Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential

Molecular Cell

Volumn 14, Issue 4, 2004, Pages 465-477

  Berkes, Charlotte A ^a,b   Bergstrom, Donald A ^a,c   Penn, Bennett H ^a,b   Seaver, Karen J ^a   Knoepfler, Paul S ^a   Tapscott, Stephen J ^a,b,c  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; MYOD PROTEIN; MYOGENIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHROMATIN; EMBRYO; FIBROBLAST; GENE LOCUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION;

ANIMALS; BASE SEQUENCE; BINDING SITES; BODY PATTERNING; CELL DIFFERENTIATION; CELL LINEAGE; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC MARKERS; HOMEODOMAIN PROTEINS; MACROMOLECULAR SUBSTANCES; MICE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; MYOD PROTEIN; NIH 3T3 CELLS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 2442575665     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(04)00260-6     Document Type: Article

References (48)

1. Amacher S.L., Buskin J.N., Hauschka S.D. Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle. Mol. Cell. Biol. 13:1993;2753-2764
2. Asahara H., Dutta S., Kao H.Y., Evans R.M., Montminy M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol. Cell. Biol. 19:1999;8219-8225
3. Bergstrom D.A., Tapscott S.J. Molecular distinction between specification and differentiation in the myogenic basic helix-loop-helix transcription factor family. Mol. Cell. Biol. 21:2001;2404-2412
4. Bergstrom D.A., Penn B.H., Strand A., Perry R.L.S., Rudnicki M.A., Tapscott S.J. Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression. Mol. Cell. 9:2002;587-600
5. Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H.H. A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. EMBO J. 8:1989;701-709
6. Calvo K.R., Knoepfler P.S., Sykes D.B., Pasillas M.P., Kamps M.P. Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF. potential mechanisms or cooperativity with Hoxa9 in myeloid leukemia Proc. Natl. Acad. Sci. USA. 98:2001;13120-13125
7. Casares F., Mann R.S. Control of antennal versus leg development in Drosophila. Nature. 392:1998;723-726
8. Chang C.P., Jacobs Y., Nakamura T., Jenkins N.A., Copeland N.G., Cleary M.L. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol. 17:1997;5679-5687
9. Cirillo L.A., Lin F.R., Cuesta I., Friedman D., Jarnik M., Zaret K.S. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol. Cell. 9:2002;279-289
10. Davis R.L., Cheng P.F., Lassar A.B., Weintraub H. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell. 60:1990;733-746
11. Edmondson D.G., Olson E.N. A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program. Genes Dev. 3:1989;628-640
12. Ekker S.C., Jackson D.G., von Kessler D.P., Sun B.I., Young K.E., Beachy P.A. The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J. 13:1994;3551-3560
13. Filippova G.N., Thienes C.P., Penn B.H., Cho D.H., Hu Y.J., Moore J.M., Klesert T.R., Lobanenkov V.V., Tapscott S.J. CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus. Nat. Genet. 28:2001;335-343
14. Gerber A.N., Klesert T.R., Bergstrom D.A., Tapscott S.J. Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin. a mechanism for lineage determination in myogenesis Genes Dev. 11:1997;436-450
15. Hasty P., Bradley A., Morris J.H., Edmondson D.G., Venuti J.M., Olson E.N., Klein W.H. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature. 364:1993;501-506
16. Hoey T., Levine M. Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature. 332:1988;858-861
17. Hollenberg S.M., Cheng P.F., Weintraub H. Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination. Proc. Natl. Acad. Sci. USA. 90:1993;8028-8032
18. Huang J., Blackwell T.K., Kedes L., Weintraub H. Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection. Mol. Cell. Biol. 16:1996;3893-3900
19. Jaynes J.B., Johnson J.E., Buskin J.N., Gartside C.L., Hauschka S.D. The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer. Mol. Cell. Biol. 8:1988;62-70
20. Jen Y., Weintraub H., Benezra R. Overexpression of Id protein inhibits the muscle differentiation program. in vivo association of Id with E2A proteins Genes Dev. 6:1992;1466-1479
21. Knoepfler P.S., Kamps M.P. The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and Class I Hox proteins - evidence for selective targeting of E2a-Pbx1 to a subset of Pbx-recognition elements. Oncogene. 14:1997;2521-2531
