Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 17, 2005, Pages 5240-5252

  Shie, Jiun Jie ^a   Fang, Jim Min ^a,b   Kuo, Tun Hsun ^c   Kuo, Chih Jung ^c   Liang, Po Huang ^b,c   Huang, Hung Jyun ^a   Wu, Yin Ta ^b   Jan, Jia Tsrong ^d   Cheng, Yih Shyun E ^b   Wong, Chi Huey ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d NATIONAL DEFENSE UNIVERSITY   (Taiwan)

Author keywords

, Unsaturated esters; 3CL protease inhibitors; Antiviral agent; Cell based assay; Peptides; Severe acute respiratory syndrome

Indexed keywords

4 (DIMETHYLAMINO)CINNAMIC ACID; ANTIVIRUS AGENT; CINNAMIC ACID DERIVATIVE; DIPEPTIDE DERIVATIVE; ETHYL 4 [2 (2,4 DIMETHOXYCINNAMYL)AMINO 1 OXO 3 PHENYL]PROPYLAMINO 2 PENTENOATE; ETHYL 4 [2 (3,4 METHYLENEDIOXYCINNAMYL)AMINO 1 OXO 3 PHENYL]PROPYLAMINO 5 PHENYL 2 PENTENOATE; ETHYL 4 [2 (4 NITROCINNAMYL)AMINO 1 OXO 3 PHENYL]PROPYLAMINO 2 PENTENOATE; ETHYL 4 [2 [(4 DIMETHYLAMINO)CINNAMYL]AMINO 1 OXO 3 PHENYL]PROPYLAMINO 2 PENTENOATE; ETHYL 5 PHENYL 4 [2 (4 PHENYLCINNAMYL)AMINO 1 OXO 3 PHENYL]PROPYLAMINO 2 PENTENOATE; PHENYLALANINE DERIVATIVE; PROTEINASE INHIBITOR; RUPINTRIVIR; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; IC 50; NONHUMAN; POLYMERIZATION; SEVERE ACUTE RESPIRATORY SYNDROME;

ANIMALS; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ENZYME INHIBITORS; ESTERS; ISOXAZOLES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; PYRROLIDINONES; VERO CELLS; VIRAL PROTEINS;

CORONAVIRUS;

EID: 22844437876     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.05.065     Document Type: Article

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