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Volumn 95, Issue 9, 2000, Pages 2860-2868

Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN;

EID: 0034194058     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.9.2860.009k35_2860_2868     Document Type: Article
Times cited : (446)

References (55)
  • 1
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: Understanding their relation
    • Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science. 1996;272:54.
    • (1996) Science , vol.272 , pp. 54
    • Ahmed, R.1    Gray, D.2
  • 2
    • 0024833875 scopus 로고
    • Effects of aging on the immune system
    • Weigle WO. Effects of aging on the immune system. Hosp Prac. 1989;24:112.
    • (1989) Hosp Prac. , vol.24 , pp. 112
    • Weigle, W.O.1
  • 3
    • 0027381336 scopus 로고
    • Lymphocyte subsets and natural killer activity in healthy old people and centenarians
    • Sansoni P, Cossarizza A, Brianti V, et al. Lymphocyte subsets and natural killer activity in healthy old people and centenarians. Blood. 1993;82: 2767.
    • (1993) Blood , vol.82 , pp. 2767
    • Sansoni, P.1    Cossarizza, A.2    Brianti, V.3
  • 4
    • 0030035583 scopus 로고    scopus 로고
    • The aging immune system: Primer and prospectus
    • Miller RA. The aging immune system: primer and prospectus. Science. 1996;273:70.
    • (1996) Science , vol.273 , pp. 70
    • Miller, R.A.1
  • 5
    • 0029000748 scopus 로고
    • Molecular alterations in the aging immune system
    • Hodes RJ. Molecular alterations in the aging immune system. J Exp Med. 1995;182:1.
    • (1995) J Exp Med. , vol.182 , pp. 1
    • Hodes, R.J.1
  • 6
    • 0028891555 scopus 로고
    • The immunology of exceptional individual: The lesson of centenarians
    • Franceschi C, Monti D, Sansoni P, Cossarizza A. The immunology of exceptional individual: the lesson of centenarians. Immunol Today. 1995;16: 12.
    • (1995) Immunol Today , vol.16 , pp. 12
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossarizza, A.4
  • 7
    • 0028812436 scopus 로고
    • Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy
    • Mackall CL, Fleisher TA, Brown MR, et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med. 1995;332:143.
    • (1995) N Engl J Med. , vol.332 , pp. 143
    • Mackall, C.L.1    Fleisher, T.A.2    Brown, M.R.3
  • 8
    • 0022377731 scopus 로고
    • The involution of the aging human thymic epithelium is independent of puberty: A morphometric study
    • Steinman GG, Klaus B, Muller-Hermenlink KH. The involution of the aging human thymic epithelium is independent of puberty: a morphometric study. Scand J Immunol. 1985;22:563.
    • (1985) Scand J Immunol. , vol.22 , pp. 563
    • Steinman, G.G.1    Klaus, B.2    Muller-Hermenlink, K.H.3
  • 9
    • 17444372347 scopus 로고    scopus 로고
    • Changes in thymic function with age and during the treatment of HIV infection
    • Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection Nature. 1998;396: 690.
    • (1998) Nature , vol.396 , pp. 690
    • Douek, D.C.1    McFarland, R.D.2    Keiser, P.H.3
  • 10
    • 17444379333 scopus 로고    scopus 로고
    • Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
    • Hellerstein M, Hanley MB, Cesar D, et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat Med. 1999;5:83.
    • (1999) Nat Med. , vol.5 , pp. 83
    • Hellerstein, M.1    Hanley, M.B.2    Cesar, D.3
  • 11
    • 0030913588 scopus 로고    scopus 로고
    • T-cell regeneration: All repertoires are not created equal
    • Mackall CL, Hakim FT, Gress RE. T-cell regeneration: all repertoires are not created equal. Immunol Today. 1997;18:245.
    • (1997) Immunol Today , vol.18 , pp. 245
    • Mackall, C.L.1    Hakim, F.T.2    Gress, R.E.3
  • 12
    • 0023934515 scopus 로고
    • Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CD29, and Pgp-1) and have enhanced IFN-g production
    • Sanders ME, Makgoba MW, Sharrow SO, et al. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CD29, and Pgp-1) and have enhanced IFN-g production. J Immunol. 1988;140: 1401.
    • (1988) J Immunol. , vol.140 , pp. 1401
    • Sanders, M.E.1    Makgoba, M.W.2    Sharrow, S.O.3
  • 13
    • 0027262235 scopus 로고
    • Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition
    • Picker LJ, Treer JR, Ferguson DB, Collins PA, Buck, D, Terstappen LW. Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. J Immunol. 1993;150:1105.
    • (1993) J Immunol. , vol.150 , pp. 1105
    • Picker, L.J.1    Treer, J.R.2    Ferguson, D.B.3    Collins, P.A.4    Buck, D.5    Terstappen, L.W.6
  • 14
    • 0027935476 scopus 로고
    • Antigen-independent activation of naive and memory resting T cells by a cytokine combination
    • Unutmaz D, Pileri P, Abrignani S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med. 1994;180:1159.
    • (1994) J Exp Med. , vol.180 , pp. 1159
    • Unutmaz, D.1    Pileri, P.2    Abrignani, S.3
  • 15
    • 0023893710 scopus 로고
    • Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells
    • Akbar AN, Terry L, Beverley PCL, Janossy G. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol. 1988;140: 2171.
    • (1988) J Immunol. , vol.140 , pp. 2171
    • Akbar, A.N.1    Terry, L.2    Beverley, P.C.L.3    Janossy, G.4
  • 16
    • 0026445567 scopus 로고
    • Lifespan of human lymphocyte subsets defined by CD45 isoforms
    • Michie CA, McLean A, Alcock C, Beverley PCL. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature. 1992;360:264.
    • (1992) Nature , vol.360 , pp. 264
    • Michie, C.A.1    McLean, A.2    Alcock, C.3    Beverley, P.C.L.4
  • 18
    • 0025973989 scopus 로고
    • Cyclic regulation of CD45 isoform expression in a long term human CD4+ CD45rA+ T cell line
    • Rothstein DM, Yamada A, Schlossmann SF, Morimoto C. Cyclic regulation of CD45 isoform expression in a long term human CD4+ CD45RA+ T cell line. J Immunol. 1991;146:1175.
    • (1991) J Immunol. , vol.146 , pp. 1175
    • Rothstein, D.M.1    Yamada, A.2    Schlossmann, S.F.3    Morimoto, C.4
  • 19
    • 0028153999 scopus 로고
    • + peripheral blood lymphocytes
    • + peripheral blood lymphocytes. J Exp Med. 1994;179:857.
    • (1994) J Exp Med. , vol.179 , pp. 857
    • Roth, M.D.1
  • 22
    • 0032104145 scopus 로고    scopus 로고
    • High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
    • McCune JM, Lottus R, Schmidt DK, et al. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest. 1998;101:2301.
    • (1998) J Clin Invest. , vol.101 , pp. 2301
    • McCune, J.M.1    Lottus, R.2    Schmidt, D.K.3
  • 23
    • 0025916387 scopus 로고
    • The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
    • Itoh N, Yonehara S, Ishii A, et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 1991; 66:233.
    • (1991) Cell , vol.66 , pp. 233
    • Itoh, N.1    Yonehara, S.2    Ishii, A.3
  • 24
    • 0024347970 scopus 로고
    • Monoclonal antibody-mediated tumor regression by induction of apoptosis
    • Trauth BC, Klas C, Peters AMJ, et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science. 1989;245:301.
    • (1989) Science , vol.245 , pp. 301
    • Trauth, B.C.1    Klas, C.2    Peters, A.M.J.3
  • 25
    • 0028226620 scopus 로고
    • Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes
    • Yoshino T, Kondo E, Cao L, et al. Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood. 1994;83:1856.
    • (1994) Blood , vol.83 , pp. 1856
    • Yoshino, T.1    Kondo, E.2    Cao, L.3
  • 26
    • 0028299065 scopus 로고
    • The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis
    • Salmon M, Pilling D, Borthwick NJ, et al. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur J Immunol. 1994;24:892.
    • (1994) Eur J Immunol. , vol.24 , pp. 892
    • Salmon, M.1    Pilling, D.2    Borthwick, N.J.3
  • 27
    • 0026645139 scopus 로고
    • Apoptotic cell death of primed CD45RO+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis
    • Uehara T, Miyawaki T, Ohta K, et al. Apoptotic cell death of primed CD45RO+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis. Blood. 1992;80:452.
    • (1992) Blood , vol.80 , pp. 452
    • Uehara, T.1    Miyawaki, T.2    Ohta, K.3
  • 28
    • 0026497684 scopus 로고
    • Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood
    • Miyawaki T, Uehara T, Nibu R, et al. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol. 1992;149:3753.
    • (1992) J Immunol. , vol.149 , pp. 3753
    • Miyawaki, T.1    Uehara, T.2    Nibu, R.3
  • 29
    • 0029012097 scopus 로고
    • Differential expression of Fas antigen and Bcl-2 protein on CD4+ T cells, CD8+ T cells, and monocytes
    • Shinohara S, Sawada T, Nishioka Y, et al. Differential expression of Fas antigen and Bcl-2 protein on CD4+ T cells, CD8+ T cells, and monocytes. Cell Immunol. 1995;163:303.
    • (1995) Cell Immunol. , vol.163 , pp. 303
    • Shinohara, S.1    Sawada, T.2    Nishioka, Y.3
  • 30
    • 0030981153 scopus 로고    scopus 로고
    • Susceptibility of apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors
    • Phelouzat MA, Laforge T, Arbogast A, Quadri RA, Boutet S, Proust J. Susceptibility of apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors. Mach Aging Dev. 1997;96:35.
    • (1997) Mach Aging Dev. , vol.96 , pp. 35
    • Phelouzat, M.A.1    Laforge, T.2    Arbogast, A.3    Quadri, R.A.4    Boutet, S.5    Proust, J.6
  • 32
    • 0032519426 scopus 로고    scopus 로고
    • Increased apoptosis of T cell subsets in aging humans: Altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax
    • Aggarwal S, Gupta S. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J Immunol. 1998;160:1627.
    • (1998) J Immunol. , vol.160 , pp. 1627
    • Aggarwal, S.1    Gupta, S.2
  • 33
    • 0029048581 scopus 로고
    • Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals
    • Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med. 1995;181:2029.
    • (1995) J Exp Med. , vol.181 , pp. 2029
    • Katsikis, P.D.1    Wunderlich, E.S.2    Smith, C.A.3    Herzenberg, L.A.4    Herzenberg, L.A.5
  • 34
    • 0028329009 scopus 로고
    • The apoptosis-1/ Fas protein in human systemic lupus erythematosus
    • Mysler E, Bini P, Drappa J, et al. The apoptosis-1/ Fas protein in human systemic lupus erythematosus. J Clin Invest. 1994;93:1029.
    • (1994) J Clin Invest. , vol.93 , pp. 1029
    • Mysler, E.1    Bini, P.2    Drappa, J.3
  • 35
    • 0025336034 scopus 로고
    • Necessity of the assessment of health status in human immunogerontological studies: Evaluation of the Senieur protocol
    • Ligthart GJ, Corberand JK, Geertzen HGM, et al. Necessity of the assessment of health status in human immunogerontological studies: evaluation of the Senieur protocol. Mech Aging Dev. 1990; 55:89.
    • (1990) Mech Aging Dev. , vol.55 , pp. 89
    • Ligthart, G.J.1    Corberand, J.K.2    Geertzen, H.G.M.3
  • 37
    • 15844364600 scopus 로고    scopus 로고
    • CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians/ implications for T cell memory
    • Cossarizza A, Ortolani C, Paganelli R, et al. CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians/ implications for T cell memory. Mech Ageing Dev. 1996;86:173.
    • (1996) Mech Ageing Dev. , vol.86 , pp. 173
    • Cossarizza, A.1    Ortolani, C.2    Paganelli, R.3
  • 38
    • 0030024279 scopus 로고    scopus 로고
    • Immunology taught by viruses
    • Zinkernagel RM. Immunology taught by viruses. Science. 1996;271:173.
    • (1996) Science , vol.271 , pp. 173
    • Zinkernagel, R.M.1
  • 39
    • 0343989554 scopus 로고    scopus 로고
    • Infection, host defense, and mucosal immunity
    • Abraham GN, McCormick AM, Albright Y, Goldstein AD, eds. Rockville, MD: US Depart of Health and Human Services. NIH Publication 96-4018
    • Iglewski BH, Lamm ME, Doherty PC, et al. Infection, host defense, and mucosal immunity. In: Abraham GN, McCormick AM, Albright Y, Goldstein AD, eds. Report of the Task Force on Immunology and Aging. Rockville, MD: US Depart of Health and Human Services; 1996;51. NIH Publication 96-4018.
    • (1996) Report of the Task Force on Immunology and Aging , pp. 51
    • Iglewski, B.H.1    Lamm, M.E.2    Doherty, P.C.3
  • 40
    • 0014949096 scopus 로고
    • An immunological approach to aging
    • Burnet FM. An immunological approach to aging. Lancet. 1970;2:358.
    • (1970) Lancet , vol.2 , pp. 358
    • Burnet, F.M.1
  • 41
  • 42
    • 0032163414 scopus 로고    scopus 로고
    • Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood
    • Aspinall R, Carroll J, Jiang S. Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood. Exp Gerontol. 1998;33:581.
    • (1998) Exp Gerontol. , vol.33 , pp. 581
    • Aspinall, R.1    Carroll, J.2    Jiang, S.3
  • 43
    • 0027221526 scopus 로고
    • + T cells contain cells with high levels of lymphocyte function-associated antigen-1 expression, a phenotype of primed T cells
    • + T cells contain cells with high levels of lymphocyte function-associated antigen-1 expression, a phenotype of primed T cells. J Immunol. 1993;150:429.
    • (1993) J Immunol. , vol.150 , pp. 429
    • Okumura, M.1    Fujii, Y.2    Inada, K.3    Makahara, K.4    Matsuda, H.5
  • 45
    • 0031715650 scopus 로고    scopus 로고
    • Age-related modifications of the human alpha-beta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets
    • Wack A, Cossarizza A, Heltal S, et al. Age-related modifications of the human alpha-beta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol. 1998;10: 1281.
    • (1998) Int Immunol. , vol.10 , pp. 1281
    • Wack, A.1    Cossarizza, A.2    Heltal, S.3
  • 47
    • 0033559127 scopus 로고    scopus 로고
    • Postthymic development of CD28-CD8+ T cells subsets: Age-associated expansion and shift from memory to naive phenotype
    • Nociari MM, Telford W, Russo C. Postthymic development of CD28-CD8+ T cells subsets: age-associated expansion and shift from memory to naive phenotype. J Immunol. 1999;162:3327.
    • (1999) J Immunol. , vol.162 , pp. 3327
    • Nociari, M.M.1    Telford, W.2    Russo, C.3
  • 48
    • 0029968318 scopus 로고    scopus 로고
    • Shortened telemores in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+ CD8+ counterparts
    • Monteiro J, Batliwalla F, Ostrer H, Gregersen PK. Shortened telemores in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+ CD8+ counterparts. J Immunol. 1996;156:3587.
    • (1996) J Immunol. , vol.156 , pp. 3587
    • Monteiro, J.1    Batliwalla, F.2    Ostrer, H.3    Gregersen, P.K.4
  • 49
    • 0027976958 scopus 로고
    • Clonal populations of T cells in normal elderly humans: The T cell equivalent to "benign monoclonal gammapathy."
    • Posnett DN, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy." J Exp Med. 1994;179:609.
    • (1994) J Exp Med. , vol.179 , pp. 609
    • Posnett, D.N.1    Sinha, R.2    Kabak, S.3    Russo, C.4
  • 50
    • 17144440358 scopus 로고    scopus 로고
    • Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy
    • Mackall CL, Fleisher TA, Brown MR, et al. Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood. 1997;89:3700.
    • (1997) Blood , vol.89 , pp. 3700
    • Mackall, C.L.1    Fleisher, T.A.2    Brown, M.R.3
  • 51
    • 0030833497 scopus 로고    scopus 로고
    • Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells
    • Hakim FT, Cepeda R, Kaimei S, et al. Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood. 1997;90: 3789.
    • (1997) Blood , vol.90 , pp. 3789
    • Hakim, F.T.1    Cepeda, R.2    Kaimei, S.3
  • 52
    • 0031964216 scopus 로고    scopus 로고
    • Contribution of CD4+, CD8+ CD28+, and CD8+ CD28-T cells to CD3+ Lymphocyte homeostasis during the natural course of HIV-1 infection
    • Caruso A, Licenziati S, Canaris AD, et al. Contribution of CD4+, CD8+ CD28+, and CD8+ CD28-T cells to CD3+ Lymphocyte homeostasis during the natural course of HIV-1 infection. J Clin Invest. 1998;101:137.
    • (1998) J Clin Invest. , vol.101 , pp. 137
    • Caruso, A.1    Licenziati, S.2    Canaris, A.D.3
  • 53
    • 0031907427 scopus 로고    scopus 로고
    • Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
    • Gorochov G, Neumann AU, Kereveur A, et al. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat Med. 1998;4:215.
    • (1998) Nat Med. , vol.4 , pp. 215
    • Gorochov, G.1    Neumann, A.U.2    Kereveur, A.3
  • 54
    • 0029009021 scopus 로고
    • T-cell dynamics of immunodeficiency
    • Roederer M. T-cell dynamics of immunodeficiency. Nat Med. 1995;1:621.
    • (1995) Nat Med. , vol.1 , pp. 621
    • Roederer, M.1
  • 55
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran B, Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science. 1997;277:112.
    • (1997) Science , vol.277 , pp. 112
    • Autran, B.1    Carcelain, G.2    Li, T.S.3


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