Switching the in vivo specificity of a minimal Hox-responsive element

Development

Volumn 124, Issue 10, 1997, Pages 2007-2014

  Chan, Siu Kwong ^a   Ryoo, Hyung Don ^a   Gould, Alex ^b   Krumlauf, Robb ^b   Mann, Richard S ^a  

^a Columbia University ^*  (United States)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Cooperative binding; Drosophila; Extradenticle; Homeotic genes; Mouse; pbx

Indexed keywords

HOMEODOMAIN PROTEIN;

ANIMAL TISSUE; ARTICLE; BASE PAIRING; BINDING AFFINITY; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO DEVELOPMENT; GENE SWITCHING; HOMEOBOX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BINDING SITES; DIMERIZATION; DNA; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; INSECT PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; PROMOTER REGIONS (GENETICS); REPETITIVE SEQUENCES, NUCLEIC ACID; TRANSCRIPTION FACTORS;

EID: 0030986189     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Aparicio, S., Morrison, A., Gould, A., Gilthorpe, J., Chaudhuri, C., Rigby, P. W. J., Krumlauf, R. and Brenner, S. (1995). Detecting conserved regulatory elements with the model genome of the Japanese puffer fish (Fugu rubripes). Proc. Natl. Acad. Sci. USA 92, 1684-1688.
2. Bergson, C. and McGinnis, W. (1990). An autoregulatory enhancer element of the Drosophila homeotic gene Deformed. EMBO J. 9, 4287-97.
3. Botas, J. (1993). Control of morphogenesis and differentiation by HOM/Hox genes. Curr. Op. Cell. Biol. 5, 1015-1022.
4. Burglin, T. (1994). A comprehensive classification of homeobox genes. In Guidebook to the Homeobox Genes (ed. D. Duboule), pp. 26-71. Oxford, UK: Oxford University Press.
5. Chan, S.-K., Jaffe, L., Capovilla, M., Botas, J. and Mann, R. S. (1994). The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell 78, 603-615.
6. Chan, S.-K. and Mann, R. S. (1993). The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences. Genes Dev. 7, 796-811.
7. Chan, S.-K. and Mann, R. S. (1996). A structural model for an extradenticle-HOX-DNA complex accounts for the choice of HOX protein in the heterodimer. Proc. Natl. Acad. Sci. USA 93, 5223-5228.
8. Chan, S.-K., Pöpperl, H., Krumlauf, R. and Mann, R. S. (1996). An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif. EMBO J. 15, 2477-2488.
9. Chang, C.-P., Brocchieri, L., Shen, W.-F., Largman, C. and Cleary, M. (1996). Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the HOX locus. Mol. Cell Biol. 16, 1734-1745.
10. Chang, C.-P., Shen, W.-F., Rozenfeld, S., Lawrence, H. J., Largman, C. and Cleary, M. (1995). Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox Proteins. Genes Dev. 9, 663-674.
11. Chouinard, S. and Kaufman, T. C. (1991). Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster: evidence for both positive and negative autogenous regulation. Development 113, 1267-1280.
12. Desplan, C., Theis, J. and O'Farrell, P. H. (1988). The sequence specificity of homeodomain-DNA interaction. Cell 54, 1081-90.
13. Ekker, S., von Kessler, D. and Beachy, P. (1992). Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J. 11, 4059-4072.
14. Ekker, S. C., Jackson, D. G., von Kessler, D. P., Sun, B. I., Young, K. E. and Beachy, P. A. (1994). The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J. 13, 3551-3560.
15. Ekker, S. C., Young, K. E., von Kessler, D. P. and Beachy, P. A. (1991) Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila. EMBO J. 10, 1179-86.
16. Furukubo-Tokunaga, K., Flister, S. and Gehring, W. J. (1993). Functional specificity of the Antennapedia homeodomain. Proc. Natl. Acad. Sci. USA 90, 6360-4.
17. Garcia-Bellido, A. (1975). Genetic control of wing disc development in Drosophila. In Cell Patterning, Ciba Found Symp. (ed. S. Brenner), pp. ?? Associated Scientific Publishers, New York.
18. Gehring, W. J., Qian, Y. Q., Billeter, M., Furukubo-Tokunaga, K., Schier, A. F., Resendez-Perez, D., Affolter, M., Otting, G. and Wuthrich, K. (1994) Homeodomain-DNA recognition. Cell 78, 211-23.
19. Gonzalez-Crespo, S. and Morata, G. (1995). Control of Drosophila adult pattern by extradenticle. Development 121, 2117-2125.
20. Gould, A., Morrison, A., Sproat, G., White, R. and Krumlauf, R. (1997). Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns. Genes Dev. 11, 900-913.
21. Goutte, C. and Johnson, A. D. (1993). Yeast a1 and alpha 2 homeodomain proteins form a DNA-binding activity with properties distinct from those of either protein. J. Mol. Biol. 233, 359-71.
22. Goutte, C. and Johnson, A. D. (1994). Recognition of a DNA operator by a dimer composed of two different homeodomain proteins. EMBO J. 13, 1434-42.
