-
1
-
-
0346435111
-
A brief historical review of the waterfall/cascade of blood coagulation
-
E.W. Davie A brief historical review of the waterfall/cascade of blood coagulation J. Biol. Chem. 278 2003 50819
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50819
-
-
Davie, E.W.1
-
2
-
-
0026476381
-
Thrombin is a Na(+)-activated enzyme
-
C.M. Wells, and E. Di Cera Thrombin is a Na(+)-activated enzyme Biochemistry 31 1992 11721
-
(1992)
Biochemistry
, vol.31
, pp. 11721
-
-
Wells, C.M.1
Di Cera, E.2
-
3
-
-
28344436780
-
Protease-activated receptors in hemostasis, thrombosis and vascular biology
-
S.R. Coughlin Protease-activated receptors in hemostasis, thrombosis and vascular biology J. Thromb. Haemost. 3 2005 1800 1814
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 1800-1814
-
-
Coughlin, S.R.1
-
4
-
-
0024558370
-
The roles of protein C and thrombomodulin in the regulation of blood coagulation
-
C.T. Esmon The roles of protein C and thrombomodulin in the regulation of blood coagulation J. Biol. Chem. 264 1989 4743
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 4743
-
-
Esmon, C.T.1
-
5
-
-
0029895009
-
TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex
-
L. Bajzar, J. Morser, and M. Nesheim TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex J. Biol. Chem. 271 1996 16603
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 16603
-
-
Bajzar, L.1
Morser, J.2
Nesheim, M.3
-
6
-
-
0024431034
-
The refined 1.9 a crystal structure of human alpha-thrombin: Interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment
-
W. Bode, I. Mayr, and U. Baumann The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment EMBO J. 8 1989 3467
-
(1989)
EMBO J.
, vol.8
, pp. 3467
-
-
Bode, W.1
Mayr, I.2
Baumann, U.3
-
7
-
-
0027050807
-
The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships
-
W. Bode, D. Turk, and A. Karshikov The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships Protein Sci. 1 1992 426
-
(1992)
Protein Sci.
, vol.1
, pp. 426
-
-
Bode, W.1
Turk, D.2
Karshikov, A.3
-
8
-
-
0027409404
-
A player of many parts: The spotlight falls on thrombin's structure
-
M.T. Stubbs, and W. Bode A player of many parts: the spotlight falls on thrombin's structure Thromb. Res. 69 1993 1
-
(1993)
Thromb. Res.
, vol.69
, pp. 1
-
-
Stubbs, M.T.1
Bode, W.2
-
9
-
-
0028912561
-
The clot thickens: Clues provided by thrombin structure
-
M.T. Stubbs, and W. Bode The clot thickens: clues provided by thrombin structure Trends Biochem. Sci. 20 1995 23
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 23
-
-
Stubbs, M.T.1
Bode, W.2
-
10
-
-
0030811924
-
Comparative analysis of haemostatic proteinases: Structural aspects of thrombin, factor Xa, factor IXa and protein C
-
W. Bode, H. Brandstetter, T. Mather, and M.T. Stubbs Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C Thromb. Haemost. 78 1997 501
-
(1997)
Thromb. Haemost.
, vol.78
, pp. 501
-
-
Bode, W.1
Brandstetter, H.2
Mather, T.3
Stubbs, M.T.4
-
11
-
-
27144505651
-
Molecular recognition mechanisms of thrombin
-
J.A. Huntington Molecular recognition mechanisms of thrombin J. Thromb. Haemost. 3 2005 1861
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 1861
-
-
Huntington, J.A.1
-
12
-
-
0018781771
-
The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding: II. the binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-trypsinogen
-
W. Bode The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding: II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-trypsinogen J. Mol. Biol. 127 1979 357
-
(1979)
J. Mol. Biol.
, vol.127
, pp. 357
-
-
Bode, W.1
-
13
-
-
0028586082
-
The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: Changes accompanying activation and exosite binding to thrombin
-
J. Vijayalakshmi, K.P. Padmanabhan, K.G. Mann, and A. Tulinsky The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin Protein Sci. 3 1994 2254
-
(1994)
Protein Sci.
, vol.3
, pp. 2254
-
-
Vijayalakshmi, J.1
Padmanabhan, K.P.2
Mann, K.G.3
Tulinsky, A.4
-
15
-
-
0028884430
-
Identification of residues linked to the slow→fast transition of thrombin
-
E.R. Guinto, A. Vindigni, and Y.M. Ayala Identification of residues linked to the slow→fast transition of thrombin Proc. Natl. Acad. Sci. U. S. A. 92 1995 11185
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 11185
-
-
Guinto, E.R.1
Vindigni, A.2
Ayala, Y.M.3
-
16
-
-
0025837452
-
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors
-
D.W. Banner, and P. Hadvary Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors J. Biol. Chem. 266 1991 20085
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 20085
-
-
Banner, D.W.1
Hadvary, P.2
-
17
-
-
0026465007
-
Refined 2.3 a X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. a starting point for improving antithrombotics
-
H. Brandstetter, D. Turk, and H.W. Hoeffken Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics J. Mol. Biol. 226 1992 1085
-
(1992)
J. Mol. Biol.
, vol.226
, pp. 1085
-
-
Brandstetter, H.1
Turk, D.2
Hoeffken, H.W.3
-
18
-
-
0026548768
-
The interaction of thrombin with fibrinogen. a structural basis for its specificity
-
M.T. Stubbs, H. Oschkinat, and I. Mayr The interaction of thrombin with fibrinogen. A structural basis for its specificity Eur. J. Biochem. 206 1992 187
-
(1992)
Eur. J. Biochem.
, vol.206
, pp. 187
-
-
Stubbs, M.T.1
Oschkinat, H.2
Mayr, I.3
-
19
-
-
0026657151
-
The structure of residues 7-16 of the a alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution
-
P.D. Martin, W. Robertson, and D. Turk The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution J. Biol. Chem. 267 1992 7911
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 7911
-
-
Martin, P.D.1
Robertson, W.2
Turk, D.3
-
20
-
-
0034711216
-
Interaction of the factor XIII activation peptide with alpha-thrombin. Crystal structure of its enzyme-substrate analog complex
-
C. Sadasivan, and V.C. Yee Interaction of the factor XIII activation peptide with alpha-thrombin. Crystal structure of its enzyme-substrate analog complex J. Biol. Chem. 275 2000 36942
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36942
-
-
Sadasivan, C.1
Yee, V.C.2
-
21
-
-
0021080275
-
Promotion of thrombin-catalyzed activation of factor XIII by fibrinogen
-
T.J. Janus, S.D. Lewis, L. Lorand, and J.A. Shafer Promotion of thrombin-catalyzed activation of factor XIII by fibrinogen Biochemistry 22 1983 6269
-
(1983)
Biochemistry
, vol.22
, pp. 6269
-
-
Janus, T.J.1
Lewis, S.D.2
Lorand, L.3
Shafer, J.A.4
-
22
-
-
0025923430
-
Glu-192-Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin
-
B.F. Le Bonniec, and C.T. Esmon Glu-192-Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin Proc. Natl. Acad. Sci. U. S. A. 88 1991 7371
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 7371
-
-
Le Bonniec, B.F.1
Esmon, C.T.2
-
23
-
-
0030959346
-
The thrombin E192Q-BPTI complex reveals gross structural rearrangements: Implications for the interaction with antithrombin and thrombomodulin
-
A. Van de Locht, W. Bode, and R. Huber The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin EMBO J. 16 1997 2977
-
(1997)
EMBO J.
, vol.16
, pp. 2977
-
-
Van De Locht, A.1
Bode, W.2
Huber, R.3
-
24
-
-
0028084791
-
Molecular recognition by thrombin. Role of the slow→fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components
-
Y. Ayala, and E. Di Cera Molecular recognition by thrombin. Role of the slow→fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components J. Mol. Biol. 235 1994 733
-
(1994)
J. Mol. Biol.
, vol.235
, pp. 733
-
-
Ayala, Y.1
Di Cera, E.2
-
27
-
-
3843133006
-
Molecular dissection of Na+ binding to thrombin
-
A.O. Pineda, C.J. Carrell, and L.A. Bush Molecular dissection of Na+ binding to thrombin J. Biol. Chem. 279 2004 31842
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31842
-
-
Pineda, A.O.1
Carrell, C.J.2
Bush, L.A.3
-
28
-
-
0037387204
-
The molecular basis of thrombin allostery revealed by a 1.8 a structure of the "slow" form
-
J.A. Huntington, and C.T. Esmon The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form Structure (Camb). 11 2003 469
-
(2003)
Structure (Camb).
, vol.11
, pp. 469
-
-
Huntington, J.A.1
Esmon, C.T.2
-
29
-
-
2942703945
-
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery
-
W.J. Carter, T. Myles, and C.S. Gibbs Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery J. Biol. Chem. 279 2004 26387
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 26387
-
-
Carter, W.J.1
Myles, T.2
Gibbs, C.S.3
-
30
-
-
25144446242
-
Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin
-
V. De Filippis, E. De Dea, F. Lucatello, and R. Frasson Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin Biochem. J. 390 2005 485
-
(2005)
Biochem. J.
, vol.390
, pp. 485
-
-
De Filippis, V.1
De Dea, E.2
Lucatello, F.3
Frasson, R.4
-
31
-
-
0016796849
-
The refined crystal structure of bovine beta-trypsin at 1.8 a resolution: II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0
-
W. Bode, and P. Schwager The refined crystal structure of bovine beta-trypsin at 1.8 A resolution: II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0 J. Mol. Biol. 98 1975 693 717
-
(1975)
J. Mol. Biol.
, vol.98
, pp. 693-717
-
-
Bode, W.1
Schwager, P.2
-
32
-
-
0025329390
-
The structure of a complex of recombinant hirudin and human alpha-thrombin
-
T.J. Rydel, K.G. Ravichandran, and A. Tulinsky The structure of a complex of recombinant hirudin and human alpha-thrombin Science 249 1990 277
-
(1990)
Science
, vol.249
, pp. 277
-
-
Rydel, T.J.1
Ravichandran, K.G.2
Tulinsky, A.3
-
34
-
-
0025309452
-
Crystal structure of the thrombin-hirudin complex: A novel mode of serine protease inhibition
-
M.G. Grütter, J.P. Priestle, and J. Rahuel Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition EMBO J. 9 1990 2361
-
(1990)
EMBO J.
, vol.9
, pp. 2361
-
-
Grütter, M.G.1
Priestle, J.P.2
Rahuel, J.3
-
36
-
-
22844449689
-
Hirudin binding reveals key determinants of thrombin allostery
-
K.E. Mengwasser, L.A. Bush, and P. Shih Hirudin binding reveals key determinants of thrombin allostery J. Biol. Chem. 280 2005 26997
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26997
-
-
Mengwasser, K.E.1
Bush, L.A.2
Shih, P.3
-
37
-
-
0028784163
-
Two heads are better than one: Crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin
-
A. van de Locht, D. Lamba, and M. Bauer Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin EMBO J. 14 1995 5149
-
(1995)
EMBO J.
, vol.14
, pp. 5149
-
-
Van De Locht, A.1
Lamba, D.2
Bauer, M.3
-
38
-
-
0029957955
-
The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
-
A. van de Locht, M.T. Stubbs, and W. Bode The ornithodorin-thrombin crystal structure, a key to the TAP enigma? EMBO J. 15 1996 6011
-
(1996)
EMBO J.
