Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage

Free Radical Biology and Medicine

Volumn 22, Issue 3, 1997, Pages 479-487

  Kumagai, Yoshito ^a,c   Arimoto, Toyoko ^b   Shinyashiki, Masaru ^c   Shimojo, Nobuhiro ^c   Nakai, Yumi ^b   Yoshikawa, Toshikazu ^d   Sagai, Masaru ^b  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Active oxygen; Bioactivation; Diesel exhaust particles; DNA damage; Free radicals; NADPH cytochrome P450 reductase

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; FREE RADICAL; GLUTATHIONE; HYDROXYL RADICAL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; ARTICLE; DNA DAMAGE; ELECTRON SPIN RESONANCE; ENZYME ACTIVATION; ENZYME SUBSTRATE; EXHAUST GAS; LUNG TOXICITY; MALE; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALS; BOROHYDRIDES; DNA DAMAGE; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLUTATHIONE; HYDROXYL RADICAL; MALE; MICE; MICE, INBRED ICR; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; SUPEROXIDES; VEHICLE EMISSIONS;

EID: 0031034402     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(96)00341-3     Document Type: Article

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