Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx

EMBO Journal

Volumn 15, Issue 13, 1996, Pages 3385-3393

  Peltenburg, Lucy T C ^a,b   Murre, Cornelis ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cooperative DNA binding; Engrailed; Homeodomain proteins; Hox; Pbx

Indexed keywords

HEXAPEPTIDE; HOMEODOMAIN PROTEIN; TRYPTOPHAN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

MURINAE;

EID: 0030035691     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00704.x     Document Type: Article

References (41)

1. Billeter, M., Qian, Y.Q., Otting, G., Muller, M., Gehring, W. and Wüthrich, K. (1993) Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex. J. Mol. Biol., 234, 1084-1093.
2. Bürglin, T.R. (1994) A comprehensive classification of homeobox genes. In Duboule, D. (ed.), Guidebook to the Homeobox Genes. Oxford University Press, Oxford, UK, pp. 27-71.
3. Chan, S.-K. and Mann, R.S. (1993) The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxyterminal sequences. Genes Dev., 7, 796-811.
4. Chan, S.-K., Jaffe, L., Capovilla, M., Botas, J. and Mann, R.S. (1994) The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeodomain protein. Cell, 78, 603-615.
5. Chang, C.-P., Shen, W.-F., Rozenfeld, S., Lawrence, H.J., Largman, C. and Cleary, M.L. (1995) Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev., 9, 663-674.
6. Desplan, C., Theis, J. and O'Farrell, P.H. (1988) The sequence specificity of homeodomain-DNA interaction. Cell, 54, 1081-1090.
7. Duboule, D. and Dollé, P. (1989) The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J., 8, 1497-1505.
8. Flegel, W.A., Singson, A.W., Margolis, J.S., Bang, A.G., Posakony, J.W. and Murre, C. (1993) Dpbx, a new homeobox gene closely related to the human proto-oncogene pbx1: molecular structure and developmental expression. Mech. Dev., 41, 155-161.
9. Gibson, G., Schier, A., Lemotte, P. and Gehring, W.J. (1990) The specificities of sex combs reduced and antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell, 62, 1087-1103.
10. Gill, S.C. and von Hippel, P.H. (1989) Calculation of protein extinction coefficients from amino acid sequence data. Anal. Biochem., 182, 319-326.
11. Hoey, T. and Levine, M. (1988) Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature, 332, 858-861.
12. Johnson, A. (1992) A combinatorial regulatory circuit in budding yeast. In McKnight, S.L. and Yamamoto, K.R. (eds), Transcriptional Regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 975-1006.
13. Johnson, F.B., Parker, E. and Krasnow, M.A. (1995) extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction. Proc. Natl Acad. Sci. USA, 92, 739-743.
14. Kamps, M.P., Murre, C., Sun, X.-H. and Baltimore, D. (1990) A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell, 60, 547-555.
15. Knoepfler, P.S. and Kamps, M.P. (1995) The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbxl, and enhances DNA binding by Pbx1. Mol. Cell. Biol., 15, 5811-5819.
16. Krumlauf, R. (1994) Hox genes in vertebrate development. Cell, 78, 191-201.
17. Kuziora, M.A. and McGinnis, W. (1989) A homeodomain substitution changes the regulatory specificity of the deformed protein in Drosophila embryos. Cell, 59, 563-571.
18. Laughon, A. and Scott, M. (1984) Sequence of a Drosophila segmentation gene: protein structure homology with DNA binding proteins. Nature, 310, 25-31.
19. Lawrence, P.A. and Morata, G. (1994) Homeobox genes: their function in Drosophila segmentation and pattern formation. Cell, 78, 181-189.
20. Li, T., Stark, M.R., Johnson, A.D. and Wolberger, C. (1995) Crystal structure of the MATa1/MATα2 homeodomain heterodimer bound to DNA. Science, 270, 262-269.
