Hox cofactors in vertebrate development

Developmental Biology

Volumn 291, Issue 2, 2006, Pages 193-206

  Moens, Cecilia B ^a   Selleri, Licia ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Fly; Hexapeptide motif; Hox; Hox cofactors; Mouse; Pbx; Vertebrate development; Zebrafish

Indexed keywords

HOMEODOMAIN PROTEIN; HOX PROTEIN; TRANSCRIPTION FACTOR;

CELL PROLIFERATION; DNA BINDING; FISH; GENE ACTIVITY; GENE MUTATION; IN VITRO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; VERTEBRATE;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 33644976371     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2005.10.032     Document Type: Review

References (149)

1. M. Abu-Shaar, and R.S. Mann Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development Development 125 1998 3821 3830
2. M. Abu-Shaar, H.D. Ryoo, and R.S. Mann Control of the nuclear localization of Extradenticle by competing nuclear import and export signals Genes Dev. 13 1999 935 945
3. S. Aldaz, G. Morata, and N. Azpiazu Patterning function of homothorax/extradenticle in the thorax of Drosophila Development 132 2005 439 446
4. C. Alexandre, and J.P. Vincent Requirements for transcriptional repression and activation by Engrailed in Drosophila embryos Development 130 2003 729 739
5. T.D. Allen, Y.X. Zhu, T.S. Hawley, and R.G. Hawley TALE homeoproteins as HOX11-interacting partners in T-cell leukemia Leuk. Lymphoma 39 2000 241 256
6. B. Appel, and S. Sakonju Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products UBX and ABD-A in Drosophila embryos EMBO J. 12 1993 1099 1109
7. B.R. Arenkiel, P. Tvrdik, G.O. Gaufo, and M.R. Capecchi Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry Genes Dev. 18 2004 1539 1552
8. V. Azcoitia, M. Aracil, A.C. Martinez, and M. Torres The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo Dev. Biol. 280 2005 307 320
9. C.A. Berkes, D.A. Bergstrom, B.H. Penn, K.J. Seaver, P.S. Knoepfler, and S.J. Tapscott Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential Mol. Cell 14 2004 465 477
10. J. Berthelsen, V. Zappavigna, E. Ferretti, F. Mavilio, and F. Blasi The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity EMBO J. 17 1998 1434 1445
11. J. Berthelsen, C. Kilstrup-Nielsen, F. Blasi, F. Mavilio, and V. Zappavigna The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH Genes Dev. 13 1999 946 953
12. N. Beslu, J. Krosl, M. Laurin, N. Mayotte, K.R. Humphries, and G. Sauvageau Molecular interactions involved in HOXB4-induced activation of HSC self-renewal Blood 104 2004 2307 2314
13. J. Borrow, A.M. Shearman, V.P. Stanton Jr., R. Becher, T. Collins, A.J. Williams, I. Dube, F. Katz, Y.L. Kwong, C. Morris, K. Ohyashiki, K. Toyama, J. Rowley, and D.E. Housman The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9 Nat. Genet. 12 1996 159 167
14. A. Brendolan, E. Ferretti, V. Salsi, K. Moses, S. Quaggin, F. Blasi, M.L. Cleary, and L. Selleri A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny Development 132 2005 (Jul.) 3113 3126 (Erratum in: Development. 2005 Aug;132(15):3575)
15. N.M. Brooke, J. Garcia-Fernandez, and P.W. Holland The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster Nature 392 1998 920 922
16. T.R. Burglin Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals Nucleic Acids Res. 25 1997 4173 4180
17. T.R. Burglin The PBC domain contains a MEINOX domain: coevolution of Hox and TALE homeobox genes? Dev. Genes Evol. 208 1998 113 116
18. T.R. Burglin Homeodomain proteins R.A. Meyers Encyclopedia of Molecular Cell Biology and Molecular Medicine vol. 6 2005 Wiley-VCH 179 222
19. K.R. Calvo, D.B. Sykes, M. Pasillas, and M.P. Kamps Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression Mol. Cell. Biol. 20 2000 3274 3285
20. M.R. Capecchi Hox genes and mammalian development Cold Spring Harbor Symp. Quant. Biol. 62 1997 273 281
21. E.M. Carpenter, J.M. Goddard, O. Chisaka, N.R. Manley, and M.R. Capecchi Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain Development 118 1993 1063 1075
22. F. Casares, and R.S. Mann Control of antennal versus leg development in Drosophila Nature 392 1998 723 726
23. S.K. Chan, L. Jaffe, M. Capovilla, J. Botas, and R.S. Mann The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein Cell 78 1994 603 615
24. S.K. Chan, H.D. Ryoo, A. Gould, R. Krumlauf, and R.S. Mann Switching the in vivo specificity of a minimal Hox-responsive element Development 124 1997 2007 2014
25. C.P. Chang, W.F. Shen, S. Rozenfeld, H.J. Lawrence, C. Largman, and M.L. Cleary Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins Genes Dev. 9 1995 663 674
26. C.P. Chang, Y. Jacobs, T. Nakamura, N.A. Jenkins, N.G. Copeland, and M.L. Cleary Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins Mol. Cell. Biol. 17 1997 5679 5687
27. F. Chen, and M.R. Capecchi Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions Dev. Biol. 181 1997 186 196
28. H. Chen, C. Rossier, Y. Nakamura, A. Lynn, A. Chakravarti, and S.E. Antonarakis Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3 Genomics 41 1997 193 200
29. S.K. Choe, N. Vlachakis, and C.G. Sagerstrom Meis family proteins are required for hindbrain development in the zebrafish Development 129 2002 585 595
30. B.G. Condie, and M.R. Capecchi Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions Nature 370 1994 304 307
31. K.L. Cooper, W.M. Leisenring, and C.B. Moens Autonomous and nonautonomous functions for Hox/Pbx in branchiomotor neuron development Dev. Biol. 253 2003 200 213
32. T.N. Dear, I. Sanchez-Garcia, and T.H. Rabbitts The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes Proc. Natl. Acad. Sci. U. S. A. 90 1993 4431 4435
33. T.N. Dear, W.H. Colledge, M.B. Carlton, I. Lavenir, T. Larson, A.J. Smith, A.J. Warren, M.J. Evans, M.V. Sofroniew, and T.H. Rabbitts The Hox11 gene is essential for cell survival during spleen development Development 121 1995 2909 2915
34. G. Deflorian, N. Tiso, E. Ferretti, D. Meyer, F. Blasi, M. Bortolussi, and F. Argenton Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation Development 131 2004 613 627
35. Di Giacomo, G., Koss, M., Capellini, T.D., Brendolan, A., Popperl, H., Selleri, L., in press. Spatio-temporal expression of Pbx3 during mouse organogenesis. Gene Expr. Patterns.
