Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning

Development

Volumn 128, Issue 21, 2001, Pages 4139-4151

  Waskiewicz, A J ^a   Rikhof, H A ^a   Hernandez, R E ^a   Moens, C B ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Hindbrain; Hox; Meis; Patterning; Pbx; Rhombomere; Segmentation; Zebrafish

Indexed keywords

EXTRADENTICLE PROTEIN; HOMEODOMAIN PROTEIN; HOMOTHORAX PROTEIN; HOX PROTEIN; LAZARUS PROTEIN; PBX PROTEIN; PBX4 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BRAIN DEVELOPMENT; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; DROSOPHILA; EMBRYO; EMBRYO PATTERN FORMATION; EMBRYO SEGMENTATION; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC CODE; GENETIC REGULATION; GENETIC TRANSCRIPTION; MULTIGENE FAMILY; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RHOMBENCEPHALON; TRANSCRIPTION REGULATION; VERTEBRATE; ZEBRA FISH; ZYGOTE;

ANIMALS; BODY PATTERNING; DNA-BINDING PROTEINS; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DOMINANT; HOMEODOMAIN PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM PROTEINS; RHOMBENCEPHALON; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 0035176828     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Control of the nuclear localization of Extradenticle by competing nuclear import and export signals
2. Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype
3. Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila
4. An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters
5. The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity
6. The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH
7. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin
8. Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins
9. An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif
10. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins
11. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins
12. The sequence specificity of homeodomain-DNA interaction
13. Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity
14. Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila
15. Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins
16. Homeodomain-DNA recognition
17. Hoxa-2 mutant mice exhibit homeotic transformations of skeletal elements derived from cranial neural crest
18. Antagonism between extradenticle function and Hedgehog signalling in the developing limb
19. Divergent homeo box proteins recognize similar DNA sequences in Drosophila
20. Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed
21. Radiation hybrid mapping of the zebrafish genome
22. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
23. Direct interaction of two homeoproteins, homothorax and extradenticle, is essential for EXD nuclear localization and function
24. Brain neurons which project to the spinal cord in young larvae of the zebrafish
25. Stages of embryonic development of the zebrafish
26. The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1. Physically contacts Pbx1, and enhances DNA binding by Pbx1
27. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
28. Hox homeobox genes and regionalisation of the nervous system
29. Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS
30. Mutational analysis of the Drosophila homothorax gene
31. Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates
32. Cross-regulation in the mouse HoxB complex: The expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1
33. The specificity of homeotic gene function
34. Extra specificity from extradenticle: The partnership between HOX and PBX/EXD homeodomain proteins
35. Conserved regulation of proximodistal limb axis development by Meis1/Hth
36. Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes
37. Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH- 2 mice
38. Identification of a new family of Pbx-related homeobox genes
39. The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins
40. The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation
41. The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila
42. Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity
43. Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx
44. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
45. Lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish
46. Zebrafish hox genes: Expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino
47. Extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
48. Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
49. A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene
50. Consensus-degenerate hybrid oligonucleotide primers for amplification of distantly related sequences
51. Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex
52. A Meis family protein caudalizes neural cell fates in Xenopus
53. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells
54. Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
55. Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
56. Expression of Meis and Pbx genes and their protein products in the developing telencephalon: Implications for regional differentiation
57. Extradenticle raises the DNA binding specificity of homeotic selector gene products
58. A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b
59. Meis3 synergizes with Pbx4 and Hoxb1b in promoting Hindbrain Fates in the zebrafish
60. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
61. Genetic control of segmentation in the vertebrate hindbrain
62. Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: Disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos