메뉴 건너뛰기




Volumn 1, Issue 1, 2004, Pages 139-154

Neurodegeneration and Neuroprotection in Parkinson Disease

Author keywords

alpha synuclein; PARK genes; Parkin gene; ubiquitin pathway

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA TOCOPHEROL; ALPHAPRODINE; CATECHOLAMINE; CEP 1347; CREATINE; DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LEVODOPA; MANGANESE; MINOCYCLINE; NEUROMELANIN; PARKIN; PETHIDINE; PLACEBO; RILUZOLE; ROTENONE; SELEGILINE; UBIDECARENONE; NEUROPROTECTIVE AGENT;

EID: 3543056130     PISSN: 15455343     EISSN: 15455351     Source Type: Journal    
DOI: 10.1602/neurorx.1.1.139     Document Type: Article
Times cited : (220)

References (158)
  • 1
    • 0003148419 scopus 로고    scopus 로고
    • Parkinsonism
    • Rowland L. (Ed), Lippincott Williams & Wilkins, Philadelphia
    • Fahn S., and Przedborski S. Parkinsonism. In: Rowland L. (Ed). Merritt's neurology (2000), Lippincott Williams & Wilkins, Philadelphia 679-693
    • (2000) Merritt's neurology , pp. 679-693
    • Fahn, S.1    Przedborski, S.2
  • 2
    • 0038727936 scopus 로고    scopus 로고
    • Description of Parkinson's disease as a clinical syndrome
    • Fahn S. Description of Parkinson's disease as a clinical syndrome. Ann NY Acad Sci 991 (2003) 1-14
    • (2003) Ann NY Acad Sci , vol.991 , pp. 1-14
    • Fahn, S.1
  • 3
    • 0029094141 scopus 로고
    • Decreased single-photon emission computed tomographic [123I]beta-CIT striatal uptake correlates with symptom severity in Parkinson's disease
    • Seibyl J., Marek K., Quinlan D., Sheff K., Zoghbi S., Zea-Ponce Y., et al. Decreased single-photon emission computed tomographic [123I]beta-CIT striatal uptake correlates with symptom severity in Parkinson's disease. Ann Neurol 38 (1995) 589-598
    • (1995) Ann Neurol , vol.38 , pp. 589-598
    • Seibyl, J.1    Marek, K.2    Quinlan, D.3    Sheff, K.4    Zoghbi, S.5    Zea-Ponce, Y.6
  • 4
    • 0028931484 scopus 로고
    • Assessment of disease severity in parkinsonism with fluorine-18-fluorodeoxyglucose and PET
    • Eidelberg D., Moeller J., Ishikawa T., Dhawan V., Spetsieris P., Chaly T., et al. Assessment of disease severity in parkinsonism with fluorine-18-fluorodeoxyglucose and PET. J Nucl Med 36 (1995) 378-383
    • (1995) J Nucl Med , vol.36 , pp. 378-383
    • Eidelberg, D.1    Moeller, J.2    Ishikawa, T.3    Dhawan, V.4    Spetsieris, P.5    Chaly, T.6
  • 5
    • 0028172598 scopus 로고
    • Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic Parkinsonism
    • Snow B., Lee C., Schulzer M., Mak E., and Calne D. Longitudinal fluorodopa positron emission tomographic studies of the evolution of idiopathic Parkinsonism. Ann Neurol 36 (1994) 759-764
    • (1994) Ann Neurol , vol.36 , pp. 759-764
    • Snow, B.1    Lee, C.2    Schulzer, M.3    Mak, E.4    Calne, D.5
  • 6
    • 0029981856 scopus 로고    scopus 로고
    • An [F-18]dopa-PET and clinical study of the rate of progression in Parkinson's disease
    • Morrish P., Sawle G., and Brooks D. An [F-18]dopa-PET and clinical study of the rate of progression in Parkinson's disease. Brain 119 (1996) 585-591
    • (1996) Brain , vol.119 , pp. 585-591
    • Morrish, P.1    Sawle, G.2    Brooks, D.3
  • 7
    • 0033910602 scopus 로고    scopus 로고
    • Correlation of Parkinson's disease severity and duration with 123I-FP-CIT SPECT striatal uptake
    • Benamer H., Patterson J., Wyper D., Hadley D., Macphee G., and Grosset D. Correlation of Parkinson's disease severity and duration with 123I-FP-CIT SPECT striatal uptake. Mov Disord 15 (2000) 692-698
    • (2000) Mov Disord , vol.15 , pp. 692-698
    • Benamer, H.1    Patterson, J.2    Wyper, D.3    Hadley, D.4    Macphee, G.5    Grosset, D.6
  • 8
    • 0028826015 scopus 로고
    • The frequency of idiopathic Parkinson's disease by age, ethnic group, and sex in northern Manhattan, 1988-1993
    • Mayeux R., Marder K., Cote L., Denaro J., Hemenegildo N., Mejia H., et al. The frequency of idiopathic Parkinson's disease by age, ethnic group, and sex in northern Manhattan, 1988-1993. Am J Epidemiol 142 (1995) 820-827
    • (1995) Am J Epidemiol , vol.142 , pp. 820-827
    • Mayeux, R.1    Marder, K.2    Cote, L.3    Denaro, J.4    Hemenegildo, N.5    Mejia, H.6
  • 9
    • 0031013848 scopus 로고    scopus 로고
    • Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease
    • de Rijk M., Tzourio C., Breteler M., Dartigues J., Amaducci L., Lopez-Pousa S., et al. Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease. J Neurol Neurosurg Psychiatry 62 (1997) 10-15
    • (1997) J Neurol Neurosurg Psychiatry , vol.62 , pp. 10-15
    • de Rijk, M.1    Tzourio, C.2    Breteler, M.3    Dartigues, J.4    Amaducci, L.5    Lopez-Pousa, S.6
  • 10
    • 0033819269 scopus 로고    scopus 로고
    • Influence of strict, intermediate, and broad diagnostic criteria on the age- and sex-specific incidence of Parkinson's disease
    • Bower J., Maraganore D., McDonnell S., and Rocca W. Influence of strict, intermediate, and broad diagnostic criteria on the age- and sex-specific incidence of Parkinson's disease. Mov Disord 15 (2000) 819-825
    • (2000) Mov Disord , vol.15 , pp. 819-825
    • Bower, J.1    Maraganore, D.2    McDonnell, S.3    Rocca, W.4
  • 11
    • 0037246310 scopus 로고    scopus 로고
    • Systematic review of incidence studies of Parkinson's disease
    • Twelves D., Perkins K., and Counsell C. Systematic review of incidence studies of Parkinson's disease. Mov Disord 18 (2003) 19-31
    • (2003) Mov Disord , vol.18 , pp. 19-31
    • Twelves, D.1    Perkins, K.2    Counsell, C.3
  • 12
    • 0034649437 scopus 로고    scopus 로고
    • Parkinson's disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. ILSA Working Group. Italian Longitudinal Study on Aging
    • Baldereschi M., Di Carlo A., Rocca W., Vanni P., Maggi S., Perissinotto E., et al. Parkinson's disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. ILSA Working Group. Italian Longitudinal Study on Aging. Neurology 55 (2000) 1358-1363
    • (2000) Neurology , vol.55 , pp. 1358-1363
    • Baldereschi, M.1    Di Carlo, A.2    Rocca, W.3    Vanni, P.4    Maggi, S.5    Perissinotto, E.6
  • 13
    • 0037388651 scopus 로고    scopus 로고
    • Parkinson disease with old-age onset: a comparative study with subjects with middle-age onset
    • Diederich N., Moore C., Leurgans S., Chmura T., and Goetz C. Parkinson disease with old-age onset: a comparative study with subjects with middle-age onset. Arch Neurol 60 (2003) 529-533
    • (2003) Arch Neurol , vol.60 , pp. 529-533
    • Diederich, N.1    Moore, C.2    Leurgans, S.3    Chmura, T.4    Goetz, C.5
  • 14
    • 0026569594 scopus 로고
    • Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of idiopathic Parkinson's disease
    • Kish S., Shannak K., Rajput A., Deck J., and Hornykiewicz O. Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of idiopathic Parkinson's disease. J Neurochem 58 (1992) 642-648
    • (1992) J Neurochem , vol.58 , pp. 642-648
    • Kish, S.1    Shannak, K.2    Rajput, A.3    Deck, J.4    Hornykiewicz, O.5
  • 16
    • 0035138143 scopus 로고    scopus 로고
    • Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease
    • Booij J., Bergmans P., Winogrodzka A., Speelman J., and Wolters E. Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease. Synapse 39 (2001) 101-108
    • (2001) Synapse , vol.39 , pp. 101-108
    • Booij, J.1    Bergmans, P.2    Winogrodzka, A.3    Speelman, J.4    Wolters, E.5
  • 17
    • 0033959077 scopus 로고    scopus 로고
    • Preservation of midbrain catecholaminergic neurons in very old human subjects
    • Kubis N., Faucheux B., Ransmayr G., Damier P., Duyckaerts C., Henin D., et al. Preservation of midbrain catecholaminergic neurons in very old human subjects. Brain 123 (2000) 366-373
    • (2000) Brain , vol.123 , pp. 366-373
    • Kubis, N.1    Faucheux, B.2    Ransmayr, G.3    Damier, P.4    Duyckaerts, C.5    Henin, D.6
  • 18
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: substantia nigra regional selectivity
    • Fearnley J., and Lees A. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114 (1991) 2283-2301
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.1    Lees, A.2
  • 19
    • 0000555418 scopus 로고
    • Piperidine derivatives. Part III. 4-arylpiperidines
    • Zeiring A., Berger L., Heineman S., and Lee J. Piperidine derivatives. Part III. 4-arylpiperidines. J Org Chem 12 (1947) 894-903
    • (1947) J Org Chem , vol.12 , pp. 894-903
    • Zeiring, A.1    Berger, L.2    Heineman, S.3    Lee, J.4
  • 20
    • 33947466070 scopus 로고
    • The aminomethylation of olefins. IV. The formation of 1-alkyl-4-aryl-1.2.3.6-tetrahydropyridines
    • Schmidle C., and Mansfield R. The aminomethylation of olefins. IV. The formation of 1-alkyl-4-aryl-1.2.3.6-tetrahydropyridines. Am J Chem 78 (1955) 425-428
    • (1955) Am J Chem , vol.78 , pp. 425-428
    • Schmidle, C.1    Mansfield, R.2
  • 21
    • 0018608356 scopus 로고
    • Chronic Parkinsonism secondary to intravenous injection of meperidine analogues
    • Davis G., Williams A., Markey S., Ebert M., Caine E., Reichert C., et al. Chronic Parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res 1 (1979) 249-254
    • (1979) Psychiatry Res , vol.1 , pp. 249-254
    • Davis, G.1    Williams, A.2    Markey, S.3    Ebert, M.4    Caine, E.5    Reichert, C.6
  • 22
    • 0021753399 scopus 로고
    • Chronic parkinsonism secondary to intranasal administration of a product of meperidine-analogue synthesis
    • Wright J., Wall R., Perry T., and Paty D. Chronic parkinsonism secondary to intranasal administration of a product of meperidine-analogue synthesis. N Engl J Med 310 (1984) 325
    • (1984) N Engl J Med , vol.310 , pp. 325
    • Wright, J.1    Wall, R.2    Perry, T.3    Paty, D.4
  • 23
    • 0005444118 scopus 로고
    • Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Langston J., and Ballard P. Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N Engl J Med 309 (1983) 310
    • (1983) N Engl J Med , vol.309 , pp. 310
    • Langston, J.1    Ballard, P.2
  • 24
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston J., Ballard P., Tetrud J., and Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219 (1983) 979-980
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.1    Ballard, P.2    Tetrud, J.3    Irwin, I.4
  • 26
    • 0001496694 scopus 로고
    • A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methl-4-phenyl-1,2,36-tetrahydropyridine
    • Burns R., Chiueh C., Markey S., Ebert M., Jacobowitz D., and Kopin I. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methl-4-phenyl-1,2,36-tetrahydropyridine. Proc Natl Acad Sci USA 80 (1983) 4546-4550
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4546-4550
    • Burns, R.1    Chiueh, C.2    Markey, S.3    Ebert, M.4    Jacobowitz, D.5    Kopin, I.6
  • 27
    • 0026458624 scopus 로고
    • Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Widner H., Tetrud J., Rehncrona S., Snow B., Brundin P., Gustavii B., et al. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). N Engl J Med 327 (1992) 1556-1563
    • (1992) N Engl J Med , vol.327 , pp. 1556-1563
    • Widner, H.1    Tetrud, J.2    Rehncrona, S.3    Snow, B.4    Brundin, P.5    Gustavii, B.6
  • 28
    • 0014705297 scopus 로고
    • Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophane
    • Mena I., Court J., Fuenzalida S., Papavasiliou P., and Cotzias G. Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophane. N Engl J Med 282 (1970) 5-10
    • (1970) N Engl J Med , vol.282 , pp. 5-10
    • Mena, I.1    Court, J.2    Fuenzalida, S.3    Papavasiliou, P.4    Cotzias, G.5
  • 29
    • 0015988134 scopus 로고
    • Chronic manganese intoxication
    • Cook D., Fahn S., and Brait K. Chronic manganese intoxication. Arch Neurol 30 (1974) 59-64
    • (1974) Arch Neurol , vol.30 , pp. 59-64
    • Cook, D.1    Fahn, S.2    Brait, K.3
  • 31
    • 0026608742 scopus 로고
    • Epidemiology of Parkinson's disease
    • Tanner C. Epidemiology of Parkinson's disease. Neurol Clin 10 (1992) 317-329
    • (1992) Neurol Clin , vol.10 , pp. 317-329
    • Tanner, C.1
  • 33
    • 0036714747 scopus 로고    scopus 로고
    • A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease
    • Hernan M., Takkouche B., Caamano-Isorna F., and Gestal-Otero J. A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann Neurol 52 (2002) 276-284
    • (2002) Ann Neurol , vol.52 , pp. 276-284
    • Hernan, M.1    Takkouche, B.2    Caamano-Isorna, F.3    Gestal-Otero, J.4
  • 35
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M., Lavedan C., Leroy E., Ide S., Dehejia A., Dutra A., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.1    Lavedan, C.2    Leroy, E.3    Ide, S.4    Dehejia, A.5    Dutra, A.6
  • 36
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18 (1998) 106-108
    • (1998) Nat Genet , vol.18 , pp. 106-108
    • Kruger, R.1    Kuhn, W.2    Muller, T.3    Woitalla, D.4    Graeber, M.5    Kosel, S.6
  • 38
    • 0027489773 scopus 로고
    • Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
    • Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci USA 90 (1993) 11282-11286
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11282-11286
    • Ueda, K.1    Fukushima, H.2    Masliah, E.3    Xia, Y.4    Iwai, A.5    Yoshimoto, M.6
  • 39
    • 0032952414 scopus 로고    scopus 로고
    • Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
    • Engelender S., Kaminsky Z., Guo X., Sharp A., Amaravi R., Kleiderlein J., et al. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat Genet 22 (1999) 110-114
    • (1999) Nat Genet , vol.22 , pp. 110-114
    • Engelender, S.1    Kaminsky, Z.2    Guo, X.3    Sharp, A.4    Amaravi, R.5    Kleiderlein, J.6
  • 40
    • 0036777847 scopus 로고    scopus 로고
    • Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease
    • Uversky V., Li J., Bower K., and Fink A. Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease. Neurotoxicology 23 (2002) 527-536
    • (2002) Neurotoxicology , vol.23 , pp. 527-536
    • Uversky, V.1    Li, J.2    Bower, K.3    Fink, A.4
  • 41
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
    • Conway K., Rochet J., Bieganski R., and Lansbury Jr. P. Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294 (2001) 1346-1349
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.1    Rochet, J.2    Bieganski, R.3    Lansbury Jr., P.4
  • 42
    • 34247141410 scopus 로고    scopus 로고
    • Certain metals trigger fibrillation of methionine-oxidized alpha-synuclein
    • Yamin G., Glaser C., Uversky V., and Fink A. Certain metals trigger fibrillation of methionine-oxidized alpha-synuclein. J Biol Chem 16 (2003) 16
    • (2003) J Biol Chem , vol.16 , pp. 16
    • Yamin, G.1    Glaser, C.2    Uversky, V.3    Fink, A.4
  • 43
    • 0035887860 scopus 로고    scopus 로고
    • Induction of alpha-synuclein aggregation by intracellular nitrative insult
    • Paxinou E., Chen Q., Weisse M., Giasson B., Norris E., Rueter S., et al. Induction of alpha-synuclein aggregation by intracellular nitrative insult. J Neurosci 21 (2001) 8053-8061
    • (2001) J Neurosci , vol.21 , pp. 8053-8061
    • Paxinou, E.1    Chen, Q.2    Weisse, M.3    Giasson, B.4    Norris, E.5    Rueter, S.6
  • 44
    • 0036364454 scopus 로고    scopus 로고
    • The cell biology of alpha-synuclein: a sticky problem?
    • Cole N., and Murphy D. The cell biology of alpha-synuclein: a sticky problem?. Neuromolecular Med 1 (2002) 95-109
    • (2002) Neuromolecular Med , vol.1 , pp. 95-109
    • Cole, N.1    Murphy, D.2
  • 45
    • 0032102455 scopus 로고    scopus 로고
    • The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
    • Clayton D., and George J. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 21 (1998) 249-254
    • (1998) Trends Neurosci , vol.21 , pp. 249-254
    • Clayton, D.1    George, J.2
  • 46
    • 0023722437 scopus 로고
    • Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
    • Maroteaux L., Campanelli J., and Scheller R. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 8 (1988) 2804-2815
    • (1988) J Neurosci , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.2    Scheller, R.3
  • 47
    • 0034077041 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    • Abeliovich A., Schmitz Y., Farinas I., Choi-Lundberg D., Ho W., Verdugo J., et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25 (2000) 239-252
    • (2000) Neuron , vol.25 , pp. 239-252
    • Abeliovich, A.1    Schmitz, Y.2    Farinas, I.3    Choi-Lundberg, D.4    Ho, W.5    Verdugo, J.6
  • 48
    • 0037109727 scopus 로고    scopus 로고
    • Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
    • Cabin D., Shimazu K., Murphy D., Cole N., Gottschalk W., McIlwain K., et al. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci 22 (2002) 8797-8807
    • (2002) J Neurosci , vol.22 , pp. 8797-8807
    • Cabin, D.1    Shimazu, K.2    Murphy, D.3    Cole, N.4    Gottschalk, W.5    McIlwain, K.6
  • 49
    • 0034193399 scopus 로고    scopus 로고
    • Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
    • Murphy D., Rueter S., Trojanowski J., and Lee V. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J Neurosci 20 (2000) 3214-3220
    • (2000) J Neurosci , vol.20 , pp. 3214-3220
    • Murphy, D.1    Rueter, S.2    Trojanowski, J.3    Lee, V.4
  • 50
    • 0037092442 scopus 로고    scopus 로고
    • A role for alpha-synuclein in the regulation of dopamine biosynthesis
    • Perez R., Waymire J., Lin E., Liu J., Guo F., and Zigmond M. A role for alpha-synuclein in the regulation of dopamine biosynthesis. J Neurosci 22 (2002) 3090-3099
    • (2002) J Neurosci , vol.22 , pp. 3090-3099
    • Perez, R.1    Waymire, J.2    Lin, E.3    Liu, J.4    Guo, F.5    Zigmond, M.6
  • 51
    • 0035066885 scopus 로고    scopus 로고
    • Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
    • Lee F., Liu F., Pristupa Z., and Niznik H. Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J 15 (2001) 916-926
    • (2001) FASEB J , vol.15 , pp. 916-926
    • Lee, F.1    Liu, F.2    Pristupa, Z.3    Niznik, H.4
  • 54
    • 0037064078 scopus 로고    scopus 로고
    • Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line
    • Lotharius J., Barg S., Wiekop P., Lundberg C., Raymon H., and Brundin P. Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem 277 (2002) 38884-38894
    • (2002) J Biol Chem , vol.277 , pp. 38884-38894
    • Lotharius, J.1    Barg, S.2    Wiekop, P.3    Lundberg, C.4    Raymon, H.5    Brundin, P.6
  • 55
    • 0035854437 scopus 로고    scopus 로고
    • Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease
    • Shimura H., Schlossmacher M., Hattori N., Frosch M., Trockenbacher A., Schneider R., et al. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science 293 (2001) 263-269
    • (2001) Science , vol.293 , pp. 263-269
    • Shimura, H.1    Schlossmacher, M.2    Hattori, N.3    Frosch, M.4    Trockenbacher, A.5    Schneider, R.6
  • 56
    • 0041589248 scopus 로고    scopus 로고
    • Alpha-synuclein is degraded by both autophagy and the proteasome
    • Webb J., Ravikumar B., Atkins J., Skepper J., and Rubinsztein D. Alpha-synuclein is degraded by both autophagy and the proteasome. J Biol Chem 28 (2003) 25009-25013
    • (2003) J Biol Chem , vol.28 , pp. 25009-25013
    • Webb, J.1    Ravikumar, B.2    Atkins, J.3    Skepper, J.4    Rubinsztein, D.5
  • 57
    • 0032499264 scopus 로고    scopus 로고
    • Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    • Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392 (1998) 605-608
    • (1998) Nature , vol.392 , pp. 605-608
    • Kitada, T.1    Asakawa, S.2    Hattori, N.3    Matsumine, H.4    Yamamura, Y.5    Minoshima, S.6
  • 58
    • 0342368772 scopus 로고    scopus 로고
    • Association between early-onset Parkinson's disease and mutations in the parkin gene
    • Lucking C., Durr A., Bonifati V., Vaughan J., De Michele G., Gasser T., et al. Association between early-onset Parkinson's disease and mutations in the parkin gene. N Engl J Med 342 (2000) 1560-1567
    • (2000) N Engl J Med , vol.342 , pp. 1560-1567
    • Lucking, C.1    Durr, A.2    Bonifati, V.3    Vaughan, J.4    De Michele, G.5    Gasser, T.6
  • 59
    • 0034848395 scopus 로고    scopus 로고
    • Lewy bodies and parkinsonism in families with parkin mutations
    • Farrer M., Chan P., Chen R., Tan L., Lincoln S., Hernandez D., et al. Lewy bodies and parkinsonism in families with parkin mutations. Ann Neurol 50 (2001) 293-300
    • (2001) Ann Neurol , vol.50 , pp. 293-300
    • Farrer, M.1    Chan, P.2    Chen, R.3    Tan, L.4    Lincoln, S.5    Hernandez, D.6
  • 60
    • 12244262766 scopus 로고    scopus 로고
    • Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
    • Foroud T., Uniacke S., Liu L., Pankratz N., Rudolph A., Halter C., et al. Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease. Neurology 60 (2003) 796-801
    • (2003) Neurology , vol.60 , pp. 796-801
    • Foroud, T.1    Uniacke, S.2    Liu, L.3    Pankratz, N.4    Rudolph, A.5    Halter, C.6
  • 61
    • 0034700158 scopus 로고    scopus 로고
    • Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
    • Zhang Y., Gao J., Chung K., Huang H., Dawson V., and Dawson T. Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci USA 97 (2000) 13354-13359
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13354-13359
    • Zhang, Y.1    Gao, J.2    Chung, K.3    Huang, H.4    Dawson, V.5    Dawson, T.6
  • 62
    • 0037422010 scopus 로고    scopus 로고
    • Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
    • Staropoli J., McDermott C., Martinat C., Schulman B., Demireva E., and Abeliovich A. Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37 (2003) 735-749
    • (2003) Neuron , vol.37 , pp. 735-749
    • Staropoli, J.1    McDermott, C.2    Martinat, C.3    Schulman, B.4    Demireva, E.5    Abeliovich, A.6
  • 63
    • 0037137702 scopus 로고    scopus 로고
    • Parkin protects against the toxicity associated with mutant alpha-synuclein
    • Petrucelli L., O'Farrell C., Lockhart P., Baptista M., Kehoe K., Vink L., et al. Parkin protects against the toxicity associated with mutant alpha-synuclein. Neuron 36 (2002) 1007-1019
    • (2002) Neuron , vol.36 , pp. 1007-1019
    • Petrucelli, L.1    O'Farrell, C.2    Lockhart, P.3    Baptista, M.4    Kehoe, K.5    Vink, L.6
  • 65
    • 0037428241 scopus 로고    scopus 로고
    • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    • Bonifati V., Rizzu P., van Baren M., Schaap O., Breedveld G., Krieger E., et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299 (2003) 256-259
    • (2003) Science , vol.299 , pp. 256-259
    • Bonifati, V.1    Rizzu, P.2    van Baren, M.3    Schaap, O.4    Breedveld, G.5    Krieger, E.6
  • 66
    • 0037151769 scopus 로고    scopus 로고
    • Molecular features of human ubiquitin-like SUMO genes and their encoded proteins
    • Su H., and Li S. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296 (2002) 65-73
    • (2002) Gene , vol.296 , pp. 65-73
    • Su, H.1    Li, S.2
  • 67
    • 0035813135 scopus 로고    scopus 로고
    • DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
    • Takahashi K., Taira T., Niki T., Seino C., Iguchi-Ariga S., and Ariga H. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J Biol Chem 276 (2001) 37556-37563
    • (2001) J Biol Chem , vol.276 , pp. 37556-37563
    • Takahashi, K.1    Taira, T.2    Niki, T.3    Seino, C.4    Iguchi-Ariga, S.5    Ariga, H.6
  • 68
    • 0034906096 scopus 로고    scopus 로고
    • Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat
    • Mitsumoto A., Nakagawa Y., Takeuchi A., Okawa K., Iwamatsu A., and Takanezawa Y. Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat. Free Radic Res 35 (2001) 301-310
    • (2001) Free Radic Res , vol.35 , pp. 301-310
    • Mitsumoto, A.1    Nakagawa, Y.2    Takeuchi, A.3    Okawa, K.4    Iwamatsu, A.5    Takanezawa, Y.6
  • 69
    • 0032576605 scopus 로고    scopus 로고
    • Aggresomes: a cellular response to misfolded proteins
    • Johnston J., Ward C., and Kopito R. Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143 (1998) 1883-1898
    • (1998) J Cell Biol , vol.143 , pp. 1883-1898
    • Johnston, J.1    Ward, C.2    Kopito, R.3
  • 70
    • 0037073747 scopus 로고    scopus 로고
    • Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells
    • Lee H., and Lee S. Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells. J Biol Chem 277 (2002) 48976-48983
    • (2002) J Biol Chem , vol.277 , pp. 48976-48983
    • Lee, H.1    Lee, S.2
  • 71
    • 0037033074 scopus 로고    scopus 로고
    • Parkin accumulation in aggresomes due to proteasome impairment
    • Junn E., Lee S., Suhr U., and Mouradian M. Parkin accumulation in aggresomes due to proteasome impairment. J Biol Chem 277 (2002) 47870-47877
    • (2002) J Biol Chem , vol.277 , pp. 47870-47877
    • Junn, E.1    Lee, S.2    Suhr, U.3    Mouradian, M.4
  • 72
    • 0035800097 scopus 로고    scopus 로고
    • Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease
    • Volles M., Lee S., Rochet J., Shtilerman M., Ding T., Kessler J., et al. Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry 40 (2001) 7812-7819
    • (2001) Biochemistry , vol.40 , pp. 7812-7819
    • Volles, M.1    Lee, S.2    Rochet, J.3    Shtilerman, M.4    Ding, T.5    Kessler, J.6
  • 73
    • 0021680307 scopus 로고
    • Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP
    • Javitch J., and Snyder S. Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP. Eur J Pharmacol 106 (1984) 455-456
    • (1984) Eur J Pharmacol , vol.106 , pp. 455-456
    • Javitch, J.1    Snyder, S.2
  • 74
    • 0030877835 scopus 로고    scopus 로고
    • Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter
    • Gainetdinov R., Fumagalli F., and Caron M. Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. J Neurochem 69 (1997) 1322-1325
    • (1997) J Neurochem , vol.69 , pp. 1322-1325
    • Gainetdinov, R.1    Fumagalli, F.2    Caron, M.3
  • 75
    • 0032125186 scopus 로고    scopus 로고
    • Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter
    • Fumagalli F., Gainetdinov R., Valenzano K., and Caron M. Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. J Neurosci 18 (1998) 4861-4869
    • (1998) J Neurosci , vol.18 , pp. 4861-4869
    • Fumagalli, F.1    Gainetdinov, R.2    Valenzano, K.3    Caron, M.4
  • 76
    • 0022515585 scopus 로고
    • Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+
    • Ramsay R., Salach J., and Singer T. Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+. Biochem Biophys Res Commun 134 (1986) 743-748
    • (1986) Biochem Biophys Res Commun , vol.134 , pp. 743-748
    • Ramsay, R.1    Salach, J.2    Singer, T.3
  • 78
    • 0030053169 scopus 로고    scopus 로고
    • Sulfonylurea-sensitive potassium current evoked by sodium-loading in rat midbrain dopamine neurons
    • Seutin V., Shen K., North R., and Johnson S. Sulfonylurea-sensitive potassium current evoked by sodium-loading in rat midbrain dopamine neurons. Neuroscience 71 (1996) 709-719
    • (1996) Neuroscience , vol.71 , pp. 709-719
    • Seutin, V.1    Shen, K.2    North, R.3    Johnson, S.4
  • 79
    • 0037101540 scopus 로고    scopus 로고
    • Stimulation-dependent regulation of secretory vesicle pH, volume, and quantal size
    • Pothos E., Mosharov E., Liu K., Setlik W., Baldini G., Gershon M., et al. Stimulation-dependent regulation of secretory vesicle pH, volume, and quantal size. J Physiol (Lond) 542 (2002) 453-476
    • (2002) J Physiol (Lond) , vol.542 , pp. 453-476
    • Pothos, E.1    Mosharov, E.2    Liu, K.3    Setlik, W.4    Baldini, G.5    Gershon, M.6
  • 81
    • 0036310237 scopus 로고    scopus 로고
    • Inhibition of brain mitochondrial respiration by dopamine: involvement of H(2)O(2) and hydroxyl radicals but not glutathione-protein-mixed disulfides
    • Gluck M., Ehrhart J., Jayatilleke E., and Zeevalk G. Inhibition of brain mitochondrial respiration by dopamine: involvement of H(2)O(2) and hydroxyl radicals but not glutathione-protein-mixed disulfides. J Neurochem 82 (2002) 66-74
    • (2002) J Neurochem , vol.82 , pp. 66-74
    • Gluck, M.1    Ehrhart, J.2    Jayatilleke, E.3    Zeevalk, G.4
  • 82
    • 0035144650 scopus 로고    scopus 로고
    • Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
    • Przedborski S., Chen Q., Vila M., Giasson B., Djaldatti R., Vukosavic S., et al. Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. J Neurochem 76 (2001) 637-640
    • (2001) J Neurochem , vol.76 , pp. 637-640
    • Przedborski, S.1    Chen, Q.2    Vila, M.3    Giasson, B.4    Djaldatti, R.5    Vukosavic, S.6
  • 84
    • 0019812302 scopus 로고
    • Magnitude and duration of hyperactivity following neonatal 6-hydroxydopamine is related to the extent of brain dopamine depletion
    • Miller F., Heffner T., Kotake C., and Seiden L. Magnitude and duration of hyperactivity following neonatal 6-hydroxydopamine is related to the extent of brain dopamine depletion. Brain Res 229 (1981) 123-132
    • (1981) Brain Res , vol.229 , pp. 123-132
    • Miller, F.1    Heffner, T.2    Kotake, C.3    Seiden, L.4