, vol.15
, pp. 6011
-
-
Van De Locht, A.1
Stubbs, M.T.2
Bode, W.3
-
39
-
-
0030666566
-
Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug
-
P. Fuentes-Prior, C. Noeske-Jungblut, and P. Donner Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug Proc. Natl. Acad. Sci. U. S. A. 94 1997 11845
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 11845
-
-
Fuentes-Prior, P.1
Noeske-Jungblut, C.2
Donner, P.3
-
40
-
-
1542297770
-
Crystal structure of the complex between thrombin and the central "e" region of fibrin
-
I. Pechik, J. Madrazo, and M.W. Mosesson Crystal structure of the complex between thrombin and the central "E" region of fibrin Proc. Natl. Acad. Sci. U. S. A. 101 2004 2718
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 2718
-
-
Pechik, I.1
Madrazo, J.2
Mosesson, M.W.3
-
41
-
-
0037205399
-
Substrate recognition drives the evolution of serine proteases
-
T. Rose, and E. Di Cera Substrate recognition drives the evolution of serine proteases J. Biol. Chem. 277 2002 19243
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 19243
-
-
Rose, T.1
Di Cera, E.2
-
42
-
-
0029819059
-
Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen a alpha: Geometry of the catalytic triad and interactions of the P1′, P2′, and P3′ substrate residues
-
P.D. Martin, M.G. Malkowski, and J. DiMaio Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1′, P2′, and P3′ substrate residues Biochemistry 35 1996 13030
-
(1996)
Biochemistry
, vol.35
, pp. 13030
-
-
Martin, P.D.1
Malkowski, M.G.2
Dimaio, J.3
-
43
-
-
0026072517
-
Domains specifying thrombin-receptor interaction
-
T.K. Vu, V.I. Wheaton, and D.T. Hung Domains specifying thrombin-receptor interaction Nature 353 1991 674
-
(1991)
Nature
, vol.353
, pp. 674
-
-
Vu, T.K.1
Wheaton, V.I.2
Hung, D.T.3
-
44
-
-
28344436780
-
Protease-activated receptors in hemostasis, thrombosis and vascular biology
-
S.R. Coughlin Protease-activated receptors in hemostasis, thrombosis and vascular biology J. Thromb. Haemost. 3 2005 1800
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 1800
-
-
Coughlin, S.R.1
-
45
-
-
0028209977
-
Crystallographic structures of thrombin complexed with thrombin receptor peptides: Existence of expected and novel binding modes
-
I.I. Mathews, K.P. Padmanabhan, and V. Ganesh Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes Biochemistry 33 1994 3266
-
(1994)
Biochemistry
, vol.33
, pp. 3266
-
-
Mathews, I.I.1
Padmanabhan, K.P.2
Ganesh, V.3
-
46
-
-
0035501805
-
Molecular mapping of thrombin-receptor interactions
-
Y.M. Ayala, A.M. Cantwell, and T. Rose Molecular mapping of thrombin-receptor interactions Proteins 45 2001 107
-
(2001)
Proteins
, vol.45
, pp. 107
-
-
Ayala, Y.M.1
Cantwell, A.M.2
Rose, T.3
-
47
-
-
0035818425
-
Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib
-
R. De Cristofaro, E. De Candia, and R. Landolfi Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib Biochemistry 40 2001 13268
-
(2001)
Biochemistry
, vol.40
, pp. 13268
-
-
De Cristofaro, R.1
De Candia, E.2
Landolfi, R.3
-
48
-
-
0242384136
-
Targeting thrombin-rational drug design from natural mechanisms
-
J.A. Huntington, and T.P. Baglin Targeting thrombin-rational drug design from natural mechanisms Trends Pharmacol. Sci. 24 2003 589
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, pp. 589
-
-
Huntington, J.A.1
Baglin, T.P.2
-
49
-
-
0037143655
-
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
-
T.P. Baglin, R.W. Carrell, and F.C. Church Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism Proc. Natl. Acad. Sci. U. S. A. 99 2002 11079
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 11079
-
-
Baglin, T.P.1
Carrell, R.W.2
Church, F.C.3
-
50
-
-
11244267323
-
The staphylocoagulase family of zymogen activator and adhesion proteins
-
P. Panizzi, R. Friedrich, and P. Fuentes-Prior The staphylocoagulase family of zymogen activator and adhesion proteins Cell. Mol. Life Sci. 61 2004 2793
-
(2004)
Cell. Mol. Life Sci.
, vol.61
, pp. 2793
-
-
Panizzi, P.1
Friedrich, R.2
Fuentes-Prior, P.3
-
51
-
-
0141929350
-
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
-
R. Friedrich, P. Panizzi, and P. Fuentes-Prior Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation Nature 425 2003 535
-
(2003)
Nature
, vol.425
, pp. 535
-
-
Friedrich, R.1
Panizzi, P.2
Fuentes-Prior, P.3
-
52
-
-
33644866813
-
Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation
-
R. Friedrich, P. Panizzi, and S. Kawabata Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation JBC 281 2006 1188
-
(2006)
JBC
, vol.281
, pp. 1188
-
-
Friedrich, R.1
Panizzi, P.2
Kawabata, S.3
-
53
-
-
33644858159
-
Fibrinogen substrate recognition by staphylocoagulase•(pro)thrombin complexes
-
P. Panizzi, R. Friedrich, and P. Fuentes-Prior Fibrinogen substrate recognition by staphylocoagulase•(pro)thrombin complexes JBC 281 2006 1179
-
(2006)
JBC
, vol.281
, pp. 1179
-
-
Panizzi, P.1
Friedrich, R.2
Fuentes-Prior, P.3
-
54
-
-
0024464072
-
Structural and functional properties of human alpha-thrombin, phosphopyridoxylated alpha-thrombin, and gamma T-thrombin. Identification of lysyl residues in alpha-thrombin that are critical for heparin and fibrin(ogen) interactions
-
F.C. Church, C.W. Pratt, and C.M. Noyes Structural and functional properties of human alpha-thrombin, phosphopyridoxylated alpha-thrombin, and gamma T-thrombin. Identification of lysyl residues in alpha-thrombin that are critical for heparin and fibrin(ogen) interactions J. Biol. Chem. 264 1989 18419
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 18419
-
-
Church, F.C.1
Pratt, C.W.2
Noyes, C.M.3
-
55
-
-
0027972583
-
Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III
-
Z.R. Gan, Y. Li, and Z. Chen Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III J. Biol. Chem. 269 1994 1301
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 1301
-
-
Gan, Z.R.1
Li, Y.2
Chen, Z.3
-
57
-
-
0025730441
-
Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models
-
S.T. Olson, H.R. Halvorson, and I. Bjork Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models J. Biol. Chem. 266 1991 6342
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 6342
-
-
Olson, S.T.1
Halvorson, H.R.2
Bjork, I.3
-
58
-
-
0024456056
-
Anti-thrombin activities of heparin. Effect of saccharide chain length on thrombin inhibition by heparin cofactor II and by antithrombin
-
B. Bray, D.A. Lane, and J.M. Freyssinet Anti-thrombin activities of heparin. Effect of saccharide chain length on thrombin inhibition by heparin cofactor II and by antithrombin Biochem. J. 262 1989 225
-
(1989)
Biochem. J.
, vol.262
, pp. 225
-
-
Bray, B.1
Lane, D.A.2
Freyssinet, J.M.3
-
59
-
-
0036882395
-
Serpin structure, mechanism, and function
-
P.G. Gettins Serpin structure, mechanism, and function Chem. Rev. 102 2002 4751
-
(2002)
Chem. Rev.
, vol.102
, pp. 4751
-
-
Gettins, P.G.1
-
60
-
-
4344590703
-
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin
-
W. Li, D.J. Johnson, C.T. Esmon, and J.A. Huntington Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin Nat. Struct. Mol. Biol. 11 2004 857
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 857
-
-
Li, W.1
Johnson, D.J.2
Esmon, C.T.3
Huntington, J.A.4
-
61
-
-
4344710558
-
The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity
-
A. Dementiev, M. Petitou, J.M. Herbert, and P.G. Gettins The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity Nat. Struct. Mol. Biol. 11 2004 863
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 863
-
-
Dementiev, A.1
Petitou, M.2
Herbert, J.M.3
Gettins, P.G.4
-
62
-
-
0028332939
-
Molecular mapping of the heparin-binding exosite of thrombin
-
J.P. Sheehan, and J.E. Sadler Molecular mapping of the heparin-binding exosite of thrombin Proc. Natl. Acad. Sci. U. S. A. 91 1994 5518
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 5518
-
-
Sheehan, J.P.1
Sadler, J.E.2
-
63
-
-
0025730441
-
Quantitative characterization of the thrombin-heparin interaction
-
S.T. Olson Quantitative characterization of the thrombin-heparin interaction J. Biol. Chem. 266 1999 6342
-
(1999)
