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Volumn 6, Issue 2, 2006, Pages 95-104

Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease

Author keywords

Cognition; Dopaminergic system; Lifestyle; Neurodegenerative disorders; Neurotrophins

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; 3 ETHYNYL 5 (1 METHYL 2 PYRROLIDINYL)PYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING); AMPA RECEPTOR; AMPA RECEPTOR AGONIST; BRAIN DERIVED NEUROTROPHIC FACTOR; BROMOCRIPTINE; CHOLINERGIC RECEPTOR; DOPAMINE; DOPAMINE RECEPTOR; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMATE RECEPTOR; GPI 1485; HERBACEOUS AGENT; ION CHANNEL; LADOSTIGIL; LEVODOPA; LY 503430; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN; NICOTINE; OXYGENASE; PRAMIPEXOLE; RASAGILINE; SELEGILINE; TSUKUBAENOLIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33645068212     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500360     Document Type: Review
Times cited : (110)

References (134)
  • 1
    • 14844325779 scopus 로고    scopus 로고
    • Molecular pathogenesis of Parkinson disease
    • Eriksen JL, Wszolek Z, Petrucelli L. Molecular pathogenesis of Parkinson disease. Arch Neurol 2005; 62: 353-357.
    • (2005) Arch Neurol , vol.62 , pp. 353-357
    • Eriksen, J.L.1    Wszolek, Z.2    Petrucelli, L.3
  • 2
    • 3543056130 scopus 로고    scopus 로고
    • Neurodegeneration and neuroprotection in Parkinson disease
    • Fahn S, Sulzer D. Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx 2004; 1: 139-154.
    • (2004) NeuroRx , vol.1 , pp. 139-154
    • Fahn, S.1    Sulzer, D.2
  • 3
    • 0033813571 scopus 로고    scopus 로고
    • Neurotrophic factors in Alzheimer's and Parkinson's disease brain
    • Siegel GJ, Chauhan NB. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Brain Res Rev 2000; 33: 199-227.
    • (2000) Brain Res Brain Res Rev , vol.33 , pp. 199-227
    • Siegel, G.J.1    Chauhan, N.B.2
  • 4
    • 0028215334 scopus 로고
    • Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs
    • Seroogy KB, Lundgren KH, Tran TM, Guthrie KM, Isackson PJ, Gall CM. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. J Comp Neurol 1994; 342: 321-334.
    • (1994) J Comp Neurol , vol.342 , pp. 321-334
    • Seroogy, K.B.1    Lundgren, K.H.2    Tran, T.M.3    Guthrie, K.M.4    Isackson, P.J.5    Gall, C.M.6
  • 5
    • 13444273332 scopus 로고    scopus 로고
    • Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons
    • Porritt MJ, Batchelor PE, Howells DW. Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons. Exp Neurol 2005; 192: 226-234.
    • (2005) Exp Neurol , vol.192 , pp. 226-234
    • Porritt, M.J.1    Batchelor, P.E.2    Howells, D.W.3
  • 6
    • 21544446985 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta
    • Baquet ZC, Bickford PC, Jones KR. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 2005; 25: 6251-6259.
    • (2005) J Neurosci , vol.25 , pp. 6251-6259
    • Baquet, Z.C.1    Bickford, P.C.2    Jones, K.R.3
  • 7
    • 0242637444 scopus 로고    scopus 로고
    • BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice
    • Fumagalli F, Racagni G, Colombo E, Riva MA. BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice. Mol Psychiatr 2003a; 8: 898-899.
    • (2003) Mol Psychiatr , vol.8 , pp. 898-899
    • Fumagalli, F.1    Racagni, G.2    Colombo, E.3    Riva, M.A.4
  • 9
    • 0141591462 scopus 로고    scopus 로고
    • Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons
    • Cyr M, Beaulieu JM, Laakso A, Sotnikova TD, Yao WD, Bohn LM et al. Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons. Proc Natl Acad Sci 2003; 100: 11035-11040.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 11035-11040
    • Cyr, M.1    Beaulieu, J.M.2    Laakso, A.3    Sotnikova, T.D.4    Yao, W.D.5    Bohn, L.M.6
  • 10
    • 0034948210 scopus 로고    scopus 로고
    • Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice
    • Dluzen DE, Gao X, Story GM, Anderson LI, Kucera J, Walro JM. Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice. Exp Neurol 2001; 170: 121-128.
    • (2001) Exp Neurol , vol.170 , pp. 121-128
    • Dluzen, D.E.1    Gao, X.2    Story, G.M.3    Anderson, L.I.4    Kucera, J.5    Walro, J.M.6
  • 12
    • 26444562924 scopus 로고    scopus 로고
    • Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra
    • Jul 21; [Epub ahead of print]
    • von Bohlen Und Halbach O, Minichiello L, Unsicker K. Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra. FASEB J 2005 Jul 21; [Epub ahead of print].
    • (2005) FASEB J
    • von Bohlen Und Halbach, O.1    Minichiello, L.2    Unsicker, K.3
  • 13
    • 1942456752 scopus 로고    scopus 로고
    • BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line
    • Kohno R, Sawada H, Kawamoto Y, Uemura K, Shibasaki H, Shimohama S. BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. Biochem Biophys Res Commun 2004; 318: 113-118.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 113-118
    • Kohno, R.1    Sawada, H.2    Kawamoto, Y.3    Uemura, K.4    Shibasaki, H.5    Shimohama, S.6
  • 14
    • 0033597983 scopus 로고    scopus 로고
    • Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease
    • Mogi M, Togari A, Kondo T, Mizuno Y, Komure O, Kuno S et al. Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci Lett 1999; 270: 45-48.
    • (1999) Neurosci Lett , vol.270 , pp. 45-48
    • Mogi, M.1    Togari, A.2    Kondo, T.3    Mizuno, Y.4    Komure, O.5    Kuno, S.6
  • 15
    • 0033602009 scopus 로고    scopus 로고
    • Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra
    • Parain K, Murer MG, Yan Q, Faucheux B, Agid Y, Hirsch E et al. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport 1999; 10: 557-561.
    • (1999) Neuroreport , vol.10 , pp. 557-561
    • Parain, K.1    Murer, M.G.2    Yan, Q.3    Faucheux, B.4    Agid, Y.5    Hirsch, E.6
  • 17
    • 0034525420 scopus 로고    scopus 로고
    • Changes in cytokines and neurotrophins in Parkinson's disease
    • Nagatsu T, Mogi M, Ichinose H, Togari A. Changes in cytokines and neurotrophins in Parkinson's disease. J Neural Transm Suppl 2000; 60: 277-290.
    • (2000) J Neural Transm Suppl , vol.60 , pp. 277-290
    • Nagatsu, T.1    Mogi, M.2    Ichinose, H.3    Togari, A.4
  • 18
    • 0037462449 scopus 로고    scopus 로고
    • BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    • Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A et al. BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112: 257-269.
    • (2003) Cell , vol.112 , pp. 257-269
    • Egan, M.F.1    Kojima, M.2    Callicott, J.H.3    Goldberg, T.E.4    Kolachana, B.S.5    Bertolino, A.6
  • 19
    • 0345714697 scopus 로고    scopus 로고
    • Related Articles, Links Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset
    • Hong CJ, Liu HC, Liu TY, Lin CH, Cheng CY, Tsai SJ. Related Articles, Links Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset. Neurosci Lett 2003; 353: 75-77.
    • (2003) Neurosci Lett , vol.353 , pp. 75-77
    • Hong, C.J.1    Liu, H.C.2    Liu, T.Y.3    Lin, C.H.4    Cheng, C.Y.5    Tsai, S.J.6
  • 20
    • 0142125347 scopus 로고    scopus 로고
    • Toward identification of susceptibility genes for sporadic Parkinson's disease
    • Toda T, Momose Y, Murata M, Tamiya G, Yamamoto M, Hattori N et al. Toward identification of susceptibility genes for sporadic Parkinson's disease. J Neurol 2003; 250(Suppl 3): III40-III43.
    • (2003) J Neurol , vol.250 , Issue.SUPPL. 3
    • Toda, T.1    Momose, Y.2    Murata, M.3    Tamiya, G.4    Yamamoto, M.5    Hattori, N.6
  • 21
    • 22144434671 scopus 로고    scopus 로고
    • The BDNF Val(66)Met polymorphism has a gender specific influence on planning ability in Parkinson's disease
    • Foltynie T, Lewis SG, Goldberg TE, Blackwell AD, Kolachana BS, Weinberger DR et al. The BDNF Val(66)Met polymorphism has a gender specific influence on planning ability in Parkinson's disease. J Neurol 2005; 252: 833-838.
    • (2005) J Neurol , vol.252 , pp. 833-838
    • Foltynie, T.1    Lewis, S.G.2    Goldberg, T.E.3    Blackwell, A.D.4    Kolachana, B.S.5    Weinberger, D.R.6
  • 22
    • 0038443019 scopus 로고    scopus 로고
    • Lack of association between the BDNF Val66Met polymorphism and Parkinson's disease in a Swedish population
    • Hakansson A, Melke J, Westberg L, Shahabi HN, Buervenich S, Carmine A et al. Lack of association between the BDNF Val66Met polymorphism and Parkinson's disease in a Swedish population. Ann Neurol 2003; 53: 823.
    • (2003) Ann Neurol , vol.53 , pp. 823
    • Hakansson, A.1    Melke, J.2    Westberg, L.3    Shahabi, H.N.4    Buervenich, S.5    Carmine, A.6
  • 23
    • 20144370557 scopus 로고    scopus 로고
    • Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease
    • Liu QR, Walther D, Drgon T, Polesskaya O, Lesnick TG, Strain KJ et al. Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am J Med Genet B Neuropsychiatr Genet 2005; 134: 93-103.
    • (2005) Am J Med Genet B Neuropsychiatr Genet , vol.134 , pp. 93-103
    • Liu, Q.R.1    Walther, D.2    Drgon, T.3    Polesskaya, O.4    Lesnick, T.G.5    Strain, K.J.6
  • 24
    • 0002542906 scopus 로고
    • Blood-brain-cerebrospinal fluid barriers
    • Siegel G, Agranoff B, Albers RW, Molinoff P (eds). Raven press: New York
    • Betz AL, Goldstein GW, Katzman R. Blood-brain-cerebrospinal fluid barriers. In: Siegel G, Agranoff B, Albers RW, Molinoff P (eds). Basic Neurochemistry. Raven press: New York, 1989, pp. 591-606.
    • (1989) Basic Neurochemistry , pp. 591-606
    • Betz, A.L.1    Goldstein, G.W.2    Katzman, R.3
  • 25
    • 0026574673 scopus 로고
    • Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
    • Knusel B, Beck KD, Winslow JW, Rosenthal A, Burton LE, Widmer HR et al. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. J Neurosci 1992; 12: 4391-4402.
    • (1992) J Neurosci , vol.12 , pp. 4391-4402
    • Knusel, B.1    Beck, K.D.2    Winslow, J.W.3    Rosenthal, A.4    Burton, L.E.5    Widmer, H.R.6
  • 26
    • 0028289716 scopus 로고
    • Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression
    • Yan Q, Matheson C, Sun J, Radeke MJ, Feinstein SC, Miller JA. Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression. Exp Neurol 1994; 127: 23-36.
    • (1994) Exp Neurol , vol.127 , pp. 23-36
    • Yan, Q.1    Matheson, C.2    Sun, J.3    Radeke, M.J.4    Feinstein, S.C.5    Miller, J.A.6
  • 27
    • 0030838238 scopus 로고    scopus 로고
    • Immortalized neural progenitor cells for CNS gene transfer and repair
    • Martinez-Serrano A, Bjorklund A. Immortalized neural progenitor cells for CNS gene transfer and repair. Trends Neurosci 1997; 20: 530-538.
    • (1997) Trends Neurosci , vol.20 , pp. 530-538
    • Martinez-Serrano, A.1    Bjorklund, A.2
  • 29
    • 0034589049 scopus 로고    scopus 로고
    • Neuropathology of fetal nigra transplants for Parkinson's disease
    • Kordower JH, Sortwell CE. Neuropathology of fetal nigra transplants for Parkinson's disease. Prog Brain Res 2000; 127: 333-344.
    • (2000) Prog Brain Res , vol.127 , pp. 333-344
    • Kordower, J.H.1    Sortwell, C.E.2
  • 30
    • 0041701529 scopus 로고    scopus 로고
    • Gene therapy for neurological disease
    • Tuszynski MH. Gene therapy for neurological disease. Expert Opin Biol Ther 2003; 3: 815-828.
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 815-828
    • Tuszynski, M.H.1
  • 31
    • 0029610630 scopus 로고
    • Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease
    • Levivier M, Przedborski S, Bencsics C, Kang UJ. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J Neurosci 1995; 15: 7810-7820.
    • (1995) J Neurosci , vol.15 , pp. 7810-7820
    • Levivier, M.1    Przedborski, S.2    Bencsics, C.3    Kang, U.J.4
  • 32
    • 0029978443 scopus 로고    scopus 로고
    • Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration
    • Galpern WR, Frim DM, Tatter SB, Altar CA, Beal MF, Isacson O. Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. Cell Transplant 1996; 5: 225-232.
    • (1996) Cell Transplant , vol.5 , pp. 225-232
    • Galpern, W.R.1    Frim, D.M.2    Tatter, S.B.3    Altar, C.A.4    Beal, M.F.5    Isacson, O.6
  • 33
    • 0030571034 scopus 로고    scopus 로고
    • The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: Role of BDNF gene expression
    • Hung HC, Lee EH. The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: role of BDNF gene expression. Brain Res Mol Brain Res 1996; 41: 14-26.
    • (1996) Brain Res Mol Brain Res , vol.41 , pp. 14-26
    • Hung, H.C.1    Lee, E.H.2
  • 34
    • 33645084128 scopus 로고    scopus 로고
    • In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury
    • [Epub ahead of print]
    • Jain A, Kim YT, McKeon RJ, Bellamkonda RV. In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. Biomaterials 2005 [Epub ahead of print].
    • (2005) Biomaterials
    • Jain, A.1    Kim, Y.T.2    McKeon, R.J.3    Bellamkonda, R.V.4
  • 35
    • 0036829006 scopus 로고    scopus 로고
    • Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches
    • Thoenen H, Sendtner M. Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nat Neurosci 2002; 5 Suppl: 1046-1050.
    • (2002) Nat Neurosci , vol.5 , Issue.SUPPL. , pp. 1046-1050
    • Thoenen, H.1    Sendtner, M.2
  • 36
    • 0032765275 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex
    • Croll SD, Suri C, Compton DL, Simmons MV, Yancopoulos GD, Lindsay RM et al. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 1999; 93: 1491-1506.
    • (1999) Neuroscience , vol.93 , pp. 1491-1506
    • Croll, S.D.1    Suri, C.2    Compton, D.L.3    Simmons, M.V.4    Yancopoulos, G.D.5    Lindsay, R.M.6
  • 38
    • 0344441260 scopus 로고    scopus 로고
    • Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling
    • Lahteinen S, Pitkanen A, Koponen E, Saarelainen T, Castren E. Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling. Neuroscience 2003; 122: 1081-1092.
    • (2003) Neuroscience , vol.122 , pp. 1081-1092
    • Lahteinen, S.1    Pitkanen, A.2    Koponen, E.3    Saarelainen, T.4    Castren, E.5
  • 39
    • 0026486342 scopus 로고
    • Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum
    • Okazawa H, Murata M, Watanabe M, Kamei M, Kanazawa I. Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum. FEBS Lett 1992; 313: 138-142.
    • (1992) FEBS Lett , vol.313 , pp. 138-142
    • Okazawa, H.1    Murata, M.2    Watanabe, M.3    Kamei, M.4    Kanazawa, I.5
  • 40
    • 0035799569 scopus 로고    scopus 로고
    • BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
    • Guillin O, Diaz J, Carroll P, Griffon N, Schwartz JC, Sokoloff P. BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Nature 2001; 411: 86-89.
    • (2001) Nature , vol.411 , pp. 86-89
    • Guillin, O.1    Diaz, J.2    Carroll, P.3    Griffon, N.4    Schwartz, J.C.5    Sokoloff, P.6
  • 41
    • 0031593727 scopus 로고    scopus 로고
    • Dopamine D3 receptor is decreased and D2 receptor is elevated in the striatum of Parkinson's disease
    • Ryoo HL, Pierrotti D, Joyce JN. Dopamine D3 receptor is decreased and D2 receptor is elevated in the striatum of Parkinson's disease. Mov Disord 1998; 13: 788-797.
    • (1998) Mov Disord , vol.13 , pp. 788-797
    • Ryoo, H.L.1    Pierrotti, D.2    Joyce, J.N.3
  • 42
    • 1842334441 scopus 로고    scopus 로고
    • Anterograde transport of brain-derived neurotrophic factor and its role in the brain
    • Altar CA, Cai N, Bliven T, Juhasz M, Conner JM, Acheson AL et al. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 1997; 389: 856-860.
    • (1997) Nature , vol.389 , pp. 856-860
    • Altar, C.A.1    Cai, N.2    Bliven, T.3    Juhasz, M.4    Conner, J.M.5    Acheson, A.L.6
  • 43
    • 6944242126 scopus 로고    scopus 로고
    • Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members
    • Weinreb O, Bar-Am O, Amit T, Chillag-Talmor O, Youdim MB. Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members. FASEB J 2004; 18: 1471-1473.
    • (2004) FASEB J , vol.18 , pp. 1471-1473
    • Weinreb, O.1    Bar-Am, O.2    Amit, T.3    Chillag-Talmor, O.4    Youdim, M.B.5
  • 44
    • 17844406615 scopus 로고    scopus 로고
    • Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives
    • Mandel S, Weinreb O, Amit T, Youdim MB. Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives. Brain Res Brain Res Rev 2005; 48: 379-387.
    • (2005) Brain Res Brain Res Rev , vol.48 , pp. 379-387
    • Mandel, S.1    Weinreb, O.2    Amit, T.3    Youdim, M.B.4
  • 45
    • 23144441835 scopus 로고    scopus 로고
    • Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline
    • Youdim MB, Maruyama W, Naoi M. Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline. Drugs Today 2005a; 41: 369-391.
    • (2005) Drugs Today , vol.41 , pp. 369-391
    • Youdim, M.B.1    Maruyama, W.2    Naoi, M.3
  • 46
    • 11144245220 scopus 로고    scopus 로고
    • Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders
    • Youdim MB, Buccafusco JJ. Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders. Trends Pharmacol Sci 2005; 26: 27-35.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 27-35
    • Youdim, M.B.1    Buccafusco, J.J.2
  • 47
    • 0038155162 scopus 로고    scopus 로고
    • Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor
    • Sagi Y, Weinstock M, Youdim MB. Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor. J Neurochem 2003; 86: 290-297.
    • (2003) J Neurochem , vol.86 , pp. 290-297
    • Sagi, Y.1    Weinstock, M.2    Youdim, M.B.3
  • 48
    • 2642529309 scopus 로고    scopus 로고
    • Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo
    • Bar-Am O, Yogev-Falach M, Amit T, Sagi Y, Youdim MB. Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo. J Neurochem 2004; 89: 1119-1125.
    • (2004) J Neurochem , vol.89 , pp. 1119-1125
    • Bar-Am, O.1    Yogev-Falach, M.2    Amit, T.3    Sagi, Y.4    Youdim, M.B.5
  • 49
    • 0141610593 scopus 로고    scopus 로고
    • Parkinson's disease: Is the initial treatment established?
    • Ahlskog JE. Parkinson's disease: Is the initial treatment established? Curr Neurol Neurosci Rep 2003; 3: 289-295.
    • (2003) Curr Neurol Neurosci Rep , vol.3 , pp. 289-295
    • Ahlskog, J.E.1
  • 50
    • 20844449074 scopus 로고    scopus 로고
    • Long-term efficacy and safety of pramipexole in advanced Parkinson's disease: Results from a European multicenter trial
    • Moller JC, Oertel WH, Koster J, Pezzoli G, Provinciali L. Long-term efficacy and safety of pramipexole in advanced Parkinson's disease: results from a European multicenter trial. Mov Disord 2005; 20: 602-610.
    • (2005) Mov Disord , vol.20 , pp. 602-610
    • Moller, J.C.1    Oertel, W.H.2    Koster, J.3    Pezzoli, G.4    Provinciali, L.5
  • 51
    • 13844281345 scopus 로고    scopus 로고
    • Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor
    • Joyce JN, Woolsey C, Ryoo H, Borwege S, Hagner D. Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor. BMC Biol 2004; 2: 22.
    • (2004) BMC Biol , vol.2 , pp. 22
    • Joyce, J.N.1    Woolsey, C.2    Ryoo, H.3    Borwege, S.4    Hagner, D.5
  • 52
    • 5044238005 scopus 로고    scopus 로고
    • Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells
    • Presgraves SP, Borwege S, Millan MJ, Joyce JN. Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells. Exp Neurol 2004; 190: 157-170.
    • (2004) Exp Neurol , vol.190 , pp. 157-170
    • Presgraves, S.P.1    Borwege, S.2    Millan, M.J.3    Joyce, J.N.4
  • 53
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 2003; 9: 589-595.
    • (2003) Nat Med , vol.9 , pp. 589-595
    • Gill, S.S.1    Patel, N.K.2    Hotton, G.R.3    O'Sullivan, K.4    McCarter, R.5    Bunnage, M.6
  • 54
    • 0141758191 scopus 로고    scopus 로고
    • Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus
    • Fumagalli F, Bedogni F, Maragnoli ME, Gennarelli M, Perez J, Racagni G et al. Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus. J Neurosci Res 2003b; 74: 74-80.
    • (2003) J Neurosci Res , vol.74 , pp. 74-80
    • Fumagalli, F.1    Bedogni, F.2    Maragnoli, M.E.3    Gennarelli, M.4    Perez, J.5    Racagni, G.6
  • 55
    • 0028953328 scopus 로고
    • Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease
    • Takayama H, Ray J, Raymon HK, Baird A, Hogg J, Fisher LJ et al. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat Med 1995; 1: 53-58.
    • (1995) Nat Med , vol.1 , pp. 53-58
    • Takayama, H.1    Ray, J.2    Raymon, H.K.3    Baird, A.4    Hogg, J.5    Fisher, L.J.6
  • 56
    • 0034618804 scopus 로고    scopus 로고
    • The high molecular weight fibroblast growth factor-2 isoforms (21 000 mol. Wt and 23 000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro
    • Grothe C, Schulze A, Semkova I, Muller-Ostermeyer F, Rege A, Wewetzer K. The high molecular weight fibroblast growth factor-2 isoforms (21 000 mol. Wt and 23 000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro. Neuroscience 2000; 100: 73-86.
    • (2000) Neuroscience , vol.100 , pp. 73-86
    • Grothe, C.1    Schulze, A.2    Semkova, I.3    Muller-Ostermeyer, F.4    Rege, A.5    Wewetzer, K.6
  • 57
    • 9644279805 scopus 로고    scopus 로고
    • Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain
    • Bustos G, Abarca J, Campusano J, Bustos V, Noriega V, Aliaga E. Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain. Brain Res Rev 2004; 47: 126-144.
    • (2004) Brain Res Rev , vol.47 , pp. 126-144
    • Bustos, G.1    Abarca, J.2    Campusano, J.3    Bustos, V.4    Noriega, V.5    Aliaga, E.6
  • 58
    • 0026701318 scopus 로고
    • Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease
    • Rabey JM, Nissipeanu P, Korczyn AD. Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease. J Neural Transm Park Dis Dement Sect 1992; 4: 277-282.
    • (1992) J Neural Transm Park Dis Dement Sect , vol.4 , pp. 277-282
    • Rabey, J.M.1    Nissipeanu, P.2    Korczyn, A.D.3
  • 59
    • 0032730121 scopus 로고    scopus 로고
    • Effect of memantine (NMDA antagonist) on Parkinson's disease: A double-blind crossover randomized study
    • Merello M, Nouzeilles MI, Cammarota A, Leiguarda R. Effect of memantine (NMDA antagonist) on Parkinson's disease: A double-blind crossover randomized study. Clin Neuropharmacol 1999; 22: 273-276.
    • (1999) Clin Neuropharmacol , vol.22 , pp. 273-276
    • Merello, M.1    Nouzeilles, M.I.2    Cammarota, A.3    Leiguarda, R.4
  • 60
    • 0034764208 scopus 로고    scopus 로고
    • The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain
    • Marvanova M, Lakso M, Pirhonen J, Nawa H, Wong G, Castren E. The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain. Mol Cell Neurosci 2001; 18: 247-258.
    • (2001) Mol Cell Neurosci , vol.18 , pp. 247-258
    • Marvanova, M.1    Lakso, M.2    Pirhonen, J.3    Nawa, H.4    Wong, G.5    Castren, E.6
  • 62
    • 0038637139 scopus 로고    scopus 로고
    • LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease
    • Murray TK, Whalley K, Robinson CS, Ward MA, Hicks CA, Lodge D et al. LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease. J Pharmacol Exp Ther 2003; 306: 752-762.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 752-762
    • Murray, T.K.1    Whalley, K.2    Robinson, C.S.3    Ward, M.A.4    Hicks, C.A.5    Lodge, D.6
  • 63
    • 0242302346 scopus 로고    scopus 로고
    • mGluRs: A target for pharmacotherapy in Parkinson disease
    • Feeley Kearney JA, Albin RL. mGluRs: A target for pharmacotherapy in Parkinson disease. Exp Neurol 2003; 184(Suppl 1): S30-6.
    • (2003) Exp Neurol , vol.184 , Issue.SUPPL. 1
    • Feeley Kearney, J.A.1    Albin, R.L.2
  • 64
    • 0036537039 scopus 로고    scopus 로고
    • Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra
    • Campusano JM, Abarca J, Forray MI, Gysling K, Bustos G. Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra. Biochem Pharmacol 2002; 63: 1343-1352.
    • (2002) Biochem Pharmacol , vol.63 , pp. 1343-1352
    • Campusano, J.M.1    Abarca, J.2    Forray, M.I.3    Gysling, K.4    Bustos, G.5
  • 65
    • 0035145543 scopus 로고    scopus 로고
    • Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction
    • Matarredona ER, Santiago M, Venero JL, Cano J, Machado A. Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction. J Neurochem 2001; 76: 351-360.
    • (2001) J Neurochem , vol.76 , pp. 351-360
    • Matarredona, E.R.1    Santiago, M.2    Venero, J.L.3    Cano, J.4    Machado, A.5
  • 66
    • 0032550103 scopus 로고    scopus 로고
    • Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia
    • Bond A, O'Neill MJ, Hicks CA, Monn JA, Lodge D. Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. Neuroreport 1998; 9: 1191-1193.
