Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils

Journal of Allergy and Clinical Immunology

Volumn 109, Issue 5, 2002, Pages 847-853

  Devouassoux, Gilles ^a   Saxon, Andrew ^a   Metcalfe, Dean D ^a   Prussin, Calman ^a   Colomb, Maurice G ^a   Brambilla, Christian ^a   Diaz Sanchez, David ^a  

^a University of California   (United States)

Author keywords

Allergy; Basophil; Diesel exhaust particles; Histamine; IL 4; Pollution

Indexed keywords

ACETYLCYSTEINE; HISTAMINE; IMMUNOGLOBULIN E; INTERLEUKIN 4;

ALLERGIC DISEASE; ARTICLE; BASOPHIL; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXHAUST GAS; FLOW CYTOMETRY; HISTAMINE RELEASE; HUMAN; KINETICS; PATHOGENESIS; POLLUTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0036252482     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.122843     Document Type: Article

References (36)

1. Upper respiratory tract environmental tobacco smoke sensitivity
2. Global increases in allergic respiratory disease: The possible role of diesel exhaust particles
3. Effects of environment on atopic status and respiratory disorders in children
4. Effects of diesel organic extracts on chemokine production by peripheral blood mononuclear cells
5. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers
6. Airway inflammation after controlled exposure to diesel exhaust particulates
7. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice
8. Combined nasal challenge with diesel exhaust particles and allergen induces in vivo IgE isotype switching
9. Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles
10. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern
11. Diesel exhaust particulates for the production of IgE antibody in mice
12. Effects of inhaled diesel exhaust on immune responses after lung immunization
13. IL-4 production in mediastinal lymph node cells in mice intratracheally instilled with diesel exhaust particulates and antigen
14. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms
15. The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease
16. Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived
17. Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: A study with a new cell exposure system to freshly generated DE in vitro
18. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways
19. Involvement of altered B7 expression in dioxin immunotoxicity: B7 transfection restores the CTL but not the autoantibody response to the P815 mastocytoma
20. Exposure to diesel exhaust aggravates nasal allergic reaction in guinea pigs
21. Airway inflammation following exposure to diesel exhaust: A study of time kinetics using induced sputum
22. Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa
23. Frequency and characterization of antigen-specific IL-4- and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects
24. Macrophage activation by polycyclic aromatic hydrocarbons: Evidence for the involvement of stress-activated protein kinases, activator protein-1, and antioxidant response elements
25. Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse
26. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages
27. The adjuvancy activity of pyrene in diesel exhaust particles on IgE antibody production in mice
28. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
29. CD40 and IgE: Synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells
30. Diesel exhaust enhances allergic airway inflammation and hyperresponsiveness in mice
31. Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity
32. Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation
33. Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: Importance in cytokine transcription
34. An essential role for free radicals and derived species in signal transduction
35. Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver
36. Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression