Apoptosis induced by HIV-1 infection of the central nervous system

Journal of Clinical Investigation

Volumn 98, Issue 9, 1996, Pages 1979-1990

  Shi, Bin ^a,c   De Girolami, Umberto ^b,c   He, Jianglin ^a,c   Wang, Shu ^a,c   Lorenzo, Alfredo ^c,d   Busciglio, Jorge ^c,d   Gabuzda, Dana ^a,c  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

AIDS; apoptosis; dementia; encephalitis; HIV

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; DEMENTIA; FETUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; NERVE CELL CULTURE; PRIORITY JOURNAL; VIRUS ENCEPHALITIS;

EID: 0029858321     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119002     Document Type: Article

References (50)

1. Brew, B.J., M. Rosenblum, K. Cronin, and R.W. Price. 1995. AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations. Ann. Neurol. 38:563-570.
2. Epstein, L.G., and H.E. Gendelman. 1993. Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms Ann. Neurol. 33:429-430.
3. Gabuzda, D.H., and M.S. Hirsch. 1987. Neurologic manifestations of infection with human immunodeficiency virus. Ann. Intern. Med. 107:383-391.
4. Glass, J.D., S.L. Wesselingh, O.A. Seines, and J.C. McArthur. 1993. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology. 43: 2230-2237.
5. Price, R.W. 1988. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science (Wash. DC). 239:586-591.
6. Gabuzda, D.H., D.D. Ho, M.S. de la Monte, T.R. Rota, and R.A. Sobel. 1986. Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann. Neurol. 20:289-295.
7. Glass, J.D., H. Fedor, S.L. Wesselingh, and J.C. McArthur. 1995. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann. Neurol. 38:755-762.
8. Ward, J.M., T.J. O'Leary, G.B. Baskin, R. Benveniste, C.A. Harris, P.L. Nara, and R.H. Rhodes. 1987. Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. Am. J. Pathol. 127:199-205.
9. Wiley, C.A., R.D. Schrier, J.A. Nelson, P.W. Lampert, and M.B.A. Oldstone. 1986. Cellular localization of human immunodeficiency virus within the brains of acquired immunodeficiency patients. Proc. Natl. Acad. Sci. USA 83: 7089-7093.
10. Moses, A.L., F.E. Bloom, C.D. Pauza, and J.A. Nelson. 1993. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc. Natl. Acad. Sci. USA. 90:10474-10478.
11. Ranki, A., M. Nyberg, V. Ovod, M. Haltia, I. Elovaara, R. Raininko, H. Haapasalo, and K. Krohn. 1995. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS. 9:1001-1008.
12. Saito, Y., L.R. Sharer, L.G. Epstein, J. Michaels, M. Mintz, M. Louder, K. Golding, T.A. Cvetkovich, and B.M. Blumberg. 1994. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology. 44:474-481.
13. Tornatore, C., R. Chandra, J.R. Berger, and E.O. Major. 1991. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology. 44:481-487.
14. Kure, K., J.F. Llena, W.D. Lyman, R. Soeiro, K.M. Weidenheim, A. Hirano, and D.W. Dickson. 1991. Human immunodeficiency virus-1 infection of the nervous system: an autopsy study of 268 adult, pediatric, and fetal brains. Hum. Pathol. 22:700-710.
15. Navia, B., E.S. Cho, C.K. Petito, and R.W. Price. 1986. The AIDS dementia complex. II. Neuropathology. Ann Neurol. 19:525-535.
16. Power, C., P-A. Kong, T.O. Crawford, S. Wesselingh, J.D. Glass, J.C. McArthur, and B.D. Trapp. 1993. Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier. Ann. Neurol. 34:339-350.
17. Smith, T.W., U. DeGirolami, D. Henin, F. Bolgert, and J.-J. Hauw. 1990. Human immunodeficiency virus (HIV) leukoencephalopathy and the microcirculation. J. Neuropathol. Exp. Neurol 49:357-370.
18. Wiley, C.A., and C. Achim. 1994. Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann. Neurol. 36:673-676.
19. Everall, I.P., J.D. Glass, J. McArthur, E. Spargo, and L. Lantos. 1994. Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia. Acta Neuropathol. 88:538-544.
20. Ketzler, S., S. Weis, H. Haug, and H. Budka. 1990. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol. 80:92-94.
21. Masliah, E., C.L. Achim, N. Ge, R. DeTeresa, R.D. Terry, and C.A. Wiley. 1992. Spectrum of human immunodeficiency virus-associated neocortical damage. Ann. Neurol. 32:321-329.
22. Wiley, C.A., E. Masliah, M. Morey, C. Lemere, R. DeTeresa, M. Grafe, L. Hansen, and R. Terry. 1991. Neocortical damage during HIV infection. Ann. Neurol. 29:651-657.
23. Sinclair, E., F. Gray, A. Ciardi, and F. Scaravilli. 1994. Immunohistochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV-positive patients. J. Neuropath. Exp. Neurol. 53:43-50.
24. Pulliam, L., B.G. Herndier, N.M. Tang, and M.S. McGrath. 1991. Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J. Clin. Invest. 87:503-512.
25. Gelbard, H.A., H.S. Nottet, S. Swindells, M. Jett, K.A. Dzenko, P. Genis, R. White, L. Wang, Y. Choi, D. Zhang et al. 1994. Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J. Virol 68:4628-4635.
26. Genis, P., M. Jett, E.W. Bernton, T. Boyle, H.A. Gelbard, K. Dzenki, R.W. Keane, L. Resnick, Y. Mizrachi, D.J. Volsky et al. 1992. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med. 176:1703-1718.
27. Magnuson, D.S.K., B.E. Knudsen, J.D. Geiger, R.M. Brownstone, and A. Nath. 1995. Human immunodeficiency virus type 1 Tat activates non-N-methyl-D-asparate excitatory amino acid receptors and causes neurotoxicity. Ann. Neurol. 37:373-380.
28. Wesselingh, S.L., C. Power, J.D. Glass, W.R. Tyor, J.C. McArthur, J.M. Farber, J.W. Griffin, and D.E. Griffin. 1993. Intracerebral cytokine messenger RNA expression in AIDS dementia. Ann. Neurol. 33:576-582.
29. Oyaizu, N., and S. Pahwa. 1995. Role of apoptosis in HIV disease pathogenesis. J. Clin. Immunol. 15:217-231.
30. Adie-Biassette, H., Y. Levy, M. Colombel, F. Poron, S. Natchev, C. Keohane, and F. Gray. 1995. Neuronal apoptosis in HIV infection in adults. Neuropathol. Appl. Neurobiol. 21:218-227.
31. Gelbard, H.A., H.J. James, L.R. Sharer, S.W. Perry, Y. Saito, A.M. Kazee, B.M. Blumberg, and L.G. Epstein. 1995. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol. Appl. Neurobiol. 21:208-217.
32. Petito, C.K., and B. Roberts. 1995. Evidence of apoptotic cell death in HIV encephalitis. Am. J. Pathol. 146:1121-1130.
33. Zazopoulos, E., and W. Haseltine. 1993. Effect of nef alleles on replication of human immunodeficiency virus type 1. Virology. 194:20-27.
34. Collman, R., J.W. Balliet, S.A. Gregory, H. Friedman, D.L. Kolson, N. Nathanson, and A. Srinivasan. 1992. An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic stain of human immunodeficiency virus type 1. J. Virol. 66:7517-7521.
35. Li, Y., H. Hui, C.J. Burgess, R.W. Price, P.M. Sharp, B.H. Hahn, and G.M. Shaw. 1992. Complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: evidence for limited defectiveness and complementation. J. Virol. 66:6587-6600.
36. Busciglio, J., J. Yeh, and B.A. Yankner. 1993. β-amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins J. Neurochem. 61: 1565-1668.
37. Rho, H.M., B. Poiesz, W. Ruscetti, and R. C. Gallo. 1981. Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line. Virology. 112:355-360.
38. Gavrieli, Y., Y. Sherman, and S.A. Ben-Sasson. 1992. Detection of programmed cell death in vitro via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
39. Lee, S.C., W. Liu, Y. Kress, W.D. Lyman, and D.W. Dickson. 1993. Productive infection of human fetal microglia by HIV-1. Am. J. Pathol. 143:1032-1039.
40. Sharpless, N., D. Gilbert, B. Vandercam, J.M. Zhou, E. Verdin, G. Ronnett, E. Friedman, and M. Dubois-Dalcq. 1992. The restricted nature of HlV-1 tropism for cultured neural cells. Virology. 191:813-825.
41. Petito, C.K., and K.S. Cash. 1992. Blood-brain barrier abnormalities in the acquired immunodeficiency syndrome: immunohistochemical localization of serum proteins in postmortem brain. Ann. Neurol. 32:658-666.
42. Dreyer, E.B., P.K. Kaiser, J.T. Offerman, and S.A. Lipton. 1990. HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science (Wash. DC). 248:364-367.
43. Müller, W.E.G., H.C. Schröder, H. Ushijima, J. Dapper, and J. Bermann. 1992. gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine. Eur. J. Pharmacol. 226:209-214.
44. Li, C.J., D.J. Friedman, C. Wang, V. Metelev, and A.B. Pardee. 1995. Induction of apoptosis in uninfected T lymphocytes by HIV-1 Tat protein. Science (Wash. DC). 268:429-431.
45. Lewis, J., S.L. Wesselingh, D.E. Griffin, and J.M. Hardwick. 1996. Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence. J. ViroL 70:1828-1835.
46. Polunovsky, V.A., B. Chen, C. Henke, D. Snover, C. Wendt, D.H. Ingbar, and P.B. Bitterman. 1993. Role of mesenchymal cell death in lung remodeling after injury. J. Clin. Invest. 92:388-397.
47. Fuks, Z., R.S. Persaud, A. Alfieri, M. McLoughlin, D. Ehleiter, J.L. Schwartz, A.P. Seddon, C. Cordon-Cardo, and A. Haimovitz-Friedman. 1994. Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Research. 54:2582-2590.
48. Sgonc, R., M.S. Gruschwitz, H. Dietrich, H. Recheis, M.E. Gershwin, and G. Wick. 1996. Endothetial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J. Clin. Invest. 98:785-792.
49. An, S.F., F. Gray, and F. Scaravilli, F. 1995. Programmed cell death in brains of HIV-1-positive pre-AIDS patients. Lancet. 346:911-912.
50. Power, C., J.C. McArthur, R.T. Johnson, D.E. Griffin, J.D. Glass, S. Perryman, and B. Chesebro. 1994. Demented and nondemented patients with AIDS differ in brain derived human immunodeficiency virus type 1 envelope sequences. J. Virol. 68:4643-4649.