Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

Environmental and Molecular Mutagenesis

Volumn 38, Issue 2-3, 2001, Pages 180-190

  Mitra, Sankar ^a   Boldogh, Istvan ^a   Izumi, Tadahide ^a   Hazra, Tapas K ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Base excision repair; Coordination of repair pathway; Oxidative DNA damage; Reactive oxygen species; Replication associated repair

Indexed keywords

DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA BASE; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE EPSILON; DNA GLYCOSYLTRANSFERASE; DNA POLYMERASE; NUCLEOTIDE; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; DNA ADDUCT; DNA DAMAGE; DNA REPLICATION; DNA STRAND; ENZYME REGULATION; ENZYME SPECIFICITY; EXCISION REPAIR; HUMAN; OXIDATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; DNA DAMAGE; DNA REPAIR; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

ZIZIPHUS MAURITIANA;

EID: 0035163137     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.1070     Document Type: Article

References (59)

1. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
2. DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
3. hMYH cell cycle dependent expression, subcellular localization, and association with replication foci: Evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs
4. Release of ultraviolet light-induced thymine dimmers from DNA in E. coli K-12
5. Reactions of oxyl radicals with DNA
6. p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex
7. Defective transcription coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G
8. Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts
9. Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta
10. DNA polymerase beta is required for efficient DNA strand break repair induced by methyl methane sulfonate but not by hydrogen peroxide
11. 6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli
12. Proliferating cell nuclear antigen facilitates excision in long-patch base excision repair
13. BRCA1 required for transcription-coupled repair of oxidative DNA damage
14. Mutagenesis by 8-oxoguanine: An enemy within
15. DNA damage in the nucleosome core is refractory to repair by human excision nuclease
16. Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis
17. The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation
18. Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII
19. Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: Potential coordination of the initial steps in base excision repair
20. Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease direct identification of Lys-212 as the active nucleophilic residue
21. Deletion analysis of human AP-endonuclease: Minimum sequence required for the endonuclease activity
22. Intragenic suppression of an active site mutation in the human apurinic/apyrimidinic endonuclease
23. Second pathway for completion of human DNA base excision-repair: Reconstitution with purified proteins and requirement for DNase IV (FEN1)
24. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
25. Reconstitution of DNA base excision-repair with purified human proteins: Interaction between DNA polymerase beta and the XRCC1 protein
26. Repair of alkylation and oxidative damage in mitochondrial DNA
27. Transcription coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences
28. Transcription-coupled repair of 8-oxoguanine: Requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome
29. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells
30. Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: An alternative pathway of base excision DNA repair
31. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair
32. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
33. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)
34. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice
35. Regulation of repair of alkylation damage in mammalian genomes
36. Complexities of DNA base excision repair in mammalian cells
37. DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
38. Junction ribonuclease: An activity in Okazaki fragment processing
39. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication
40. Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs
41. Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage
42. p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress
43. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria
44. 6-methylguanine to a protein cysteine residue
45. Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
46. Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair
47. Long patch base excision repair with purified human proteins
48. Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction
49. Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5′-deoxyribose phosphate lyase activities
50. FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair
51. The disappearance of thymine dimmers from DNA: An error correcting mechanism
52. DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract
53. Requirement of mammalian DNA polymerase-beta in base-excision repair
54. XRCC1 keeps DNA from getting stranded
55. Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP-endonuclease: Bypass of the AP lyase activity step
56. 6-methylguanine-acceptor protein in cell extracts
57. Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1
58. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair
59. Passing the baton in base excision repair