Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

Journal of Cell Science

Volumn 115, Issue 13, 2002, Pages 2757-2770

  Fotin Mleczek, Mariola ^a   Henkler, Frank ^a   Samel, Dierk ^a   Reichwein, Monica ^a   Hausser, Angelika ^a   Parmryd, Ingela ^a   Scheurich, Peter ^a   Schmid, Johannes A ^a   Wajant, Harald ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Caspase 8; Cell death; TNF; TNF R2; TRAF2

Indexed keywords

ADAPTOR PROTEIN; CASPASE 8; CD30 ANTIGEN; CD40 ANTIGEN; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; APOPTOSIS REGULATORY PROTEIN; BIRC2 PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 9; FASLG PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; INSECT PROTEIN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PROTEIN; TNFSF10 PROTEIN, HUMAN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STIMULATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS REACTION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PROCESSING; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; BIOLOGICAL MODEL; DOWN REGULATION; DRUG EFFECT; EUKARYOTIC CELL; GENETICS; METABOLISM; RHABDOMYOSARCOMA;

ADAPTOR PROTEIN COMPLEX 2; ANTIGENS, CD; ANTIGENS, CD30; ANTIGENS, CD40; APOPTOSIS; CASPASES; DOWN-REGULATION; EUKARYOTIC CELLS; HELA CELLS; HUMAN; INSECT PROTEINS; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; RHABDOMYOSARCOMA; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR; APOPTOSIS REGULATORY PROTEINS; CASPASE 8; CASPASE 9; FAS LIGAND PROTEIN; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TNF RECEPTOR-ASSOCIATED FACTOR 1; TNF RECEPTOR-ASSOCIATED FACTOR 2; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036629347     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Translocation of TRAF proteins regulates apoptotic threshold of cells
2. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
3. Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity
4. Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)
5. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes
6. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
7. Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75
8. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
9. The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF
10. CD30-dependent degradation of TRAF2: Implications for negative regulation of TRAF signaling and the control of cell survival
11. Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1
12. TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis
13. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
14. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
15. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: A role for TNF-R1 activation by endogenous membrane-anchored TNF
16. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
17. The p70 tumor necrosis factor receptor mediates cytotoxicity
18. A novel function of CD40: Induction of cell death in transformed cells
19. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
20. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis
21. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
22. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
23. NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
24. Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells
25. Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes
26. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
27. The TNF and TNF receptor superfamilies: Integrating mammalian biology
28. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy imilar to the human X-linked disorder incontinentia pigmenti 1336
29. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
30. Involvement of the tumor necrosis factor receptor p75 in mediating cytotoxicity and gene regulating activities
31. Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells
32. Regulated commitment of TNF receptor signaling: A molecular switch for death or activation
33. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
34. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
35. Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice
36. Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts
37. NEMO/IKK gamma-deficient mice model incontinentia pigmenti
38. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
39. The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is upregulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase
40. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
41. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo
42. Critical roles of TRAF2 and TRAF5 in TNF-induced NF-kB activation and protection from cell death
43. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma
44. Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice
45. Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor
46. Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells
47. Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF
48. Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction
49. TNF receptor associated factors in cytokine signaling
50. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)
51. The TNF-receptor-associated factor family: Scaffold molecules for cytokine receptors, kinases and their regulators
52. Tumor necrosis factor receptor and Fas signaling mechanisms
53. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
54. Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: Requirement of the TNF receptor-associated factor-2 binding site
55. TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60
56. The essential role of MEKK3 in TNF-induced NF-kappaB activation
57. Induction of apoptosis in mature T cells by tumour necrosis factor