Viruses and the brain: From inflammation to dementia

Clinical Science

Volumn 110, Issue 4, 2006, Pages 393-407

  Wang, Tongguang ^a   Rumbaugh, Jeffrey A ^a   Nath, Avindra ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dementia; Encephalitis; HIV; Immunomodulation; Inflammation; Neuropathogenesis

Indexed keywords

ANTIRETROVIRUS AGENT;

DEMENTIA; ENCEPHALITIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; INFLAMMATION; NERVE CELL DEGENERATION; NERVOUS SYSTEM INJURY; NEUROPATHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS PATHOGENESIS;

AIDS DEMENTIA COMPLEX; BLOOD-BRAIN BARRIER; BRAIN; DEMENTIA; ENCEPHALITIS; HIV-1; HUMANS; VIRUS DISEASES;

EID: 33645572480     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20050278     Document Type: Review

References (200)

1. Nach, A., Jankovic, J. and Pettigrew, L. C. (1987) Movement disorders and AIDS. Neurology 37, 37-41
2. McArthur, J. C., Hoover, D. R., Bacellar, H. et al. (1993) Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study. Neurology 43, 2245-2252
3. Neuenburg, J. K., Brodt, H. R., Herndier, B. G. et al. (2002) HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy. J. Acquired Immune Defic. Syndr. 31, 171-177
4. Sacktor, N. (2002) The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J. Neurovirol. 8 (Suppl. 2), 115-121
5. Dore, G. J., McDonald, A., Li, Y., Kaldor, J. M. and Brew, B. J. (2003) Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 17, 1539-1545
6. McArthur, J. C., Haughey, N., Gartner, S. et al. (2003) Human immunodeficiency virus-associated dementia: an evolving disease. J. Neurovirol. 9, 205-221
7. Sacktor, N., McDermott, M. P., Marder, K. et al. (2002) HIV-associated cognitive impairment before and after the advent of combination therapy. J. Neurovirol. 8, 136-142
8. Navia, B. A. and Price, R. W. (1987) The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immunodeficiency virus infection. Arch. Neurol. 44, 65-69
9. Janssen, E. S., Wanyanwi, O. C., Selik, R. M. and Stehr-Green, J. K. (1992) Epidemiology of human immunodeficiency encephalopathy in the United States. Neurology 42, 1472-1476
10. Beckett, A., Summergrad, P., Manschreck, T. et al. (1987) Symptomatic HIV infection of the CNS in a patient without clinical evidence of immune deficiency. Am. J. Psychiatry 144, 1342-1344
11. Welch, K. and Morse, A. (2002) The clinical profile of end-stage AIDS in the era of highly active antiretroviral therapy. AIDS Patient Care STDs 16, 75-81
12. Turchan, J., Pocernich, C. B., Gairola, C. et al. (2003) Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology 60, 307-314
13. Gelbard, H. A. (1999) Neuroprotective strategies for HIV-1-associated neurologic disease. Ann. N.Y. Acad. Sci. 890, 312-313
14. Torres-Munoz, J., Stockton, P., Tacoronte, N., Roberts, B., Maronpot, R. R. and Petito, C. K. (2001) Detection of HIV-1 gene sequences in hippocampal neurons isolated from postmortem AIDS brains by laser capture microdissection. J. Neuropathol. Exp. Neurol. 60, 885-892
15. Garden, G. A., Budd, S. L., Tsai, E. et al. (2002) Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J. Neurosci. 22, 4015-4024
16. Adle-Biassette, H., Levy, Y., Colombel, M. et al. (1995) Neuronal apoptosis in HIV infection in adults. Neuropathol. Appl. Neurobiol. 21, 218-227
17. Gelbard, H. A., James, H. J., Sharer, L. R. et al. (1995) Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol. Appl. Neurobiol. 21, 208-217
18. Petito, C. K. and Roberts, B. (1995) Evidence of apoptotic cell death in HIV encephalitis. Am. J. Pathol. 146, 1121-1130
19. Shi, B., De Girolami, U., He, J. et al. (1996) Apoptosis induced by HIV-1 infection of the central nervous system. J. Clin. Invest. 98, 1979-1990
20. Adle-Biassette, H., Chretien, F., Wingertsmann, L. et al. (1999) Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage. Neuropathol. Appl. Neurobiol. 25, 123-133
21. Gray, F., Adle-Biassette, H., Chretien, F. et al. (2001) Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments. Clin. Neuropathol. 20, 146-155
22. Masliah, E., Heaton, R. K., Marcotte, T. D. et al. (1997) Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. Ann. Neurol. 42, 963-972
