Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 24, 2005, Pages 5365-5369

  Martina, Erika ^a   Stiefl, Nikolaus ^a   Degel, Björn ^a   Schulz, Franziska ^a   Breuning, Alexander ^a   Schiller, Markus ^a   Vicik, Radim ^a   Baumann, Knut ^a   Ziebuhr, John ^a   Schirmeister, Tanja ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Aziridine; Inhibitor; Main protease; SARS

Indexed keywords

AZIRIDINE; AZIRIDINE DERIVATIVE; AZIRIDINYL PEPTIDE; CARBOXYLIC ACID DERIVATIVE; ETHYLENE OXIDE DERIVATIVE; PEPTIDE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG IDENTIFICATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; SARS CORONAVIRUS; SCREENING TEST; SEVERE ACUTE RESPIRATORY SYNDROME;

AZIRIDINES; BINDING SITES; CYSTEINE ENDOPEPTIDASES; HUMANS; PEPTIDES; PROTEASE INHIBITORS; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL PROTEINS;

CORONAVIRUS; SARS CORONAVIRUS; SARS COV;

EID: 27444439747     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.012     Document Type: Article

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