink M, Vogel G. Infectious diseases: hungry for details, scientists zoom in on SARS genomes. Science 2003;300:715-7.
5. Wenzel RP, Edmond MB. Managing SARS amidst uncertainty. N Engl J Med 2003;348:1947-8.
6. Holmes KV, Enjuanes L. Virology: the SARS coronavirus: a postgenomic era. Science 2003;300:1377-8.
7. Hegyi A, Friebe A, Gorbalenya AE, Ziebuhr I. Mutational analysis of the active centre of coronavirus 3C-like proteases. J Gen Virol 2002;83:581-93.
8. Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS et al. The genome sequence of the SARS-associated coronavirus. Science 2003;300:1399-404.
9. Rota PA, Oberste MS, Monroe SS, Nix WA. Campagnoli R, Icenogle JP et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003;300:1394-9.
10. Herold J, Gorbalenya AE, Thiel V, Schelle B, Siddell SG. Proteolytic processing at the amino terminus of human coronavirus 229E gene 1-encoded polyproteins: identification of a papain-like proteinase and its substrate. J Virol 1998;72:910-8.
11. Ziebuhr J, Thiel V, Gorbalenya AE. The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond. J Biol Chem 2001;276:33220-2.
12. Ziebuhr J, Siddell SG. Processing of the human coronavirus 229E replicase polyproteins by the virus-encoded 3C-like proteinase: identification of proteolytic products and cleavage sites common to ppla and pplab. J Virol 1999;73:177-85.
13. Taitzoglou IA, Tsantarliotou M, Zervos I, Kouretas D, Kokolis NA. Inhibition of human and ovine acrosomal enzymes by tannic acid in vitro. Reproduction 2001;121:131-7.
14. Leone M, Zhai D, Sareth S, Kitada S, Reed JC, Pellecchia M. Cancer prevention by tea polyphenols is linked to their direct inhibition of anti-apoptotic Bcl-2-family proteins. Cancer Res 2003;63:8118-21.
15. Kazi A, Urbizu DA, Kuhn DJ, Acebo AL, Jackson ER, Greenfelder GP et al. A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells. Int J Mol Med 2003; 12:879-87.
16. Leung LK, Su Y, Chen R, Zhang Z, Huang Y, Chen ZY. Theaflavins in black tea and catechins in green tea are equally effective antioxidants. J Nutr 2001;131:2248-51.
17. Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science 2003;300:1763-7.
18. Chen CN, Liang CM, Lai JR, Tsai YJ, Tsay JS, Lin JK. Capillary electrophoretic determination of theanine, caffeine, and catechins in fresh tea leaves and oolong tea and their effects on rat neurosphere adhesion and migration. J Agric Food Chem 2003;51:7495-503.
19. Harbowy ME, Balentine DA. Tea chemistry. Crit Rev Plant Sci 1997;16:415-80.
20. Clark KJ, Grant PG, Sarr AB, Belakere JR, Swaggerty CL, Phillips TD et al. An in vitro study of theaflavins extracted from black tea to neutralize bovine rotavirus and bovine coronavirus infections. Vet Microbiol 1998;63:147-57.
21. Leung, WK., To KF, Chan PK, Chan HL, Wu AK, Lee N, Yuen KY, Sung, JJ. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology 2003;125:1011-7.