Turning cells red: Signal transduction mediated by erythropoietin

Trends in Cell Biology

Volumn 15, Issue 3, 2005, Pages 146-155

  Richmond, Terri D ^a,b   Chohan, Manprit ^a,b   Barber, Dwayne L ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRUTON TYROSINE KINASE; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; JANUS KINASE 2; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN BCL 2; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING;

BURST FORMING UNIT E; CELL STIMULATION; CELL SURVIVAL; COLONY FORMING UNIT E; COLONY FORMING UNIT GEMM; ENZYME ACTIVATION; ERYTHROBLAST; ERYTHROCYTE; ERYTHROPOIESIS; GENE TARGETING; HEMATOPOIETIC STEM CELL; MYELOID PROGENITOR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RETICULOCYTE; REVIEW; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

EID: 14744299761     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2005.01.007     Document Type: Review

References (81)

1. H. Ludwig, and K. Strasser Symptomatology of anemia Semin. Oncol. 28 2001 7 14
2. H. Zhu Detecting and responding to hypoxia Nephrol. Dial. Transplant. 17 Suppl 1 2002 3 7
3. A.D. D'Andrea Expression cloning of the murine erythropoietin receptor Cell 57 1989 277 285
4. B.A. Witthuhn JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin Cell 74 1993 227 236
5. D.M. Wojchowski Signal transduction in the erythropoietin receptor system Exp. Cell Res. 253 1999 143 156
6. S.N. Constantinescu The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction Trends Endocrinol. Metab. 10 1999 18 23
7. J.Y. Cheung, and B.A. Miller Molecular mechanisms of erythropoietin signaling Nephron 87 2001 215 222
8. I.A. Wilson, and L.K. Jolliffe The structure, organization, activation and plasticity of the erythropoietin receptor Curr. Opin. Struct. Biol. 9 1999 696 704
9. K.F. Kubatzky Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor Curr. Biol. 11 2001 110 115
10. N. Seubert Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer Mol. Cell 12 2003 1239 1250
11. S.N. Constantinescu The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif Mol. Cell 7 2001 377 385
12. L.J. Huang The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor Mol. Cell 8 2001 1327 1338
13. H. Wu Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor Cell 83 1995 59 67
14. C.S. Lin Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis Genes Dev. 10 1996 154 164
15. M.W. Kieran Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor Proc. Natl. Acad. Sci. U. S. A. 93 1996 9126 9131
16. E. Parganas Jak2 is essential for signaling through a variety of cytokine receptors Cell 93 1998 385 395
17. H. Neubauer Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis Cell 93 1998 397 409
18. H. Zang The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis EMBO J. 20 2001 3156 3166
19. K. Li Attenuated signaling by a phosphotyrosine-null Epo receptor form in primary erythroid progenitor cells Blood 102 2003 3147 3153
20. X. Yu Erythropoietin receptor signalling is required for normal brain development Development 129 2002 505 516
21. H. Wu Inactivation of erythropoietin leads to defects in cardiac morphogenesis Development 126 1999 3597 3605
22. N. Suzuki Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality Blood 100 2002 2279 2288
23. A.C. Heinrich A mouse model for visualization and conditional mutations in the erythroid lineage Blood 104 2004 659 666
24. M. von Lindern The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro Blood 94 1999 550 559
25. S. Carotta Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells Blood 104 2004 1873 1880
26. P. Saharinen Regulation of the Jak2 tyrosine kinase by its pseudokinase domain Mol. Cell. Biol. 20 2000 3387 3395
27. J. Feng Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop Mol. Cell. Biol. 17 1997 2497 2501
28. L.S. Argetsinger Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity Mol. Cell. Biol. 24 2004 4955 4967
29. E.P. Feener Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling Mol. Cell. Biol. 24 2004 4968 4978
30. P.A. Tilbrook Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells EMBO J. 16 1997 1610 1619
31. E. Ingley Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis Oncogene 24 2004 336 343
32. U. Schmidt Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors J. Exp. Med. 199 2004 785 795
33. A. Halupa A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution Blood 105 2005 552 561
34. K. Kirito Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation Blood 99 2002 102 110
35. C.K. Lee STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation Immunity 17 2002 63 72
36. S. Teglund Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses Cell 93 1998 841 850
37. M. Socolovsky Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction Cell 98 1999 181 191
38. H.L. Bradley Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells Blood 100 2002 3983 3989
39. Y. Cui Inactivation of Stat in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival and differentiation Mol. Cell. Biol. 24 2004 8037 8047
40. D.L. Barber Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells Blood 89 1997 55 64
41. J.M. Mason The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor J. Biol. Chem. 275 2000 4398 4406
42. T. Tauchi Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis Blood 87 1996 4495 4501
43. R. Haq Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases J. Biol. Chem. 277 2002 17359 17366
44. S.M. Jacobs-Helber JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells Blood 96 2000 933 940
45. S. Uddin Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells Proc. Natl. Acad. Sci. U. S. A. 101 2004 147 152
46. K. Tamura Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis Cell 102 2000 221 231
47. H. Bao Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells) Blood 93 1999 3757 3773
48. H. Huddleston Functional p85alpha gene is required for normal murine fetal erythropoiesis Blood 102 2003 142 145
49. D. Bouscary Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation Blood 101 2003 3436 3443
50. Y. Kashii A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction Blood 96 2000 941 949
51. D.H. Castrillon Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a Science 301 2003 215 218
52. W.J. Bakker FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1 J. Cell Biol. 164 2004 175 184
53. N. Motoyama Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice Science 267 1995 1506 1510
54. K.U. Wagner Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly Development 127 2000 4949 4958
55. H. Dolznig Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblasts Curr. Biol. 12 2002 1076 1085
56. J.N. Ihle The Stat family in cytokine signaling Curr. Opin. Cell Biol. 13 2001 211 217
57. M. Socolovsky Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts Blood 98 2001 3261 3273
58. B.A. Miller Identification of the erythropoietin receptor domain required for calcium channel activation J. Biol. Chem. 274 1999 20465 20472
59. X. Chu Erythropoietin modulates calcium influx through TRPC2 J. Biol. Chem. 277 2002 34375 34382
60. X. Chu Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx J. Biol. Chem. 279 2004 10514 10522
61. L. Stowers Loss of sex discrimination and male-male aggression in mice deficient for TRP2 Science 295 2002 1493 1500
62. B.G. Leypold Altered sexual and social behaviors in trp2 mutant mice Proc. Natl. Acad. Sci. U. S. A. 99 2002 6376 6381
63. R. Starr A family of cytokine-inducible inhibitors of signalling Nature 387 1997 917 921
64. R. Ketteler The cytokine-inducible Src homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells J. Biol. Chem. 278 2003 2654 2660
65. A. Sasaki CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2 J. Biol. Chem. 275 2000 29338 29347
66. M. Hortner A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor Eur. J. Biochem. 269 2002 2516 2526
67. D. Ungureanu Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1 Mol. Cell. Biol. 22 2002 3316 3326
68. M.K. Sarna Differential regulation of SOCS genes in normal and transformed erythroid cells Oncogene 22 2003 3221 3230
69. J.C. Marine SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality Cell 98 1999 609 616
70. D. Metcalf Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1 Leukemia 13 1999 926 934
71. J.C. Marine SOCS3 is essential in the regulation of fetal liver erythropoiesis Cell 98 1999 617 627
72. A.W. Roberts Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3 Proc. Natl. Acad. Sci. U. S. A. 98 2001 9324 9329
73. B.G. Neel The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling Trends Biochem. Sci. 28 2003 284 293
74. U. Klingmuller Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals Cell 80 1995 729 738
75. T.M. Saxton Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2 EMBO J. 16 1997 2352 2364
76. C.K. Qu Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells Mol. Cell. Biol. 18 1998 6075 6082
77. J. Irie-Sasaki CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling Nature 409 2001 349 354
78. M.P. Myers TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B J. Biol. Chem. 276 2001 47771 47774
79. P.D. Simoncic The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3 Curr. Biol. 12 2002 446 453
80. C.D. Helgason Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span Genes Dev. 12 1998 1610 1620
81. J. Kalesnikoff The role of SHIP in cytokine-induced signaling Rev. Physiol. Biochem. Pharmacol. 149 2003 87 103