23. Subbiah, P., Mouton, P., Fedor, H., McArthur, J. C. and Glass, J. D. (1996) Stereological analysis of cerebral atrophy in human immunodeficiency virus-associated dementia. J. Neuropathol. Exp. Neurol. 55, 1032-1037
24. Post, M. J., Levin, B. E., Berger, J. R., Duncan, R., Quencer, R. M. and Calabro, G. (1992) Sequential cranial MR findings of asymptomatic and neurologically symptomatic HIV+ subjects. AJNR, Am. J. Neuroradiol. 13, 359-370
25. Levy, R. M., Bredesen, D. E. and Rosenblum, M. L. (1985) Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J. Neurosurg. 62, 475-495
26. Levy, R. M., Rosenbloom, S. and Perrett, L. V. (1986) Neuroradiologic findings in AIDS: a review of 200 cases. AJR, Am. J. Roentgenol. 147, 977-983
27. Bursztyn, E. M., Lee, B. C. and Bauman, J. (1984) CT of acquired immunodeficiency syndrome. AJNR, Am. J. Neuroradiol. 5, 711-714
28. Post, M. J., Berger, J. R. and Quencer, R. M. (1991) Asymptomatic and neurologically symptomatic HIV-seropositive individuals: prospective evaluation with cranial MR imaging. Radiology 178, 131-139
29. Post, M. J., Berger, J. R., Duncan, R., Quencer, R. M., Pall, L. and Winfield, D. (1993) Asymptomatic and neurologically symptomatic HIV-seropositive subjects: results of long-term MR imaging and clinical follow-up. Radiology 188, 727-733
30. Archibald, S. L., Masliah, E., Fennema-Notestine, C. et al. (2004) Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss. Arch. Neurol. 61, 369-376
31. Arendt, G., Hefter, H., Nelles, H. W., Hilperath, F. and Strohmeyer, G. (1993) Age-dependent decline in cognitive information processing of HIV-positive individuals detected by event-related potential recordings. J. Neurol. Sci. 115, 223-229
32. Paul, R., Cohen, R., Navia, B. and Tashima, K. (2002) Relationships between cognition and structural neuroimaging findings in adults with human immunodeficiency virus type-1. Neurosci. Biobehav. Rev. 26, 353-359
33. Navia, B. A., Cho, E. S., Petiio, C. K. and Price, R. W. (1986) The AIDS dementia complex: II Neuropathology. Ann. Neurol. 19, 525-535
34. Vitkovic, L. and da Cunha, A. (1995) Role for astrocytosis in HIV-1-associated dementia. Curr. Top. Microbiol. Immunol. 202, 105-116
35. Saito, Y., Sharer, L. R., Epstein, L. G. et al. (1994) Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 44, 474-481
36. Ranki, A., Nvberg, M., Ovod, V. et al. (1995) Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS 9, 1001-1008
37. Tornatore, C., Chandra, R., Berger, J. R. and Major, E. O. (1994) HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44, 481-487
38. Chen, P., Mayne, M., Power, C. and Nath, A. (1997) The Tat protein of HIV-1 induces tumor necrosis factor-α production: implications for HIV associated neurological diseases. J. Biol. Chem. 272, 22385-22388
39. Lafortune, L., Nalbantoglu, J. and Antel, J. P. (1996) Expression of tumor necrosis factor α (TNFα) and interleukin 6 (IL-6) mRNA in adult human astrocytes: comparison with adult microglia and fetal astrocytes. J. Neuropathol. Exp. Neurol. 55, 515-521
40. Power, C., Kong, P. A., Crawford, T. O. et al. (1993) Cerebral white matter changes in AIDS dementia: alterations of the blood-brain barrier. Ann. Neurol. 34, 339-350
41. Dallasta, L. M., Pisarov, L. A., Esplen, J. E. et al. (1999) Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am. J. Pathol. 155, 1915-1927
42. Petito, C. K. and Cash, K. S. (1992) Blood-brain barrier abnormalities in AIDS: immunohistochemical localization of serum proteins in postmortem brain. Ann. Neurol. 32, 658-666
43. Thurnher, M. M., Schindler, E. G., Thurnher, S. A., Pernerstorfer-Schon, H., Kleibl-Popov, C. and Rieger, A. (2000) Highly active antiretroviral therapy for patients with AIDS dementia complex: effect on MR imaging findings and clinical course. AJNR, Am. J. Neuroradiol. 21, 670-678
44. Avison, M. J., Nath, A., Greene-Avison, R., Schmitt, F. A., Greenberg, R. N. and Berger, J. R. (2004) Neuroimaging correlates of HIV-associated BBB compromise. J. Neuroimmunol. 157, 140-146
45. Hegg, C. C., Hu, S., Peterson, P. K. and Thayer, S. A. (2000) β-Chemokines and human immunodeficiency virus type-1 proteins evoke intracellular calcium increases in human microglia. Neuroscience 98, 191-199
46. Weeks, B. S. (1998) The role of HIV-1 activated leukocyte adhesion mechanisms and matrix metalloproteinase secretion in AIDS pathogenesis. Int. J. Mol. Med. 1, 361-366
47. Tyor, W. R., Wesselingh, S. L., Griffin, J. W., McArthur, J. C. and Griffin, D. E. (1995) Unifying hypothesis for the pathogenesis of HIV-associated dementia complex, vacuolar myelopathy, and sensory neuropathy. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 9, 379-388
48. Price, R. W. and Brew, B. J. (1988) The AIDS dementia complex. J. Infect. Dis. 158, 1079-1083
49. Everall, I., Luthert, P. and Lantos, P. L. (1993) A review of neuronal damage in human immunodeficiency virus infection: its assessment, possible mechanism and relationship to dementia. J. Neuropathol. Exp. Neurol. 52, 561-566
50. Pulliam, L., Gascon, R., Stubblebine, M., McGuire, D. and McGrath, M. S. (1997) Unique monocyte subset in patients with AIDS dementia. Lancet 349, 692-695
51. Gartner, S. (2000) HIV infection and dementia. Science 287, 602-604
52. Sippy, B. D., Hofman, F. M., Wallach, D. and Hinton, D. R. (1995) Increased expression of tumor necrosis factor-α receptors in the brains of patients with AIDS. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 10, 511-521
53. Tyor, W. R., Glass, J. D. and Friffin, J. W. (1992) Cytokine expression in the brain during AIDS. Ann. Neurol. 31, 349-360
54. Vallat-Decouvelaere, A. V., Chretien, F., Gras, G., Le Pavec, G., Dormont, D. and Gray, F. (2003) Expression of excitatory amino acid transporter-1 in brain macrophages and microglia of HIV-infected patients. A neuroprotective role for activated microglia? J. Neuropathol. Exp. Neurol. 62, 475-485
55. Gras, G., Chretien, F., Vallat-Decouvelaere, A. V. et al. (2003) Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? Brain Pathol. 13, 211-222
56. Nath, A. and Geiger, J. D. (1998) Neurobiological aspects of HIV infections: neurotoxic mechanisms. Prog. Neurobiol. 54, 19-33
57. Nath, A. (1999) Pathobiology of HIV dementia. Sem. Neurol. 19, 113-128
58. Nath, A., Conant, K., Chen, P., Scott, C. and Major, E. O. (1999) Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes: a hit and run phenomenon. J. Biol. Chem. 274, 17098-17102
59. Bruce-Keller, A. J., Chauhan, A., Dimayuga, F. O., Gee, J., Keller, J. N. and Nath, A. (2003) Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain. J. Neurosci. 23, 8417-8422
60. Chauhan, A., Turchan, J., Pocernich, C. et al. (2003) Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport. J. Biol. Chem. 278, 13512-13519
61. Magnuson, D. S., Knudsen, B. E., Geiger, J. D., Brownstone, R. M. and Nath, A. (1995) Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann. Neurol. 37, 373-380
62. Merrill, J. E. and Benveniste, E. N. (1996) Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 19, 331-338
63. Yoshioka, M., Bradley, W. G., Shapshak, P. et al. (1995) Role of immune activation and cytokine expression in HIV-1-associated neurologic diseases. Adv. Neuroimmunol. 5, 335-358
64. Bagetta, G., Corasaniti, M. T., Berliocchi, L. et al. (1999) Involvement of interleukin-1β in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat. Neuroscience 89, 1051-1066
65. Wesselingh, S. L., Power, C., Glass, J. D. et al. (1993) Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann. Neurol. 33, 576-582
66. Griffin, D. E. (1997) Cytokines in the brain during viral infection: clues to HIV-associated dementia. J. Clin. Invest. 100, 2948-2951
67. Persidsky, Y., Limoges, J., Rasmussen, J., Zheng, J., Gearing, A. and Gendelman, H. E. (2001) Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFα inhibitor in SCID mice with HIV-1 encephalitis. J. Neuroimmunol. 114, 57-68
68. Viviani, B., Bartesaghi, S., Corsini, E., Galli, C. L. and Marinovich, M. (2004) Cytokines role in neurodegenerative events. Toxicol. Lett. 149, 85-89
69. Viviani, B., Corsini, E., Binaglia, M., Galli, C. L. and Marinovich, M. (2001) Reactive oxygen species generated by glia are responsible for neuron death induced by human immunodeficiency virus-glycoprotein 120 in vitro. Neuroscience 107, 51-58
70. Loddick, S. A. and Rothwell, N. J. (1996) Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J. Cereb. Blood Flow Metab. 16, 932-940
71. Nawashiro, H., Martin, D. and Hallenbeck, J. M. (1997) Neuroprotective effects of TNF binding protein in focal cerebral ischemia. Brain Res. 778, 265-271
72. Rothwell, N., Allan, S. and Toulmond, S. (1997) The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications. J. Clin. Invest. 100, 2648-2652
73. Strijbos, P. J. and Rothwell, N. J. (1995) Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. J. Neurosci. 15, 3468-3474
74. Long-En, C., Seaber, A. V., Wong, G. H. W. and Urbaniak, J. R. (1996) Tumor necrosis factor promotes motor functional recovery in crushed peripheral nerve. Neurochem. Int. 29, 197-203
75. Bruce, A. J., Boling, W., Kindy, M. S. et al. (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat. Med. 2, 788-794
76. Scherbel, U., Raghupathi, R., Nakamura, M. et al. (1999) Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proc. Natl. Acad. Sci. U.S.A. 96, 8721-8726
77. MacEwan, D. J. (2002) TNF receptor subtype signalling: differences and cellular consequences. Cell. Signalling 14, 477-492
78. Fotin-Mleczek, M., Henkler, F., Samel, D. et al. (2002) Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. J. Cell Sci. 115, 2757-2770
79. Segui, B., Cuvillier, O., Adam-Klages, S. et al. (2001) Involvement of FAN in TNF-induced apoptosis. J. Clin. Invest. 108, 143-151
80. Cutler, R. G. and Mattson, M. P. (2001) Sphingomyelin and ceramide as regulators of development and lifespan. Mech. Ageing Dev. 122, 895-908
81. Han, Y., He, T., Huang, D., Pardo, C. A. and Ransohoff, R. M. (2001) TNF-α mediates SDF-1α-induced NF-κB activation and cytotoxic effects in primary astrocytes. J. Clin. Invest. 108, 425-435
82. Yeh, M. W., Kaul, M., Zheng, J. et al. (2000) Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of L-cysteine. J. Immunol. 164, 4265-4270
83. Fine, S. M., Angel, R. A., Perry, S. W. et al. (1996) Tumor necrosis factor α inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia. J. Biol. Chem. 271, 15303-15306
84. Bezzi, P., Domereq, M., Brambilla, L. et al. (2001) CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity. Nat. Neurosci. 4, 702-710
85. Floden, A. M., Li, S. and Combs, C. K. (2005) β-Amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor α and NMDA receptors. J. Neurosci. 25, 2566-2575
86. Lipton, S. A. and Stamler, J. S. (1994) Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology 33, 1229-1233
87. Lipton, S. A., Singel, D. J. and Stamler, J. S. (1994) Neuroprotective and neurodestructive effects of nitric oxide and redox congeners. Ann. N.Y. Acad. Sci. 738, 382-387
88. Sims, J. E. (2002) IL-1 and IL-18 receptors, and their extended family. Curr. Opin. Immunol. 14, 117-122
89. Vezzani, A., Conti, M., De Luigi, A. et al. (1999) Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J. Neurosci. 19, 5054-5065
90. Vecchiet, J., Dalessandro, M., Falasca, K. et al. (2003) Increased production of oncostatin-M by lymphomononuclear cells from HIV-1-infected patients with neuroAIDS. J. Acquired Immune Defic. Syndr. 32, 464-465
91. Ensoli, F., Fiorelli, V., DeCristofaro, M. et al. (1999) Inflammatory cytokines and HIV-1-associated neurodegeneration: oncostatin-M produced by mononuclear cells from HIV-1-infected individuals induces apoptosis of primary neurons. J. Immunol. 162, 6268-6277
92. Horuk, R., Hesselgesser, J., Zhou, Y. et al. (1998) The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains. J. Biol. Chem. 273, 386-391
93. Horuk, R. (2001) Chemokine receptors. Cytokine Growth Factor Rev. 12, 313-335
94. Rossi, D. and Zlotnik, A. (2000) The biology of chemokines and their receptors. Annu. Rev. Immunol. 18, 217-242
95. Cartier, L., Hartley, O., Dubois-Dauphin, M. and Krause, K.-H. (2005) Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res. Rev. 48, 16-42
96. Andjelkovic, A. V., Kerkovich, D., Shanley, J., Pulliam, L. and Pachter, J. S. (1999) Expression of binding sites for β chemokines on human astrocytes. Glia 28, 225-235
97. Albright, A. V., Shieh, J. T. C., Itoh, T. et al. (1999) Microglia express CCRs, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. J. Virol. 73, 205-213
98. Hesselgesser, J. and Horuk, R. (1999) Chemokine and chemokine receptor expression in the central nervous system. J. Neurovirol. 5, 13-26
99. Biber, K., Dijkstra, I., Trebst, C., De Groot, C. J., Ransohoff, R. M. and Boddeke, H. W. (2002) Functional expression of CXCR3 in cultured mouse and human astrocytes and microglia. Neuroscience 112, 487-497
100. van der Meer, P., Ulrich, A. M., Gonzalez-Scarano, F. and Lavi, E. (2000) Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCR4 in the human brain: potential mechanisms for HIV dementia. Exp. Mol. Pathol. 69, 192-201
101. Murakami, T. and Yamamoto, N. (2000) Roles of chemokines and chemokine receptors in HIV-1 infection. Int. J. Hematol. 72, 412-417
102. Glass, J. D., Fedor, H., Wesselingh, S. L. and McArthur, J. C. (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann. Neurol. 38, 755-762
103. Koenig, S., Gendelman, H. E., Orenstein, J. M. et al. (1986) Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233, 1089-1093
104. Persidsky, Y., Zheng, J., Miller, D. and Gendelman, H. E. (2000) Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementia. J. Leukocyte Biol. 68, 413-422
105. Weiss, J. M., Downie, S. A., Lyman, W. D. and Berman, J. W. (1998) Astrocyte-derived monocyte-chemoattractant protein-1 directs the transmigration of leukocytes across a model of the human blood-brain barrier. J. Immunol. 161, 6896-6903
106. Vallat, A. V., De Girolami, U., He, J. et al. (1998) Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS. Am. J. Pathol. 152, 167-178
107. Conant, K., Garzino-Demo, A., Nath, A. et al. (1998) Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc. Natl. Acad. Sci. U.S.A. 95, 3117-3121
108. Wasmuth, J.-C., Nischalke, H.-D., Jutte, A. et al. (2004) Chemokine mRNA levels in mononucleated cells of HIV-infected patients before and after initiation of PI-versus NNRTI-containing HAART. Antiviral Res. 61, 207-212
109. Cartier, L., Dubois-Dauphin, M., Hartley, O., Irminger-Finger, I. and Krause, K.-H. (2003) Chemokine-induced cell death in CCR5-expressing neuroblastoma cells. J. Neuroimmunol. 145, 27-39
110. Letendre, S. L., Lanier, E. R. and McCutchan, J. A. (1999) Cerebrospinal fluid β chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1. J. Infect. Dis. 180, 310-319
111. Kaul, M. and Lipton, S. A. (1999) Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc. Natl. Acad. Sci. U.S.A. 96, 8212-8216
112. Corasaniti, M. T., Piccirilli, S., Paoletti, A. et al. (2001) Evidence that the HIV-1 coat protein gp120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor. Neurosci. Lett. 312, 67-70
113. Dityatev, A. and Schachner, M. (2003) Extracellular matrix molecules and synaptic plasticity. Nat. Rev. Neurosci. 4, 456-468
114. Descamps, F. J., Van den Steen, P. E., Nelissen, I., Van Damme, J. and Opdenakker, G. (2003) Remnant epitopes generate autoimmunity: from rheumatoid arthritis and multiple sclerosis to diabetes. Adv. Exp. Med. Biol. 535, 69-77
115. Kieseier, B. C., Seifert, T., Giovannoni, G. and Hartung, H.-P. (1999) Matrix metalloproteinases in inflammatory demyelination: targets for treatment. Neurology 53, 20-25
116. Liuzzi, G. M., Mastroianni, C. M., Santacroce, M. P. et al. (2000) Increased activity of matrix metalloproteinases in the cerebrospinal fluid of patients with HIV-associated neurological diseases. J. Neurovirol. 6, 156-163
117. Conant, K., McArthur, J. C., Griffin, D. E., Sjulson, L., Wahl, L. M. and Irani, D. N. (1999) Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia. Ann. Neurol. 46, 391-398
118. Sundstrom, J. B., Mosunjac, M., Martinson, D. E. et al. (2001) Effects of norepinephrine, HIV type 1 infection, and leukocyte interactions with endothelial cells on the expression of matrix metalloproteinases. AIDS Res. Hum. Retroviruses 17, 1605-1614
119. Suryadevara, R., Holter, S., Borgmann, K. et al. (2003) Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia. Glia 44, 47-56
120. Chen, Z.-L., Indyk, J. A. and Strickland, S. (2003) The hippocampal laminin matrix is dynamic and critical for neuronal survival. Mol. Biol. Cell 14, 2665-2676
121. McGowan, S. E. and Murray, J. J. (1987) Direct effects of neutrophil oxidants on elastase-induced extracellular matrix proteolysis. Am. Rev. Respir. Dis. 135, 1286-1293
122. Langford, D. and Masliah, E. (2001) Crosstalk between components of the blood brain barrier and cells of the CNS in microglial activation in AIDS. Brain Pathol. 11, 306-312
123. Ghorpade, A., Persidskaia, R., Suryadevara, R. et al. (2001) Mononuclear phagocyte differentiation, activation, and viral infection regulate matrix metalloproteinase expression: implications for human immunodeficiency virus type 1-associated dementia. J. Virol. 75, 6572-6583
124. Liao, Z., Roos, J. W. and Hildreth, J. E. (2000) Increased infectivity of HIV type 1 particles bound to cell surface and solid-phase ICAM-1 and VCAM-1 through acquired adhesion molecules LFA-1 and VLA-4. AIDS Res. Hum. Retroviruses 16, 355-366
125. Diesing, T. S., Swindells, S., Gelbard, H. and Gendelman, H. E. (2002) HIV-1-associated dementia: a basic science and clinical perspective. AIDS Read. 12, 358-368
126. Wang, T., Liu, B., Qin, L., Wilson, B. and Hong, J. S. (2004) Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures. J. Neuroimmunol. 147, 68-72
127. Qin, L., Liu, Y., Wang, T. et al. (2004) NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J. Biol. Chem. 279, 1415-1421
128. Klein, J. A. and Ackerman, S. L. (2003) Oxidative stress, cell cycle, and neurodegeneration. J. Clin. Invest. 111, 785-793
129. Gupta, A., Rosenberger, S. F. and Bowden, G. T. (1999) Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 20, 2063-2073
130. Rosenberger, J., Petrovics, G. and Buzas, B. (2001) Oxidative stress induces proorphanin FQ and proenkephalin gene expression in astrocytes through p38- and ERK-MAP kinases and NF-κB. J. Neurochem. 79, 35-44
131. Gil, L., Martinez, G., Gonzalez, I. et al. (2003) Contribution to characterization of oxidative stress in HIV/AIDS patients. Pharmacol. Res. 47, 217-224
132. Bautista, A. P. (2001) Free radicals, chemokines, and cell injury in HIV-1 and SIV infections and alcoholic hepatitis. Free Radical Biol. Med. 31, 1527-1532
133. Boven, L. A., Gomes, L., Hery, C. et al. (1999) Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. J. Immunol. 162, 4319-4327
134. Hori, K., Burd, P. R., Furuke, K., Kutza, J., Weih, K. A. and Clouse, K. A. (1999) Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome. Blood 93, 1843-1850
135. Mollace, V., Nottet, H. S. L. M., Clayette, P. et al. (2001) Oxidative stress and neuroAIDS: triggers, modulators and novel antioxidants. Trends Neurosci. 24, 411-416
136. Liu, B., Gao, H. M., Wang, J. Y. et al. (2002) Role of nitric oxide in inflammation-mediated neurodegeneration. Ann. N.Y. Acad. Sci. 962, 318-331
137. Koka, P., He, K., Zack, J. A. et al. (1995) Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor α, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J. Exp. Med. 182, 941-951
138. Kong, L.-Y., Wilson, B. C., McMillian, M. K., Bing, G., Hudson, P. M. and Hong, J.-S. (1996) The effects of the HIV-1 envelope protein gp120 on the production of nitric oxide and proinflammatory cytokines in mixed glial cell cultures. Cell. Immunol. 172, 77-83
139. Boven, L. A., Gomes, L., Hery, C. et al. (1999) Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. J. Immunol. 162, 4319-4327
140. Sheng, W. S., Hu, S., Hegg, C. C., Thayer, S. A. and Peterson, P. K. (2000) Activation of human microglial cells by HIV-1 gp41 and Tat proteins. Clin. Immunol. 96, 243-251
141. Coyle, J. T. and Puttfarcken, P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695
142. Beckman, J. S. and Koppenol, W. H. (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. 271, C1424-C1437
143. Bal-Price, A., Moneer, Z. and Brown, G. C. (2002) Nitric oxide induces rapid, calcium-dependent release of vesicular glutamate and ATP from cultured rat astrocytes. Glia 40, 312-323
144. Chao, C. C., Hu, S. X., Ehrlich, L. and Peterson, P. K. (1995) Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav. Immun. 9, 355-365
145. Hu, S., Sheng, W. S., Ehrlich, E. C., Peterson, P. K. and Chao, C. C. (2000) Cytokine effects on glutamate uptake by human astrocytes. Neuroimmunomodulation 7, 153-159
146. Kim, T-A., Avraham, H. K., Koh, Y.-H., Jiang, S., Park, I.-W. and Avraham, S. (2003) HIV-1 Tat-mediated apoptosis in human brain microvascular endothelial cells. J. Immunol. 170, 2629-2637
147. Stamler, J. S. (1994) Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell 78, 931-936
148. Castagna, A., Le Grazie, C., Accordini, A. et al. (1995) Cerebrospinal fluid S-adenosylmethionine (SAMe) and glutathione concentrations in HIV infection: effect of parenteral treatment with SAMe. Neurology 45, 1678-1683
149. Yano, S., Yano, N., Rodriguez, N. et al. (1998) Suppression of intracellular hydrogen peroxide generation and catalase levels in CD8+ T-lymphocytes from HIV+ individuals. Free Radical Biol. Med. 24, 349-359
