Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates

Journal of Virology

Volumn 73, Issue 1, 1999, Pages 205-213

  Albright, Andrew V ^a   Shieh, Joseph T C ^a   Itoh, Takayuki ^b   Lee, Benhur ^c   Pleasure, David ^b   O'Connor, Michael J ^d   Doms, Robert W ^c   González Scarano, Francisco ^a,e  

^a Depts of Neurology and Microbiology   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Laboratory Medicine ^*  (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5;

ARTICLE; CONTROLLED STUDY; DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MICROGLIA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; VIRUS ISOLATION;

EID: 0032889037     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.1.205-213.1999     Document Type: Article

References (17)

1. Albright, A. V., J. Strizki, J. M. Harouse, E. Lavi, M. O'Connor, and F. González-Scarano. 1996. HIV-1 infection of cultured human adult oligodendrocytes. Virology 217:211-219.
2. Benveniste, E. N. 1997. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J. Mol. Med. 75:165-173.
3. Choe, H., M. Farzan, M. Konkel, K. Martin, Y. Sun, L. Marcon, M. Cayabyab, M. Berman, M. E. Dorf, N. Gerard, C. Gerard, and J. Sodroski. 1998. The orphan seven-transmembrane receptor Apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1. J. Virol. 72:6113-6118.
4. Cohen, J. 1998. AIDS therapies: exploring how to get at - and eradicate - hidden HIV. Science 279:1854.
5. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, C. B. Davis, S. C. Peiper, T. J. Schall, D. R. Liftman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
6. Deng, H. K., D. Unutmaz, V. N. KewalRamani, and D. R. Littman. 1997. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296-300.
7. Doms, R. W., and S. C. Peiper. 1997. Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry. Virology 235:179-190.
8. Edinger, A. L., J. L. Mankowski, B. J. Doranz, B. J. Margulies, B. Lee, J. Rucker, M. Sharron, T. L. Hoffman, J. F. Berson, M. C. Zink, V. M. Hirsch, J. E. Clements, and R. W. Doms. 1997. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. Proc. Natl. Acad. Sci. USA 94:14742-14747.
9. Edinger, A. L., T. L. Hoffman, M. Sharron, B. Lee, B. O'Dowd, and R. W. Doms. 1998. Use of GPR1, GPR15, and STRL33 as coreceptors by diverse HIV-1 and SIV envelope proteins. Virology 249:367-378.
10. Edinger, A. L., T. L. Hoffman, M. Sharron, B. Lee, Y. Yi, W. Choe, D. L. Kolson, B. Mitrovic, Y. Zhou, D. Faulds, R. G. Collman, J. Hesselgesser, R. Horuk, and R. W. Doms. 1998. An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus. J. Virol. 72:7934-7940.
11. Endres, M. J., P. R. Clapham, M. Marsh, M. Ahuja, J. D. Turner, A. McKnight, J. F. Thomas, B. Stoebenau-Haggerty, S. Chose, P. J. Vance, T. N. C. Wells, C. A. Power, N. R. Landau, and J. A. Hoxie. 1996. CD4-independent infection of HIV-2 is mediated by fusin/CXCR4. Cell 87:745-756.
12. Farzan, M., H. Choe, K. Martin, L. Marcon, W. Hofmann, G. Karlsson, Y. Sun, P. Barrett, N. Marchand, N. Sullivan, N. Gerard, C. Gerard, and J. Sodroski. 1997. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J. Exp. Med. 186:405-411.
13. Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877.
14. Gartner, S., and M. Popovic. 1990. Macrophage tropism of HIV-1. AIDS Res. Hum. Retroviruses 6:1017-1021.
15. Gartner, S., R. A. McDonald, E. A. Hunter, F. Bouwman, Y. Liu, and M. Popovic. 1997. gp120 sequence variation in brain and in T-lymphocyte human immunodeficiency virus type 1 primary isolates. J. Hum. Virol. 1:3-18.
16. Ghorpade, A-, M. Q. Xia, B. T. Hyman, Y. Persidsky, A. Nukuna, P. Bock, M. Che, J. Limoges, H. E. Gendelman, and C. R. Maekay. 1998. Role of the β-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia. J. Virol. 72:3351-3361.
17. Gonzalez-Scarano, F., R. E. Shope, C. E. Calisher, and N. Nathanson. 1982. Characterization of monoclonal antibodies against the G1 and N proteins of LaCrosse and Tahyna, two California serogroup bunyaviruses. Virology 120:42-53.