Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones

Experimental Gerontology

Volumn 31, Issue 6, 1996, Pages 655-668

  Pawelec, Graham ^a,d   Sansom, David ^b   Rehbein, Arnika ^a   Adibzadeh, Medi ^a   Beckman, Ian ^a,c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Bath Inst for Rheumatic Diseases   (United Kingdom)

^c FLINDERS MEDICAL CENTRE   (Australia)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

activation induced cell death; CD28; costimulation; immunosenescence; T lymphocyte aging; T lymphocyte clones; T lymphocyte proliferation

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; FAS ANTIGEN; INTERLEUKIN 2; LYMPHOCYTE SURFACE MARKER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CYTOTOXICITY; GENETIC TRANSFECTION; HELPER CELL; HUMAN; HUMAN CELL; LIFESPAN; MIXED LYMPHOCYTE CULTURE; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0030297442     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(96)00097-6     Document Type: Article

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