150. Adamson, D. C., McArthur, J. C., Dawson, T. M. and Dawson, V. L. (1999) Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS. Mol. Med. 5, 98-109
151. Adamson, D. C., Wildemann, B., Sasaki, M. et al. (1996) Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 274, 1917-1921
152. Mitchell, J. A., Akarasereenont, P., Thiemermann, C., Flower, R. J. and Vane, J. R. (1993) Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A. 90, 11693-11697
153. Feng, L., Sun, W., Xia, Y. et al. (1993) Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch. Biochem. Biophys. 307, 361-368
154. Wang, T., Qin, L., Liu, B. et al. (2004) Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J. Neurochem. 88, 939-947
155. Feng, Z. H., Wang, T. G., Li, D. D. et al. (2002) Cyclooxygenase-2- deficient mice are resistant to 1-methyl-4-phenyll,2,3,6-tetrahydropyridine- induced damage of dopaminergic neurons in the substantia nigra. Neurosci. Lett. 329, 354-358
156. Wang, T., Pei, Z., Zhang, W. et al. (2005) MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration. FASEB J. 19, 1134-1136
157. Consilvio, C., Vincent, A. M. and Feldman, E. L. (2004) Neuroinflammation, COX-2, and ALS: a dual role? Exp. Neurol. 187, 1-10
158. Pereira, C. F., Boven, L. A., Middel, J., Verhoef, J. and Nottet, H. S. L. M. (2000) Induction of cyclooxygenase-2 expression during HIV-1-infected monocyte-derived macrophage and human brain microvascular endothelial cell interactions. J. Leukocyte Biol. 68, 423-428
159. Corasaniti, M. T., Bellizzi, C., Russo, R., Colica, C., Amantea, D. and Di Renzo, G. (2003) Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells. Toxicol. Lett. 139, 213-219
160. Griffin, D. E., Wesselingh, S. L. and McArthur, J. C. (1994) Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia. Ann. Neurol. 35, 592-597
161. Limoges, J., Persidsky, Y., Bock, P. and Gendelman, H. E. (1997) Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice. J. Infect. Dis. 175, 1368-1381
162. Ehrlich, K., Sicking, C., Respondek, M. and Peskar, B. M. (2004) Interaction of cyclooxygenase isoenzymes, nitric oxide, and afferent neurons in gastric mucosal defense in rats. J. Pharmacol. Exp. Ther. 308, 277-283
163. Lokensgard, J. R., Hu, S., Sheng, W. et al. (2001) Robust expression of TNF-α, IL-1β, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus. J. Neurovirol. 7, 208-219
164. Marques, C. P., Hu, S., Sheng, W., Cheeran, M. C., Cox, D. and Lokensgard, J. R. (2004) Interleukin-10 attenuates production of HSV-induced inflammatory mediators by human microglia. Glia 47, 358-366
165. Nahmias, A. J., Hirsch, M. S., Kramer, J. H. and Murphy, F. A. (1969) Effect of antithymocyte serum on herpesvirus hominis (type 1) infection in adult mice. Proc. Soc. Exp. Biol. Med. 132, 696-698
166. Davis, L. E. and Johnson, R. T. (1979) An explanation for the localization of herpes simplex encephalitis? Ann. Neurol. 5, 2-5
167. Barnett, E. M., Jacobsen, G., Evans, G., Cassell, M. and Perlman, S. (1994) Herpes simplex encephalitis in the temporal cortex and limbic system after trigeminal nerve inoculation. J. Infect. Dis. 169, 782-786
168. Whitley, R., Lakeman, A. D., Nahmias, A. and Roizman, B. (1982) DNA restriction-enzyme analysis of herpes simplex virus isolates obtained from patients with encephalitis. N. Engl. J. Med. 307, 1060-1062
169. Baringer, J. R. and Swoveland, P. (1973) Recovery of herpes-simplex virus from human trigeminal ganglions. N. Engl. J. Med. 288, 648-650
170. Baringer, J. R. and Pisani, P. (1994) Herpes simplex virus genomes in human nervous system tissue analyzed by polymerase chain reaction. Ann. Neurol. 36, 823-829
171. Joly, E., Mucke, L. and Oldstone, M. B. (1991) Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science 253, 1283-1285
172. Mucke, L. and Oldstone, M. B. (1992) The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV). J. Neuroimmunol. 36, 193-198
173. Neumann, H., Cavalie, A., Jenne, D. E. and Wekerle, H. (1995) Induction of MHC class I genes in neurons. Science 269, 549-552
174. Steiner, I. and Kennedy, P. G. (1995) Herpes simplex virus latent infection in the nervous system. J. Neurovirol. 1, 19-29
