The hypoxic tumor microenvironment and gene expression

Seminars in Radiation Oncology

Volumn 14, Issue 3, 2004, Pages 207-214

  Leo, Cornelia ^a   Giaccia, Amato J ^a   Denko, Nicholas C ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; HELIX LOOP HELIX PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ANGIOGENESIS; APOPTOSIS; CANCER INHIBITION; CANCER INVASION; CELL METABOLISM; CYTOPATHOLOGY; DRUG TARGETING; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HYPOXIA; METASTASIS; MITOSIS INHIBITION; NONHUMAN; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SOLID TUMOR; TRANSCRIPTION REGULATION; TUMOR VASCULARIZATION;

EID: 3142622910     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semradonc.2004.04.007     Document Type: Article

References (68)

1. Hockel M., Schlenger K., Aral B., et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:1996;4509-4515
2. Nordsmark M., Overgaard M., Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 41:1996;31-39
3. Fyles A., Milosevic M., Hedley D., et al. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol. 20:2002;680-687
4. Brizel D.M., Scully S.P., Harrelson J.M., et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56:1996;941-943
5. Harris A.L. Hypoxia - A key regulatory factor in tumour growth. Nat Rev Cancer. 2:2002;38-47
6. Denko N.C., Giaccia A.J. Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis. Cancer Res. 61:2001;795-798
7. Graeber T.G., Osmanian C., Jacks T., et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 379:1996;88-91
8. Chen E.Y., Fujinaga M., Giaccia A.J. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology. 60:1999;215-225
9. Ryan H.E., Lo J., Johnson R.S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17:1998;3005-3015
10. Iyer N.V., Kotch L.E., Agani F., et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 α Genes Dev. 12:1998;149-162
11. Dvorak H.F. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 315:1986;1650-1659
12. Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 3:2003;721-732
13. Giaccia A., Siim B.G., Johnson R.S. HIF-1 as a target for drug development. Nat Rev Drug Discov. 2:2003;803-811
14. Wang G.L., Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem. 270:1995;1230-1237
15. Maxwell P.H., Wiesener M.S., Chang G.W., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275
16. Jaakkola P., Mole D.R., Tian Y.M., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 292:2001;468-472
17. Ivan M., Kondo K., Yang H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation Implications for O2 sensing. Science. 292:2001;464-468
18. Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 294:2001;1337-1340
19. Epstein A.C., Gleadle J.M., McNeill L.A., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107:2001;43-54
20. Lando D., Peet D.J., Gorman J.J., et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16:2002;1466-1471
21. Wenger R.H. Cellular adaptation to hypoxia O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 16:2002;1151-1162
22. Koong A.C., Chen E.Y., Mivechi N.F., et al. Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). Cancer Res. 54:1994;5273-5279
23. May M.J., Ghosh S. Rel/NF-kappa B and I kappa B proteins An overview. Semin Cancer Biol. 8:1997;63-73
24. Yan S.F., Lu J., Zou Y.S., et al. Hypoxia-associated induction of early growth response-1 gene expression. J Biol Chem. 274:1999;15030-15040
25. Paulding W.R., Czyzyk-Krzeska M.F. Hypoxia-induced regulation of mRNA stability. Adv Exp Med Biol. 475:2000;111-121
26. Czyzyk-Krzeska M.F., Bendixen A.C. Identification of the poly(C) binding protein in the complex associated with the 3′ untranslated region of erythropoietin messenger RNA. Blood. 93:1999;2111-2120
27. Levy N.S., Chung S., Furneaux H., et al. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem. 273:1998;6417-6423
28. Shih S.C., Claffey K.P. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. J Biol Chem. 274:1999;1359-1365
29. Denko N., Wernke-Dollries K., Johnson A.B., et al. Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. J Biol Chem. 278:2003;5744-5749
30. Koumenis C., Alarcon R., Hammond E., et al. Regulation of p53 by hypoxia Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol. 21:2001;1297-1310
31. Yun Z., Maecker H.L., Johnson R.S., et al. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13 A mechanism for regulation of adipogenesis by hypoxia. Dev Cell. 2:2002;331-341
32. Koumenis C., Naczki C., Koritzinsky M., et al. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α Mol Cell Biol. 22:2002;7405-7416
