DNA damage responses to oxidative stress

DNA Repair

Volumn 3, Issue 8-9, 2004, Pages 1109-1115

  Barzilai, Ari ^a   Yamamoto, Ken Ichi ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Damage; DNA; Oxidative stress

Indexed keywords

ATM PROTEIN;

AEROBIC CELL CULTURE; APOPTOSIS; CELL CYCLE; CELL FATE; CELL HYPOXIA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; EXCISION REPAIR; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW;

ANIMALS; ANOXIA; APOPTOSIS; CELL CYCLE; CELL LINEAGE; DNA DAMAGE; DNA REPAIR; HUMANS; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

ZIZIPHUS MAURITIANA;

EID: 3242886115     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2004.03.002     Document Type: Review

References (74)

1. Zhou B.B., Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature. 408(6811):2000;433-439
2. Iliakis G., et al. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene. 22(37):2003;5834-5847
3. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3(3):2003;155-168
4. Rich T., et al. Defying death after DNA damage. Nature. 407(6805):2000;777-783
5. van Gent D.C., et al. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2(3):2001;196-206
6. Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27(3):2001;247-254
7. D'Amours D., Jackson S.P. The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 3(5):2002;317-327
8. Petrini J.H., Stracker T.H. The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 13(9):2003;458-462
9. Van Den Bosch M., et al. The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep. 4(9):2003;844-849
10. T. Uziel, Y. Lerenthal, L. Moyal, Y. Andegeko, L. Mittelman, Y. Shiloh, Requirement of MRN complex for ATM activation, EMBO J. 22 (2003) 5612-5621.
11. Redon C., et al. Histone H2A variants H2AX and H2AZ. Curr. Opin. Genet. Dev. 12(2):2002;162-169
12. Hammond E.M., et al. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J. Biol. Chem. 278(14):2003;12207-12213
13. Huang X., et al. DNA damage induced by DNA topoisomerase I- and topoisomerase II inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis. Cell Cycle. 2(6):2003;614-619
14. Foray N., et al. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J. 22(11):2003;2860-2871
15. Maser R.S., et al. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell Biol. 17(10):1997;6087-6096
16. Nelms B.E., et al. In situ visualization of DNA double-strand break repair in human fibroblasts. Science. 280(5363):1998;590-592
17. Shiloh Y. ATM and ATR: networking cellular responses to DNA damage. Curr. Opin. Genet. Dev. 11(1):2001;71-77
18. Shiloh Y., Kastan M.B. ATM: genome stability, neuronal development, and cancer cross paths. Adv. Cancer Res. 83:2001;209-254
19. Abraham R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15(17):2001;2177-2196
20. Durocher D., Jackson S.P., et al. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13(2):2001;225-231
21. Khanna K.K. ATM, a central controller of cellular responses to DNA damage. Cell Death Differ. 8(11):2001;1052-1065
22. Lavin M.F., Shiloh Y. The genetic defect in ataxia-telangiectasia. Annu. Rev. Immunol. 15:1997;177-202
23. Stewart G.S., et al. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell. 99(6):1999;577-587
24. Digweed M., et al. Nijmegen breakage syndrome: consequences of defective DNA double strand break repair. Bioessays. 21(8):1999;649-656
25. Tauchi H., et al. Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. Genomics. 55(2):1999;242-247
26. Andegeko Y., et al. Nuclear retention of ATM at sites of DNA double strand breaks. J. Biol. Chem. 276(41):2001;38224-38230
27. Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421(6922):2003;499-506
28. DiTullio R.A. Jr., et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat. Cell Biol. 4(12):2002;998-1002
29. Fernandez-Capetillo O., et al. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4(12):2002;993-997
30. Wang B., et al. 53BP1 a mediator of the DNA damage checkpoint. Science. 298(5597):2002;1435-1438
31. Mochan T.A., et al. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res. 63(24):2003;8586-8591
32. Xu X., Stern D.F., et al. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 17(13):2003;1842-1848
33. Lou Z., et al. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J. Biol. Chem. 278(16):2003;13599-13602
34. Lou Z., et al. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature. 421(6926):2003;957-961
35. Goldberg M., et al. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature. 421(6926):2003;952-956
36. Wang Y., et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14(8):2000;927-939
37. Cortez D., et al. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science. 286(5442):1999;1162-1166
38. Gatei M., et al. Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res. 60(12):2000;3299-3304
39. Gatei M., et al. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J. Biol. Chem. 276(20):2001;17276-17280
40. Semenza G.L. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell. 107(1):2001;1-3
41. Porwol T. Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species. Respir. Physiol. 128(3):2001;331-348
42. Roy S., et al. Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart. J. Biol. Chem. 278(47):2003;47129-47135
43. Barzilai A., et al. ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair (Amst.). 1(1):2002;3-25
44. Reichenbach J., et al. Anti-oxidative capacity in patients with ataxia telangiectasia. Clin. Exp. Immunol. 117(3):1999;535-539
45. Yi M., et al. Response of fibroblast cultures from ataxia-telangiectasia patients to oxidative stress. Cancer Lett. 54(1-2):1990;43-50
46. Watters D.J. Oxidative stress in ataxia telangiectasia. Redox Rep. 8(1):2003;23-29
47. Shackelford R.E., et al. Desferrioxamine treatment increases the genomic stability of ataxia-telangiectasia cells. DNA Repair (Amst.). 2(9):2003;971-981
48. Kohen R., Nyska A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol. Pathol. 30(6):2002;620-650
49. Mitra S., et al. Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage. Environ. Mol. Mutagen. 38(2-3):2001;180-190
50. Charames G.S., Bapat B. Genomic instability and cancer. Curr. Mol. Med. 3(7):2003;589-596
51. Paz-Elizur T., et al. DNA repair activity for oxidative damage and risk of lung cancer. J. Natl. Cancer Inst. 95(17):2003;1312-1319
52. Cooper P.K., et al. Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G. Science. 275(5302):1997;990-993
53. Le Page F., et al. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. Cancer Res. 60(19):2000;5548-5552
54. Offer H., et al. p53 Modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress. Cancer Res. 61(1):2001;88-96
55. Offer H., et al. Structural and functional involvement of p53 in BER in vitro and in vivo. Oncogene. 20(5):2001;581-589
56. Davies K.J. The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life. 48(1):1999;41-47
57. Clopton D.A., Saltman P. Low-level oxidative stress causes cell-cycle specific arrest in cultured cells. Biochem. Biophys. Res. Commun. 210(1):1995;189-196
58. Leroy C., et al. Silent repair accounts for cell cycle specificity in the signaling of oxidative DNA lesions. EMBO J. 20(11):2001;2896-2906
59. Sharpless N.E., DePinho R.A. p53: good cop/bad cop. Cell. 110(1):2002;9-12
60. Migliaccio E., et al. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J. 16(4):1997;706-716
61. Migliaccio E., et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 402(6759):1999;309-313
62. Trinei M., et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene. 21(24):2002;3872-3878
63. Helt C.E., et al. p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity. Toxicol. Sci. 63(2):2001;214-222
64. Chen K., et al. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. J. Biol. Chem. 278(41):2003;39527-39533
65. Koumenis C., et al. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol. Cell Biol. 21(4):2001;1297-1310
66. Bresgen N., et al. Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis. J. Neurosci. Res. 72(3):2003;327-333
67. Shackelford R.E., et al. Oxidative stress and cell cycle checkpoint function. Free Radic. Biol. Med. 28(9):2000;1387-1404
68. Shackelford R.E., et al. The ataxia-telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J. Biol. Chem. 276(24):2001;21951-21959
69. Cicchillitti L., et al. Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130. J. Biol. Chem. 278(21):2003;19509-19517
70. Savitsky P.A., Finkel T. Redox regulation of Cdc25C. J. Biol. Chem. 277(23):2002;20535-20540
71. Schuller-Levis G.B., Park E. Taurine: new implications for an old amino acid. FEMS Microbiol. Lett. 226(2):2003;195-202
72. Golubnitschaja O., et al. DNA damage and expression of checkpoint genes p21(WAF1/CIP1) and 14-3-3 sigma in taurine-deficient cardiomyocytes. Biochem. Pharmacol. 66(3):2003;511-517
73. Pearce A.K., Humphrey T.C. Integrating stress-response and cell-cycle checkpoint pathways. Trends Cell Biol. 11(10):2001;426-433
74. Wang X., et al. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Mol. Cell Biol. 20(13):2000;4543-4552