Crystal structure of the human α-thrombin-haemadin complex: An exosite II-binding inhibitor

EMBO Journal

Volumn 19, Issue 21, 2000, Pages 5650-5660

  Richardson, John L ^a   Kröger, Burkhard ^b   Hoeffken, Wolfgang ^b   Sadler, J Evan ^c   Pereira, Pedro ^a   Huber, Robert ^a   Bode, Wolfram ^a   Fuentes Prior, Pablo ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b BASF SE   (Germany)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Coagulation; Crystal structure; Heparin binding exosite; Hirudin; Thrombin inhibitor

Indexed keywords

ANTICOAGULANT AGENT; HAEMADIN; HIRUDIN; MEIZOTHROMBIN; SERINE PROTEINASE; THROMBIN; THROMBIN INHIBITOR; THROMBOMODULIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTICOAGULATION; ARTICLE; BLOOD VISCOSITY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HUMAN; LEECH; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HIRUDINS; HUMANS; INVERTEBRATE HORMONES; LEECHES; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SOLUTIONS; THROMBIN;

EID: 0034329465     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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