The control of trunk Hox specificity and activity by extradenticle

Genes and Development

Volumn 13, Issue 13, 1999, Pages 1704-1716

  Ryoo, Hyung Don ^a   Mann, Richard S ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Cooperative DNA binding; Extradenticle; Hox specificity; Pbx

Indexed keywords

AMINO ACID; DNA; PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BASE PAIRING; BINDING SITE; CELLULAR DISTRIBUTION; DEVELOPMENT; DNA BINDING; DROSOPHILA; EMBRYO; GENE; NONHUMAN; PRIORITY JOURNAL;

EID: 0008231153     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.13.1704     Document Type: Article

References (68)

1. Abu-Shaar, M. and R.S. Mann. 1998. Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development 125: 3821-3830.
2. Abu-Shaar, M., H.D. Ryoo, and R.S. Mann. 1999. Control of the nuclear localization of Extradenticle by competing localization and export signals. Genes & Dev. 13: 935-945.
3. Andrew, D.J. 1998. Regulation and formation of the Drosophila salivary glands. Ann. N.Y. Acad. Sci. 15: 55-69.
4. Aspland, S.E. and R.A. White. 1997. Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila. Development 124: 741-747.
5. Azpiazu, N. and G. Morata. 1998. Functional and regulatory interactions between Hox and extradenticle genes. Genes & Dev. 12: 261-273.
6. Biggin, M. and W. McGinnis. 1997. Regulation of segmentation and segmental identity by Drosophila homeoproteins: The role of DNA-binding in functional activity and specificity. Development 124: 4425-4433.
7. Brand, A. and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
8. Burglin, T.R. and G. Ruvkun. 1992. New motif in PBX genes. Nat. Genet. 1: 319-320.
9. Carr, A. and M.D. Biggin. 1999. A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA-binding in Drosophila embryos. EMBO J. 18: 1598-1608.
10. Casanova, J., E. Sanchez-Herrero, A. Busturia, and G. Morata. 1987. Double and triple mutant combinations of the bithorax complex of Drosophila. EMBO J. 6: 3103-3109.
11. Casares, F. and R.S. Mann. 1998. Control of antennal versus leg development in Drosophila. Nature 392: 723-726.
12. Chan, S.-K. and R.S. Mann. 1993. The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences. Genes & Dev. 7: 796-811.
13. _. 1996. A structural model for an extradenticle-HOX-DNA complex accounts for the choice of HOX protein in the heterodimer. Proc. Natl. Acad. Sci. 93: 5223-5228.
14. Chan, S.-K., H.D. Ryoo, L. Jaffe, M. Capovilla, J. Botas, and R.S. Mann. 1994. The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell 78: 603-615.
15. Chan, S.-K., H. Pöpperl, R. Krumlauf, and R.S. Mann. 1996. An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif. EMBO J. 15: 2477-2488.
16. Chan, S.-K., A. Gould, R. Krumlauf, and R. Mann. 1997. Switching the in vivo specificity of a minimal Hox-responsive element. Development 124: 2007-2014.
17. Chang, C.-P., L. Brocchieri, W.-F. Shen, C. Largman, and M. Cleary. 1996. Pbx modulation of box homeodomain amino-terminal arms establishes different DNA-binding specificities across the HOX locus. Mol. Cell. Biol. 16: 1734-1745.
18. Condie, J.M., J.A. Mustard, and D. Brower. 1991. Generation of anti-Antennapedia monoclonal antibodies and Antennapedia protein expression in imaginal discs. Dros. Inf. Serv. 70: 52-54.
19. Dearolf, C.R., J. Ropol, and C.S. Parker. 1989. The caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis. Nature 341: 340-343.
20. Ekker, S.C., D.G. Jackson, D.P. von Kessler, B.I. Sun, K.E. Young, and P.A. Beachy. 1994. The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J. 13: 3551-3560.
21. Fraenkel, E. and C.O. Pabo. 1998. Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex. Nat. Struct. Biol. 5: 692-697.