175. Leake, C. J. and Johnson, R. T. (1987) The pathogenesis of Japanese encephalitis virus in Culex tritaeniorhynchus mosquitoes. Trans. R. Soc. Trop. Med. Hyg. 81, 681-685
176. Johnson, R. T., Burke, D. S., Elwell, M. et al. (1985) Japanese encephalitis: immunocytochemical studies of viral antigen and inflammatory cells in fatal cases. Ann. Neurol. 18, 567-573
177. Grimstad, P. R., Ross, Q. E. and Craig, Jr, G. B. (1980) Aedes triseriatus (Diptera: Culicidae) and La Crosse virus. II. Modification of mosquito feeding behavior by virus infection. J. Med. Entomol. 17, 1-7
178. Wesselingh, S. L., Levine, B., Fox, R. J., Choi, S. and Griffin, D. E. (1994) Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response. J. Immunol. 152, 1289-1297
179. Murphy, F. A. (1977) Rabies pathogenesis. Arch. Virol. 54, 279-297
180. Hemachudha, T., Laothamatas, J. and Rupprecht, C. E. (2002) Human rabies: a disease of complex neuropathogenetic mechanisms and diagnostic challenges. Lancet Neurol. 1, 101-109
181. Lewis, P., Fu, Y. and Lentz, T. L. (2000) Rabies virus entry at the neuromuscular junction in nerve-muscle cocultures. Muscle Nerve 23, 720-730
182. Ceccaldi, P. E., Gillet, J. P. and Tsiang, H. (1989) Inhibition of the transport of rabies virus in the central nervous system. J. Neuropathol. Exp. Neurol. 48, 620-630
183. Tsiang, H. (1993) Pathophysiology of rabies virus infection of the nervous system. Adv. Virus Res. 42, 375-412
184. Etessami, R., Conzelmann, K. K., Fadai-Ghotbi, B., Natelson, B., Tsiang, H. and Ceccaldi, P. E. (2000) Spread and pathogenic characteristics of a G-deficient rabies virus recombinant: an in vitro and in vivo study. J. Gen. Virol. 81, 2147-2153
185. Dupont, J. R. and Earle, K. M. (1965) Human rabies encephalitis. A study of forty-nine fatal cases with a review of the literature. Neurology 15, 1023-1034
186. Fu, Z. F. and Jackson, A. C. (2005) Neuronal dysfunction and death in rabies virus infection. J. Neurovirol. 11, 101-106
187. Camelo, S., Lafage, M. and Lafon, M. (2000) Absence of the p55 Kd TNF-α receptor promotes survival in rabies virus acute encephalitis. J. Neurovirol. 6, 507-518
188. Major, E. O., Amemiya, K., Tornatore, C. S., Houff, S. A. and Berger, J. R. (1992) Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin. Microbiol. Rev. 5, 49-73
189. Wroblewska, Z., Wellish, M. and Gilden, D. (1980) Growth of JC virus in adult human brain cell cultures. Arch. Virol. 65, 141-148
190. Du Pasquier, R. A., Corey, S., Margolin, D. H. et al. (2003) Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual. Neurology 61, 775-782
191. Koralnik, I. J., Wuthrich, C., Dang, X. et al. (2005) JC virus granule cell neuronopathy: A novel clinical syndrome distinct from progressive multifocal leukoencephalopathy. Ann. Neurol. 57, 576-580
192. Aksamit, A. J., Sever, T. L. and Major, E. O. (1986) Progressive multifocal leukoencephalopathy: JC virus detection by in situ hybridization compared with immunohistochemistry. Neurology 36, 499-504
193. Du Pasquier, R. A., Schmitz, J. E., Jean-Jacques, J. et al. (2004) Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals. J. Virol. 78, 10206-10210
194. Du Pasquier, R. A., Kuroda, M. J., Zheng, Y., Jean-Jacques, J., Letvin, N. L. and Koralnik, I. J. (2004) A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control or progressive multifocal leukoencephalopathy. Brain 127, 1970-1978
195. Du Pasquier, R. A. and Koralnik, I. J. (2003) Inflammatory reaction in progressive multifocal leukoencephalopathy: harmful or beneficial? J. Neurovirol. 9 (Suppl. 1), 25-31
196. Kibrick, S. (1964) Current status of coxsackie and echo viruses in human disease. Prog. Med. Virol. 10, 27-70
197. Grist, N. R., Bell, E. J. and Assaad, F. (1978) Enteroviruses in human disease. Prog. Med. Virol. 24, 114-157
198. Kamei, S., Hersch, S. M., Kurata, T. and Takei, Y. (1990) Coxsackie B antigen in the central nervous system of a patient with fatal acute encephalitis: immunohistochemical studies of formalin-fixed paraffin-embedded tissue. Acta Neuropathol. (Berl). 80, 216-221
199. Pruitt, A. A. (1998) Infections of the nervous system. Neural. Clin. 16, 419-447
200. Hashimoto, I. and Hagiwara, A. (1982) Studies on the pathogenesis of and propagation of enterovirus 71 in Poliomyelitis-like disease in monkeys. Acta Neuropathol. (Berl). 58, 125-132