22. Knoepfler P.S., Calvo K.R., Chen H., Antonarakis S.E., Kamps M.P. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. USA. 94:1997;14553-14558
23. Knoepfler P.S., Bergstrom D.A., Uetsuki T., Dac-Korytko I., Sun Y.H., Wright W.E., Tapscott S.J., Kamps M.P. A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with Pbx-Meis1/Prep1. Nucleic Acids Res. 27:1999;3752-3761
24. Liu Y., MacDonald R.J., Swift G.H. DNA binding and transcriptional activation by a Pdx1-Pbx1b-Meis2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. J. Biol. Chem. 276:2001;17985-17993
25. Maeda R., Ishimura A., Mood K., Park E.K., Buchberg A.M., Daar I.O. Xpbx1b and Xmeis1b play a collaborative role in hindbrain and neural crest gene expression in Xenopus embryos. Proc. Natl. Acad. Sci. USA. 99:2002;5448-5453
26. Mann R.S., Affolter M. Hox proteins meet more partners. Curr. Opin. Genet. Dev. 8:1998;423-429
27. Miner J.H., Wold B. Herculin, a fourth member of the MyoD family of myogenic regulatory genes. Proc. Natl. Acad. Sci. USA. 87:1990;1089-1093
28. Monica M., Galili N., Nourse J., Saltman D., Cleary M.L. Pbx2 and Pbx3, new homeobox genes with extensive homology to the human proto-oncogene Pbx1. Mol. Cell. Biol. 11:1991;6149-6157
29. Nabeshima Y.K., Hanaoka M., Hayasaka M., Esumi E., Li S., Nonaka I. Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature. 364:1993;532-535
30. Rauskolb C., Wieschaus E. Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. EMBO J. 13:1994;3561-3569
31. Rudnicki M.A., Schnegelsberg P.N., Stead R.H., Braun T., Arnold H.H., Jaenisch R. MyoD or Myf5 is required for the formation of skeletal muscle. Cell. 75:1993;1351-1359
32. Saleh M., Rambaldi I., Yang X.J., Featherstone M.S. Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. Mol. Cell. Biol. 20:2000;8623-8633
33. Schaner C.E., Deshpande G., Schedl P.D., Kelly W.G. A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies. Dev. Cell. 5:2003;747-757
34. Schnabel C.A., Selleri L., Cleary M.L. Pbx1 is essential for adrenal development and urogenital differentiation. Genesis. 37:2003;123-130
35. Selleri L., Depew M.J., Jacobs Y., Chanda S.K., Tsang K.Y., Cheah K.S.E., Rubenstein J.L.R., O'Gorman S., Cleary M.L. Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development. 128:2001;3543-3557
36. Shen W.F., Montgomery J.C., Rozenfeld S., Moskow J.J., Lawrence J.J., Buchberg A.M., Largman C. AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol. Cell. Biol. 17:1997;6448-6458
37. Storey J.D., Tibshirani R. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. USA. 100:2003;9440-9445
38. Tapscott S.J., Davis R.L., Thayer M.J., Cheng P.F., Weintraub H., Lassar A.B. MyoD1. a nuclear phosphoprotein requiring a region of myc homology to activate myogenesis Science. 242:1988;405-411
39. Tapscott S.J., Lassar A.B., Weintraub H. A novel myoblast enhancer element mediates MyoD transcription. Mol. Cell. Biol. 12:1992;4994-5003
40. Triesman J., Gonczy P., Vashishtha M., Harris E., Desplan C. A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell. 59:1989;553-562
41. Van Auken K., Weaver D., Robertson B., Sundaram M., Saldi T., Edgar L., Elling U., Lee M., Boese Q., Wood W.B. Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis. Development. 129:2002;5255-5268
42. Walter J., Dever C.A., Biggin M.D. Two homeodomain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos. Genes Dev. 8:1994;1678-1692
43. Wagner K., Mincheva A., Korn B., Licther P., Popperl H. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis. Mech. Dev. 103:2001;127-131
44. Wang Y., Jaenisch R. Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently. Development. 124:1997;2507-2513
45. Waskiewicz A.J., Rikhof H.A., Hernandez R.E., Moens C.B. Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning. Development. 128:2001;4139-4151
46. Waskiewicz A.J., Rikhof H.A., Moens C.B. Eliminating zebrafish Pbx proteins reveals a hindbrain ground state. Dev. Cell. 3:2002;723-733
47. Weintraub H., Tapscott S.J., Davis R.L., Thayer M.J., Adam M.A., Lassar A.B., Miller A.D. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc. Natl. Acad. Sci. USA. 86:1989;5434-5438
48. Weintraub H., Dwarki V.J., Verma I., Davis R.L., Hollenberg S., Snider L., Lassar A.B., Tapscott S.J. Muscle-specific transcriptional activation by MyoD. Genes Dev. 5:1991;1377-1386