Regulation of Hox target genes by a DNA bound homothorax/Hox/extradenticle complex

Development

Volumn 126, Issue 22, 1999, Pages 5137-5148

  Ryoo, Hyung Don ^a   Marty, Thomas ^b   Casares, Fernando ^a   Affolter, Markus ^b   Mann, Richard S ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Biocenter   (Switzerland)

Author keywords

Drosophila melanogaster; Estradenticle; homothorax; Hox; MEIS; pbx

Indexed keywords

DNA; HOMEODOMAIN PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; DNA; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER;

EID: 0033404512     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Abu-Shaar, M. and Mann, R. S. (1998). Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development 125, 3821-3830.
2. Abu-Shaar, M., Ryoo, H. D. and Mann, R. S. (1999). Control of the nuclear localization of Extradenticle by competing localization and export signals. Genes Dev. 13, 935-945.
3. Bachiller, D., Macias, A., Duboule, D. and Morata, G. (1994). Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes. EMBO J. 13, 1930-1941.
4. Berthelsen, J., Kilstrup-Nielsen, C., Blasi, F., Mavilio, F. and Zappavigna, V. (1999). The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev. 13, 946-953.
5. Berthelsen, J., Zappavigna, V., Ferretti, E., Mavilio, F. and Blasi, F. (1998a). The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J. 17, 1434-1445.
6. Berthelsen, J., Zappavigna, V., Mavilio, F. and Blasi, F. (1998b). Prep1, a novel functional partner of Pbx proteins. EMBO J. 17, 1423-1433.
7. Brand, A. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
8. Bürglin, T. (1997). Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucl. Acid Res. 25, 4173-4180.
9. Burke, A. C., Nelson, C. E., Morgan, B. A. and Tabin, C. (1995). Hox genes and the evolution of vertebrate axial morphology. Development 121, 333-346.
10. Calleja, M., Moreno, E., Pelaz, S. and Morata, G. (1996). Visualization of Gene Expression in Living Adult Drosophila. Science 274, 252-255.
11. Casares, F. and Mann, R. S. (1998). Control of antennal versus leg development in Drosophila. Nature 392, 723-726.
12. Chan, S.-K., Jaffe, L., Capovilla, M., Botas, J. and Mann, R. S. (1994). The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with Extradenticle, another homeoprotein. Cell 78, 603-615.
13. Chan, S.-K. and Mann, R. S. (1996). A structural model for an extradenticle-HOX-DNA complex accounts for the choice of HOX protein in the heterodimer. Proc. Natl. Acad. Sci. USA 93, 5223-5228.
14. Chan, S.-K., Pöpperl, H., Krumlauf, R. and Mann, R. S. (1996). An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif. EMBO J. 15, 2477-2488.
15. Chan, S.-K., Ryoo, H. D., Gould, A., Krumlauf, R. and Mann, R. (1997). Switching the in vivo specificity of a minimal Hox-responsive element. Development 124, 2007-2014.
16. Chang, C. P., Jacobs, Y., Nakamura, T., Jenkins, N. A., Copeland, N. G. and Cleary, M. L. (1997). Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol. 17, 5679-5687.
17. Cohen, S. M., Bronner, G., Kuttner, F., Jurgens, G. and Jackle, H. (1989). Distal-less encodes a homoeodomain protein required for limb development in Drosophila. Nature 338, 432-434.
18. Czerny, T., Halder, G., Kloter, U., Souabni, A., Gehring, W. J. and Busslinger, M. (1999). twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol. Cell 3, 297-307.
19. Di Rocco, G., Mavilio, F. and Zappavigna, V. (1997). Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex. EMBO J. 16, 3644-3654.
20. Ekker, S. C., Jackson, D. G., von Kessler, D. P., Sun, B. I., Young, K. E. and Beachy, P. A. (1994). The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J. 13, 3551-3560.
21. Garcia-Bellido, A. (1975). Genetic control of wing disc development in Drosophila. In Cell Patterning, Ciba Found Symp, pp. 161-182. New York: Associated Scientific Publishers.
22. Gehring, W. J., Affolter, M. and Burglin, T. (1994). Homeodomain proteins. Ann. Rev. Biochem. 63, 487-526.
23. Gibson, G., Schier, A., LeMotte, P. and Gehring, W. J. (1990). The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell 62, 1087-1103.
24. Gonzalez-Crespo, S., Abu-Shaar, M., Torres, M., Martínez-A, C., Mann, R. S. and Morata, G. (1998). Antagonism between extradenticle function and Hedgehog signalling in the development limb. Nature 394, 196-200.
25. Gonzalez-Crespo, S. and Morata, G. (1995). Control of Drosophila adult pattern by extradenticle. Development 121, 2117-2125.
26. Gonzalez-Crespo, S. and Morata, G. (1996). Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite. Development 122, 3921-3928.
27. Gorfinkiel, N., Morata, G. and Guerrero, I. (1997). The homeobox gene Distal-less induces ventral appendage development in Drosophila. Genes Dev. 11, 2259-2271.
28. Grieder, N., Marty, T., Ryoo, H.-D., Mann, R. S. and Affolter, M. (1997). Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling. EMBO J. 16, 7402-7410.
29. Halder, G., Callaerts, P. and Gehring, W. J. (1995). Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267, 1788-1792.
30. Jacobs, Y., Schnabel, C. A. and Cleary, M. L. (1999). Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol. Cell. Biol. 19, 5134-5142.
31. Kenyon, C. (1994). If birds can fly, why can't we? Homeotic genes and evolution. Cell 78, 175-180.
32. Kim, J., Sebring, A., Esch, J. J., Kraus, M. E., Vorwerk, K., Magee, J. and Carroll, S. B. (1996). Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382, 133-138.
33. Knoepfler, P., Calvo, K., Chen, H., Antonarakis, S. and Kamps M. (1997) Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. USA 94, 14553-14558.
34. Kurant, E., Pai, C.-Y., Sharf, R., Halachmi, N., Sun, Y. and Salzberg, A. (1998). dorsotonals/homothorax, the Drosophila homologue of meisI. interacts with extradenticle in patterning of the embryonic PNS. Development 125, 1037-1048.
35. Lewis, E. B. (1978). A gene complex controlling segmentation in Drosophila. Nature 276, 565-570.
36. Li, X. and McGinnis, W. M. (1999). Activity regulation of Hox proteins, a mechanism for altering functional specificity in development and evolution. Proc. Natl. Acad. Sci. USA 96, 6802-6807.
37. Li, X., Murre, C. and McGinnis, W. (1999). Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation. EMBO J. 18, 198-211.
38. Lu, Q., Knoepfler, P., Scheele, J., Wright, D. and Kamps, M. (1995). Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell. Biol. 15, 3786-3795.
39. Maconochie, M. K., Nonchev, S., Studer, M., Chan, S. K., Popperl, H., Sham, M. H., Mann, R. S. and Krumlauf, R. (1997). Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes Dev. 11, 1885-1895.
40. Malicki, J., Schughart, K. and McGinnis, W. (1990). Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae. Cell 63, 961-967.
41. Mann, R. S. (1995). The specificity of homeotic gene function. BioEssays 17, 855-863.
42. Mann, R. and Abu-Shaar, M. (1996). Nuclear import of the homeodomain protein Extradenticle in response to Decapentaplegic and Wingless signalling. Nature 383, 630-633.
43. Mann, R. S. and Affolter, M. (1998). Hox proteins meet more partners. Curr. Op. Genet. Dev. 8, 423-429.
44. Mann, R. S. and Chan, S.-K. (1996). Extra specificity from extradenticle: The partnership between HOX and exd/pbx homeodomain proteins. Trends Gen. 12, 258-262.
45. Mann, R. S. and Hogness, D. S. (1990). Functional dissection of Ultrabithorax proteins in D. melanogaster. Cell 60, 597-610.
46. Martin-Bermudo, M. D., Dunin-Borkowski, O. M. and Brown, N. H. (1997). Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domain. EMBO J. 16, 4184-4193.
47. McGinnis, N., Kuziora, M. A. and McGinnis, W. (1990). Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae. Cell 63, 969-976.
48. McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68, 283-302.
49. Moskow, J., Bullrich, F., Juebner, K., Daar, I. and Buchberg, A. (1995). Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol. Cell. Biol. 15, 5434-5443.
50. Nakamura, T., Jenkins, N. A. and Copeland, N. G. (1996). Identification of a new family of Pbx-related homeobox genes. Oncogene 13, 2235-2242.
51. Pai, C.-Y., Kuo, T., Jaw, T., Kurant, E., Chen, C., Bessarab, D., Salzberg, A. and Sun, Y. (1998). The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila. Genes Dev. 12, 435-446.
52. Passner, J. M., Ryoo, H. D., Shen, L., Mann, R. S. and Aggarwal, A. K. (1999). Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 397, 714-718.
53. Phelan, M. L. and Featherstone, M. S. (1997). Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers. J. Biol. Chem. 272, 8635-8643.
54. Phelan, M. L., Rambaldi, I. and Featherstone, M. (1995) Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol. Cell. Bio 15, 3989-3997.
55. Pinsonneault, J., Florence, B., Vaessin, H. and McGinnis, W. (1997). A model for extradenticle function as a switch that changes HOX proteins from repressors to activators. EMBO J. 16, 2032-2042.
56. Piper, D. E., Batchelor, A. H., Chang, C.-P., Cleary, M. L. and Wolberger, C. (1999). Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell 96, 587-597.
57. Pirrotta, V. (1988). Vectors for P-mediated transformation in Drosophila. In Vectors, A Survey of Molecular Cloning Vectors Their Uses, pp. 437-456. Boston: Butterworth.
58. Pöpperl, H., Bienz, M., Studer, M., Chan, S.-K., Aparicio, S., Brenner, S., Mann, R. and Krumlauf, R. (1995). Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx. Cell 81, 1031-1042.
59. Rauskolb, C., Peifer, M. and Wieschaus, E. (1993). extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell 74, 1-20.
60. Rauskolb, C., Smith, K., Peifer, M. and Wieschaus, E. (1995). extradenticle determines segmental identities throughout development. Development 121, 3663-3671.
61. Rieckhof, G., Casares, F., Ryoo, H. D., Abu-Shaar, M. and Mann, R. S. (1997). Nuclear translocation of Extradenticle requires homothorax, which encodes an Extradenticle-related homeodomain protein. Cell 91, 171-183.
62. Ryoo, H.-D. and Mann, R. S. (1999). The control of trunk Hox specficity and activity by Extradenticle. Genes Dev. 13, 1704-1716.
63. Sánchez-Herrero, E., Vernos, I., Marco, R. and Morata, G. (1985). Genetic organisation of Drosophila bithorax complex. Nature 313, 108-113.
64. Shen, W. F., Chang, C. P., Rozenfeld, S., Sauvageau, G., Humphries, R. K., Lu, M., Lawrence, H. J., Cleary, M. L. and Largman, C. (1996). Hox homeodomuin proteins exhibit selective complex stabilities with Pbx and DNA. Nuc. Acid Res. 24, 898-906.
65. Steelman, S., Moskow, J. J., Muzynski, K., North, C., Druck, T., Montgomery, J. C., Huebner, K., Daar, I. O. and Buchberg, A. M. (1997). Identification of a conserved family of Meis1-related homeobox genes. Gen. Res. 7, 142-156.
66. Swift, G. H., Liu, Y., Rose, S. D., Bischof, L. J., Steelman, S., Buchberg, A. M., Wright, C. V. and MacDonald, R. J. (1998). An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRGI (MEIS2). Mol. Cell. Biol. 18, 5109-5120.
67. Tremml, G. and Bienz, M. (1992). Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation. Development 116, 447-456.
68. Warren, R. W., Nagy, L., Selegue, J., Gates, J. and Carroll, S. (1994). Evolution of homeotic gene regulation and function in flies and butterflies. Nature 372, 458-461.
69. Weatherbee, S., Halder, G., Kim, J., Hudson, A. and Carroll, S. (1998). Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila hatere. Genes Dev. 12, 1474-1482.
70. Williams, J. A., Bell, J. B. and Carroll, S. B. (1991). Control of Drosophila wing and haltere development by the nuclear vestigial gene product. Genes Dev. 5, 2481-2495.
71. Wu, J. and Cohen, S. M. (1999). Proximodistal axis formation in the Drosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less. Development 126, 109-117.
72. Zhao, J. J., Lazzarini, R. A. and Pick, L. (1993). The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene. Genes Dev. 7, 343-354.