Age-related accumulation of oxidative DNA damage and alterations in levels of p16INK4a/CDKN2a, p21WAF1/CIP1/SDI1 and p27KIP1 in human CD4+ T cell clones in vitro

Mechanisms of Ageing and Development

Volumn 122, Issue 11, 2001, Pages 1151-1167

  Hyland, Paul ^a   Barnett, Christopher ^a   Pawelec, Graham ^b   Barnett, Yvonne ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Cyclin dependent kinase inhibitors; Oxidative DNA damage; P16; P21; P27; T cell clone replicative lifespans

Indexed keywords

CD4 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR; DNA; MESSENGER RNA; PROTEIN P16; PROTEIN P21; PROTEIN P27; REACTIVE OXYGEN METABOLITE;

AGING; APOPTOSIS; ARTICLE; CELL LEVEL; CELL SURVIVAL; COMET ASSAY; CONTROLLED STUDY; CYTOLOGY; DNA DAMAGE; HUMAN; HUMAN CELL; LIFESPAN; LYMPHOCYTE CLONE; OXIDATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; AGING; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL CYCLE PROTEINS; CELL DIVISION; CELL FRACTIONATION; CELLS, CULTURED; CLONE CELLS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; DNA; DNA DAMAGE; HUMANS; MIDDLE AGED; OXIDATION-REDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0035018928     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00254-8     Document Type: Article

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