J. Biol. Chem.
, vol.266
, pp. 6342
-
-
Olson, S.T.1
-
64
-
-
0027288125
-
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin
-
R.K. Arni, K. Padmanabhan, and K.P. Padmanabhan Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin Biochemistry 32 1993 4727
-
(1993)
Biochemistry
, vol.32
, pp. 4727
-
-
Arni, R.K.1
Padmanabhan, K.2
Padmanabhan, K.P.3
-
65
-
-
0031574020
-
New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK
-
P.D. Martin, M.G. Malkowski, and J. Box New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK Structure 5 1997 1681
-
(1997)
Structure
, vol.5
, pp. 1681
-
-
Martin, P.D.1
Malkowski, M.G.2
Box, J.3
-
66
-
-
0034329465
-
Crystal structure of the human alpha-thrombin-haemadin complex: An exosite II-binding inhibitor
-
J.L. Richardson, B. Kröger, and W. Hoeffken Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor EMBO J. 19 2000 5650
-
(2000)
EMBO J.
, vol.19
, pp. 5650
-
-
Richardson, J.L.1
Kröger, B.2
Hoeffken, W.3
-
67
-
-
0037176829
-
Characterization of the residues involved in the human alpha-thrombin-haemadin complex: An exosite II-binding inhibitor
-
J.L. Richardson, P. Fuentes-Prior, and J.E. Sadler Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor Biochemistry 41 2002 2535
-
(2002)
Biochemistry
, vol.41
, pp. 2535
-
-
Richardson, J.L.1
Fuentes-Prior, P.2
Sadler, J.E.3
-
68
-
-
0035852682
-
A thrombin receptor function for platelet glyco protein Ib-IX unmasked by cleavage of glycoprotein V
-
V. Ramakrishnan, F. DeGuzman, and M. Bao A thrombin receptor function for platelet glyco protein Ib-IX unmasked by cleavage of glycoprotein V Proc. Natl. Acad. Sci. U. S. A. 98 2001 1823
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 1823
-
-
Ramakrishnan, V.1
Deguzman, F.2
Bao, M.3
-
69
-
-
0035877749
-
Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib
-
G. Soslau, R. Class, and D.A. Morgan Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib J. Biol. Chem. 276 2001 21173
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21173
-
-
Soslau, G.1
Class, R.2
Morgan, D.A.3
-
71
-
-
0038157329
-
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation
-
J.J. Dumas, R. Kumar, and J. Seehra Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation Science 301 2003 222
-
(2003)
Science
, vol.301
, pp. 222
-
-
Dumas, J.J.1
Kumar, R.2
Seehra, J.3
-
72
-
-
0037815126
-
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
-
R. Celikel, R.A. McClintock, and J.R. Roberts Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha Science 301 2003 218
-
(2003)
Science
, vol.301
, pp. 218
-
-
Celikel, R.1
McClintock, R.A.2
Roberts, J.R.3
-
73
-
-
2942669901
-
The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function
-
T.E. Adams, M.F. Hockin, K.G. Mann, and S.J. Everse The crystal structure of activated protein C-inactivated bovine factor Va: implications for cofactor function Proc. Natl. Acad. Sci. U. S. A. 101 2004 8918
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 8918
-
-
Adams, T.E.1
Hockin, M.F.2
Mann, K.G.3
Everse, S.J.4
-
74
-
-
1042276751
-
Activation of factor VIII and mechanisms of cofactor action
-
P.J. Fay Activation of factor VIII and mechanisms of cofactor action Blood Rev. 18 2004 1
-
(2004)
Blood Rev.