33. Denko N.C., Fontana L.A., Hudson K.M., et al. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene. 22:2003;5907-5914
34. Seagroves T.N., Ryan H.E., Lu H., et al. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol. 21:2001;3436-3444
35. Ebert B.L., Firth J.D., Ratcliffe P.J. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem. 270:1995;29083-29089
36. Wykoff C.C., Beasley N.J., Watson P.H., et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res. 60:2000;7075-7083
37. Hockel M., Schlenger K., Hockel S., et al. Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res. 59:1999;4525-4528
38. Bruick R.K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci U S A. 97:2000;9082-9087
39. Ohi N., Tokunaga A., Tsunoda H., et al. A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. Cell Death Differ. 6:1999;314-325
40. Kubasiak L.A., Hernandez O.M., Bishopric N.H., et al. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc Natl Acad Sci U S A. 99:2002;12825-12830
41. Alarcon R.M., Denko N.C., Giaccia A.J. Genetic determinants that influence hypoxia-induced apoptosis. Novartis Found Symp. 240:2001;115-128. discussion 128-132
42. Soengas M.S., Alarcon R.M., Yoshida H., et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science. 284:1999;156-159
43. Dong Z., Venkatachalam M.A., Wang J., et al. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. HIF-1-independent mechanisms. J Biol Chem. 276:2001;18702-18709
44. Schmedtje J.F. Jr, Ji Y.S., Liu W.L., et al. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem. 272:1997;601-608
45. Chiarugi V., Magnelli L., Gallo O. Cox-2, iNOS and p53 as play-makers of tumor angiogenesis. Int J Mol Med. 2:1998;715-719. (review)
46. Sun Y., Tang X.M., Half E., et al. Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res. 62:2002;6323-6328
47. Subbaramaiah K., Dannenberg A.J. Cyclooxygenase 2 a molecular target for cancer prevention and treatment. Trends Pharmacol Sci. 24:2003;96-102
48. Young S.D., Marshall R.S., Hill R.P. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A. 85:1988;9533-9537
49. Pennacchietti S., Michieli P., Galluzzo M., et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell. 3:2003;347-361
50. Bajou K., Noel A., Gerard R.D., et al. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat Med. 4:1998;923-928
51. Rofstad E.K., Rasmussen H., Galappathi K., et al. Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Res. 62:2002;1847-1853
52. Krishnamachary B., Berg-Dixon S., Kelly B., et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63:2003;1138-1143
53. Muller A., Homey B., Soto H., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 410:2001;50-56
54. Staller P., Sulitkova J., Lisztwan J., et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature. 425:2003;307-311
55. Zhong H., De Marzo A.M., Laughner E., et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 59:1999;5830-5835
56. Bos R., van der Groep P., Greijer A.E., et al. Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer. 97:2003;1573-1581
57. Birner P., Schindl M., Obermair A., et al. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 60:2000;4693-4696
58. Beasley N.J., Leek R., Alam M., et al. Hypoxia-inducible factors HIF-1α and HIF-2α in head and neck cancer Relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 62:2002;2493-2497
59. Airley R., Loncaster J., Davidson S., et al. Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin Cancer Res. 7:2001;928-934
60. Airley R.E., Loncaster J., Raleigh J.A., et al. GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix Relationship to pimonidazole binding. Int J Cancer. 104:2003;85-91
61. Loncaster J.A., Harris A.L., Davidson S.E., et al. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61:2001;6394-6399
62. Chia S.K., Wykoff C.C., Watson P.H., et al. Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J Clin Oncol. 19:2001;3660-3668
63. Swinson D.E., Jones J.L., Richardson D., et al. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol. 21:2003;473-482
64. West C.M., Cooper R.A., Loncaster J.A., et al. Tumor vascularity A histological measure of angiogenesis and hypoxia. Cancer Res. 61:2001;2907-2910
65. Hudson C.C., Liu M., Chiang G.G., et al. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol Cell Biol. 22:2002;7004-7014
66. Zundel W., Schindler C., Haas-Kogan D., et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14:2000;391-396
67. Blouw B., Song H., Tihan T., et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell. 4:2003;133-146
68. Brown J.M., Giaccia A.J. The unique physiology of solid tumors opportunities (and problems) for cancer therapy. Cancer Res. 58:1998;1408-1416