    • (1998) Neuroreport , vol.9 , pp. 1191-1193
    • Bond, A.1    O'Neill, M.J.2    Hicks, C.A.3    Monn, J.A.4    Lodge, D.5
  • 67
    • 0031786473 scopus 로고    scopus 로고
    • Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death
    • Battaglia G, Bruno V, Ngomba RT, Di Grezia R, Copani A, Nicoletti F. Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death. Eur J Pharmacol 1998; 356: 271-274.
    • (1998) Eur J Pharmacol , vol.356 , pp. 271-274
    • Battaglia, G.1    Bruno, V.2    Ngomba, R.T.3    Di Grezia, R.4    Copani, A.5    Nicoletti, F.6
  • 68
    • 0030690931 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors prevent nitric oxide-induced programmed cell death
    • Vincent AM, Mohammad Y, Ahmad I, Greenberg R, Maiese K. Metabotropic glutamate receptors prevent nitric oxide-induced programmed cell death. J Neurosci Res 1997; 50: 549-564.
    • (1997) J Neurosci Res , vol.50 , pp. 549-564
    • Vincent, A.M.1    Mohammad, Y.2    Ahmad, I.3    Greenberg, R.4    Maiese, K.5
  • 69
    • 0029078869 scopus 로고
    • Cigarette smoking and protection from Parkinson's disease: False association or etiologic clue?
    • Morens DM, Grandinetti A, Reed D, White LR, Ross GW. Cigarette smoking and protection from Parkinson's disease: False association or etiologic clue? Neurology 1995; 45: 1041-1051.
    • (1995) Neurology , vol.45 , pp. 1041-1051
    • Morens, D.M.1    Grandinetti, A.2    Reed, D.3    White, L.R.4    Ross, G.W.5
  • 70
    • 0030065436 scopus 로고    scopus 로고
    • Beneficial effects of nicotine and cigarette smoking: The real, the possible and the spurious
    • Baron JA. Beneficial effects of nicotine and cigarette smoking: The real, the possible and the spurious. Br Med Bull 1996; 52: 58-73.
    • (1996) Br Med Bull , vol.52 , pp. 58-73
    • Baron, J.A.1
  • 71
    • 0033842094 scopus 로고    scopus 로고
    • Smoking and Parkinson's and Alzheimer's disease: Review of the epidemiological studies
    • Fratiglioni L, Wang HX. Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies. Behav Brain Res 2000; 113: 117-120.
    • (2000) Behav Brain Res , vol.113 , pp. 117-120
    • Fratiglioni, L.1    Wang, H.X.2
  • 72
    • 0036777468 scopus 로고    scopus 로고
    • Nicotine and nicotinic receptors; relevance to Parkinson's disease
    • Quik M, Kulak JM. Nicotine and nicotinic receptors; relevance to Parkinson's disease. Neurotoxicology 2002; 23: 581-594.
    • (2002) Neurotoxicology , vol.23 , pp. 581-594
    • Quik, M.1    Kulak, J.M.2
  • 74
    • 4344698859 scopus 로고    scopus 로고
    • Smoking, nicotine and Parkinson's disease
    • Quik M. Smoking, nicotine and Parkinson's disease. Trends Neurosci 2004; 27: 561-568.
    • (2004) Trends Neurosci , vol.27 , pp. 561-568
    • Quik, M.1
  • 76
    • 0018896952 scopus 로고
    • Cigarette smoking and Parkinson disease: 1. Comparison of cases with matched neighbors
    • Baumann RJ, Jameson HD, McKean HE, Haack DG, Weisberg LM. Cigarette smoking and Parkinson disease: 1. Comparison of cases with matched neighbors. Neurology 1980; 30: 839-843.
    • (1980) Neurology , vol.30 , pp. 839-843
    • Baumann, R.J.1    Jameson, H.D.2    McKean, H.E.3    Haack, D.G.4    Weisberg, L.M.5
  • 78
    • 0035196324 scopus 로고    scopus 로고
    • Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
    • Zhou FM, Liang Y, Dani JA. Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nat Neurosci 2001; 4: 1224-1229.
    • (2001) Nat Neurosci , vol.4 , pp. 1224-1229
    • Zhou, F.M.1    Liang, Y.2    Dani, J.A.3
  • 79
    • 0031826455 scopus 로고    scopus 로고
    • Effects of SIB-1508Y, a novel neuronal nicotinic acetylcholine receptor agonist, on motor behavior in parkinsonian monkeys
    • Schneider JS, Pope-Coleman A, Van Velson M, Menzaghi F, Lloyd GK. Effects of SIB-1508Y, a novel neuronal nicotinic acetylcholine receptor agonist, on motor behavior in parkinsonian monkeys. Mov Disord 1998; 13: 637-642.
    • (1998) Mov Disord , vol.13 , pp. 637-642
    • Schneider, J.S.1    Pope-Coleman, A.2    Van Velson, M.3    Menzaghi, F.4    Lloyd, G.K.5
  • 80
    • 0032808086 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys
    • Schneider JS, Tinker JP, Van Velson M, Menzaghi F, Lloyd GK. Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J Pharmacol Exp Ther 1999; 290: 731-739.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 731-739
    • Schneider, J.S.1    Tinker, J.P.2    Van Velson, M.3    Menzaghi, F.4    Lloyd, G.K.5
  • 81
    • 0035798302 scopus 로고    scopus 로고
    • Nicotine administration reduces striatal MPP+ levels in mice
    • Quik M, Di Monte DA. Nicotine administration reduces striatal MPP+ levels in mice. Brain Res 2001; 917: 219-224.
    • (2001) Brain Res , vol.917 , pp. 219-224
    • Quik, M.1    Di Monte, D.A.2
  • 82
    • 0031741246 scopus 로고    scopus 로고
    • Nicotine prevents experimental parkinsonism in rodents and induces striatal increase of neurotrophic factors
    • Maggio R, Riva M, Vaglini F, Fornai F, Molteni R, Armogida M et al. Nicotine prevents experimental parkinsonism in rodents and induces striatal increase of neurotrophic factors. J Neurochem 1998; 71: 2439-2446.
    • (1998) J Neurochem , vol.71 , pp. 2439-2446
    • Maggio, R.1    Riva, M.2    Vaglini, F.3    Fornai, F.4    Molteni, R.5    Armogida, M.6
  • 83
    • 0033528692 scopus 로고    scopus 로고
    • Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine
    • French SJ, Humby T, Horner CH, Sofroniew MV, Rattray M. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Brain Res Mol Brain Res 1999; 67: 124-136.
    • (1999) Brain Res Mol Brain Res , vol.67 , pp. 124-136
    • French, S.J.1    Humby, T.2    Horner, C.H.3    Sofroniew, M.V.4    Rattray, M.5
  • 84
    • 0034727894 scopus 로고    scopus 로고
    • Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus
    • Kenny PJ, File SE, Rattray M. Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus. Brain Res Mol Brain Res 2000; 85: 234-238.
    • (2000) Brain Res Mol Brain Res , vol.85 , pp. 234-238
    • Kenny, P.J.1    File, S.E.2    Rattray, M.3
  • 86
    • 10844237451 scopus 로고    scopus 로고
    • Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders
    • Sacco KA, Bannon KL, George TP. Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders. J Psychopharmacol 2004; 18: 457-474.
    • (2004) J Psychopharmacol , vol.18 , pp. 457-474
    • Sacco, K.A.1    Bannon, K.L.2    George, T.P.3
  • 87
    • 0030751425 scopus 로고    scopus 로고
    • Nicotinic system involvement in Alzheimer's and Parkinson's disease. Implications for therapeutics
    • Newhouse PA, Potter A, Levin ED. Nicotinic system involvement in Alzheimer's and Parkinson's disease. Implications for therapeutics. Drugs Aging 1997; 11: 206-228.
    • (1997) Drugs Aging , vol.11 , pp. 206-228
    • Newhouse, P.A.1    Potter, A.2    Levin, E.D.3
  • 88
    • 0034998137 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons
    • Guo X, Dawson VL, Dawson TM. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci 2001; 13: 1683-1693.
    • (2001) Eur J Neurosci , vol.13 , pp. 1683-1693
    • Guo, X.1    Dawson, V.L.2    Dawson, T.M.3
  • 89
    • 0035846834 scopus 로고    scopus 로고
    • The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats
    • Ross DT, Guo H, Howorth P, Chen Y, Hamilton GS, Steiner JP. The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats. Neurosci Lett 2001; 297: 113-116.
    • (2001) Neurosci Lett , vol.297 , pp. 113-116
    • Ross, D.T.1    Guo, H.2    Howorth, P.3    Chen, Y.4    Hamilton, G.S.5    Steiner, J.P.6
  • 90
    • 4244043155 scopus 로고    scopus 로고
    • Regeneration of dopaminergic function in 6-hydroxydopamine-lesioned rats by neuroimmunophilin ligand treatment
    • Zhang C, Steiner JP, Hamilton GS, Hicks TP, Poulter MO. Regeneration of dopaminergic function in 6-hydroxydopamine-lesioned rats by neuroimmunophilin ligand treatment. J Neurosci 2001; 21: RC156.
    • (2001) J Neurosci , vol.21
    • Zhang, C.1    Steiner, J.P.2    Hamilton, G.S.3    Hicks, T.P.4    Poulter, M.O.5
  • 91
    • 0037466474 scopus 로고    scopus 로고
    • Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain
    • Tanaka K, Fujita N, Ogawa N. Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain. Brain Res 2003; 970: 250-253.
    • (2003) Brain Res , vol.970 , pp. 250-253
    • Tanaka, K.1    Fujita, N.2    Ogawa, N.3
  • 92
    • 4744356752 scopus 로고    scopus 로고
    • Hydrophobic dipeptide Leu-Ile protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis
    • Nitta A, Nishioka H, Fukumitsu H, Furukawa Y, Sugiura H, Shen L et al. Hydrophobic dipeptide Leu-Ile protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis. J Neurosci Res 2004; 78: 250-258.
    • (2004) J Neurosci Res , vol.78 , pp. 250-258
    • Nitta, A.1    Nishioka, H.2    Fukumitsu, H.3    Furukawa, Y.4    Sugiura, H.5    Shen, L.6
  • 93
    • 4344694987 scopus 로고    scopus 로고
    • Neuroimmunophilins: A novel drug therapy for the reversal of neurodegenerative disease?
    • Poulter MO, Payne KB, Steiner JP. Neuroimmunophilins: A novel drug therapy for the reversal of neurodegenerative disease? Neuroscience 2004; 128: 1-6.
    • (2004) Neuroscience , vol.128 , pp. 1-6
    • Poulter, M.O.1    Payne, K.B.2    Steiner, J.P.3
  • 94
    • 0033581334 scopus 로고    scopus 로고
    • Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice
    • Sauer H, Francis JM, Jiang H, Hamilton GS, Steiner JP. Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice. Brain Res 1999; 842: 109-118.
    • (1999) Brain Res , vol.842 , pp. 109-118
    • Sauer, H.1    Francis, J.M.2    Jiang, H.3    Hamilton, G.S.4    Steiner, J.P.5
  • 95
    • 0037226964 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons
    • Li FQ, Cheng XX, Liang XB, Wang XH, Xue B, He QH et al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol 2003; 179: 28-37.
    • (2003) Exp Neurol , vol.179 , pp. 28-37
    • Li, F.Q.1    Cheng, X.X.2    Liang, X.B.3    Wang, X.H.4    Xue, B.5    He, Q.H.6
  • 96
    • 14744299761 scopus 로고    scopus 로고
    • Turning cells red: Signal transduction mediated by erythropoietin
    • Richmond TD, Chohan M, Barber DL. Turning cells red: Signal transduction mediated by erythropoietin. Trends Cell Biol 2005; 15: 146-155.
    • (2005) Trends Cell Biol , vol.15 , pp. 146-155
    • Richmond, T.D.1    Chohan, M.2    Barber, D.L.3
  • 97
    • 0344441759 scopus 로고    scopus 로고
    • Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic-ischemic brain injury
    • Aydin A, Genc K, Akhisaroglu M, Yorukoglu K, Gokmen N, Gonullu E. Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic-ischemic brain injury. Brain Dev 2003; 25: 494-498.
    • (2003) Brain Dev , vol.25 , pp. 494-498
    • Aydin, A.1    Genc, K.2    Akhisaroglu, M.3    Yorukoglu, K.4    Gokmen, N.5    Gonullu, E.6
  • 98
    • 0037047154 scopus 로고    scopus 로고
    • Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma
    • Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C et al. Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci USA 2002; 99: 9450-9455.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9450-9455
    • Gorio, A.1    Gokmen, N.2    Erbayraktar, S.3    Yilmaz, O.4    Madaschi, L.5    Cichetti, C.6
  • 100
    • 13844251822 scopus 로고    scopus 로고
    • Erythropoietin treatment improves neurological functional recovery in EAE mice
    • Zhang J, Li Y, Cui Y, Chen J, Lu M, Elias SB et al. Erythropoietin treatment improves neurological functional recovery in EAE mice. Brain Res 2005; 1034: 34-39.
    • (2005) Brain Res , vol.1034 , pp. 34-39
    • Zhang, J.1    Li, Y.2    Cui, Y.3    Chen, J.4    Lu, M.5    Elias, S.B.6
  • 101
    • 8644228438 scopus 로고    scopus 로고
    • The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin
    • Wang X, Zhu C, Wang X, Gerwien JG, Schrattenholz A, Sandberg M et al. The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin. J Neurochem 2004; 91: 900-910.
    • (2004) J Neurochem , vol.91 , pp. 900-910
    • Wang, X.1    Zhu, C.2    Wang, X.3    Gerwien, J.G.4    Schrattenholz, A.5    Sandberg, M.6
  • 102
    • 0035793485 scopus 로고    scopus 로고
    • Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production
    • Genc S, Kuralay F, Genc K, Akhisaroglu M, Fadiloglu S, Yorukoglu K et al. Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production. Neurosci Lett 2001; 298: 139-141.
    • (2001) Neurosci Lett , vol.298 , pp. 139-141
    • Genc, S.1    Kuralay, F.2    Genc, K.3    Akhisaroglu, M.4    Fadiloglu, S.5    Yorukoglu, K.6
  • 103
    • 0037087120 scopus 로고    scopus 로고
    • Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro
    • Genc S, Akhisaroglu M, Kuralay F, Genc K. Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro. Neurosci Lett 2002; 321: 73-76.
    • (2002) Neurosci Lett , vol.321 , pp. 73-76
    • Genc, S.1    Akhisaroglu, M.2    Kuralay, F.3    Genc, K.4
  • 104
    • 17444398206 scopus 로고    scopus 로고
    • Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor
    • Viviani B, Bartesaghi S, Corsini E, Villa P, Ghezzi P, Garau A et al. Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor. J Neurochem 2005; 93: 412-421.
    • (2005) J Neurochem , vol.93 , pp. 412-421
    • Viviani, B.1    Bartesaghi, S.2    Corsini, E.3    Villa, P.4    Ghezzi, P.5    Garau, A.6
  • 105
    • 0035004146 scopus 로고    scopus 로고
    • Cannabinoid receptor activation and elevated cyclic AMP reduce glutamate neurotoxicity
    • Hampson AJ, Grimaldi M. Cannabinoid receptor activation and elevated cyclic AMP reduce glutamate neurotoxicity. Eur J Neurosci 2001; 13: 1529-1536.
    • (2001) Eur J Neurosci , vol.13 , pp. 1529-1536
    • Hampson, A.J.1    Grimaldi, M.2
  • 106
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
    • Nagayama T, Sinor AD, Simon RP, Chen J, Graham SH, Jin K et al. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J Neurosci 1999; 19: 2987-2995.
    • (1999) J Neurosci , vol.19 , pp. 2987-2995
    • Nagayama, T.1    Sinor, A.D.2    Simon, R.P.3    Chen, J.4    Graham, S.H.5    Jin, K.6
  • 107
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
    • Ramirez BG, Blazquez C, Gomez del Pulgar T, Guzman M, de Ceballos ML. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J Neurosci 2005; 25: 1904-1913.
    • (2005) J Neurosci , vol.25 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    Gomez del Pulgar, T.3    Guzman, M.4    de Ceballos, M.L.5
  • 108
    • 0042530283 scopus 로고    scopus 로고
    • The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats
    • Gilgun-Sherki Y, Melamed E, Mechoulam R, Offen D. The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats. Pharmacol Toxicol 2003; 93: 66-70.
    • (2003) Pharmacol Toxicol , vol.93 , pp. 66-70
    • Gilgun-Sherki, Y.1    Melamed, E.2    Mechoulam, R.3    Offen, D.4
  • 109
    • 0035846577 scopus 로고    scopus 로고
    • Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: A pilot study
    • Sieradzan KA, Fox SH, Hill M, Dick JP, Crossman AR, Brotchie JM. Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study. Neurology 2001; 57: 2108-2111.
    • (2001) Neurology , vol.57 , pp. 2108-2111
    • Sieradzan, K.A.1    Fox, S.H.2    Hill, M.3    Dick, J.P.4    Crossman, A.R.5    Brotchie, J.M.6
  • 110
    • 17444370570 scopus 로고    scopus 로고
    • Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease
    • Lastres-Becker I, Molina-Holgado F, Ramos JA, Mechoulam R, Fernandez-Ruiz J. Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease. Neurobiol Dis 2005; 19: 96-107.
    • (2005) Neurobiol Dis , vol.19 , pp. 96-107
    • Lastres-Becker, I.1    Molina-Holgado, F.2    Ramos, J.A.3    Mechoulam, R.4    Fernandez-Ruiz, J.5
  • 111
    • 18844450416 scopus 로고    scopus 로고
    • In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol
    • Butovsky E, Juknat A, Goncharov I, Elbaz J, Eilam R, Zangen A et al. In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol. J Neurochem 2005; 93: 802-811.
    • (2005) J Neurochem , vol.93 , pp. 802-811
    • Butovsky, E.1    Juknat, A.2    Goncharov, I.3    Elbaz, J.4    Eilam, R.5    Zangen, A.6
  • 112
    • 0030051986 scopus 로고    scopus 로고
    • Dietary lipids and antioxidants in Parkinson's disease: A population-based, case-control study
    • Logroscino G, Marder K, Cote L, Tang MX, Shea S, Mayeux R. Dietary lipids and antioxidants in Parkinson's disease: A population-based, case-control study. Ann Neurol 1996; 39: 89-94.
    • (1996) Ann Neurol , vol.39 , pp. 89-94
    • Logroscino, G.1    Marder, K.2    Cote, L.3    Tang, M.X.4    Shea, S.5    Mayeux, R.6
  • 113
    • 0032757596 scopus 로고    scopus 로고
    • Therapeutic value of exercise training in Parkinson's disease
    • Reuter I, Engelhardt M, Stecker K, Baas H. Therapeutic value of exercise training in Parkinson's disease. Med Sci Sports Exerc 1999; 31: 1544-1549.
    • (1999) Med Sci Sports Exerc , vol.31 , pp. 1544-1549
    • Reuter, I.1    Engelhardt, M.2    Stecker, K.3    Baas, H.4
  • 114
    • 20444444306 scopus 로고    scopus 로고
    • Effectiveness of exercise therapy: A best-evidence summary of systematic reviews
    • Excercise Therapy Group
    • Smidt N, de Vet HC, Bouter LM, Dekker J, Excercise Therapy Group. Effectiveness of exercise therapy: A best-evidence summary of systematic reviews. Aust J Physiother 2005; 51: 71-85.
    • (2005) Aust J Physiother , vol.51 , pp. 71-85
    • Smidt, N.1    de Vet, H.C.2    Bouter, L.M.3    Dekker, J.4
  • 115
    • 25444533023 scopus 로고    scopus 로고
    • Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice Neurosci
    • van Praag H, Shubert T, Zhao C, Gage FH J. Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice Neurosci. J Neurosci 2005; 25: 8680-8685.
    • (2005) J Neurosci , vol.25 , pp. 8680-8685
    • van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.J.4
  • 116
    • 19944427435 scopus 로고    scopus 로고
    • Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
    • Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA et al. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci USA 2004; 101: 18171-18176.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 18171-18176
    • Maswood, N.1    Young, J.2    Tilmont, E.3    Zhang, Z.4    Gash, D.M.5    Gerhardt, G.A.6
  • 117
    • 0346749428 scopus 로고    scopus 로고
    • Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: Involvement of dopamine transporter and trophic factors
    • Bezard E, Dovero S, Belin D, Duconger S, Jackson-Lewis V, Przedborski S et al. Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: Involvement of dopamine transporter and trophic factors. J Neurosci 2003; 23: 10999-11007.
    • (2003) J Neurosci , vol.23 , pp. 10999-11007
    • Bezard, E.1    Dovero, S.2    Belin, D.3    Duconger, S.4    Jackson-Lewis, V.5    Przedborski, S.6
  • 118
  • 119
    • 0036850342 scopus 로고    scopus 로고
    • Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
    • Gomez-Pinilla F, Ying Z, Roy RR, Molteni R, Edgerton VR. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J Neurophysiol 2002; 88: 2187-2195.
    • (2002) J Neurophysiol , vol.88 , pp. 2187-2195
    • Gomez-Pinilla, F.1    Ying, Z.2    Roy, R.R.3    Molteni, R.4    Edgerton, V.R.5
  • 120
    • 9644270414 scopus 로고    scopus 로고
    • Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    • Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 2004; 20: 2580-2590.
    • (2004) Eur J Neurosci , vol.20 , pp. 2580-2590
    • Vaynman, S.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 121
    • 1342343120 scopus 로고    scopus 로고
    • Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin
    • Ding Y, Li J, Luan X, Ding YH, Lai Q, Rafols JA et al. Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin. Neuroscience 2004; 124: 583-591.
    • (2004) Neuroscience , vol.124 , pp. 583-591
    • Ding, Y.1    Li, J.2    Luan, X.3    Ding, Y.H.4    Lai, Q.5    Rafols, J.A.6
  • 122
    • 16244423295 scopus 로고    scopus 로고
    • Treadmill training ameliorates dopamine loss but not behavioral deficits in hemi-parkinsonian rats
    • Poulton NP, Muir GD. Treadmill training ameliorates dopamine loss but not behavioral deficits in hemi-parkinsonian rats. Exp Neurol 2005; 193: 181-197.
    • (2005) Exp Neurol , vol.193 , pp. 181-197
    • Poulton, N.P.1    Muir, G.D.2
  • 123
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • The Parkinson Study Group
    • The Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1993; 328: 176-183.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 124
    • 7244240590 scopus 로고    scopus 로고
    • Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats
    • Wu A, Ying Z, Gomez-Pinilla F. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 2004; 21: 1457-1467.
    • (2004) J Neurotrauma , vol.21 , pp. 1457-1467
    • Wu, A.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 125
    • 23044453495 scopus 로고    scopus 로고
    • Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism
    • Brown AM, Deutch AY, Colbran RJ. Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism. Eur J Neurosci 2005; 22: 247-256.
    • (2005) Eur J Neurosci , vol.22 , pp. 247-256
    • Brown, A.M.1    Deutch, A.Y.2    Colbran, R.J.3
  • 126
    • 0031009853 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: Studies in vivo and in vitro
    • Ivkovic S, Polonskaia O, Farinas I, Ehrlich ME. Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: Studies in vivo and in vitro. Neuroscience 1997; 79: 509-516.
    • (1997) Neuroscience , vol.79 , pp. 509-516
    • Ivkovic, S.1    Polonskaia, O.2    Farinas, I.3    Ehrlich, M.E.4
  • 127
    • 0035212784 scopus 로고    scopus 로고
    • Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitro
    • Stroppolo A, Guinea B, Tian C, Sommer J, Ehrlich ME. Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitro. J Neurochem 2001; 79: 1027-1032.
    • (2001) J Neurochem , vol.79 , pp. 1027-1032
    • Stroppolo, A.1    Guinea, B.2    Tian, C.3    Sommer, J.4    Ehrlich, M.E.5
  • 128
    • 0037426599 scopus 로고    scopus 로고
    • A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus
    • Blanquet PR, Mariani J, Derer P. A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. Neuroscience 2003; 118: 477-490.
    • (2003) Neuroscience , vol.118 , pp. 477-490
    • Blanquet, P.R.1    Mariani, J.2    Derer, P.3
  • 129
    • 23644437308 scopus 로고    scopus 로고
    • Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease
    • Jul 11; [Epub ahead of print]
    • Sun M, Kong L, Wang X, Lu XG, Gao Q, Geller AI. Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease. Brain Res 2005 Jul 11; [Epub ahead of print].
    • (2005) Brain Res
    • Sun, M.1    Kong, L.2    Wang, X.3    Lu, X.G.4    Gao, Q.5    Geller, A.I.6
  • 130
    • 24044489242 scopus 로고    scopus 로고
    • Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H(2)O(2)-induced neuronal death
    • Onyango IG, Tuttle JB, Bennett Jr JP. Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H(2)O(2)-induced neuronal death. Neurobiol Dis 2005; 20: 141-154.
    • (2005) Neurobiol Dis , vol.20 , pp. 141-154
    • Onyango, I.G.1    Tuttle, J.B.2    Bennett Jr., J.P.3
  • 131
    • 23944445784 scopus 로고    scopus 로고
    • Activity-dependent modulation of the BDNF receptor TrkB: Mechanisms and implications
    • Nagappan G, Lu B. Activity-dependent modulation of the BDNF receptor TrkB: Mechanisms and implications. Trends Neurosci 2005; 28: 464-471.
    • (2005) Trends Neurosci , vol.28 , pp. 464-471
    • Nagappan, G.1    Lu, B.2
  • 132
    • 0033821342 scopus 로고    scopus 로고
    • Antidepressant drug exposure is associated with mRNA levels of tyrosine receptor kinase B in major depressive disorder
    • Bayer TA, Schramm M, Feldmann N, Knable MB, Falkai P. Antidepressant drug exposure is associated with mRNA levels of tyrosine receptor kinase B in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatr 2000; 24: 881-888.
    • (2000) Prog Neuropsychopharmacol Biol Psychiatr , vol.24 , pp. 881-888
    • Bayer, T.A.1    Schramm, M.2    Feldmann, N.3    Knable, M.B.4    Falkai, P.5
  • 133
    • 0037218768 scopus 로고    scopus 로고
    • Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
    • Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E et al. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci 2003; 23: 349-357.
    • (2003) J Neurosci , vol.23 , pp. 349-357
    • Saarelainen, T.1    Hendolin, P.2    Lucas, G.3    Koponen, E.4    Sairanen, M.5    MacDonald, E.6
  • 134
    • 0034040626 scopus 로고    scopus 로고
    • Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis
    • Mutoh T, Sobue G, Hamano T, Kuriyama M, Hirayama M, Yamamoto M et al. Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis. Neurochem Res 2000; 25: 239-245.
    • (2000) Neurochem Res , vol.25 , pp. 239-245
    • Mutoh, T.1    Sobue, G.2    Hamano, T.3    Kuriyama, M.4    Hirayama, M.5    Yamamoto, M.6


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