  • 85
    • 0028329215 scopus 로고
    • Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress
    • Cubells J., Rayport S., Rajendran G., and Sulzer D. Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress. J Neurosci 14 (1994) 2260-2271
    • (1994) J Neurosci , vol.14 , pp. 2260-2271
    • Cubells, J.1    Rayport, S.2    Rajendran, G.3    Sulzer, D.4
  • 86
    • 0028947076 scopus 로고
    • Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: impact of methamphetamine
    • Giovanni A., Liang L., Hastings T., and Zigmond M. Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: impact of methamphetamine. J Neurochem 64 (1995) 1819-1825
    • (1995) J Neurochem , vol.64 , pp. 1819-1825
    • Giovanni, A.1    Liang, L.2    Hastings, T.3    Zigmond, M.4
  • 87
    • 0025647857 scopus 로고
    • Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action
    • Sulzer D., and Rayport S. Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action. Neuron 5 (1990) 797-808
    • (1990) Neuron , vol.5 , pp. 797-808
    • Sulzer, D.1    Rayport, S.2
  • 88
    • 0011738348 scopus 로고    scopus 로고
    • Dopamine-induced toxicity and quinone modification of proteins: implications for Parkinson's disease
    • Creveling C. (Ed), F. P. Graham, Johnson City, TN
    • Hastings T., and Berman S. Dopamine-induced toxicity and quinone modification of proteins: implications for Parkinson's disease. In: Creveling C. (Ed). Role of catechol quinone species in cellular toxicity (1999), F. P. Graham, Johnson City, TN 69-89
    • (1999) Role of catechol quinone species in cellular toxicity , pp. 69-89
    • Hastings, T.1    Berman, S.2
  • 89
    • 0001672745 scopus 로고    scopus 로고
    • Intraneuronal dopamine-quinone synthesis: a review
    • Sulzer D., and Zecca L. Intraneuronal dopamine-quinone synthesis: a review. Neurotoxicity Res 1 (2000) 181-195
    • (2000) Neurotoxicity Res , vol.1 , pp. 181-195
    • Sulzer, D.1    Zecca, L.2
  • 90
    • 0018095085 scopus 로고
    • Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
    • Graham D. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol Pharmacol 14 (1978) 633-643
    • (1978) Mol Pharmacol , vol.14 , pp. 633-643
    • Graham, D.1
  • 91
    • 0035112815 scopus 로고    scopus 로고
    • Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter
    • Whitehead R., Ferrer J., Javitch J., and Justice J. Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter. J Neurochem 76 (2001) 1242-1251
    • (2001) J Neurochem , vol.76 , pp. 1242-1251
    • Whitehead, R.1    Ferrer, J.2    Javitch, J.3    Justice, J.4
  • 92
    • 0034624017 scopus 로고    scopus 로고
    • The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium (MPP+) triggers intracellular dopamine oxidation: a novel mechanism of toxicity
    • Lotharius J., and O'Malley K. The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium (MPP+) triggers intracellular dopamine oxidation: a novel mechanism of toxicity. J Biol Chem 275 (2000) 38581-38588
    • (2000) J Biol Chem , vol.275 , pp. 38581-38588
    • Lotharius, J.1    O'Malley, K.2
  • 93
    • 0034882387 scopus 로고    scopus 로고
    • Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment
    • Davidson C., Gow A., Lee T., and Ellinwood E. Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment. Brain Res Brain Res Rev 36 (2001) 1-22
    • (2001) Brain Res Brain Res Rev , vol.36 , pp. 1-22
    • Davidson, C.1    Gow, A.2    Lee, T.3    Ellinwood, E.4
  • 94
    • 0031079599 scopus 로고    scopus 로고
    • S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity
    • Matthews R., Yang L., and Beal M. S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. Exp Neurol 143 (1997) 282-286
    • (1997) Exp Neurol , vol.143 , pp. 282-286
    • Matthews, R.1    Yang, L.2    Beal, M.3
  • 95
    • 0036326167 scopus 로고    scopus 로고
    • The neuromelanin of human substantia nigra and its interaction with metals
    • Zecca L., Tampellini D., Gatti A., Crippa R., Eisner M., Sulzer D., et al. The neuromelanin of human substantia nigra and its interaction with metals. J Neural Transm 109 (2002) 663-672
    • (2002) J Neural Transm , vol.109 , pp. 663-672
    • Zecca, L.1    Tampellini, D.2    Gatti, A.3    Crippa, R.4    Eisner, M.5    Sulzer, D.6
  • 97
    • 12944305793 scopus 로고    scopus 로고
    • Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
    • Sulzer D., Bogulavsky J., Larsen K., Behr G., Karatekin E., Kleinman M., et al. Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc Natl Acad Sci USA 97 (2000) 11869-11874
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11869-11874
    • Sulzer, D.1    Bogulavsky, J.2    Larsen, K.3    Behr, G.4    Karatekin, E.5    Kleinman, M.6
  • 98
    • 0036066121 scopus 로고    scopus 로고
    • Autophagy in neurons: a review
    • Larsen K., and Sulzer D. Autophagy in neurons: a review. Histol Histopathol 17 (2002) 897-908
    • (2002) Histol Histopathol , vol.17 , pp. 897-908
    • Larsen, K.1    Sulzer, D.2
  • 99
    • 0026713852 scopus 로고
    • A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter
    • Liu Y., Peter D., Roghani A., Schuldiner S., Prive G., Eisenberg D., et al. A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Cell 70 (1992) 539-551
    • (1992) Cell , vol.70 , pp. 539-551
    • Liu, Y.1    Peter, D.2    Roghani, A.3    Schuldiner, S.4    Prive, G.5    Eisenberg, D.6
  • 100
    • 0034307584 scopus 로고    scopus 로고
    • Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size
    • Pothos E., Larsen K., Krantz D., Liu Y.-J., Edwards R., and Sulzer D. Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size. J Neurosci 20 (2000) 7297-7306
    • (2000) J Neurosci , vol.20 , pp. 7297-7306
    • Pothos, E.1    Larsen, K.2    Krantz, D.3    Liu, Y.-J.4    Edwards, R.5    Sulzer, D.6
  • 101
    • 0037109770 scopus 로고    scopus 로고
    • Methamphetamine-induced degeneration of dopaminergic neurons occurs via autophagy triggered by elevated cytosolic dopamine
    • Larsen K., Fon E., LaVoie M., Hastings T., Edwards R., and Sulzer D. Methamphetamine-induced degeneration of dopaminergic neurons occurs via autophagy triggered by elevated cytosolic dopamine. J Neurosci 22 (2002) 8951-8960
    • (2002) J Neurosci , vol.22 , pp. 8951-8960
    • Larsen, K.1    Fon, E.2    LaVoie, M.3    Hastings, T.4    Edwards, R.5    Sulzer, D.6
  • 102
    • 0033118563 scopus 로고    scopus 로고
    • Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice
    • Fumagalli F., Gainetdinov R., Wang Y., Valenzano K., Miller G., and Caron M. Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. J Neurosci 19 (1999) 2424-2431
    • (1999) J Neurosci , vol.19 , pp. 2424-2431
    • Fumagalli, F.1    Gainetdinov, R.2    Wang, Y.3    Valenzano, K.4    Miller, G.5    Caron, M.6
  • 103
    • 0031959343 scopus 로고    scopus 로고
    • Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice
    • Gainetdinov R., Fumagalli F., Wang Y., Jones S., Levey A., Miller G., et al. Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. J Neurochem 70 (1998) 1973-1978
    • (1998) J Neurochem , vol.70 , pp. 1973-1978
    • Gainetdinov, R.1    Fumagalli, F.2    Wang, Y.3    Jones, S.4    Levey, A.5    Miller, G.6
  • 104
    • 0037426917 scopus 로고    scopus 로고
    • Pathways to Parkinsonism
    • Cookson M. Pathways to Parkinsonism. Neuron 37 (2003) 7-10
    • (2003) Neuron , vol.37 , pp. 7-10
    • Cookson, M.1
  • 105
    • 0037468831 scopus 로고    scopus 로고
    • Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by pael-R in Drosophila
    • Yang Y., Nishimura I., Imai Y., Takahashi R., and Lu B. Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by pael-R in Drosophila. Neuron 37 (2003) 911-924
    • (2003) Neuron , vol.37 , pp. 911-924
    • Yang, Y.1    Nishimura, I.2    Imai, Y.3    Takahashi, R.4    Lu, B.5
  • 106
    • 0037189591 scopus 로고    scopus 로고
    • Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein
    • Ribeiro C., Carneiro K., Ross C., Menezes J., and Engelender S. Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein. J Biol Chem 277 (2002) 23927-23933
    • (2002) J Biol Chem , vol.277 , pp. 23927-23933
    • Ribeiro, C.1    Carneiro, K.2    Ross, C.3    Menezes, J.4    Engelender, S.5
  • 107
    • 0035894855 scopus 로고    scopus 로고
    • Expression of A53T mutant, but not wild-type, α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
    • Stefanis L., Larsen K., Rideout H., Sulzer D., and Greene L. Expression of A53T mutant, but not wild-type, α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J Neurosci 21 (2001) 9549-9560
    • (2001) J Neurosci , vol.21 , pp. 9549-9560
    • Stefanis, L.1    Larsen, K.2    Rideout, H.3    Sulzer, D.4    Greene, L.5
  • 108
    • 0031883733 scopus 로고    scopus 로고
    • Lysosomes, a meeting point of proteins, chaperones, and proteases
    • Cuervo A., and Dice J. Lysosomes, a meeting point of proteins, chaperones, and proteases. J Mol Med 76 (1998) 6-12
    • (1998) J Mol Med , vol.76 , pp. 6-12
    • Cuervo, A.1    Dice, J.2
  • 109
    • 0026504821 scopus 로고
    • Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity
    • Iacopino A., Christakos S., German D., Sonsalla P., and Altar C. Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity. Brain Res Mol Brain Res 13 (1992) 251-261
    • (1992) Brain Res Mol Brain Res , vol.13 , pp. 251-261
    • Iacopino, A.1    Christakos, S.2    German, D.3    Sonsalla, P.4    Altar, C.5
  • 111
    • 0034012173 scopus 로고    scopus 로고
    • In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium
    • Staal R., Hogan K., Liang C., German D., and Sonsalla P. In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium. J Pharmacol Exp Ther 293 (2000) 329-335
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 329-335
    • Staal, R.1    Hogan, K.2    Liang, C.3    German, D.4    Sonsalla, P.5
  • 112
    • 0033570331 scopus 로고    scopus 로고
    • The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels
    • Liss B., Neu A., and Roeper J. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. J Neurosci 19 (1999) 8839-8848
    • (1999) J Neurosci , vol.19 , pp. 8839-8848
    • Liss, B.1    Neu, A.2    Roeper, J.3
  • 113
    • 0031783647 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture
    • Burke R., Antonelli M., and Sulzer D. Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture. J Neurochem 71 (1998) 517-525
    • (1998) J Neurochem , vol.71 , pp. 517-525
    • Burke, R.1    Antonelli, M.2    Sulzer, D.3
  • 114
    • 0033678297 scopus 로고    scopus 로고
    • Apoptosis as a general cell death pathway in neurodegenerative diseases
    • Offen D., Elkon H., and Melamed E. Apoptosis as a general cell death pathway in neurodegenerative diseases. J Neural Transm Suppl 58 (2000) 153-166
    • (2000) J Neural Transm Suppl , vol.58 , pp. 153-166
    • Offen, D.1    Elkon, H.2    Melamed, E.3
  • 115
    • 0001485756 scopus 로고    scopus 로고
    • MPTP: a review of its mechanisms of neurotoxicity
    • Przedborksi S., and Vila M. MPTP: a review of its mechanisms of neurotoxicity. Clin Neurosci Res 1 (2001) 407-418
    • (2001) Clin Neurosci Res , vol.1 , pp. 407-418
    • Przedborksi, S.1    Vila, M.2
  • 117
    • 0037366093 scopus 로고    scopus 로고
    • Activation of microglia by human neuromelanin is NF-κB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease
    • Wilms H., Rosenstiel P., Sievers J., Deuschl G., Zecca L., and Lucius R. Activation of microglia by human neuromelanin is NF-κB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease. FASEB J 17 (2003) 500-502
    • (2003) FASEB J , vol.17 , pp. 500-502
    • Wilms, H.1    Rosenstiel, P.2    Sievers, J.3    Deuschl, G.4    Zecca, L.5    Lucius, R.6
  • 118
    • 0038641723 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
    • Teismann P., Tieu K., Choi D., Wu D., Naini A., Hunot S., et al. Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Natl Acad Sci USA 100 (2003) 5473-5478
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5473-5478
    • Teismann, P.1    Tieu, K.2    Choi, D.3    Wu, D.4    Naini, A.5    Hunot, S.6
  • 119
    • 0024456653 scopus 로고
    • Effect of deprenyl on the progression of disability in early Parkinson's disease
    • Parkinson Study Group. Effect of deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 321 (1989) 1364-1371
    • (1989) N Engl J Med , vol.321 , pp. 1364-1371
    • Parkinson Study Group1
  • 120
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 328 (1993) 176-183
    • (1993) N Engl J Med , vol.328 , pp. 176-183
    • Parkinson Study Group1
  • 121
    • 0026596575 scopus 로고
    • Selegiline as initial treatment in de novo parkinsonian patients
    • Myllyla V., Sotaniemi K., Vuorinen J., and Heinonen E. Selegiline as initial treatment in de novo parkinsonian patients. Neurology 42 (1992) 339-343
    • (1992) Neurology , vol.42 , pp. 339-343
    • Myllyla, V.1    Sotaniemi, K.2    Vuorinen, J.3    Heinonen, E.4
  • 122
    • 0345019854 scopus 로고    scopus 로고
    • Selegiline delays the onset of disability in de novo parkinsonian patients. Swedish Parkinson Study Group
    • Palhagen S., Heinonen E., Hagglund J., Kaugesaar T., Kontants H., Maki-Ikola O., et al. Selegiline delays the onset of disability in de novo parkinsonian patients. Swedish Parkinson Study Group. Neurology 51 (1998) 520-525
    • (1998) Neurology , vol.51 , pp. 520-525
    • Palhagen, S.1    Heinonen, E.2    Hagglund, J.3    Kaugesaar, T.4    Kontants, H.5    Maki-Ikola, O.6
  • 124
    • 0036231440 scopus 로고    scopus 로고
    • Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial
    • Shoulson I., Oakes D., Fahn S., Lang A., Langston J., LeWitt P., et al. Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial. Ann Neurol 51 (2002) 604-612
    • (2002) Ann Neurol , vol.51 , pp. 604-612
    • Shoulson, I.1    Oakes, D.2    Fahn, S.3    Lang, A.4    Langston, J.5    LeWitt, P.6
  • 125
    • 0031711224 scopus 로고    scopus 로고
    • Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis
    • Beal M. Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis. Ann Neurol 44 (1998) S110-S114
    • (1998) Ann Neurol , vol.44
    • Beal, M.1
  • 127
    • 0030271253 scopus 로고    scopus 로고
    • Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat
    • Barneoud P., Mazadier M., Miquet J., Parmentier S., Dubedat P., Doble A., et al. Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat. Neuroscience 74 (1996) 971-983
    • (1996) Neuroscience , vol.74 , pp. 971-983
    • Barneoud, P.1    Mazadier, M.2    Miquet, J.3    Parmentier, S.4    Dubedat, P.5    Doble, A.6
  • 128
    • 0034056425 scopus 로고    scopus 로고
    • The protective effect of riluzole in the MPTP model of Parkinson's disease in mice is not due to a decrease in MPP(+) accumulation
    • Boireau A., Dubedat P., Bordier F., Imperato A., and Moussaoui S. The protective effect of riluzole in the MPTP model of Parkinson's disease in mice is not due to a decrease in MPP(+) accumulation. Neuropharmacology 39 (2000) 1016-1020
    • (2000) Neuropharmacology , vol.39 , pp. 1016-1020
    • Boireau, A.1    Dubedat, P.2    Bordier, F.3    Imperato, A.4    Moussaoui, S.5
  • 129
    • 0036368298 scopus 로고    scopus 로고
    • Neuroprotective effect of riluzole in a primate model of Parkinson's disease: behavioral and histological evidence
    • Obinu M., Reibaud M., Blanchard V., Moussaoui S., and Imperato A. Neuroprotective effect of riluzole in a primate model of Parkinson's disease: behavioral and histological evidence. Mov Disord 17 (2002) 13-19
    • (2002) Mov Disord , vol.17 , pp. 13-19
    • Obinu, M.1    Reibaud, M.2    Blanchard, V.3    Moussaoui, S.4    Imperato, A.5
  • 130
    • 0036164536 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled and longitudinal study of riluzole in early Parkinson's disease
    • Jankovic J., and Hunter C. A double-blind, placebo-controlled and longitudinal study of riluzole in early Parkinson's disease. Parkinsonism Relat Disord 8 (2002) 271-276
    • (2002) Parkinsonism Relat Disord , vol.8 , pp. 271-276
    • Jankovic, J.1    Hunter, C.2
  • 131
    • 34147095927 scopus 로고    scopus 로고
    • Effect of riluzole on Parkinson's disease progression: a double-blind placebo-controlled study
    • Rascol O., Olanow W., Brooks D., Koch G., Truffinet P., and Bejuit R. Effect of riluzole on Parkinson's disease progression: a double-blind placebo-controlled study. Neurology 60 Suppl 1 (2003) A288
    • (2003) Neurology , vol.60 , Issue.SUPPL. 1
    • Rascol, O.1    Olanow, W.2    Brooks, D.3    Koch, G.4    Truffinet, P.5    Bejuit, R.6
  • 132
    • 0032100808 scopus 로고    scopus 로고
    • Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size
    • Pothos E., Davila V., and Sulzer D. Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size. J Neurosci 18 (1998) 4106-4118
    • (1998) J Neurosci , vol.18 , pp. 4106-4118
    • Pothos, E.1    Davila, V.2    Sulzer, D.3
  • 133
    • 13344277993 scopus 로고    scopus 로고
    • Functional recovery in parkinsonian monkeys treated with GDNF
    • Gash D., Zhang Z., Ovadia A., Cass W., Yi A., Simmerman L., et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 21 (1996) 252-255
    • (1996) Nature , vol.21 , pp. 252-255
    • Gash, D.1    Zhang, Z.2    Ovadia, A.3    Cass, W.4    Yi, A.5    Simmerman, L.6
  • 134
    • 0036787532 scopus 로고    scopus 로고
    • Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys
    • Grondin R., Zhang Z., Yi A., Cass W., Maswood N., Andersen A., et al. Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys. Brain 125 (2002) 2191-2201
    • (2002) Brain , vol.125 , pp. 2191-2201
    • Grondin, R.1    Zhang, Z.2    Yi, A.3    Cass, W.4    Maswood, N.5    Andersen, A.6
  • 135
    • 0037435511 scopus 로고    scopus 로고
    • Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    • Nutt J., Burchiel K., Comella C., Jankovic J., Lang A., Laws Jr. E., et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60 (2003) 69-73
    • (2003) Neurology , vol.60 , pp. 69-73
    • Nutt, J.1    Burchiel, K.2    Comella, C.3    Jankovic, J.4    Lang, A.5    Laws Jr., E.6
  • 136
    • 0000543509 scopus 로고    scopus 로고
    • Intraparenchymal putaminal administration of glial-derived neurotrophic factor in the treatment of advanced Parkinson's disease
    • Gill S., Patel N., O'Sullivan K., Brooks D., Hotton G., Svendsen C., et al. Intraparenchymal putaminal administration of glial-derived neurotrophic factor in the treatment of advanced Parkinson's disease. Neurology 58 Suppl 3 (2002) A241
    • (2002) Neurology , vol.58 , Issue.SUPPL. 3
    • Gill, S.1    Patel, N.2    O'Sullivan, K.3    Brooks, D.4    Hotton, G.5    Svendsen, C.6
  • 137
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower J., Emborg M., Bloch J., Ma S., Chu Y., Leventhal L., et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290 (2000) 767-773
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.1    Emborg, M.2    Bloch, J.3    Ma, S.4    Chu, Y.5    Leventhal, L.6
  • 138
    • 12644257556 scopus 로고    scopus 로고
    • Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
    • Steiner J., Hamilton G., Ross D., Valentine H., Guo H., Connolly M., et al. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc Natl Acad Sci USA 94 (1997) 2019-2024
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2019-2024
    • Steiner, J.1    Hamilton, G.2    Ross, D.3    Valentine, H.4    Guo, H.5    Connolly, M.6
  • 139
    • 0034998137 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons
    • Guo X., Dawson V., and Dawson T. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci 13 (2001) 1683-1693
    • (2001) Eur J Neurosci , vol.13 , pp. 1683-1693
    • Guo, X.1    Dawson, V.2    Dawson, T.3
  • 140
    • 0035910371 scopus 로고    scopus 로고
    • Immunosuppressive and non-immunosuppressive immunophilin ligands improve H(2)O(2)-induced cell damage by increasing glutathione levels in NG108-15 cells
    • Tanaka K., Fujita N., Yoshioka M., and Ogawa N. Immunosuppressive and non-immunosuppressive immunophilin ligands improve H(2)O(2)-induced cell damage by increasing glutathione levels in NG108-15 cells. Brain Res 889 (2001) 225-228
    • (2001) Brain Res , vol.889 , pp. 225-228
    • Tanaka, K.1    Fujita, N.2    Yoshioka, M.3    Ogawa, N.4
  • 141
    • 0037087049 scopus 로고    scopus 로고
    • GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum
    • Tanaka K., Yoshioka M., Miyazaki I., Fujita N., and Ogawa N. GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum. Neurosci Lett 321 (2002) 45-48
    • (2002) Neurosci Lett , vol.321 , pp. 45-48
    • Tanaka, K.1    Yoshioka, M.2    Miyazaki, I.3    Fujita, N.4    Ogawa, N.5
  • 142
    • 0032889368 scopus 로고    scopus 로고
    • Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo
    • Harper S., Bilsland J., Young L., Bristow L., Boyce S., Mason G., et al. Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo. Neuroscience 88 (1999) 257-267
    • (1999) Neuroscience , vol.88 , pp. 257-267
    • Harper, S.1    Bilsland, J.2    Young, L.3    Bristow, L.4    Boyce, S.5    Mason, G.6
  • 143
    • 0035896266 scopus 로고    scopus 로고
    • Failure of GPI compounds to display neurotrophic activity in vitro and in vivo
    • Bocquet A., Lorent G., Fuks B., Grimee R., Talaga P., Daliers J., et al. Failure of GPI compounds to display neurotrophic activity in vitro and in vivo. Eur J Pharmacol 415 (2001) 173-180
    • (2001) Eur J Pharmacol , vol.415 , pp. 173-180
    • Bocquet, A.1    Lorent, G.2    Fuks, B.3    Grimee, R.4    Talaga, P.5    Daliers, J.6
  • 144
    • 0035123909 scopus 로고    scopus 로고
    • Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys
    • Emborg M., Shin P., Roitberg B., Sramek J., Chu Y., Stebbins G., et al. Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys. Exp Neurol 168 (2001) 171-182
    • (2001) Exp Neurol , vol.168 , pp. 171-182
    • Emborg, M.1    Shin, P.2    Roitberg, B.3    Sramek, J.4    Chu, Y.5    Stebbins, G.6
  • 145
    • 0036939396 scopus 로고    scopus 로고
    • The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys
    • Eberling J., Pivirotto P., Bringas J., Steiner J., Kordower J., Chu Y., et al. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol 178 (2002) 236-242
    • (2002) Exp Neurol , vol.178 , pp. 236-242
    • Eberling, J.1    Pivirotto, P.2    Bringas, J.3    Steiner, J.4    Kordower, J.5    Chu, Y.6
  • 146
    • 0025640845 scopus 로고
    • Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease
    • Schapira A., Mann V., Cooper J., Dexter D., Daniel S., Jenner P., et al. Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J Neurochem 55 (1990) 2142-2145
    • (1990) J Neurochem , vol.55 , pp. 2142-2145
    • Schapira, A.1    Mann, V.2    Cooper, J.3    Dexter, D.4    Daniel, S.5    Jenner, P.6
  • 147
    • 0030612117 scopus 로고    scopus 로고
    • Coenzyme Q(10) levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
    • Shults C., Haas R., Passov D., and Beal M. Coenzyme Q(10) levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol 42 (1997) 261-264
    • (1997) Ann Neurol , vol.42 , pp. 261-264
    • Shults, C.1    Haas, R.2    Passov, D.3    Beal, M.4
  • 148
    • 0001115172 scopus 로고
    • Serum coenzyme Q10 level in Parkinson syndrome
    • Folkers K., Littarru G., and Yamagami T. (Eds), Elsevier Science, New York
    • Matsubara T., Azuma T., Yoshida S., and Yamagami T. Serum coenzyme Q10 level in Parkinson syndrome. In: Folkers K., Littarru G., and Yamagami T. (Eds). Biomedical and clinical aspects of coenzyme Q10 (1991), Elsevier Science, New York 159-166
    • (1991) Biomedical and clinical aspects of coenzyme Q10 , pp. 159-166
    • Matsubara, T.1    Azuma, T.2    Yoshida, S.3    Yamagami, T.4
  • 149
    • 0032555066 scopus 로고    scopus 로고
    • Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
    • Matthews R., Yang L., Browne S., Baik M., and Beal M. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA 95 (1998) 8892-8897
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8892-8897
    • Matthews, R.1    Yang, L.2    Browne, S.3    Baik, M.4    Beal, M.5
  • 150
    • 0036771852 scopus 로고    scopus 로고
    • Effects of coenzyme Q(10) in early Parkinson disease - Evidence of slowing of the functional decline
    • Shults C., Oakes D., Kieburtz K., Beal M., Haas R., Plumb S., et al. Effects of coenzyme Q(10) in early Parkinson disease - Evidence of slowing of the functional decline. Arch Neurol 59 (2002) 1541-1550
    • (2002) Arch Neurol , vol.59 , pp. 1541-1550
    • Shults, C.1    Oakes, D.2    Kieburtz, K.3    Beal, M.4    Haas, R.5    Plumb, S.6
  • 151
    • 0037379314 scopus 로고    scopus 로고
    • Bioenergetic approaches for neuroprotection in Parkinson's disease
    • discussion S47-S48
    • Beal M. Bioenergetic approaches for neuroprotection in Parkinson's disease. Ann Neurol 53 Suppl 3 (2003) S39-S47 discussion S47-S48
    • (2003) Ann Neurol , vol.53 , Issue.SUPPL. 3
    • Beal, M.1
  • 152
    • 0035807904 scopus 로고    scopus 로고
    • Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • Du Y., Ma Z., Lin S., Dodel R., Gao F., Bales K., et al. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 98 (2001) 14669-14674
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14669-14674
    • Du, Y.1    Ma, Z.2    Lin, S.3    Dodel, R.4    Gao, F.5    Bales, K.6
  • 153
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • Wu D., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., et al. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22 (2002) 1763-1771
    • (2002) J Neurosci , vol.22 , pp. 1763-1771
    • Wu, D.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6
  • 154
    • 0027496801 scopus 로고
    • Selegiline can mediate neuronal rescue rather than neuronal protection
    • Tatton W. Selegiline can mediate neuronal rescue rather than neuronal protection. Mov Disord 8 (1993) S20-S30
    • (1993) Mov Disord , vol.8
    • Tatton, W.1
  • 155
    • 0033659663 scopus 로고    scopus 로고
    • CGP 3466 protects dopaminergic neurons in lesion models of Parkinson's disease
    • Waldmeier P., Spooren W., and Hengerer B. CGP 3466 protects dopaminergic neurons in lesion models of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol 362 (2000) 526-537
    • (2000) Naunyn Schmiedebergs Arch Pharmacol , vol.362 , pp. 526-537
    • Waldmeier, P.1    Spooren, W.2    Hengerer, B.3
  • 156
    • 0021137683 scopus 로고
    • Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
    • Markey S., Johannessen J., Chiueh C., Burns R., and Herkenham M. Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Nature 311 (1984) 464-467
    • (1984) Nature , vol.311 , pp. 464-467
    • Markey, S.1    Johannessen, J.2    Chiueh, C.3    Burns, R.4    Herkenham, M.5
  • 157
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch J., D'Amato R., Strittmatter S., and Snyder S. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 82 (1985) 2173-2177
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 2173-2177
    • Javitch, J.1    D'Amato, R.2    Strittmatter, S.3    Snyder, S.4
  • 158
    • 0033807212 scopus 로고    scopus 로고
    • Images. Les corps et prolongements de Lewy
    • Duyckaerts C. Images. Les corps et prolongements de Lewy. Rev Neurol (Paris) 156 (2000) 800-801
    • (2000) Rev Neurol (Paris) , vol.156 , pp. 800-801
    • Duyckaerts, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.