Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide

Journal of Molecular Biology

Volumn 353, Issue 5, 2005, Pages 1137-1151

  Lee, Ting Wai ^a   Cherney, Maia M ^a   Huitema, Carly ^b   Liu, Jie ^b   James, Karen Ellis ^c   Powers, James C ^c   Eltis, Lindsay D ^b   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aza peptide epoxide; Main peptidase; SARS coronavirus; Structure based drug design; X ray crystallography

Indexed keywords

AZA PEPTIDE EPOXIDE; CYSTEINE; CYSTEINE PEPTIDASE INHIBITOR; ENZYME INHIBITOR; EPOXIDE; PEPTIDASE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; ATOM; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME INHIBITION; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; SARS CORONAVIRUS;

CORONAVIRUS; SARS CORONAVIRUS; SARS COV;

EID: 27144538090     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.09.004     Document Type: Article

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