23. Gross, C. T. and McGinnis, W. (1996). DEAF-1, a novel protein that binds an essential region in a Deformed response element. EMBO J. 15, 1961-70.
24. Harding, K. W., Gellon, G., McGinnis, N. and McGinnis, W. (1995) A screen for modifiers of Deformed function in Drosophila. Genetics 140, 1339-52.
25. Hoey, T. and Levine, M. (1988). Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature 332, 858-861.
26. Kalionis, B. and O'Farrell, P. H. (1993). A universal target sequence is bound in vitro by diverse homeodomains. Mech. Dev. 43, 57-70.
27. Kuziora, M. A. and McGinnis, W. (1988). Autoregulation of a Drosophila homeotic selector gene. Cell 55, 477-85.
28. Laughon, A. (1991). DNA binding specificity of homeodomains. Biochemistry 30, 11357-67.
29. Lou, L., Bergson, C. and McGinnis, W. (1995). Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer. Nucl. Acids Res. 23, 3481-7.
30. Lu, Q. and Kamps, M. (1996). Structural determinants of Pbx1 mediating cooperative DNA-binding with pentapeptide-containing HOX proteins. Mol. Cell Biol. 16, 1632-1640.
31. Lu, Q., Knoepfler, P., Scheele, J., Wright, D. and Kamps, M. (1995). Both Pbx1 and E2A-Pbx1 bind the DNA m,otif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell Biol. 15, 3786-3795.
32. Mann, R. and Abu-Shaar, M. (1996). Nuclear import of the homeodomain protein Extradenticle in response to Decapentaplegic and Wingless signalling. Nature 383, 630-633.
33. Mann, R. S. (1995). The specificity of homeotic gene function. BioEssays 17, 855-863.
34. Mann, R. S. and Chan, S.-K. (1996). Extra specificity from extradenticle: The partnership between HOX and exd/pbx homeodomain proteins. Trends Genet. 12, 258-262.
35. McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68, 283-302.
36. Morrison, A., Chaudhuri, C., Ariza-McNaughton, L., Muchamore, I., Kuroiwa, A. and Krumlauf, R. (1995). Comparative analysis of chicken Hoxb-4 regulation in transgenic mice. Mech. Dev. 53, 47-59.
37. Peifer, M. and Wieschaus, E. (1990). Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity. Genes Dev. 4, 1209-1223.
38. Peltenburg, L. T. C. and Murre, C. (1996). Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx. EMBO J. 15, 3385-3393.
39. Phelan, M. L., Rambaldi, I. and Featherstone, M. (1995). Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol. Cell Biol. 15, 3989-3997.
40. Pöpperl, H., Bienz, M., Studer, M., Chan, S.-K., Aparicio, S., Brenner, S., Mann, R. and Krumlauf, R. (1995). Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx. Cell 81, 1031-1042.
41. Pöpperl, H. and Featherstone, M. S. (1992). An autoregulatory element of the murine Hox-4.2 gene. EMBO J. 11, 3673-3680.
42. Rauskolb, C., Peifer, M. and Wieschaus, E. (1993). extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell 74, 1-20.
43. Rauskolb, C., Smith, K., Peifer, M. and Wieschaus, E. (1995). extradenticle determines segmental identities throughout development. Development 121, 3663-3671.
44. Rauskolb, C. and Wieschaus, E. (1994). Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins. EMBO J. 13, 3561-3569.
45. Regulski, M., Dessain, S., McGinnis, N. and McGinnis, W. (1991). High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene. Genes Dev. 5, 278-286.
46. Shen, W. F., Chang, C. P., Rozenfeld, S., Sauvageau, G., Humphries, R. K., Lu, M., Lawrence, H. J., Cleary, M. L. and Largman, C. (1996). Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA. Nucl. Acids Res. 24, 898-906.
47. Tremml, G. and Bienz, M. (1992). Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation. Development 116, 447-456.
48. van Dijk, M. and Murre, C. (1994). extradenticle raises the DNA binding specificity of homeotic selector gene products. Cell 78, 617-624.
49. Vincent, J. P., Kassis, J. A. and O'Farrell, P. H. (1990). A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos. EMBO J. 9, 2573-2578.
50. Wilkinson, D. G., Bhatt, S., Cook, M., Boncinelli, E. and Krumlauf, R. (1989). Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature 341, 405-9.
51. Xue, D., Finney, M., Ruvkun, G. and Chalfie, M. (1992). Regulation of the mec-3 gene by the C. elegans homeoproteins UNC-86 and MEC-3. EMBO J. 11, 4969-79.
52. Xue, D., Tu, Y. and Chalfie, M. (1993). Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3. Science 261, 1324-8.
53. Zeng, C., Pinsonneault, J., Gellon, G., McGinnis, N. and McGinnis, W. (1994) Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos. EMBO J. 13, 2362-77.
54. Zeng, W., Andrew, D. J., Mathies, L. D., Horner, M. A. and Scott, M. P. (1993). Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomian is critical to functional specificity. Development 118, 339-352.