Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro

Journal of Medicinal Chemistry

Volumn 47, Issue 25, 2004, Pages 6113-6116

  Jain, Rajendra P ^a   Pettersson, Hanna I ^a   Zhang, Jianmin ^a   Aull, Katherine D ^a   Fortin, Pascal D ^b   Huitema, Carly ^b   Eltis, Lindsay D ^b   Parrish, Jonathan C ^a   James, Michael N G ^a   Wishart, David S ^a   Vederas, John C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3C LIKE PROTEINASE; ACETYLVALYLTHREONYLLEUCINE; GLUTAMINE DERIVATIVE; HYDRAZIDE; KETONE DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; TRIPEPTIDE; UNCLASSIFIED DRUG; VIRUS ENZYME;

BINDING SITE; CONFERENCE PAPER; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME SUBSTRATE; IC 50; NONHUMAN; SARS CORONAVIRUS; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; GLUTAMINE; KETONES; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 9744247544     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0494873     Document Type: Conference Paper

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