, vol.18
, pp. 1
-
-
Fay, P.J.1
-
75
-
-
0029935853
-
Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII
-
C.T. Esmon, and P. Lollar Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII J. Biol. Chem. 271 1996 13882
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13882
-
-
Esmon, C.T.1
Lollar, P.2
-
76
-
-
0035816595
-
An extensive interaction interface between thrombin and factor V is required for factor V activation
-
T. Myles, T.H. Yun, S.W. Hall, and L.L. Leung An extensive interaction interface between thrombin and factor V is required for factor V activation J. Biol. Chem. 276 2001 25143
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25143
-
-
Myles, T.1
Yun, T.H.2
Hall, S.W.3
Leung, L.L.4
-
77
-
-
0037108447
-
Structural requirements for the activation of human factor VIII by thrombin
-
T. Myles, T.H. Yun, and L.L. Leung Structural requirements for the activation of human factor VIII by thrombin Blood 100 2002 2820
-
(2002)
Blood
, vol.100
, pp. 2820
-
-
Myles, T.1
Yun, T.H.2
Leung, L.L.3
-
78
-
-
1842840779
-
Roles of factor XI, platelets and tissue factor-initiated blood coagulation
-
P.N. Walsh Roles of factor XI, platelets and tissue factor-initiated blood coagulation J. Thromb. Haemost. 1 2003 2081
-
(2003)
J. Thromb. Haemost.
, vol.1
, pp. 2081
-
-
Walsh, P.N.1
-
79
-
-
0030067448
-
A binding site for thrombin in the apple 1 domain of factor XI
-
F.A. Baglia, and P.N. Walsh A binding site for thrombin in the apple 1 domain of factor XI J. Biol. Chem. 271 1996 3652
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 3652
-
-
Baglia, F.A.1
Walsh, P.N.2
-
80
-
-
0346850827
-
Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively
-
T.H. Yun, F.A. Baglia, and T. Myles Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively J. Biol. Chem. 278 2003 48112
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48112
-
-
Yun, T.H.1
Baglia, F.A.2
Myles, T.3
-
81
-
-
0029112841
-
Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface
-
C.T. Esmon Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface FASEB J. 9 1995 946
-
(1995)
FASEB J.
, vol.9
, pp. 946
-
-
Esmon, C.T.1
-
82
-
-
0034732094
-
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
-
P. Fuentes-Prior, Y. Iwanaga, and R. Huber Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex Nature 404 2000 518
-
(2000)
Nature
, vol.404
, pp. 518
-
-
Fuentes-Prior, P.1
Iwanaga, Y.2
Huber, R.3
-
83
-
-
0034725622
-
Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation
-
W. Wang, M. Nagashima, and M. Schneider Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation J. Biol. Chem. 275 2000 22942
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 22942
-
-
Wang, W.1
Nagashima, M.2
Schneider, M.3
-
84
-
-
0034006172
-
Solution structure of the smallest cofactor-active fragment of thrombomodulin
-
M.J. Wood, B.A. Sampoli Benitez, and E.A. Komives Solution structure of the smallest cofactor-active fragment of thrombomodulin Nat. Struct. Biol. 7 2000 200
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 200
-
-
Wood, M.J.1
Sampoli Benitez, B.A.2
Komives, E.A.3
-
85
-
-
0028338559
-
Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101
-
J. Ye, A.R. Rezaie, and C.T. Esmon Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101 J. Biol. Chem. 269 1994 17965
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17965
-
-
Ye, J.1
Rezaie, A.R.2
Esmon, C.T.3
-
86
-
-
0027411150
-
Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity
-
M. Nagashima, E. Lundh, and J.C. Leonard Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity J. Biol. Chem. 268 1993 2888
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 2888
-
-
Nagashima, M.1
Lundh, E.2
Leonard, J.C.3
-
87
-
-
0030468098
-
The 2.8 a crystal structure of Gla-domainless activated protein C
-
T. Mather, V. Oganessyan, and P. Hof The 2.8 A crystal structure of Gla-domainless activated protein C EMBO J. 15 1996 6822
-
(1996)
EMBO J.
, vol.15
, pp. 6822
-
-
Mather, T.1
Oganessyan, V.2
Hof, P.3
-
88
-
-
0029787653
-
Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin
-
B. Gerlitz, and B.W. Grinnell Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin J. Biol. Chem. 271 1996 22285
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 22285
-
-
Gerlitz, B.1
Grinnell, B.W.2
-
89
-
-
0029000452
-
Amino acids 225-235** of the protein C serine-protease domain are important for the interaction with the thrombin-thrombomodulin complex
-
A. Vincenot, P. Gaussem, and J.L. Pittet Amino acids 225-235** of the protein C serine-protease domain are important for the interaction with the thrombin-thrombomodulin complex FEBS Lett. 367 1995 153
-
(1995)
FEBS Lett.
, vol.367
, pp. 153
-
-
Vincenot, A.1
Gaussem, P.2
Pittet, J.L.3
-
90
-
-
0037518132
-
The fourth epidermal growth factor-like domain of thrombomodulin interacts with the basic exosite of protein C
-
L. Yang, and A.R. Rezaie The fourth epidermal growth factor-like domain of thrombomodulin interacts with the basic exosite of protein C J. Biol. Chem. 278 2003 10484 10490
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10484-10490
-
-
Yang, L.1
Rezaie, A.R.2
-
91
-
-
14844331743
-
Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C
-
H. Xu, L.A. Bush, and A.O. Pineda Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C J. Biol. Chem. 280 2005 7956
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7956
-
-
Xu, H.1
Bush, L.A.2
Pineda, A.O.3
-
92
-
-
24344495389
-
Mutagenesis studies toward understanding the mechanism of the cofactor function of thrombomodulin
-
A.R. Rezaie, and L. Yang Mutagenesis studies toward understanding the mechanism of the cofactor function of thrombomodulin Biophys. Chem. 117 2005 255
-
(2005)
Biophys. Chem.
, vol.117
, pp. 255
-
-
Rezaie, A.R.1
Yang, L.2
-
93
-
-
17644420041
-
The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions
-
G. Lu, S. Chhum, and S. Krishnaswamy The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions J. Biol. Chem. 280 2005 15471
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 15471
-
-
Lu, G.1
Chhum, S.2
Krishnaswamy, S.3
-
94
-
-
0141484541
-
Thrombin interactions
-
E. Di Cera Thrombin interactions CHEST 124 2003 1S
-
(2003)
CHEST
, vol.124
-
-
Di Cera, E.1
-
95
-
-
0025977159
-
Three-dimensional structure of porcine procarboxypeptidase B: A structural basis of its inactivity
-
M. Coll, A. Guasch, F.X. Aviles, and R. Huber Three-dimensional structure of porcine procarboxypeptidase B: a structural basis of its inactivity EMBO J. 10 1991 1
-
(1991)
EMBO J.
, vol.10
, pp. 1
-
-
Coll, M.1
Guasch, A.2
Aviles, F.X.3
Huber, R.4
-
96
-
-
0037155855
-
Amino acid residues in the P6-P′3 region of thrombin-activable fibrinolysis inhibitor (TAFI) do not determine the thrombomodulin dependence of TAFI activation
-
M. Schneider, M. Nagashima, and S. Knappe Amino acid residues in the P6-P′3 region of thrombin-activable fibrinolysis inhibitor (TAFI) do not determine the thrombomodulin dependence of TAFI activation J. Biol. Chem. 277 2002 9944
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 9944
-
-
Schneider, M.1
Nagashima, M.2
Knappe, S.3
-
97
-
-
0034083954
-
The plot thickens: How thrombin modulates blood clotting
-
M. Overduin, and T. de Beer The plot thickens: how thrombin modulates blood clotting Nat. Struct. Biol. 7 2000 267
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 267
-
-
Overduin, M.1
De Beer, T.2
-
98
-
-
28044444092
-
The structure of thrombin, a chameleon-like proteinase
-
W. Bode The structure of thrombin, a chameleon-like proteinase J. Thromb. Haemost. 3 2005 2379
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 2379
-
-
Bode, W.1
|