The developmental and molecular biology of genes that subdivide the body of Drosophila

Annual Review of Cell and Developmental Biology

Volumn 16, Issue , 2000, Pages 243-271

  Mann, R S ^a   Morata, G ^a  

^a Columbia University ^*  (United States)

Author keywords

Compartments; DNA binding specificity; Extradenticle; Hox genes; Selector genes

Indexed keywords

BINDING SITE; CELL COMPARTMENTALIZATION; DROSOPHILA; GENETIC ANALYSIS; MOLECULAR BIOLOGY; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW;

ANIMALS; BODY PATTERNING; DROSOPHILA; GENES, INSECT; HUMANS; INSECT PROTEINS;

EID: 0034518324     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.16.1.243     Document Type: Review

References (181)

1. Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development
2. Control of the nuclear localization of Extradenticle by competing localization and export signals
3. Function and regulation of homothorax in the wing imaginal disc of Drosophila
4. Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes
5. Protein phosphatase 2A - Mediated regulation of Sex combs reduced activity
6. The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH
7. Regulation of segmentation and segmental identity by Drosophila homeoproteins: The role of DNA binding in functional activity and specificity
8. Mechanisms of compartment formation: Evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila
9. Smoothened-mediated hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila
10. The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates
11. The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye
12. The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster
13. The TEA domain: A novel, highly conserved DNA-binding motif
14. Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
15. New motif in PBX genes
16. Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila
17. Visualization of gene expression in living adult Drosophila
18. The roles of the homeobox genes aristaless and Distalless in patterning the legs and wings of Drosophila
19. Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic, and the homeobox gene aristaless
20. The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila
21. Functional dominance among Hox genes: Repression dominates activation in the regulation of Dpp
22. A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos
23. Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes
24. Control of antennal versus leg development in Drosophila
25. A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila
26. The genital disc of Drosophila melanogaster. I. Segmental and compartmental organization
27. Compartments and organising boundaries in the Drosophila eye: The role of the homeodomain Iroquois proteins
28. The iroquois genes function as dorsal selectors in the Drosophila head
29. The segment identity functions of Ultrabithorax are contained within its homeodomain and carboxy-terminal sequences
30. Switching the in vivo specificity of a minimal Hox-responsive element
31. Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila
32. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system
33. Controlling growth of the wing: Vestigial integrates signals from the compartment boundaries
34. Distal-less encodes a homoeodomain protein required for limb development in Drosophila
35. Proximal-distal pattern formation in Drosophila graded requirement for Distal-less gene activity during limb development
36. Patterning of the Drosophila embryo by a homeodomain-deleted Ftz polypeptide
37. Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila
38. Compartments and polyclones in insect development
39. U-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formarion of bristles in Drosophila
40. Twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development
41. Compartment boundaries: At the edge of development
42. Opposing transcriptional outputs of hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P border
43. The human transcription enhancer factor-1, TEF-1, can substitute for Drosophila scalloped during wingblade development
44. Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs
45. Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila
46. The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila
47. Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein Cubitus interruptus
48. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye
49. A phosphorylation site in the ftz homeodomain is required for activity
50. Tissue-specific requirements for a phosphorylation site in the Fushi tarazu homeodomain
51. Coexpression of the homeobox genes Distalless and homothorax determines Drosophila antennal identity
52. Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor
53. The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins
54. The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs
55. The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing
56. Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins
57. Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene
58. Functional specificity of the Antennapedia homeodomain
59. The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila
60. Pattern reconstruction by dissociated imaginal disk cells of Drosophila melanogaster
61. Genetic control of wing disc development in Drosophila
62. Developmental compartmentalisation of the wing disk of Drosophila
63. Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster
64. Head and thoracic transformation caused by ectopic expression of Antennapedia during Drosophila development
65. The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
66. Pattern formation in the limbs of Drosophila: Bric a brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus
67. Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes
68. Araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing
69. Antagonism between extradenticle function and hedgehog signalling in the development limb
70. Control of Drosophila adult pattern by extradenticle
71. Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite
72. The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products
73. Are cross-regulatory interactions between homoeotic genes functionally significant?
74. The homeobox gene Distal-less induces ventral appendage development in Drosophila
75. Drosophila terminalia as an appendage-like structure
76. Proximal to distal cell communication in the Drosophila leg provides a basis for an intercalary mechanism of limb patterning
77. The role of homeotic genes in the specification of the Drosophila gonad
78. Functional evolution of the Ultrabithorax protein
79. Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling
80. Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless
81. The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors
82. Kombinate aus teilweise dissoziierten imaginalscheiben verschiedener mutanten und arten von Drosophila
83. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
84. The vestigial and scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila
85. Dorsoventral patterning in the Drosophila retina by wingless
86. A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila
87. Regulation and function of Scr, exd, and hth in the Drosophila salivary gland
88. The Drosophila homolog of the human transcription factor TEF-1, scalloped, is essential for normal taste behavior
89. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
90. A role for phosphorylation by casein kinase 2 in modulating Antennapedia function in Drosophila
91. Drosophila Mad binds to DNA and directly mediates activation of vestigial by decapentaplegic
92. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
93. Different spatial and temporal interactions between Notch, wingless, and vestigial specify proximal and distal pattern elements of the wing in Drosophila
94. Formation and specification of distal leg segments in Drosophila by dual Bar homeobox genes, BarH1 and BarH2
95. Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS
96. Abdominal-B protein isoforms exhibit distinct cuticular transformations and regulatory activities when ectopically expressed in Drosophila embryos
97. A homeodomain substitution changes the regulatory specificity of the deformed protein in Drosophila embryos
98. Altering the regulatory targets of the Deformed protein in Drosophila embryos by substituting the Abdominal-B homeodomain
99. The hedgehog morphogen and gradients of cell affinity in the abdomen of Drosophila
100. Compartments in the wing of Drosophila: A study of the engrailed gene
101. Homeobox genes: Their function in Drosophila segmentation and pattern formation
102. Morphogens, compartments, and pattern: Lessons from Drosophila?
103. Two distinct mechanisms for long-range patterning by decapentaplegic in the Drosophila wing
104. Proximal-distal axis formation in the Drosophila leg
105. Genes and developmental pathways
106. Genetic control and regulation of developmental pathways
107. Activity regulation of Hox proteins, a mechanism for altering functional specificity in development and evolution
108. Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation
109. A sequence motif distinct from Hox binding sites controls the specificity of a Hox response element
110. Eve and Ftz regulate a wide array of genes in blastoderm embryos: The selector homeoproteins directly or indirectly regulate most genes in Drosophila
111. Mapping functional specificity in the Dfd and Ubx homeodomains
112. Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions
113. Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster
114. Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development
115. Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae
116. Nuclear import of the homeodomain protein extradenticle in response to decapentaplegic and wingless signalling
117. The specificity of homeotic gene function
118. Hox proteins meet more partners
119. Extra specificity from extradenticle: The partnership between HOX and exd/pbx homeodomain proteins
120. Functional dissection of Ultrabithorax proteins in D. melanogaster
121. Dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila
122. Pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila
123. A molecular basis for transdetermination in Drosophila imaginal discs: Interactions between wingless and decapentaplegic signaling
124. Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae
125. Homeobox genes and axial patterning
126. Mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye
127. Dorsoventral lineage restriction in wing imaginal discs requires Notch
128. Regulation of LIM homeodomain activity in vivo: A tetramer of dLDB and apterous confers activity and capacity for regulation by dLMO
129. Control of compartment development by the engrailed gene in Drosophila
130. Anterior and posterior compartments in the head of Drosophila
131. Patterning mechanisms in the body trunk and the appendages of Drosophila
132. Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila
133. Genes regulating the remote wing margin enhancer in the Drosophila cut locus
134. Caudal is the Hox gene that specifies the most posterior Drosophila segment
135. Mechanisms regulating target gene selection by the homeodomain-containing protein Fushi tarazu
136. Direct and long-range action of a DPP morphogen gradient
137. The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila
138. Targeted expression of teashirt induces ectopic eyes in Drosophila
139. Organogenesis in Drosophila melanogaster: Embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes
140. Dorsal-ventral signaling in the Drosophila eye
141. Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex
142. Specific interactions between vestigial and scalloped are required to promote wing tissue proliferation in Drosophila melanogaster
143. Homothorax and iroquois-C genes are required for the establishment of territories within the developing eye disc
144. The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development
145. Structure of a HoxB1-Pbxl heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation
146. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx
147. Development of the temperature-sensitive homoeotic mutant ophthalmoptera of Drosophila melanogaster
148. Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans
149. Pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1
150. Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing
151. Extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
152. Extradenticle determines segmental identities throughout development
153. Nuclear translocation of Extradenticle requires homothorax, which encodes an Extradenticle-related homeodomain protein
154. Control of compartmental affinity boundaries by hedgehog
155. Evolution of the insect body plan as revealed by the Sex combs reduced expression pattern
156. The control of trunk Hox specificity and activity by Extradenticle
157. Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex
158. Molecular genetics of Aristaless, a prd-type homeobox gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila
159. Ectopic eye development in Drosophila induced by directed dachshund expression
160. Molecular interactions between vestigial and scalloped promote wing formation in Drosophila
161. Reconstruction of tissues by dissociated cells
162. A role of Ultrabithorax in morphological differences between Drosophila species
163. Genes controlling segmental specification in the Drosophila thorax
164. The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing
165. The differentiation of a secondary sex comb under the influence of the gene engrailed in Drosophila melanogaster
166. Directed movements and selective adhesion of embryonic amphibian cells
167. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
168. Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less
169. Chip and apterous physically interact to form a functional complex during Drosophila development
170. TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation
171. Lineagetracing cells born in different domains along the PD axis of the developing Drosophila leg
172. Control of Drosophila wing and haltere development by the nuclear vestigial gene product
173. Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary
174. Structural basis of Hox specificity
175. A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster
176. Proximodistal axis formarion in the Drosophila leg: Subdivision into proximal and distal domains by Homothorax and Distal-less
177. Mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities
178. The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz
179. Ectopic expression and function of the Antp and Scr homeotic genes: The N terminus of the homeodomian is critical to functional specificity
180. The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene