Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth

Development

Volumn 124, Issue 3, 1997, Pages 627-636

  Goff, Deborah J ^a   Tabin, Clifford J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chick limb development; Hoxd 11; Hoxd 13; Viral misexpression

Indexed keywords

ALANINE; REPETITIVE DNA; THYMIDINE; VIRUS VECTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BONE DEVELOPMENT; CELL DIVISION; CHICKEN; EMBRYO; EPIPHYSEAL CARTILAGE; FEMUR; FIBULA; FOOT; GENE EXPRESSION; HINDLIMB; LIMB BUD; LONG BONE; LOWER LEG; NONHUMAN; PHENOTYPE; POLYDACTYLY; PRIORITY JOURNAL; PROMOTER REGION; TIBIA;

ANIMALS; BONE AND BONES; CELL DIVISION; CHICK EMBRYO; EXTREMITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; PHENOTYPE;

GALLUS GALLUS; VERTEBRATA;

EID: 0031043604     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Archer, C. W., Hornbruch, A. and Wolpert, L. (1983). Growth and morphogenesis of the fibula in the chick embryo. J. Embryol. Exp. Morph. 75, 101-116.
2. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. and Struhl, K. (1989). Current Protocols in Molecular Biology. New York: Greene Publishing Associates and Wiley Interscience.
3. Chambers, J. M., Cleveland, W. S., Kleiner, B. and Tukey, P. A. (1983). Graphical Methods for Data Analysis. Boston: Duxbury Press.
4. Davis, A. P. and Capecchi, M. R. (1994). Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development 120, 2187-2198.
5. Davis, A. P. and Capecchi, M. R. (1996). A mutational analysis of the 5′ HoxD genes: dissection of genetic interactions during limb development in the mouse. Development 122, 1175-1185.
6. Davis, A. P., Witte, D. P., Hsieh-Li, H. M., Potter, S. S. and Capecchi, M. R. (1995). Absence of radius and ulna in mice lacking Hoxa-11 and Hoxd-11. Nature 375, 791-795.
7. Dollé, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambon, P. and Duboule, D. (1993). Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441.
8. Dollé, P., Izpisüa-Belmonte, J.-C., Falkenstein, H., Renucci, A. and Duboule, D. (1989). Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation. Nature 342, 767-772.
9. Duboule, D. (1994). How to make a limb? Science 266, 575-576.
10. Duboule, D. (1995). Vertbrate Hox genes and proliferation: an alternative pathway to homeosis? Cur. Opin. Genes. Dev. 5, 525-528.
11. Favier, B., Le Meur, M., Chambon, P. and Dollé, P. (1995). Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice. Proc. Natl. Acad.Sci. USA 92, 310-314.
12. Favier, B., Rijli, F. M., Fromental-Ramain, C., Fraulob, V., Chambon, P. and Dolle, P. (1996). Functional cooperation between non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton. Development 122, 449-460.
13. Fekete, D. and Cepko, C. (1993a). Retroviral infection coupled with tissue transplantation limits gene transfer in the chicken embryo. Proc. Natl. Acad. Sci. USA 90, 2350-2354.
14. Fekete, D. and Cepko, C. L. (1993b). Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo. Mol. Cell. Biol. 13, 2604-2613.
15. Fromental-Ramain, C., Warot, X., Lakkaraju, S., Favier, B., Haack, H., Birling, C., Dierich, A., Dolle, P. and Chambon, P. (1996). Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Development 122, 461-472.
16. Hamburger, V. and Hamilton, H. L. (1951). A series of normal stages in the development of the chick embryo. J. Exp. Morph. 88, 49-92.
17. Hampé, A. (1960). La compétition entre les éléments osseux du zeugopode de poulet. J. Embryol. Exp. Morph. 8, 241-245.
18. Hughes, S. H., Greenhouse, J. J., Petropoulos, C. J. and Sutrave, P. (1987). Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. J. Virol. 61, 3004-3012.
19. Janners, M. Y. and Searls, R. L. (1970). Changes in rate of cellular proliferation during the differentiation of cartilage and muscle in the mesenchyme of the embryonic chick wing. Dev. Biol. 23, 136-165.
20. Makem, S. and Mahon, K. A. (1991). Ghox4.7: a chick homeobox gene expressed primarily in limb buds with limb-type difference in expression. Development 112, 791-806.
21. Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C. J. (1996). Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol., in press.
22. Morgan, B. A., Izpisüa-Belmonte, J.-C., Duboule, D. and Tabin, C. J. (1992). Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature 358, 236-239.
23. Müller, G. B. (1989). Ancestral patterns in bird limb development: A new look at Hampé's experiment. J. Evol. Biol. 2, 31-47.
24. Muragaki, Y., Mundlos, S., Upton, J. and Olsen, B. R. (1996). Altered growth and branching patterns in synpolydactyly caused by mutations in Hoxd-13. Science 272, 548-551.
25. Nelson, C. E., Morgan, B. A., Burke, A. C., Laufer, E., DiMambro, E., Murtaugh, L. C., Gonzales, E., Tessarollo, L., Parada, L. F. and Tabin, C. (1996). Analysis of Hox gene expression in the chick limb bud. Development, 122, 1449-1466.
26. Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
27. Rogina, B. and Upholt, W. B. (1993). Cloning of full coding chicken cDNAs for the homeobox-containing gene Hoxd-13. Nucl. Acids Res. 21, 1316.
28. Small, K. M. and Potter, S. S. (1993). Homeotic transformations and limb defects in Hoxa-11 mutant mice. Genes Dev. 121, 2318-2328.
29. Storm, E. E., Huynh, T. V., Copeland, N. G., Jenkins, N. A., Kingsley, D. M. and Lee, S. J. (1994). Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature 368, 639-643.
30. van der Hoeven, F., Zákány, J. and Duboule, D. (1996). Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell 85, 1025-1035.
31. Yokouchi, Y., Nakazato, S., Yamamoto, M., Goto, Y., Kameda, T., Iba, H. and Kuroiwa, A. (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9, 2509-2522.
32. Yokouchi, Y., Sasaki, H. and Kuroiwa, A. (1991). Homeobox gene expression correlated with the bifurcation process of limb cartilage development. Nature 353, 443-445.