Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset

Neuroscience Letters

Volumn 353, Issue 1, 2003, Pages 75-77

  Hong, Chen Jee ^a,b   Liu, Hsiu Chih ^a,b   Liu, Tsung Yun ^a   Lin, Ching Hua ^c   Cheng, Chih Ya ^a,b   Tsai, Shih Jen ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c KAI SUAN PSYCHIATRIC HOSPITAL   (Taiwan)

Author keywords

Age of onset; Association study; Brain derived neurotrophic factor; Parkinson's disease; Polymorphism

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; AGED; ALLELE; ARTICLE; CHINESE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; SAMPLE; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY;

EID: 0345714697     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.09.009     Document Type: Article

References (17)

1. Dawson T.M., Dawson V.L. Rare genetic mutations shed light on the pathogenesis of Parkinson disease. J. Clin. Invest. 111:2003;145-151.
2. Duman R.S., Heninger G.R., Nestler E.J. A molecular and cellular theory of depression. Arch. Gen. Psychiatry. 54:1997;597-606.
3. Hakansson A., Melke J., Westberg L., Shahabi H.N., Buervenich S., Carmine A., Klingborg K., Grundell M.B., Schulhof B., Holmberg B., Ahlberg J., Eriksson E., Sydow O., Olson L., Johnels B., Nissbrandt H. Lack of association between the BDNF Val66Met polymorphism and Parkinson's disease in a Swedish population. Ann. Neurol. 53:2003;823.
4. Hyman C., Hofer M., Barde Y.A., Juhasz M., Yancopoulos G.D., Squinto S.P., Lindsay R.M. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature. 350:1991;230-232.
5. Lang A.E., Lozano A.M. Parkinson's disease. First of two parts. N. Engl. J. Med. 339:1998;1044-1053.
6. Lin C.N., Liu H.C., Tsai S.J., Liu T.Y., Hong C.J. Association study for Parkinson's disease and a dopamine transporter gene polymorphism (1215A/G). Eur. Neurol. 48:2002;207-209.
7. Mogi M., Togari A., Kondo T., Mizuno Y., Komure O., Kuno S., Ichinose H., Nagatsu T. Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci. Lett. 270:1999;45-48.
8. Momose Y., Murata M., Kobayashi K., Tachikawa M., Nakabayashi Y., Kanazawa I., Toda T. Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms. Ann. Neurol. 51:2002;133-136.
9. Murer M.G., Yan Q., Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog. Neurobiol. 63:2001;71-124.
10. Nakata K., Ujike H., Sakai A., Uchida N., Nomura A., Imamura T., Katsu T., Tanaka Y., Hamamura T., Kuroda S. Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder. Neurosci. Lett. 337:2003;17-20.
11. Okazawa H., Murata M., Watanabe M., Kamei M., Kanazawa I. Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum. FEBS Lett. 313:1992;138-142.
12. Owen M.J., Holmans P., McGuffin P. Association studies in psychiatric genetics. Mol. Psychiatry. 2:1997;270-273.
13. Parain K., Murer M.G., Yan Q., Faucheux B., Agid Y., Hirsch E., Raisman-Vozari R. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. NeuroReport. 10:1999;557-561.
14. Schapira A.H. Pathogenesis of Parkinson's disease. Baillieres Clin. Neurol. 6:1997;15-36.
15. Tsai S.J., Liu H.C., Liu T.Y., Cheng C.Y., Hong C.J. Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease. J. Neural. Transm. 109:2002;483-488.
16. Tsukahara T., Takeda M., Shimohama S., Ohara O., Hashimoto N. Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced parkinsonism in monkeys. Neurosurgery. 37:1995;733-739.
17. Wang S.J., Fuh J.L., Teng E.L., Liu C.Y., Lin K.P., Chen H.M., Lin C.H., Wang P.N., Ting Y.C., Wang H.C., Lin K.N., Chou P., Larson E.B., Liu H.C. A door-to-door survey of Parkinson's disease in a Chinese population in Kinmen. Arch. Neurol. 53:1996;66-71.