22. Furukubo-Tokunaga, K., S. Flister, and W.J. Gehring. 1993. Functional specificity of the Antennapedia homeodomain. Proc. Natl. Acad. Sci. 90: 6360-6364.
23. Gibson, G., A. Schier, P. LeMotte, and W.J. Gehring. 1990. The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell 62: 1087-1103.
24. Gonzalez-Crespo, S. and G. Morata. 1995. Control of Drosophila adult pattern by extradenticle. Development 121: 2117-2125.
25. Graba, Y., D. Aragnol, and J. Pradel. 1997. Drosophila Hox complex downstream targets and the function of homeotic genes. BioEssays 19: 379-388.
26. Grieder, N., T. Marty, H.-D. Ryoo, R.S. Mann, and M. Affolter. 1997. Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling. EMBO J. 16: 7402-7410.
27. Hirsch, J. and A. Aggarwal. 1995. Structure of the Even-skipped homeodomain complexed to AT-rich DNA: New perspectives on homeodomain specificity. EMBO J. 14: 6280-6291.
28. Jaffe, L., H.D. Ryoo, and R.S. Mann. 1997. A role for phosphorylation by casein kinase 2 in modulating Antennapedia function in Drosophila. Genes & Dev. 11: 1327-1340.
29. Karch, F., W. Bender, and B. Weiffenbach. 1990. abdA expression in Drosophila embryos. Genes & Dev. 4: 1573-1587.
30. Kissinger, C.R., B. Liu, E. Martin-Blanco, T.B. Kornberg, and C.O. Pabo. 1990. Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions. Cell 63: 579-590.
31. Knoepfler, P. and M. Kamps. 1995. The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1. Mol. Cell. Biol. 15: 5811-5819.
32. Kuo, Y.M., N. Jones, B. Zhou, S. Panzer, V. Larson, and S.K. Beckendorf. 1996. Salivary duct determination in Drosophila: Roles of the EGF receptor signalling pathway and the transcription factors fork head and trachealess. Development 122: 1909-1917.
33. Kuziora, M.A. and W. McGinnis. 1989. A homeodomain substitution changes the regulatory specificity of the deformed protein in Drosophila embryos. Cell 59: 563-571.
34. Li, X., C. Murre, and W. McGinnis. 1999. Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation. EMBO J. 18: 198-211.
35. Liang, Z. and M.D. Biggin. 1998. Eve and Ftz regulate a wide array of genes in blastoderm embryos: The selector homeoproteins directly or indirectly regulate most genes in Drosophila. Development 125: 4471-4482.
36. Lin, L. and W. McGinnis. 1992. Mapping functional specificity in the Dfd and Ubx homeo domains. Genes & Dev. 6: 1071-1081.
37. Lu, Q., P. Knoepfler, J. Scheele, D. Wright, and M. Kamps. 1995. Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAAT-CAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell. Biol. 15: 3786-3795.
38. Macdonald, P.M. and G. Struhl. 1986. A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature 324: 537-545.
39. Mann, R.S. and D.S. Hogness. 1990. Functional dissection of Ultrabithorax proteins in D. melanogaster. Cell 60: 597-610.
40. Mann, R. and M. Abu-Shaar. 1996. Nuclear import of the homeodomain protein Extradenticle in response to Decapentaplegic and Wingless signalling. Nature 383: 630-633.
41. Mann, R.S. and S.-K. Chan. 1996. Extra specificity from extradenticle: The partnership between HOX and exd/Pbx homeodomain proteins. Trends Genet. 12: 258-262.
42. McGinnis, W. and R. Krumlauf. 1992. Homeobox genes and axial patterning. Cell 68: 283-302.
43. Mlodzik, M. and W.J. Gehring. 1987. Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis. Cell 48: 465-478.
44. Neuteboom, S.T. and C. Murre. 1997. Pbx raises the DNA-binding specificity but not the selectivity of antennapedia Hox proteins. Mol. Cell. Biol. 17: 4696-4706.
45. Pai, C.-Y., T. Kuo, T. Jaw, E. Kurant, C. Chen, D. Bessarab, A. Salzberg, and Y. Sun. 1998. The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila. Genes & Dev. 12: 435-446.
46. Panzer, S., D. Weigel, and S.K. Beckendorf. 1992. Organogenesis in Drosophila melanogaster: Embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes. Development 114: 49-57.