36. J.F. DiMartino, L. Selleri, D. Traver, M.T. Firpo, J. Rhee, R. Warnke, S. O'Gorman, I.L. Weissman, and M.L. Cleary The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver Blood 98 2001 618 626
37. P.D. Dong, J. Chu, and G. Panganiban Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity Development 127 2000 209 216
38. D. Duboule Vertebrate Hox genes and proliferation: an alternative pathway to homeosis? Curr. Opin. Genet. Dev. 5 1995 525 528
39. A. Ebner, C. Cabernard, M. Affolter, and S. Merabet Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex Development 132 2005 1591 1600
40. B. Favier, F.M. Rijli, C. Fromental-Ramain, V. Fraulob, P. Chambon, and P. Dolle Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton Development 122 1996 449 460
41. E. Ferretti, H. Marshall, H. Popperl, M. Maconochie, R. Krumlauf, and F. Blasi Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins Development 127 2000 155 166
42. N.A. Fischbach, S. Rozenfeld, W. Shen, S. Fong, D. Chrobak, D. Ginzinger, S.C. Kogan, A. Radhakrishnan, M.M. Le Beau, C. Largman, and H.J. Lawrence HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo Blood 105 2005 1456 1466
43. M. Frasch, X. Chen, and T. Lufkin Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila Development 121 1995 957 974
44. R. Galant, C.M. Walsh, and S.B. Carroll Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites Development 129 2002 3115 3126
45. A. Gavalas, M. Davenne, A. Lumsden, P. Chambon, and F.M. Rijli Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning Development 124 1997 3693 3702
46. B. Gebelein, D.J. McKay, and R.S. Mann Direct integration of Hox and segmentation gene inputs during Drosophila development Nature 431 2004 653 659
47. M. Gendron-Maguire, M. Mallo, M. Zhang, and T. Gridley Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest Cell 75 1993 1317 1331
48. D.J. Goff, and C.J. Tabin Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth Development 124 1997 627 636
49. A. Gould, N. Itasaki, and R. Krumlauf Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway Neuron 21 1998 39 51
50. M. Hatano, C.W. Roberts, M. Minden, W.M. Crist, and S.J. Korsmeyer Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia Science 253 1991 79 82
51. B.M. Hersh, and S.B. Carroll Direct regulation of knot gene expression by Ultrabithorax and the evolution of cis-regulatory elements in Drosophila Development 132 2005 1567 1577
52. T. Hisa, S.E. Spence, R.A. Rachel, M. Fujita, T. Nakamura, J.M. Ward, D.E. Devor-Henneman, Y. Saiki, H. Kutsuna, L. Tessarollo, N.A. Jenkins, and N.G. Copeland Hematopoietic, angiogenic and eye defects in Meis1 mutant animals EMBO J. 23 2004 450 459
53. T. Hoey, and M. Levine Divergent homeo box proteins recognize similar DNA sequences in Drosophila Nature 332 1988 858 861
54. J.C. Hombria, and B. Lovegrove Beyond homeosis-HOX function in morphogenesis and organogenesis Differentiation 71 2003 461 476
55. P.M. In der Rieden, G. Mainguy, J.M. Woltering, and A.J. Durston Homeodomain to hexapeptide or PBC-interaction-domain distance: size apparently matters Trends Genet. 20 2004 76 79
56. Y. Jacobs, C.A. Schnabel, and M.L. Cleary Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity Mol. Cell. Biol. 19 1999 5134 5142
57. T.J. Jaw, L.R. You, P.S. Knoepfler, L.C. Yao, C.Y. Pai, C.Y. Tang, L.P. Chang, J. Berthelsen, F. Blasi, M.P. Kamps, and Y.H. Sun Direct interaction of two homeoproteins, homothorax and extradenticle, is essential for EXD nuclear localization and function Mech. Dev. 91 2000 279 291
58. J. Jonsson, L. Carlsson, T. Edlund, and H. Edlund Insulin-promoter-factor 1 is required for pancreas development in mice Nature 371 1994 606 609
59. R. Josephson, T. Muller, J. Pickel, S. Okabe, K. Reynolds, P.A. Turner, A. Zimmer, and R.D. McKay POU transcription factors control expression of CNS stem cell-specific genes Development 125 1998 3087 3100
60. M.P. Kamps, C. Murre, X.H. Sun, and D. Baltimore A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL Cell 60 1990 547 555
61. M.A. Kennedy, R. Gonzalez-Sarmiento, U.R. Kees, F. Lampert, N. Dear, T. Boehm, and T.H. Rabbitts HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24 Proc. Natl. Acad. Sci. U. S. A. 88 1991 8900 8904
62. S.K. Kim, L. Selleri, J.S. Lee, A.Y. Zhang, X. Gu, Y. Jacobs, and M.L. Cleary Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus Nat. Genet. 30 2002 430 435
63. P.S. Knoepfler, and M.P. Kamps The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1 Mol. Cell. Biol. 15 1995 5811 5819
64. P.S. Knoepfler, K.R. Calvo, H. Chen, S.E. Antonarakis, and M.P. Kamps Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 Proc. Natl. Acad. Sci. U. S. A. 94 1997 14553 14558
65. P.S. Knoepfler, D.A. Bergstrom, T. Uetsuki, I. Dac-Korytko, Y.H. Sun, W.E. Wright, S.J. Tapscott, and M.P. Kamps A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 Nucleic Acids Res. 27 1999 3752 3761
66. P.S. Knoepfler, D.B. Sykes, M. Pasillas, and M.P. Kamps HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation Oncogene 20 2001 5440 5448
67. M. Kobayashi, M. Fujioka, E.N. Tolkunova, D. Deka, M. Abu-Shaar, R.S. Mann, and J.B. Jaynes Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila Development 130 2003 741 751
68. D. Kostic, and M.R. Capecchi Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column Mech. Dev. 46 1994 231 247
69. J. Krosl, S. Baban, G. Krosl, S. Rozenfeld, C. Largman, and G. Sauvageau Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1 Oncogene 16 1998 3403 3412
70. R. Krumlauf Hox genes in vertebrate development Cell 78 1994 191 201
71. N.A. LaRonde-LeBlanc, and C. Wolberger Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior Genes Dev. 17 2003 2060 2072
72. H.J. Lawrence, C.D. Helgason, G. Sauvageau, S. Fong, D.J. Izon, R.K. Humphries, and C. Largman Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis Blood 89 1997 1922 1930
73. E. Longobardi, and F. Blasi Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation J. Biol. Chem. 278 2003 39235 39241
74. C.A. Loomis, E. Harris, J. Michaud, W. Wurst, M. Hanks, and A.L. Joyner The mouse Engrailed-1 gene and ventral limb patterning Nature 382 1996 360 363
75. A. Lumsden, and R. Krumlauf Patterning the vertebrate neuraxis Science 274 1996 1109 1115
76. M.K. Maconochie, S. Nonchev, M. Studer, S.K. Chan, H. Popperl, M.H. Sham, R.S. Mann, and R. Krumlauf Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1 Genes Dev. 11 1997 1885 1895
77. I. Manfroid, X. Caubit, S. Kerridge, and L. Fasano Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene Development 131 2004 1065 1073
78. N.R. Manley, and M.R. Capecchi Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands Dev. Biol. 195 1998 1 15
79. N.R. Manley, L. Selleri, A. Brendolan, J. Gordon, and M.L. Cleary Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs Dev. Biol. 276 2004 301 312
80. R.S. Mann The specificity of homeotic gene function BioEssays 17 1995 855 863
81. R.S. Mann, and M. Affolter Hox proteins meet more partners Curr. Opin. Genet. Dev. 8 1998 423 429
82. R.S. Mann, and S.K. Chan Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins Trends Genet. 12 1996 258 262
83. R.S. Mann, and G. Morata The developmental and molecular biology of genes that subdivide the body of Drosophila Annu. Rev. Cell Dev. Biol. 16 2000 243 271
84. M. Manzanares, S. Bel-Vialar, L. Ariza-McNaughton, E. Ferretti, H. Marshall, M.M. Maconochie, F. Blasi, and R. Krumlauf Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms Development 128 2001 3595 35607
85. M. Mark, T. Lufkin, J.L. Vonesch, E. Ruberte, J.C. Olivo, P. Dolle, P. Gorry, A. Lumsden, and P. Chambon Two rhombomeres are altered in Hoxa-1 mutant mice Development 119 1993 319 338
86. J.M. McClintock, M.A. Kheirbek, and V.E. Prince Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention Development 129 2002 2339 2354
87. C.L. McNulty, J.N. Peres, N. Bardine, W.M. van den Akker, and A.J. Durston Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects Development 132 2005 2861 2871
88. O. Medina-Martinez, and R. Ramirez-Solis In vivo mutagenesis of the Hoxb8 hexapeptide domain leads to dominant homeotic transformations that mimic the loss-of-function mutations in genes of the Hoxb cluster Dev. Biol. 264 2003 77 90
89. S. Merabet, Z. Kambris, M. Capovilla, H. Berenger, J. Pradel, and Y. Graba The hexapeptide and linker regions of the AbdA Hox protein regulate its activating and repressive functions Dev. Cell 4 2003 761 768
90. N. Mercader, E. Leonardo, N. Azpiazu, A. Serrano, G. Morata, C. Martinez, and M. Torres Conserved regulation of proximodistal limb axis development by Meis1/Hth Nature 402 1999 425 429
91. K. Monica, N. Galili, J. Nourse, D. Saltman, and M.L. Cleary PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 Mol. Cell. Biol. 11 1991 6149 6157
92. J.J. Moskow, F. Bullrich, K. Huebner, I.O. Daar, and A.M. Buchberg Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice Mol. Cell. Biol. 15 1995 5434 5443
93. T. Nakamura, D.A. Largaespada, M.P. Lee, L.A. Johnson, K. Ohyashiki, K. Toyama, S.J. Chen, C.L. Willman, I.M. Chen, A.P. Feinberg, N.A. Jenkins, N.G. Copeland, and J.D. Shaughnessy Jr. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia Nat. Genet. 12 1996 154 158
94. S.T. Neuteboom, L.T. Peltenburg, M.A. van Dijk, and C. Murre The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins Proc. Natl. Acad. Sci. U. S. A. 92 1995 9166 9170
95. S. Nonchev, M. Maconochie, A. Gould, A. Morrison, and R. Krumlauf Cross-regulatory interactions between Hox genes and the control of segmental expression in the vertebrate central nervous system Cold Spring Harbor Symp. Quant. Biol. 62 1997 313 323
96. J. Nourse, J.D. Mellentin, N. Galili, J. Wilkinson, E. Stanbridge, S.D. Smith, and M.L. Cleary Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor Cell 60 1990 535 545
97. M.F. Offield, T.L. Jetton, P.A. Labosky, M. Ray, R.W. Stein, M.A. Magnuson, B.L. Hogan, and C.V. Wright PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum Development 122 1996 983 995
98. B.M. Owens, and R.G. Hawley HOX and non-HOX homeobox genes in leukemic hematopoiesis Stem Cells 20 2002 364 379
99. G. Panganiban, and J.L. Rubenstein Developmental functions of the Distal-less/Dlx homeobox genes Development 129 2002 4371 4386
100. J.M. Passner, H.D. Ryoo, L. Shen, R.S. Mann, and A.K. Aggarwal Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex Nature 397 1999 714 719
101. J.A. Pederson, J.W. LaFollette, C. Gross, A. Veraksa, W. McGinnis, and J.W. Mahaffey Regulation by homeoproteins: a comparison of deformed-responsive elements Genetics 156 2000 677 686
102. B. Peers, S. Sharma, T. Johnson, M. Kamps, and M. Montminy The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain Mol. Cell. Biol. 15 1995 7091 7097
103. M. Peifer, and E. Wieschaus Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity Genes Dev. 4 1990 1209 1223
104. L.T. Peltenburg, and C. Murre Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx EMBO J. 15 1996 3385 3393
105. M.L. Phelan, I. Rambaldi, and M.S. Featherstone Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif Mol. Cell. Biol. 15 1995 3989 3997
106. J. Pinsonneault, B. Florence, H. Vaessin, and W. McGinnis A model for extradenticle function as a switch that changes HOX proteins from repressors to activators EMBO J. 16 1997 2032 2042
107. D.E. Piper, A.H. Batchelor, C.P. Chang, M.L. Cleary, and C. Wolberger Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation Cell 96 1999 587 597
108. H. Popperl, M. Bienz, M. Studer, S.K. Chan, S. Aparicio, S. Brenner, R.S. Mann, and R. Krumlauf Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx Cell 81 1995 1031 1042
109. H. Popperl, H. Rikhof, H. Chang, P. Haffter, C.B. Kimmel, and C.B. Moens Lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish Mol. Cell 6 2000 255 267
110. C. Rauskolb, and E. Wieschaus Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins EMBO J. 13 1994 3561 3569
111. C. Rauskolb, M. Peifer, and E. Wieschaus Extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1 Cell 74 1993 1101 1112
112. C. Rauskolb, K.M. Smith, M. Peifer, and E. Wieschaus extradenticle determines segmental identities throughout Drosophila development Development 121 1995 3663 3673
113. N. Rave-Harel, M.L. Givens, S.B. Nelson, H.A. Duong, D. Coss, M.E. Clark, S.B. Hall, M.P. Kamps, and P.L. Mellon TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1 J. Biol. Chem. 279 2004 30287 30297
114. S. Remacle, C. Shaw-Jackson, C. Matis, X. Lampe, J. Picard, and R. Rezsohazy Changing homeodomain residues 2 and 3 of Hoxa1 alters its activity in a cell-type and enhancer dependent manner Nucleic Acids Res. 30 2002 2663 2668
115. S. Remacle, L. Abbas, O. De Backer, N. Pacico, A. Gavalas, F. Gofflot, J.J. Picard, and R. Rezsohazy Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo Mol. Cell. Biol. 24 2004 8567 8575
116. J.W. Rhee, A. Arata, L. Selleri, Y. Jacobs, S. Arata, H. Onimaru, and M.L. Cleary Pbx3 deficiency results in central hypoventilation Am. J. Pathol. 165 2004 1343 1350
117. G.E. Rieckhof, F. Casares, H.D. Ryoo, M. Abu-Shaar, and R.S. Mann Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein Cell 91 1997 171 183
118. F.M. Rijli, M. Mark, S. Lakkaraju, A. Dierich, P. Dolle, and P. Chambon A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene Cell 75 1993 1333 1349
119. C.W. Roberts, J.R. Shutter, and S.J. Korsmeyer Hox11 controls the genesis of the spleen Nature 368 1994 747 749
120. L.K. Robertson, D.B. Bowling, J.P. Mahaffey, B. Imiolczyk, and J.W. Mahaffey An interactive network of zinc-finger proteins contributes to regionalization of the Drosophila embryo and establishes the domains of HOM-C protein function Development 131 2004 2781 2789
121. H.D. Ryoo, and R.S. Mann The control of trunk Hox specificity and activity by Extradenticle Genes Dev. 13 1999 1704 1716
122. H.D. Ryoo, T. Marty, F. Casares, M. Affolter, and R.S. Mann Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex Development 126 1999 5137 5148
123. M. Saleh, I. Rambaldi, X.J. Yang, and M.S. Featherstone Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases Mol. Cell. Biol. 20 2000 8623 8633
124. O.A. Samad, M.J. Geisen, G. Caronia, I. Varlet, V. Zappavigna, J. Ericson, C. Goridis, and F.M. Rijli Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins Development 131 2004 4071 4083
125. G. Sauvageau, U. Thorsteinsdottir, M.R. Hough, P. Hugo, H.J. Lawrence, C. Largman, and R.K. Humphries Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation Immunity 6 1997 13 22
126. C.A. Schnabel, Y. Jacobs, and M.L. Cleary HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis Oncogene 19 2000 608 616
127. C.A. Schnabel, L. Selleri, Y. Jacobs, R. Warnke, and M.L. Cleary Expression of Pbx1b during mammalian organogenesis Mech. Dev. 100 2001 131 135
128. S. Scholpp, C. Lohs, and M. Brand Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon Development 130 2003 4881 4893
129. L. Selleri, M.J. Depew, Y. Jacobs, S.K. Chanda, K.Y. Tsang, K.S. Cheah, J.L. Rubenstein, S. O'Gorman, and M.L. Cleary Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation Development 128 2001 3543 3557
130. L. Selleri, J. DiMartino, J. van Deursen, A. Brendolan, M. Sanyal, E. Boon, T. Capellini, K.S. Smith, J. Rhee, H. Popperl, G. Grosveld, and M.L. Cleary The TALE homeodomain protein Pbx2 is not essential for development and long-term survival Mol. Cell. Biol. 24 2004 5324 5331
131. N. Serrano, and F. Maschat Molecular mechanism of polyhomeotic activation by Engrailed EMBO J. 17 1998 3704 3713
132. W.F. Shen, C.P. Chang, S. Rozenfeld, G. Sauvageau, R.K. Humphries, M. Lu, H.J. Lawrence, M.L. Cleary, and C. Largman Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA Nucleic Acids Res. 24 1996 898 906
133. W.F. Shen, J.C. Montgomery, S. Rozenfeld, J.J. Moskow, H.J. Lawrence, A.M. Buchberg, and C. Largman AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins Mol. Cell. Biol. 17 1997 6448 6458
134. W. Shen, D. Chrobak, K. Krishnan, H.J. Lawrence, and C. Largman HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process J. Biol. Chem. 279 2004 39895 39904
135. S. Shirasawa, A. Arata, H. Onimaru, K.A. Roth, G.A. Brown, S. Horning, S. Arata, K. Okumura, T. Sasazuki, and S.J. Korsmeyer Rnx deficiency results in congenital central hypoventilation Nat. Genet. 24 2000 287 290
136. M. Studer, A. Lumsden, L. Ariza-McNaughton, A. Bradley, and R. Krumlauf Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1 Nature 384 1996 630 634
137. M. Studer, A. Gavalas, H. Marshall, L. Ariza-McNaughton, F.M. Rijli, P. Chambon, and R. Krumlauf Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning Development 125 1998 1025 1036
138. U. Thorsteinsdottir, G. Sauvageau, M.R. Hough, W. Dragowska, P.M. Lansdorp, H.J. Lawrence, C. Largman, and R.K. Humphries Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia Mol. Cell. Biol. 17 1997 495 505
139. U. Thorsteinsdottir, J. Krosl, E. Kroon, A. Haman, T. Hoang, and G. Sauvageau The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells Mol. Cell. Biol. 19 1999 6355 6366
140. N. Vlachakis, S.K. Choe, and C.G. Sagerstrom Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish Development 128 2001 1299 1312
141. K. Wagner, A. Mincheva, B. Korn, P. Lichter, and H. Popperl Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis Mech. Dev. 103 2001 127 131
142. A.J. Waskiewicz, H.A. Rikhof, R.E. Hernandez, and C.B. Moens Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning Development 128 2001 4139 4151
143. A.J. Waskiewicz, H.A. Rikhof, and C.B. Moens Eliminating zebrafish pbx proteins reveals a hindbrain ground state Dev. Cell 3 2002 723 733
144. T.M. Williams, M.E. Williams, and J.W. Innis Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction Dev. Biol. 277 2005 457 471
145. C.V. Wright Hox genes and the hindbrain Curr. Biol. 3 1993 618 621
146. L. Yang, M. Sym, and C. Kenyon The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development Development 132 2005 1413 1428
147. Y. Yaron, J.K. McAdara, M. Lynch, E. Hughes, and J.C. Gasson Identification of novel functional regions important for the activity of HOXB7 in mammalian cells J. Immunol. 166 2001 5058 5067
148. H.H. Yu, and C.B. Moens Semaphorin signaling guides cranial neural crest cell migration in zebrafish Dev. Biol. 280 2005 373 385
149. Y.G. Yueh, D.P. Gardner, and C. Kappen Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8 Proc. Natl. Acad. Sci. U. S. A. 95 1998 9956 9961