Changing homeodomain residues 2 and 3 of Hoxa1 alters its activity in a cell-type and enhancer dependent manner

Nucleic Acids Research

Volumn 30, Issue 12, 2002, Pages 2663-2668

  Remacle, Sophie ^a   Shaw Jackson, Chloë ^a   Matis, Christelle ^a   Lampe, Xavier ^a   Picard, Jacques ^a   Rezsöhazy, René ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ARGININE; ASPARAGINE; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; HOX PROTEIN; LYSINE; MEMBRANE COFACTOR PROTEIN; MONOMER; MUTANT PROTEIN; SOMATOSTATIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; AUTOREGULATION; CELL STRAIN COS7; CELL TYPE; CONTROLLED STUDY; ENHANCER REGION; GENETIC TRANSCRIPTION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TARGETING; WILD TYPE;

ANIMALIA;

EID: 0037096841     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf372     Document Type: Article

References (29)

1. Paralogous Hox genes: Function and regulation
2. Developmental functions of mammalian Hox genes
3. Homeodomain-DNA recognition
4. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation
5. Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
6. Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins
7. Hox proteins meet more partners
8. Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation
9. Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers
10. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins
11. Balancing import and export in development
12. Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases
13. The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function
14. Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm
15. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
16. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the Somatostatin promoter: Importance of the FPWMK motif and of the homeodomain
17. Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex
18. Synergistic activation of transcription by the human estrogen receptor bound to tandem responsive elements
19. Direct repeats as selective response elements for the thyroid hormone, retinoic acid and vitamin D3 receptors
20. Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif
21. Functional and cooperative interactions between the homeodomain PDX1, Pbx and Prep1 factors on the somatostatin promoter
22. A new technique for the assay of infectivity of human adenovirus 5 DNA
23. Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins
24. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
25. Differential and opposed transcriptional effects of protein fusions containing the VP16 activation domain
26. Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism
27. Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain
28. HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation