Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease

Biochemical and Biophysical Research Communications

Volumn 333, Issue 1, 2005, Pages 194-199

  Liu, Yu Chih ^a   Huang, Vicky ^b   Chao, Ti Chun ^c   Hsiao, Chwan Deng ^c   Lin, Atsui ^b   Chang, Ming Fu ^a   Chow, Lu Ping ^a,d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b MDS Pharma Services   (Taiwan)

^c INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

3C like protease; Fluorescence resonance energy transfer; Hexachlorophene; HPLC; Inhibitors; Kinetic analysis; Molecular docking; SARS; SARS CoV; SARS CoV 3CL protease

Indexed keywords

HEXACHLOROPHENE; NELFINAVIR; PROTEINASE; TRICLOSAN;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE TARGETING; IC 50; NONHUMAN; PRIORITY JOURNAL; SARS CORONAVIRUS; VIRUS IDENTIFICATION;

BINDING SITES; COMPUTER SIMULATION; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENDOPEPTIDASES; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; KINETICS; MODELS, MOLECULAR; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; VIRAL PROTEINS;

SARS COV;

EID: 20444433493     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.05.095     Document Type: Article

References (22)

1. C. Drosten, S. Gunther, W. Preiser, W.S. van der, H.R. Brodt, S. Becker, H. Rabenau, M. Panning, L. Kolesnikova, R.A. Fouchier, A. Berger, A.M. Burguiere, J. Cinatl, M. Eickmann, N. Escriou, K. Grywna, S. Kramme, J.C. Manuguerra, S. Muller, V. Rickerts, M. Sturmer, S. Vieth, H.D. Klenk, A.D. Osterhaus, H. Schmitz, and H.W. Doerr N. Engl. J. Med. 348 2003 1967 1976
2. J.S. Peiris, S.T. Lai, L.L. Poon, Y. Guan, L.Y. Yam, W. Lim, J. Nicholls, W.K. Yee, W.W. Yan, M.T. Cheung, V.C. Cheng, K.H. Chan, D.N. Tsang, R.W. Yung, T.K. Ng, and K.Y. Yuen Lancet 361 2003 1319 1325
3. M.A. Marra, S.J. Jones, C.R. Astell, R.A. Holt, A. Brooks-Wilson, Y.S. Butterfield, J. Khattra, J.K. Asano, S.A. Barber, S.Y. Chan, A. Cloutier, S.M. Coughlin, D. Freeman, N. Girn, O.L. Griffith, S.R. Leach, M. Mayo, H. McDonald, S.B. Montgomery, P.K. Pandoh, A.S. Petrescu, A.G. Robertson, J.E. Schein, A. Siddiqui, D.E. Smailus, J.M. Stott, G.S. Yang, F. Plummer, A. Andonov, H. Artsob, N. Bastien, K. Bernard, T.F. Booth, D. Bowness, M. Czub, M. Drebot, L. Fernando, R. Flick, M. Garbutt, M. Gray, A. Grolla, S. Jones, H. Feldmann, A. Meyers, A. Kabani, Y. Li, S. Normand, U. Stroher, G.A. Tipples, S. Tyler, R. Vogrig, D. Ward, B. Watson, R.C. Brunham, M. Krajden, M. Petric, D.M. Skowronski, C. Upton, and R.L. Roper Science 300 2003 1399 1404
4. P.A. Rota, M.S. Oberste, S.S. Monroe, W.A. Nix, R. Campagnoli, J.P. Icenogle, S. Penaranda, B. Bankamp, K. Maher, M.H. Chen, S. Tong, A. Tamin, L. Lowe, M. Frace, J.L. DeRisi, Q. Chen, D. Wang, D.D. Erdman, T.C. Peret, C. Burns, T.G Ksiazek, P.E. Rollin, A. Sanchez, S. Liffick, B. Holloway, J. Limor, K. McCaustland, M. Olsen-Rasmussen, R. Fouchier, S. Gunther, A.D. Osterhaus, C. Drosten, M.A. Pallansch, L.J. Anderson, and W.J. Bellini Science 300 2003 1394 1399
5. J. Ziebuhr, and S.G. Siddell J. Virol. 73 1999 177 185
6. J. Ziebuhr, S. Bayer, J.A. Cowley, and A.E. Gorbalenya J. Virol. 77 2003 1415 1426
7. V. Thiel, K.A. Ivanov, A. Putics, T. Hertzig, B. Schelle, S. Bayer, B. Weissbrich, E.J. Snijder, H. Rabenau, H.W. Doerr, A.E. Gorbalenya, and J. Ziebuhr J. Gen. Virol. 84 2003 2305 2315
8. A. Seybert, J. Ziebuhr, and S.G. Siddell J. Gen. Virol. 78 Pt. 1 1997 71 75
9. A. Hegyi, A. Friebe, A.E. Gorbalenya, and J. Ziebuhr J. Gen. Virol. 83 2002 581 593
10. K. Fan, P. Wei, Q. Feng, S. Chen, C. Huang, L. Ma, B. Lai, J. Pei, Y. Liu, J. Chen, and L. Lai J. Biol. Chem. 279 2004 1637 1642
11. S. Hata, T. Sato, H. Sorimachi, S. Ishiura, and K. Suzuki J. Virol. Methods 84 2000 117 126
12. G. Koren, S. King, S. Knowles, and E. Phillips CMAJ 168 2003 1289 1292
13. M. Cuendet, and J.M. Pezzuto J. Nat. Prod. 67 2004 269 272
14. J. Ziebuhr, G. Heusipp, and S.G. Siddell J. Virol. 71 1997 3992 3997
15. A. Hegyi, and J. Ziebuhr J. Gen. Virol. 83 2002 595 599
16. J.H. Zhang, T.D. Chung, and K.R. Oldenburg J. Biomol. Screen. 4 1999 67 73
17. G. Jones, P. Willett, R.C. Glen, A.R. Leach, and R. Taylor J. Mol. Biol. 267 1997 727 748
18. A.T. Brunger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, R.W. Grosse-Kunstleve, J.S. Jiang, J. Kuszewski, M. Nilges, N.S. Pannu, R.J. Read, L.M. Rice, T. Simonson, and G.L. Warren Acta Crystallogr. D Biol. Crystallogr. 54 Pt. 5 1998 905 921
19. A.C. Wallace, R.A. Laskowski, and J.M. Thornton Protein Eng. 8 1995 127 134
20. C.J. Kuo, Y.H. Chi, J.T. Hsu, and P.H. Liang Biochem. Biophys. Res. Commun. 318 2004 862 867
21. C.Y. Wu, J.T. Jan, S.H. Ma, C.J. Kuo, H.F. Juan, Y.S. Cheng, H.H. Hsu, H.C. Huang, D. Wu, A. Brik, F.S. Liang, R.S. Liu, J.M. Fang, S.T. Chen, P.H. Liang, and C.H. Wong Proc. Natl. Acad. Sci. USA 101 2004 10012 10017
22. N. Yamamoto, R. Yang, Y. Yoshinaka, S. Amari, T. Nakano, J. Cinatl, H. Rabenau, H.W. Doerr, G. Hunsmann, A. Otaka, H. Tamamura, N. Fujii, and N. Yamamoto Biochem. Biophys. Res. Commun. 318 2004 719 725