Hirudin binding reveals key determinants of thrombin allostery

Journal of Biological Chemistry

Volumn 280, Issue 29, 2005, Pages 26997-27003

  Mengwasser, Kristen E ^a   Bush, Leslie A ^a   Shih, Peter ^a   Cantwell, Angelene M ^a   Di Cera, Enrico ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; MACROMOLECULES; PHYSIOLOGY; PROTEINS;

HIRUDIN BINDING; NATURAL SUBSTRATES; PHYSIOLOGIC CONDITIONS; THROMBIN ALLOSTERY;

SUBSTRATES;

ALANINE; ARGININE; ASPARTIC ACID; FIBRINOGEN; GLYCINE; HIRUDIN; LEUCINE; LIGAND; LYSINE; THREONINE; THROMBIN;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; MACROMOLECULE; MOLECULAR RECOGNITION; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; EPITOPE MAPPING; FIBRINOGEN; HIRUDINS; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MUTATION; PROTEIN BINDING; RECEPTOR, PAR-1; THROMBIN;

EID: 22844449689     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502678200     Document Type: Article

References (46)

1. Di Cera, E. (2004) C. R. Biol. 327, 1065-1076
2. Wells, C. M., and Di Cera, E. (1992) Biochemistry 31, 11721-11730
3. Dang, O. D., Vindigni, A., and Di Cera, E. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5977-5981
4. Di Cera, E. (2003) Chest 124, 11S-17S
5. Nogami, K., Zhou, Q., Myles, T., Leung, L. L., Wakabayashi, H., and Fay, P. J. (2005) J. Biol. Chem. 280, 18476-18487
6. He, X., and Rezaie, A. R. (1999) J. Biol. Chem. 274, 4970-4976
7. Schmidt, A. E., Padmanabhan, K., Underwood, M. C., Bode, W., Mather, T., and Bajaj, S. P. (2002) J. Biol. Chem. 277, 28987-28995
8. Rezaie, A. R., and He, X. (2000) Biochemistry 39, 1817-1825
9. Zhang, E., and Tulinsky, A. (1997) Biophys. Chem. 63, 185-200
10. Di Cera, E., Guinto, E. R., Vindigni, A., Dang, Q. D., Ayala, Y. M., Wuyi, M., and Tulinsky, A. (1995) J. Biol. Chem. 270, 22089-22092
11. Krem, M. M., Prasad, S., and Di Cera, E. (2002) J. Biol. Chem. 277, 40260-40264
12. Pineda, A. O., Carrell, C. J., Bush, L. A., Prasad, S., Caccia, S., Chen, Z.-W., Mathews, F. S., and Di Cera, E. (2004) J. Biol. Chem. 279, 31842-31853
13. Krishnaswamy, S. (2005) J. Thromb. Haemost. 3, 54-67
14. Stone, S. R., and Hofsteenge, J. (1986) Biochemistry 25, 4622-4628
15. Rydel, T. J., Tulinsky, A., Bode, W., and Huber, R. (1991) J. Mol. Biol. 221, 583-601
16. Betz, A., Hofsteenge, J., and Stone, S. R. (1991) Biochem. J. 275, Pt 3, 801-803
17. Karshikov, A., Bode, W., Tulinsky, A., and Stone, S. R. (1992) Protein Sci. 1, 727-735
18. Stone, S. R., Dennis, S., and Hofsteenge, J. (1989) Biochemistry 28, 6857-6863
19. Ayala, Y. M., Vindigni, A., Nayal, M., Spolar, R. S., Record, M. T., Jr., and Di Cera, E. (1995) J. Mol. Biol. 253, 787-798
20. Braun, P. J., Dennis, S., Hofsteenge, J., and Stone, S. R. (1988) Biochemistry 27, 6517-6522
21. Betz, A., Hofsteenge, J., and Stone, S. R. (1991) Biochemistry 30, 9848-9853
22. Betz, A., Hofsteenge, J., and Stone, S. R. (1992) Biochemistry 31, 4557-4562
23. Wallace, A., Dennis, S., Hofsteenge, J., and Stone, S. R. (1989) Biochemistry 28, 10079-10084
24. Ayala, Y. M., Cantwell, A. M., Rose, T., Bush, L. A., Arosio, D., and Di Cera, E. (2001) Proteins 45, 107-116
25. Rose, T., and Di Cera, E. (2002) J. Biol. Chem. 277, 18875-18880
26. Ayala, Y., and Di Cera, E. (1994) J. Mol. Biol. 235, 733-746
27. Pineda, A. O., Cantwell, A. M., Bush, L. A., Rose, T., and Di Cera, E. (2002) J. Biol. Chem. 277, 32015-32019
28. Xu, H., Bush, L. A., Pineda, A. O., Caccia, S., and Di Cera, E. (2005) J. Biol. Chem. 280, 7956-7961
29. Di Cera, E. (1995) Thermodynamic Theory of Site-specific Binding Processes in Biological Macromolecules, Cambridge University Press, Cambridge, UK
30. Cha, S. (1975) Biochem. Pharmacol. 24, 2177-2185
31. Cha, S. (1976) Biochem. Pharmacol. 25, 2695-2702
32. Dang, Q. D., and Di Cera, E. (1994) J. Protein Chem. 13, 367-373
33. Krem, M. M., and Di Cera, E. (2003) Biophys. Chem. 100, 315-323
34. Greenspan, N. S., and Di Cera, E. (1999) Nat. Biotechnol. 17, 936-937
35. Di Cera, E. (1998) Adv. Protein Chem. 51, 59-119
36. Wells, J. A. (1990) Biochemistry 29, 8509-8517
37. Pineda, A. O., Chen, Z. W., Caccia, S., Cantwell, A. M., Savvides, S. N., Waksman, G., Mathews, F. S., and Di Cera, E. (2004) J. Biol. Chem. 279, 39824-39828
38. Bobofchak, K. M., Pineda, A. O., Mathews, F. S., and Di Cera, E. (2005) J. Biol. Chem. 280, 25644-25650
39. Guinto, E. R., Vindigni, A., Ayala, Y. M., Dang, Q. D., and Di Cera, E. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11185-11189
40. Bode, W., Turk, D., and Karshikov, A. (1992) Protein Sci. 1, 426-471
41. Vindigni, A., and Di Cera, E. (1996) Biochemistry 35, 4417-4426
42. Clackson, T., and Wells, J. A. (1995) Science 267, 383-386
43. Schreiber, G., and Fersht, A. R. (1995) J. Mol. Biol. 248, 478-486
44. Dang, Q. D., Guinto, E. R., and Di Cera, E. (1997) Nat. Biotechnol. 15, 146-149
45. Sun, W. Y., Smirnow, D., Jenkins, M. L., and Degen, S. J. (2001) Thromb. Haemostasia 85, 651-654
46. Richieri, G. V., Low, P. J., Ogata, R. T., and Kleinfeld, A. M. (1998) J. Biol. Chem. 273, 7397-7405