21. Lin, L. and McGinnis, W. (1992) Mapping functional specificity in the Dfd and Ubx homeo domains. Genes Dev., 6, 1071-1018.
22. Logan, C., Hanks, M., Nobletopham, S., Nallainathan, D., Provart, N. and Joyner, A. (1992) Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions. Dev. Genet., 13, 345-358.
23. Lu, Q., Knoepfler, P.S., Scheele, J., Wright, D.D. and Kamps, M.P. (1995) Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are oncogenes themselves. Mol. Cell. Biol., 15, 3786-3795.
24. Magli, M.C., Barba, P., Celetti, A., De Vita, G., Cillo, C. and Boncinelli, E. (1991) Coordinate regulation of HOX genes in human hematopoietic cells. Proc. Natl Acatl. Sci. USA, 88, 6348-6352.
25. McGinnis, W. and Krumlauf, R. (1992) Homeobox genes and axial patterning. Cell, 68, 283-302.
26. Monica, K., Galili, N., Nourse, J., Saltman, D. and Cleary, M.L. (1991) PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol. Cell. Biol., 11, 6149-6157.
27. Neuteboom, S.T.C., Peltenburg, L.T.C, van Dijk, M.A. and Murre, C. (1995) The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins. Proc. Natl Acad. Sci. USA. 92, 9166-9170.
28. Nourse, J., Mellentin, J.D., Galili, N., Wilkinson, J., Stanbridge, E., Smith, S.D. and Cleary, M.L. (1990) Chromosomal translocation t(1; 19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell, 60, 535-545.
29. Peers, B., Sharma, S., Johnson, T. Kamps, M.P. and Montminy, M. (1995) The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. Mol. Cell. Biol., 15, 7091-7097.
30. Peifer, M. and Wieschaus, E. (1990) Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmentai identitity. Genes. Dev., 4, 1209-1223.
31. Phelan, M.L., Rambaldi, I. and Featherstone, M.S. (1995) Cooperative interactions between Hox and Pbx proteins mediated by a conserved peptide motif. Mol. Cell. Biol., 15, 3989-3997.
32. Pöpperl, H., Bienz, M., Studer, M., Chan, S.-K., Aparicio, S., Brenner, S., Mann, R.S. and Krumlauf, R. (1995) Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Cell, 81, 1031-1042.
33. Qian, Y.Q., Otting, G., Furukubo-Tokunaga, K., Affolter, M., Gehring, W.J. and Wüthrich, K. (1992) NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein. Proc. Natl Acad. Sci. USA, 89, 10738-10742.
34. Rauskolb, C. and Wieschaus, E. (1994) Coordinate regulation of downstream genes by extradenticle and the homeotic selector genes. EMBO J., 13, 3561-3569.
35. Rauskolb, C., Peifer, M. and Wieschaus, E. (1993) Extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell, 74, 1101-1112.
36. Stark, M.R. and Johnson, A.D. (1994) Interaction between two homeodomain proteins is specified by a short C-terminal tail. Nature, 371, 429-432.
37. van Dijk, M.A. and Murre, C. (1994) extradenticle raises the DNA binding specificity of homeotic selector gene products. Cell. 78, 617-624.
38. van Dijk, M.A., Peltenburg, L.T.C. and Murre, C. (1995) Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2. Mech. Dev., 52, 99-108.
39. Vershon, A. and Johnson, A. (1993) A short, disordered protein region mediates interactions between the homeodomain of the yeast α-2 protein and the mcm1 protein. Cell, 72, 105-112.
40. Wilkinson, D.G., Bhatt, S., Cook, M., Boncinelli, E. and Krumlauf, R. (1989) Segmental expression of Hox-2 homeodomain-containing genes in the developing mouse hindbrain. Nature, 341, 405-409.
41. Zeng, W., Andrew, D., Mathies, L., Horner, M. and Scott, M. (1993) Ectopic expression and function of the Antp and Scr homeotic genes - the N-terminus of the homeodomain is critical to functional specificity. Development, 118, 339-352.