47. Passner, J.M., H.D. Ryoo, L. Shen, R.S. Mann, and A.K. Aggarwal. 1999. Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 397: 714-718.
48. Pattatucci, A.M. and T.C. Kaufman. 1991. The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development. Genetics 129: 443-461.
49. Peifer, M. and E. Wieschaus. 1990. Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity. Genes & Dev. 4: 1209-1223.
50. Percival-Smith, A., J. Weber, E. Gilfoyle, and P. Wilson. 1998. Genetic characterization of the role of the two HOX proteins, Proboscipedia and Sex Combs Reduced, in determination of adult antennal, tarsal, maxillary palp and proboscis identities in Drosophila melanogaster. Development 124: 5049-5062.
51. Phelan, M.L. and M.S. Featherstone. 1997. Distinct HOX amino-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers. J. Biol. Chem. 272: 8635-8643.
52. Phelan, M.L., R. Sadoul, and M.S. Featherstone. 1994. Functional differences between HOX proteins conferred by two residues in the homeodomain amino-terminal arm. Mol. Cell. Biol. 14: 5066-5075.
53. Pinsonneault, J., B. Florence, H. Vaessin, and W. McGinnis. 1997. A model for extradenticle function as a switch that changes HOX proteins from repressors to activators. EMBO J. 16: 2032-2042.
54. Piper, D.E., A.H. Batchelor, C.-P. Chang, M.L. Cleary, and C. Wolberger. 1999. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell 96: 587-597.
55. Pirrotta, V. 1988. Vectors for P-mediated transformation in Drosophila. In Vectors, a survey of molecular cloning vectors their uses (ed. R.L. Rodriguez and D.T. Denhardt), pp. 437-456. Butterworth, Boston, MA.
56. Pöpperl, H., M. Bienz, M. Studer, S.-K. Chan, S. Aparicio, S. Brenner, R. Mann, and R. Krumlauf. 1995. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx. Cell 81: 1031-1042.
57. Rauskolb, C. and E. Wieschaus. 1994. Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. EMBO J. 13: 3561-3569.
58. Rauskolb, C., M. Peifer, and E. Wieschaus. 1993. extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell 74: 1-20.
59. Rauskolb, C., K. Smith, M. Peifer, and E. Wieschaus. 1995. extradenticle determines segmental identities throughout development. Development 121: 3663-3671.
60. Rieckhof, G., F. Casares, H.D. Ryoo, M. Abu-Shaar, and R.S. Mann. 1997. Nuclear translocation of Extradenticle requires homothorax, which encodes an Extradenticle-related homeodomain protein. Cell 91: 171-183.
61. Shen, W.F., C.P. Chang, S. Rozenfeld, G. Sauvageau, R.K. Humphries, M. Lu, H.J. Lawrence, M.L. Cleary, and C. Largman. 1996. Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA. Nucleic Acids Res. 24: 898-906.
62. Struhl, G. 1982. Genes controlling segmental specification in the Drosophila thorax. Proc. Natl. Acad. Sci. 79: 7380-7384.
63. Struhl, G. and R.A. White. 1985. Regulation of the Ultrabithorax gene of Drosophila by other bithorax complex genes. Cell 43: 507-519.
64. Walter, J., C. Dever, and M.D. Biggin. 1994. Two homeodomain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos. Genes & Dev. 8: 1678-1692.
65. White, R.A.H. and M. Wilcox. 1985. Distribution of Ultrabithorax proteins in Drosophila. EMBO J. 4: 2035-2043.
66. Wilson, D. and C. Desplan. 1999. The structural basis for Hox specificity revealed: A molecular 'menage-â-trois'. Nat. Struct. Biol. 6: 297-300.
67. Wolberger, C., A.K. Vershon, B. Liu, A.D. Johnson, and C.O. Pabo. 1991. Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell 67: 517-528.
68. Zeng, W., D.J. Andrew, L.D. Mathies, M.A. Horner, and M.P. Scott. 1993. Ectopic expression and function of the Antp and Scr homeotic genes: The N terminus of the homeodomian is critical to functional specificity. Development 118: 339-352.